• Chondrotoxicity was evident with 9 (38%) agents, all of which were also dose-dependently chondrotoxic based on reported estimated half maximal inhibitory concentrations (est.IC50): amikacin (est. (ku.edu)
  • The minimum inhibitory concentrations (MICs) of meropenem/imipenem against BHKPC93 and BHKPC104 were 128/64 and 256/128 mg/L, respectively. (qxmd.com)
  • At sub-inhibitory concentrations of ceftazidime (CAZ), amoxicillin-clavulanic acid (AMC), and imipenem (IPM), filamentation, varying in length and proportion, was an initial response of the multidrug-resistant strain Bp1651 in exponential phase. (biomedcentral.com)
  • Similar morphology dynamics were observed for AMC-resistant strains, MSHR1655 and 724644, when exposed to sub-inhibitory concentrations of AMC. (biomedcentral.com)
  • For all B. pseudomallei strains evaluated, increased exposure time and exposure to increased concentrations of AMC at and above minimal inhibitory concentrations (MICs) in broth resulted in cell morphology shifts from filaments to spheroplasts and/or cell lysis. (biomedcentral.com)
  • We have identified that the use of imipenem and meropenem alongside either relebactam or avibactam yield low minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) for each M. abscessus subspecies, which are within the therapeutically achievable concentration ranges within the epithelial lining fluid of the lungs. (aston.ac.uk)
  • The clinical effectiveness of beta-lactams is based on the time that their unbound fraction spent above the minimum inhibitory concentrations (MICs) of the susceptible microorganisms [ 1 ] [ 2 ] . (encyclopedia.pub)
  • Minimal inhibitory concentrations (MICs) of meropenem and colistin were determined by broth microdilution method. (bvsalud.org)
  • We analyzed the findings from the discovered articles, including the reported minimal inhibitory concentrations. (cdc.gov)
  • Among the most problematic concern is the fact that determination and interpretation of minimum inhibitory concentrations (MIC and MIC BP ) are based on assumed plasma drug concentrations (PDC), yet infections generally are located in extracellular fluid (ECF) and occasionally intracellular. (vin.com)
  • Minimum inhibitory concentrations of antibiotics were determined for the gram-positive bacilli using E-test assay (AB BIODISK, Solna, Sweden) on Columbia agar supplemented with 5% sheep blood. (cdc.gov)
  • The overall spectrum is similar to that of imipenem, although meropenem is more active against Enterobacteriaceae and less active against Gram-positive bacteria. (wikipedia.org)
  • As with other β-lactams antibiotics, the effectiveness of treatment depends on the amount of time during the dosing interval that the meropenem concentration is above the minimum inhibitory concentration for the bacteria causing the infection. (wikipedia.org)
  • Meropenem has a reduced potential for seizures in comparison with imipenem. (wikipedia.org)
  • Meropenem rapidly reduces serum concentrations of valproic acid. (wikipedia.org)
  • Why is imipenem and meropenem resistance important? (cdc.gov)
  • Imipenem and meropenem are carbapenem antimicrobial agents used to treat a variety of serious infections when an organism is resistant to the primary agent of choice. (cdc.gov)
  • How much resistance to imipenem or meropenem occurs in clinical isolates? (cdc.gov)
  • What Gram-negative organisms are resistant to imipenem and/or meropenem? (cdc.gov)
  • Studies suggest meropenem may be more stable than imipenem. (cdc.gov)
  • Meropenem is slightly more active than imipenem against Gram-negative organisms. (cdc.gov)
  • Although the meropenem and imipenem MICs against E. coli J53 transconjugants carrying the bla KPC gene were 2 mg/L, this was a substantial increment in the MIC relative to the original J53 strain. (qxmd.com)
  • The observation that the bla KPC -containing plasmid had a lower copy number in this E. coli strain may explain why this plasmid did not confer phenotypic resistance against meropenem and imipenem. (qxmd.com)
  • However, meropenem and doripenem are less active against E. faecalis than imipenem. (msdmanuals.com)
  • Imipenem and meropenem penetrate into cerebrospinal fluid when meninges are inflamed. (msdmanuals.com)
  • We propose the implementation of imipenem with relebactam in place of stand-alone imipenem into the current treatment regime, alongside meropenem, as a future front-line treatment option for M. abscessus complex infections. (aston.ac.uk)
  • U kliničkim studijama je prosječan pad koncentracije valproata bio uz meropenem 67-82%, uz ertapenem 68-72% te imipenem 51% . (e-pharmaca.com)
