OrganismsChemicals and DrugsTechnology, Industry, Agriculture
ParabensPreservatives, PharmaceuticalCosmeticsFood PreservativesHydroxybenzoatesEndocrine DisruptorsTriclosanEnterobacter cloacae
TriclosanPhenolsPreservativesChemicalsMethyl parabenPropylparabenLevels of parabensPhthalates and parabensMethylparabenPropylCosmeticsBiomarker concentrationsUrinary concentrationsFormulasPreservativeSyntheticFragranceIngredientIngredientsToxicityUrinePharmaceuticalsSpoilageExposureHyaluronicBreast tissueProductsMedianCommonlyEstrogenEstimateFoundAlternativesSerumHighVitaminsHumanFreeConcernsProductFoodDissolveConclusion
Triclosan6
  • A sensitive method for measuring BPA, BP-3, triclosan, and four parabens was developed in 2005 (Ye et al. (cdc.gov)
  • Urine biomarkers of triclosan (TCS), triclocarban (TCC), parabens and benzophenone-3, bisphenols and dichlorophenols (DCP) were quantified by mass spectrometry. (biomedcentral.com)
  • Concerns about parabens and triclosan have been voiced from different sectors, and the European Commission has been monitoring these substances and limited their use. (nanowerk.com)
  • Parabens and triclosan keep bacteria and fungi from damaging shampoo and toothpaste, but they become a real problem once they get to the sea, where they affect the marine ecosystem. (nanowerk.com)
  • The study's primary author, University of Cordoba researcher María Teresa García Valverde, explains that "the combination of the Lab-on-valve system, titanium nanotubes modified with amorphous carbon as phase extraction and the measuring tool connected to the system, allows for quantifying parabens and triclosan at very low concentrations. (nanowerk.com)
  • Effects of postnatal exposure to phthalate, bisphenol a, triclosan, parabens, and per- and poly-fluoroalkyl substances on maternal postpartum depression and infant neurodevelopment: a korean mother-infant pair cohort study. (bvsalud.org)
Phenols7
  • Urinary environmental phenols and parabens were measured in a one third subsample of persons 6 years and older. (cdc.gov)
  • Many phenols and parabens are applied in cosmetics, pharmaceuticals and food, to prevent growth of bacteria and fungi. (biomedcentral.com)
  • We aimed to assess the associations of use of personal care products with urine biomarkers levels of phenols and paraben exposure, and whether urine levels (reflecting body burden of this chemical exposures) are associated with eczema, rhinitis, asthma, specific IgE and body mass index. (biomedcentral.com)
  • Reported frequency of use of personal care products correlated very well with urine biomarker levels of paraben and phenols. (biomedcentral.com)
  • Associations between maternal plasma measurements of inflammatory markers and urinary levels of phenols and parabens during pregnancy: a repeated measures study. (cdc.gov)
  • Urinary concentrations of phenols and phthalate metabolites reflect extracellular vesicle microRNA expression in follicular fluid. (cdc.gov)
  • BACKGROUND: Epidemiologic studies support associations of exposure to endocrine disrupting chemicals (EDCs), such as some phthalates, phenols, and parabens with a wide range of cognitive and behavioral traits. (cdc.gov)
Preservatives9
  • Parabens are man-made chemicals often used in small amounts as preservatives in cosmetics, pharmaceuticals, foods, and beverages. (cdc.gov)
  • Cosmetics are a source of lifetime exposure to various substances including parabens, being the most popular synthetic preservatives. (nih.gov)
  • Due to the real risk of estrogenic effects, as a result of exposure to parabens in cosmetics, simultaneous use of many cosmetic products containing these preservatives should be avoided. (nih.gov)
  • In particular, he hopes this knowledge will trickle into the beauty industry and consumers will be able to understand why companies like Re:erth continue to use preservatives like parabens even though there is so much controversy surrounding it. (cosmeticsdesign-europe.com)
  • Parabens are one of the most well-researched preservatives on the planet and it's been used for over a hundred years. (cosmeticsdesign-europe.com)
  • Parabens are chemical preservatives, and I've spent years trying to avoid them in beauty products and sunscreen. (wfae.org)
  • Paraben-free: Parabens preservatives have been linked to reproductive toxicity. (fairhavenhealth.com)
  • Parabens are antimicrobial substances that are often used as preservatives in the manufacturing of personal care products. (fairhavenhealth.com)
  • Parabens are synthetic chemicals used as preservatives in various products, including cosmetics, pharmaceuticals and food. (organicspa.com.au)
Chemicals9
  • By measuring these chemicals in urine, scientists can estimate the amount of parabens that has entered people's bodies. (cdc.gov)
