Concentrations ligands receptor epidermal growth factor. Medical search. Frequent questions

The epidermal growth factor receptor (EGFR) is hijacked by many types of cancer, including cancers of the lung, colon, kidney, and head and neck. (wikipedia.org)
This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
Selective compounds have been developed that target either the extracellular ligand-binding region of the EGFR (including a number of monoclonal antibodies [MAbs], immunotoxins, and ligand-binding cytotoxic agents) or the intracellular tyrosine kinase region (including various small-molecule inhibitors). (medscape.com)
EGFR (Epidermal growth factor receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. (thermofisher.com)
EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. (thermofisher.com)
EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. (thermofisher.com)
Phosphorylation of EGFR at certain residues is also mediated by Src-non-receptor kinase. (thermofisher.com)
EGFR activation signals multiple downstream signaling cascades such as the Ras - ERK, PI3-K - Akt, Jak - STAT and PKC pathways that help in growth and proliferation of cells. (thermofisher.com)
Upon receptor activation and signaling, EGFR is endocytosed and targeted for degradation or recycling. (thermofisher.com)
Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein and member of the protein kinase superfamily that regulates cell growth and differentiation. (biolegend.com)
Ligand binding induces EGFR dimerization and autophosphorylation, initiating the MAPK, Akt, and JNK signaling pathways. (biolegend.com)
EGFR antibody recognizes epidermal growth factor receptor (EGFR, also known as HER1 in humans), a receptor tyrosine kinase with a predicted molecular weight of 134 kDa. (genetex.com)
EGFR is a cell surface protein that binds to epidermal growth factor. (genetex.com)
Objective: Epidermoid growth factor receptor (EGFR, HER1) is overexpressed in a majority of head-and-neck cancers, including nasopharyngeal carcinoma (NPC). (tmu.edu.tw)
These inhibitors, however, effectively suppressed ligand-stimulated EGFR activation in NPC cells with a much lower concentration (≥0.1 μM). (tmu.edu.tw)
The growth-suppression activity of EGFR inhibitors was closely associated with suppression of AKT phosphorylation. (tmu.edu.tw)
Conclusions: Our data indicate that inhibition of EGFR activation is not sufficient to induce growth inhibition in NPC cells in vitro. (tmu.edu.tw)
Proliferation is upregulated through two mechanisms: (1) ATP binding to the G-protein-coupled receptor P2Y2, commencing a kinase signaling cascade that activates the serine-threonine kinase Akt, and (2) the transactivation of the epidermal growth factor receptor (EGFR), leading to a series of protein signals that activate the extracellular signal-regulated kinases (ERK) 1/2. (encyclopedia.pub)
An increase in the number of epidermal growth factor and transferrin receptors (EGFR, TrfR) is induced by Ara-C on these cells. (cnr.it)
These effects occur without changes in the affinity of EGFR and TrfR for their ligands. (cnr.it)
3H]Thymidine uptake is clearly stimulated on KB cells by nanomolar concentrations of EGF and transferrin, whereas in Ara-C-treated cells [3H]thymidine uptake is not increased by EGF and transferrin under conditions where maximal EGFR and TrfR up-regulation occurs. (cnr.it)
To understand the functional interactions between the TrkA and p75 nerve growth factor (NGF) receptors, we stably transfected LAN5 neuroblastoma cells with an expression vector for ET-R, a chimeric receptor with the extracellular domain of the epidermal growth factor receptor (EGFR), and the TrkA transmembrane and intracellular domains. (umassmed.edu)
EGFR (epidermal growth factor receptor) is a transmembrane protein and receptor for members of the epidermal growth factor (EGF) family of extracellular protein ligands. (promab.com)
It is a member of the ErbB receptor family, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). (promab.com)
Defective signaling of EGFR and other receptor tyrosine kinases in humans has been linked to diseases such as Alzheimer's disease, while overexpression has been linked to the development of various tumors. (promab.com)
Disruption of EGFR signaling by blocking the EGFR-binding site on the extracellular domain of the receptor or inhibiting intracellular tyrosine kinase activity prevents the growth of EGFR-expressing tumors and improves patient outcomes. (promab.com)
The anti-EGFR CAR in this product is approximately 56 kD and consists of anti-EGFR scFv (single-chain variable fragment) linked to a second-generation CAR (chimeric antigen receptor) containing the CD8 hinge and transmembrane domain and 4-1BB and CD3ζ signaling domains. (promab.com)
Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma. (nccs.com.sg)
In the in vitro study, U87 (low-EGFR expression) and U87-MG-EGFR (high-EGFR expression) cells were incubated with various concentrations of fluorescein and EGF-FL. (cns.org)
Although a number of studies have shown that patients with activating mutations in exons 18-21 of the epidermal growth factor receptor (EGFR) gene respond particularly well to gefitinib and erlotinib, a prospective, randomised study was needed to differentiate between the prognostic and predictive value of EGFR mutations. (ersjournals.com)
This review considers the current evidence linking biomarker profile to efficacy of epidermal growth factor receptor (EGFR)-targeted therapy in advanced nonsmall cell lung cancer (NSCLC) and the clinical implications of recent findings. (ersjournals.com)
In NSCLC, activation of the EGFR/HER1 pathway results in a signalling cascade that promotes tumour growth and progression 6 . (ersjournals.com)
Since 2011, several quinoline compounds have shown Epidermal Growth Factor Receptor (EGFR) inhibition 22 . (nature.com)