  • Istodobna primjena karbapenema (meropenem, imipenem/cilastatin, ertapenem) i valproata se ne preporučuje. (e-pharmaca.com)
  • 3. Haroutiunian S, Ratz Y, Rabinovich B, Adam M, Hoffman A. Valproic acid plasma concentration decreases in a dose-independent manner following administration of meropenem: a retrospective study. (e-pharmaca.com)
  • The effect of different carbapenem antibiotics (ertapenem, imipenem/cilastatin, and meropenem) on serum valproic acid concentrations. (e-pharmaca.com)
  • Determination of MICs of eravacycline, ceftazidime/avibactam, meropenem/vaborbactam, imipenem/relebactam was performed using Sensititre diagnostic system on EUMDROXF plates. (bvsalud.org)
  • KPCs) are Ambler class A plasmid- gene by polymerase chain reaction cin, imipenem, ertapenem, meropenem, encoded enzymes that are capable of (PCR) assay provides laboratories trimethoprim/sulfamethoxazole, piper- hydrolyzing all beta-lactam antibiotics, with a means to quickly identify the acillin, piperacillin/tazobactam and including monobactams, extended- presence of this important resistance tobramycin (Oxoid). (who.int)
  • Imipenem 500mg is a Carbapenem antibiotic used to treat severe bacterial infections by inhibiting the bacterial cell wall synthesis which is essential for bacterial growth. (drugcarts.com)
  • This study underscores the major role of carbapenem-hydrolyzing class D β-lactamases, and in particular the acquired OXA-23, in the dissemination of imipenem-resistant A. baumannii . (biomedcentral.com)
  • Currently, the MABC treatment recommendations include the use of the -lactam cefoxitin (a cephalosporin) or imipenem (a carbapenem) (22,C24). (spierarchitecturalarts.com)
  • Unlike imipenem, it is stable to dehydropeptidase-1, so can be given without cilastatin. (wikipedia.org)
  • imipenem/cilastatin decreases effects of BCG intravesical live by pharmacodynamic antagonism. (medscape.com)
  • Zicerot 500mg/500mg Injection contains Imipenem 500mg and Cilastatin 500mg used to treat bacterial infections such as Lower respiratory tract infections, Urinary tract infections, Intraabdominal infections, Bacterial septicemia, Bone and joint infections, Skin and skin structure infections, Endocarditis, and Gynecological infections. (drugcarts.com)
  • Imipenem when used with cilastatin can be more proconvulsive as Imipenam levels are raised in presence of cilastatin. (ommegaonline.org)
  • Amino Acid Neurotransmitter Levels In the Cerebral Cortex of Mice Receiving Imipenem/ Cilastatin- Lack of Excitotoxicity in the Central Nervous system. (ommegaonline.org)
  • Stenotrophomonas maltophilia isolates are intrinsically resistant to imipenem. (cdc.gov)
  • We investigated the antimicrobial efficacy of clinically meaningful, low concentrations of azithromycin against intracellular growth of two clinical isolates of Legionella pneumophila. (nih.gov)
  • Antimicrobial susceptibility profile showed that the majority of the isolates were sensitive to Imipenem and Nitrofurantoin while most were significantly resistant to, augmentin, ampicillin, cotrimoxazole, gentamicin, cefuroxime, cefotaxime, and ceftazidime. (ispub.com)
  • To identify risk factors associated with the emergence of imipenem heteroresistance, a retrospective case-control study was undertaken involving cases with subsequent clinical isolates of the same genotype showing loss of imipenem susceptibility and matched controls with isolates belonging to imipenem-susceptible MDR-AB. (shengsci.com)
  • An insertion sequence (ISAba1) was found in the promoter region of a class C β-lactamase gene (bla(ADC-29)) in most imipenem-heteroresistant MDR-AB isolates. (shengsci.com)
  • The aim of the present study was to determine the clonal relatedness of clinical isolates and to elucidate the genetic basis of imipenem resistance. (biomedcentral.com)
  • The presence of bla OXA-23 in 13% (11/83) and IS Aba1 linked bla OXA-66 in 79.5% (66/83) of clinical isolates was associated with high level imipenem resistance. (biomedcentral.com)
  • Our phenotypic analysis clearly demonstrated that A. baumannii isolates obtained from different hospitals in central Ohio were resistant to all clinically significant antibiotics, including carbapenems (imipenem). (biomedcentral.com)
  • MIC50s of 0.25 (ceftaroline with 100?g/ml ceftazidime) and 0.5?g/ml (imipenem with 100?g/ml ceftazidime) against medical MABC isolates. (spierarchitecturalarts.com)
  • Treatment of THP-1 human being macrophages infected with three different medical isolates supported the findings, as the combination of 100?g/ml ceftazidime and 0.125?g/ml ceftaroline or 100?g/ml ceftazidime and 0.25?g/ml imipenem dramatically reduced the CFU counts to near baseline levels of illness. (spierarchitecturalarts.com)