  • Urinary concentrations of parabens and other antimicrobial chemicals and their association with couples' fecundity. (nih.gov)
  • Parabens are man-made chemicals designed to prevent bacterial spoilage or to add fragrance. (natural-fertility-info.com)
  • Women had higher median urine concentrations of phenolic chemicals and reported a higher frequency of use of personal care products than men. (biomedcentral.com)
  • Several chemicals were inversley related to BMI, and lower levels of parabens was observed for participants with current eczema. (biomedcentral.com)
  • While parabens help to extend the shelf life of the cosmetics, lotions, and other personal care items, they belong to a class of chemicals known as endocrine disrupters. (fairhavenhealth.com)
  • Parabens are a class of chemicals added to skincare products to help preserve them. (eskincarestore.com)
  • This will indicate if more chemicals, fillers, parabens, or fragrances take up most of the product, compared to the more active ingredients. (organicspa.com.au)
  • Some may be unaware that they are using lubricants that contain parabens and other chemicals that may cause issues with their health as well as the fish and other sea creatures living in the tanks in which they perform. (holisticwisdom.com)
Methyl paraben1
  • In adults younger than age 60, non-Hispanic blacks had higher levels of methyl paraben than non-Hispanic whites. (cdc.gov)
Propylparaben5
  • In view of the disproportionate incidence of breast cancer in the upper outer quadrant, paraben concentrations were compared across the four regions of the breast: n-propylparaben was found at significantly higher levels in the axilla than mid (P = 0.004 Wilcoxon matched pairs) or medial (P = 0.021 Wilcoxon matched pairs) regions (P = 0.010 Friedman ANOVA). (reading.ac.uk)
  • CDC scientists found Methylparaben and propylparaben in the urine of most of the people tested, indicating widespread exposure to these parabens in the U.S. population. (cdc.gov)
  • In the EU, propylparaben can make up to 0.14% of a formula whether it's used with other parabens or on its own. (lush.com)
  • Based on the available published data of the concentrations of parabens in various kinds of cosmetics, the average ranges of systemic exposure dose (SED) for methylparaben, ethylparaben, propylparaben, and butylparaben have been calculated. (nih.gov)
  • An estimated 90% of grocery store items contain parabens such as propylparaben, methylparaben, and ethylparaben. (fairhavenhealth.com)
Levels of parabens3
  • Human health effects from environmental exposure to low levels of parabens are unknown. (cdc.gov)
  • Biomonitoring studies on levels of parabens provide physicians and public health officials with reference values so that they can determine whether people have been exposed to higher levels of parabens than are found in the general population. (cdc.gov)
  • Overall, urinary biomarker levels of parabens were lower in those with current eczema. (biomedcentral.com)
Phthalates and parabens1
  • Completely free of phthalates and parabens and packed with deeply hydrating ingredients like birch water, reishi mushrooms and snow mushrooms (which have a high concentration of polysaccharides for optimizing hydration and improving skin barrier function, respectively), it's essentially a tall glass of (certified organic) water. (yahoo.com)
Methylparaben2
  • Females had several-fold higher concentrations of methylparaben and propylparabens than males, which likely reflect the greater use of products containing parabens. (cdc.gov)
  • Moreover, evidence for the negative impact of methylparaben on skin cells has been provided, and the main factors that may intensify dermal absorption of parabens and their impact on the skin have been described. (nih.gov)
Propyl1
  • TCC was detected in 5% of adults and in 45% of adolescents, while propyl (PPB) and methyl (MPB) parabens were detected in 95% of adults and in 94% (PPB) and 99% (MPB) of adolescents. (biomedcentral.com)
Cosmetics5
  • The source of the paraben cannot be identified, but paraben was measured in the 7/40 patients who reported never having used underarm cosmetics in their lifetime. (reading.ac.uk)
  • In 2006, the industry-led Cosmetic Ingredient Review (CIR), in a partnership with the U.S. Food and Drug Administration (FDA), determined that there was no need to change CIR's original conclusion from 1984 that parabens are safe for use in cosmetics. (cdc.gov)
  • Parabens have been used since the 1920s in food and cosmetics preservation. (lush.com)
  • Because the use of cosmetics shows an increasing trend and some adverse health outcomes of parabens present in these products have been reported, the present review focused on the safety of dermal application of these compounds. (nih.gov)
  • Phenoxyethanol is used in a very low level to replace the harmful parabens used in most cosmetics. (btoxicfree.com)