  • All isolates were characterized by XCL1 whole-genome sequencing, and each was tested against ceftaroline and imipenem, alone and in combination with ceftazidime-avibactam, a newly promoted cephalosporinC-lactamase inhibitor combination. (spierarchitecturalarts.com)
  • Both resistant and susceptible B. pseudomallei strains exhibited filamentation during early exposure to AMC and CAZ at concentrations used to interpret susceptibility (based on CLSI guidelines). (biomedcentral.com)
  • Here, we assess the in vitro efficacy of two non-β-lactam based inhibitors, relebactam and avibactam, as agents against M. abscessus with their respective partner drugs imipenem and ceftazidime, as well as in triplicate combinations with additional β-lactam antibiotics against the M. abscessus complex. (aston.ac.uk)
  • We have shown that the commercially available ratio of imipenem to relebactam is the appropriate ratio for bactericidal activity against M. abscessus, whereas the ratio between ceftazidime and avibactam is redundant, due to inactivity of ceftazidime to inhibit the bacteria. (aston.ac.uk)
  • Related synergy was observed in time-kill studies against the ATCC 19977 strain using clinically attainable concentrations of either imipenem (4?g/ml) or ceftaroline (2?g/ml), while the addition of ceftazidime at concentrations of 50?g/ml showed a persistent bactericidal effect over 5?days. (spierarchitecturalarts.com)
  • Surprisingly, despite the poor activity of ceftazidime with or without avibactam, the dual -lactam mixtures of ceftazidime with either ceftaroline or imipenem showed promising synergistic activities against the MABC strains. (spierarchitecturalarts.com)
  • Clinical cure rates were 68.3% (doripenem) and 64.2% (imipenem) in the clinically evaluable and 59.0% (doripenem) and 57.8% (imipenem) in the cMITT populations. (wustl.edu)
  • CONCLUSIONS: In this large, phase III study of patients with ventilator-associated pneumonia, a 4-hr intravenous infusion of doripenem was clinically efficacious and therapeutically noninferior to imipenem. (wustl.edu)
  • However, studies have shown false resistance to imipenem in commercially prepared test panels due to degradation of the drug or to a manufacturing problem where concentrations of imipenem were too low (1,2,4,5). (cdc.gov)
  • Achieving the adequate concentration of any antibiotic at the site of infection and preventing bacterial resistance is crucial for good clinical practice. (encyclopedia.pub)
  • Molecular determinants enabling the imipenem resistant strains to exhibit co-resistance to aminoglycosides and fluoroquinolones from this geographical region were delineated. (biomedcentral.com)
  • The antibiotic in the culture medium is at an effective concentration hindering the growth of the A. baumannii without substantially killing the A. baumannii and enhances expression of A. baumannii proteins conferring resistance to the antibiotics and virulence. (um-technology.com)
  • Spheroplast formation followed by cell lysis was observed for all strains in broth containing IPM at concentrations greater than or equal to MICs, however, the time to cell lysis was variable. (biomedcentral.com)
  • Since most of these antibiotics are excreted primarily via glomerular filtration in kidneys, renal functions are critical factors affecting antimicrobial concentration [ 4 ] . (encyclopedia.pub)
  • Main efflux pumps or β-lactamase genes did not show altered mRNA levels in P. aeruginosa strains with modified different c-di-GMP concentrations. (inrs.ca)
  • In contrast, incubation of intraphagocytic L. pneumophila in the presence of antibiotics without intracellular activity (ceftizoxime, imipenem or amoxycillin-clavulanic acid) did not have any effect. (nih.gov)
  • Intra-articular antibiotics have been proposed as a treatment for septic arthritis to allow for high local concentrations without subjecting a patient to the toxicity/side effects of systemic therapy. (ku.edu)
  • Moreover this phage could be seen by electron microscopy when mobilized with several antibiotics commonly used in CF patients including, tobramycin, ciprofloxacin, cotrimoxazole, or imipenem. (biomedcentral.com)
  • Here we report the clinical impact and mechanism of imipenem heteroresistance (imipenem minimum inhibitory concentration of 6-32 μg/mL with the presence of resistant cells inside the inhibition zone of Etest strips or disks) in multidrug-resistant A. baumannii (MDR-AB). (shengsci.com)
  • Clinical cure rate was higher with doripenem than imipenem at higher Acute Physiology and Chronic Health Evaluation II scores and older ages. (wustl.edu)