Biomarker concentrations2
  • The biomarker concentrations of bisphenol S was higher in participants with positive specific IgE and females with current asthma, but did not differ by eczema or rhinitis status. (biomedcentral.com)
  • OBJECTIVE: We assessed the association of urinary biomarker concentrations of EDCs with academic achievement in adolescents as well as the potential for psychosocial factors to modify associations. (cdc.gov)
Urinary concentrations2
  • METHODS: We quantified urinary concentrations of select EDCs in 205 adolescent participants from the New Bedford Cohort (NBC), a prospective birth cohort of children born to mothers residing near the New Bedford Harbor Superfund site in Massachusetts, and estimated associations between EDCs and adolescent academic achievement assessed with the Wide Range Achievement Test (WRAT). (cdc.gov)
  • RESULTS: Urinary concentrations of antiandrogenic phthalates were inversely associated with Math Computation scores. (cdc.gov)
Formulas2
  • In fact, some studies have shown that parabens can actually be beneficial for your skin--especially when used in small amounts (like those found in cosmetic formulas). (eskincarestore.com)
  • Over 60 years of expert skin care research goes into the unique paraben-free formulas that meet the needs of pregnant mothers and their baby's developing skin. (mustelausa.com)
Preservative2
  • However, Yamasaki noted that he takes issue with cosmetic companies that use terms like paraben- or preservative-free to sell their products. (cosmeticsdesign-europe.com)
  • What consumers may not realise is that a product may be paraben-free and there are good preservative alternatives out there, but a majority of the time, the amount you have to put in to have the equivalent preservative capacity is very high. (cosmeticsdesign-europe.com)
Synthetic1
  • When I asked her why we need to add synthetic ones to our food, Mukai said, well, parabens are cheap. (wfae.org)
Fragrance3
  • It's free from fragrance, parabens, and silicones. (luxuo.com)
  • Glade air freshener spray fragrance is made without phthalates, parabens, formaldehydes. (tesco.com)
  • Fragrance free, color free and paraben free, Cococare Vitamin E Cream is a nourishing formula that benefits all skin types. (dillons.com)
Ingredient4
  • There is at least one paraben ingredient in approximately 90% of cosmetic and personal care products . (sustainablog.org)
  • A formulation of bupivacaine that provides prolonged release of the active ingredient after a single administration would simplify pain management in the postoperative period and eliminate the undesired peak plasma concentrations as a result of excessively high concentrations and reduce the risk of local and systemic reactions [ 7 ]. (hindawi.com)
  • OK, OK not quite, but the obsession with being able to decipher complex ingredient names, percentages, and concentrations is ever-growing. (popsugar.co.uk)
  • These include (but are not limited to), what the product is, the concentration of each ingredient (unless the ingredient is active), how much of the ingredient there is, how the ingredients are formulated together, if there is any special technology or innovation used, the grade of an ingredient, and where the brand sources its ingredients. (popsugar.co.uk)
Ingredients4
  • Other anti-aging creams only have 2-3 ingredients in low concentrations. (luxuo.com)
  • That's why, we've handpicked nutrient-rich ingredients, vitamins, minerals and optimal concentrations of actives for our products. (eskincarestore.com)
  • Ingredients above the one percent line are listed in descending order of concentration. (popsugar.co.uk)
  • For New Moms & Moms-to-be who just want the best for themselves and their baby's tender changing skin, Mustela provides high-quality skin care through dermatological expertise and a high concentration of natural ingredients. (mustelausa.com)
Toxicity2
  • To systematically optimize the in vitro system, two novel test performance metrics were introduced, the toxicity separation index (TSI) which quantifies how well a test differentiates between hepatotoxic and non-hepatotoxic compounds, and the toxicity estimation index (TEI) which measures how well hepatotoxic blood concentrations in vivo can be estimated. (uni-koeln.de)
  • 4) evaluation of pharmacokinetic parameters demonstrated that total blood compound concentrations and the 95%-population-based percentile of C-max were best suited to estimate human toxicity. (uni-koeln.de)
Urine4
  • Centers for Disease Control and Prevention scientists measured parabens in the urine of more than 2,548 participants aged six years and older who took part in the National Health and Nutrition Examination Survey (NHANES) during 2005-2006. (cdc.gov)