  • Leo, R.J., Ballow, C.H. Seizure activity associated with imipenem use: clinical case reports and review of the literature. (ommegaonline.org)
  • The low concentrations of bacteria could be explained because sea cucumbers could have the capacity to phagocytize bacteria. (ulpgc.es)
  • And in patients with UTI, procalcitonin blood concentrations can distinguish acute pyelonephritis from a lower UTI. (medscape.com)
  • In particular, azithromycin killed ingested legionellae in vitro at concentrations below the peak serum concentrations and below the MIC. (nih.gov)
  • The methanol extract of bark inhibited the growth of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa with the minimum inhibitory concentration of 250, 500, and 250 mu g/mL, respectively. (ua.pt)
  • imipenem is not used in meningitis because it may cause seizures. (msdmanuals.com)
  • Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice. (ommegaonline.org)
  • In vitro experiments indicated that imipenem heteroresistance, which was associated with overexpression of bla(ADC-29), could be induced by imipenem. (shengsci.com)
  • As the Imipenam is transported to brain tissue by passive diffusion, increased concentration of the drug in renal failure patient is epileptogenic and neurotoxicity [1] . (ommegaonline.org)
  • The tests were imipenem (LBXMI1 and LBXMI2), cefazolin(LBXMF1 and LBXMF2), ciprofloxacin (LBXMD1 and LBXMD2), and amoxicillin/k clavulanate (LBXMY1 and LBXMY2). (cdc.gov)
  • For example, in the "test tube", the organism is exposed to the same conditions, including drug concentrations throughout the incubation period, a situation which does not occur in the patient. (vin.com)
  • Efficacy and safety of intravenous infusion of doripenem versus imipenem in ventilator-associated pneumonia: a multicenter, randomized study. (wustl.edu)
  • This large, phase III study compared doripenem with imipenem for the treatment of ventilator-associated pneumonia. (wustl.edu)
  • 15), and geographic region and then randomly assigned to doripenem 500 mg every 8 hrs via a 4-hr intravenous infusion or imipenem 500 mg every 6 hrs or 1000 mg every 8 hrs via 30- or 60-min intravenous infusions, respectively, for 7-14 days. (wustl.edu)
  • microbiological cure was 65.0% (doripenem) and 37.5% (imipenem). (wustl.edu)
  • or = 8 microg/mL at baseline or following therapy in the doripenem arm compared with 64% (16 of 25) in the imipenem treatment group (p = .001). (wustl.edu)
  • For some substances there is also a risk assessment made on the basis of concentrations measured in the environment in Sweden and efficacy studies with high quality. (janusinfo.se)
  • B. pseudomallei cell lengths were strain-, drug- and drug concentration-dependent. (biomedcentral.com)
  • Mono Mac 6 cells infected with L. pneumophila were incubated with various concentrations of azithromycin. (nih.gov)
  • Azithromycin inhibited intracellular replication at concentrations as low as 0.125 mg/L, approximately one-quarter of the extracellular MIC. (nih.gov)
  • A characteristic of perilymph is that its concentration of sodium is high (about 150 milliequivalents per litre) and its concentration of potassium is low (about 5 milliequivalents per litre), similar to other extracellular fluids. (kenyon.edu)
  • Exosomes were also purified from untreated macrophages and used to vaccinate mice at the same concentrations. (c-metinhibitors.com)
  • Therapeutic monitoring of clarithromycin, imipenem, and linezolid in CSF and plasma revealed lower than expected concentrations, prompting alternative therapy and culture clearance on hospital day 42. (northwestern.edu)
  • RÉSUMÉ L'émergence et la propagation rapide des souches de Klebsiella pneumoniae résistantes aux antibiotiques et porteuses du gène blaKPC codant la production de carbapénèmases ont compliqué la prise en charge des infections des patients. (who.int)
  • Both fluids are segregated but derived from blood plasma implying a high concentration of nutrients and a similar pH of ~7.4. (kenyon.edu)
  • In addition to nutrients, small concentrations of immunoglobulins present in blood serum are also found in the perylimph and endolymph, filtered through by the blood-labyrinth barrier (15). (kenyon.edu)
  • 3. environmental risk assessments for certain substances based on concentrations measured in the environment in Sweden and effect studies. (janusinfo.se)
  • Together, our findings show that c-di-GMP levels modulate fitness of planktonic cultures in the presence of imipenem. (inrs.ca)
  • The dry type falls out easier and is in thinner concentration while the wet type is thicker and stickier, though it should readily fall out as well under normal circumstances. (kenyon.edu)