  • Finding a measurable amount of parabens in urine does not imply that they cause an adverse health effect. (cdc.gov)
  • Urine concentration of MPB increased in a dose-dependent manner with increased frequency of use of several cosmetic products. (biomedcentral.com)
  • For example, each doubling of the concentration of antiandrogenic phthalate metabolites in urine was associated with a 1.94 point decrease (95% CI: 3.84, -0.05) in Math Computation scores, indicating poorer performance. (cdc.gov)
Pharmaceuticals2
  • Parabens also can enter the body when pharmaceuticals, foods, and drinks containing parabens are swallowed or eaten. (cdc.gov)
  • parabens can also be used in pharmaceuticals, and in food and beverage processing. (cdc.gov)
Spoilage1
  • The FDA allows single or multiple parabens to be added to food or food packaging as antimicrobials to prevent food spoilage. (cdc.gov)
Exposure1
  • Thus it is plausible that environmental estrogens can accelerate sexual development if present in a sufficient concentration or with chronic exposure. (wikipedia.org)
Hyaluronic1
  • This vitamin C and hyaluronic acid serum contains Ole's highest concentration of vitamin C for daily use. (olehenriksen.com)
Breast tissue2
  • The concentrations of five esters of p-hydroxybenzoic acid (parabens) were measured using HPLC-MS/MS at four serial locations across the human breast from axilla to sternum using human breast tissue collected from 40 mastectomies for primary breast cancer in England between 2005 and 2008. (reading.ac.uk)
  • The problem with the study, Mukai said, is that it didn't compare the tumorous tissue to normal breast tissue, to see if similar concentrations of parabens could be found there, too. (wfae.org)
Products5
  • People can be exposed to parabens through touching, swallowing, or eating products that contain parabens. (cdc.gov)
  • Parabens in these products are absorbed through the skin. (cdc.gov)
  • 4. Skip products with parabens. (natural-fertility-info.com)
  • Avoid using products that have a high concentration of sulphates and parabens. (mensxp.com)
  • You see a lot of shampoos and beauty products advertising now as paraben-free because of the media attention that study received, not because of the science itself," she said. (wfae.org)
Median1
  • The overall median value for total paraben was 85.5 ng g−1 tissue (range 0-5134.5). (reading.ac.uk)
Commonly1
Estrogen1
  • Parabens are able to mimic hormones like estrogen which allows them to bind to estrogen receptors on cells and in turn prevent real estrogen from attaching. (fairhavenhealth.com)
Estimate1
  • This method can be used to estimate DILI risk if the maximal blood concentration (C-max) of the test compound is known. (uni-koeln.de)
Found2
  • No correlations were found between paraben concentrations and age of patient (37-91 years), length of breast feeding (0-23 months), tumour location or tumour oestrogen receptor content. (reading.ac.uk)
  • She said no direct link has ever been found between parabens and cancer. (wfae.org)
Alternatives1
Serum1
  • This serum contains a unique mixture of Vitamin C in three skin-friendly forms at a concentration that's easily absorbed, safe and gentle on the skin. (holtrenfrew.com)
High3
  • Early research from the United Kingdom shows high content of six different parabens in a study of 20 cancerous breast tumors. (natural-fertility-info.com)
  • High concentration formula: 98.7% in natural ingrédients. (jeancoutu.com)
  • The high concentration of natural Vitamin E in this rich cream makes it ideal for use on dry skin, stretch marks and minor skin irritations. (dillons.com)
Vitamins1
Human3
  • To overcome this limitation, an in vitro/in silico method was established that predicts the risk of human DILI in relation to oral doses and blood concentrations. (uni-koeln.de)
  • Special attention has been paid to the absorption of parabens and their retention in the human body in the intact form, as well as to their toxicological characteristics. (nih.gov)
  • Paraben concentrations in human fingernail and its association with personal care product use. (bvsalud.org)
Free4
Concerns1
  • She told me that most of the concerns about parabens in food arose from a 2004 study published in the Journal of Applied Toxicology . (wfae.org)
Product2
  • Often more than one paraben is used in a single product. (cdc.gov)
  • Also, take note if your hair product has paraben, or sulfate. (mensxp.com)
Food1
Dissolve1
  • Injections are prepared for parenteral use by adding Sterile Water for Injection, USP or Bacteriostatic Water for Injection, USP (benzyl alcohol or parabens preserved), to the vial and shaking to dissolve. (guidelinecentral.com)
Conclusion1
  • In conclusion, the proposed method links oral doses and blood concentrations of test compounds to the probability of hepatotoxicity. (uni-koeln.de)