Epidermal growth factor receptor (EGF R, also known as ErbB1 and HER1) is the founding member of the ErbB family of receptor tyrosine kinases. (rndsystems.com)
The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. (origene.com)

ErbB4, also called Her4 (human epidermal growth factor receptor 4), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. (bio-techne.com)
ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors. (bio-techne.com)

Because ErbB3 contains a defective kinase domain, the kinase domain of ErbB2 is responsible for initiating the tyrosine phosphorylation signal through the heterodimeric receptor. (bio-techne.com)
LY294002, a phosphatidylinositol-3 kinase (P13K)/AKT inhibitor, did suppress the growth of NPC cells. (tmu.edu.tw)
However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. (origene.com)
The effective inhibition of epidermal growth by erlotinib in our HSEs confirms the therapeutic potential of this tyrosine kinase inhibitor for cutaneous SCC patients. (thebiotechdictionary.com)
The effective inhibition of epidermal development by erlotinib inside our HSEs confirms the restorative potential of the tyrosine kinase inhibitor for cutaneous SCC individuals. (thebiotechdictionary.com)
Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib. (nccs.com.sg)
In the case of growth factor receptors such as the epidermal growth factor (EGF) receptor and platelet-derived growth factor (PDGF) receptor, the kinase must be first activated by ligand. (docksci.com)
Dorsoventral (DV) patterning of the Drosophila embryo is initiated by a broad Dorsal (Dl) nuclear gradient, which is regulated by a conserved signaling pathway that includes the Toll receptor and Pelle kinase. (sdbonline.org)
This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. (thearabidopsisbook.org)
HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche. (thearabidopsisbook.org)

While the extracellular domain contains numerous epidermal growth factor-like repeats for ligand binding, the intracellular domain is involved in cell signaling. (thermofisher.com)

Ligand binding induces receptor dimerization and autophosphorylation on multiple tyrosine residues. (rndsystems.com)
Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. (genetex.com)
We report that cytosine arabinoside (Ara-C), a cytosine analogue that at low doses causes phenotypical changes on human leukemia cells in vitro and in vivo, induces growth inhibition of oropharyngeal cancer KB and lung adenocarcinoma A549 cell lines. (cnr.it)

In-vitro antiplasmodial efficacy of 4,7-dichloroquinoline revealed a significant growth inhibition of both sensitive strains of Plasmodium falciparum with IC 50 values of 6.7 nM (CQ-s) and 8.5 nM (CQ-r). (nature.com)
20 days of imatinib or bortezomib treatment caused significant inhibition of tumor growth compared with vehicle group. (mi-rna.com)

Monomeric ErbB4 binds its ligands with low affinity. (bio-techne.com)
The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. (thearabidopsisbook.org)

NLRP3/cryopyrin is a member of the NOD-like receptor (NLR) protein family that plays a pivotal role in the inflammatory response against pathogens and cellular damage. (nature.com)

Ligand induced phosphorylation of EGF receptor creates docking sites for adaptor proteins, such as EPS15, epsin and AP-2 [ 6 , 7 ]. (biomedcentral.com)

This cell surface receptor is involved in T cell lineage commitment, thymocyte development, and Th2 differentiation. (thermofisher.com)
Enhancement of EGF-induced differentiation required at least nanomolar concentrations of NGF, consistent with the low-affinity p75 binding site. (umassmed.edu)

Clinically relevant improvements in survival have been attained by administering targeted therapy to the appropriate patient population: for example, the addition of trastuzumab to standard first-line chemotherapy in patients with human epidermal growth factor receptor-positive (HER2+) metastatic breast cancer 3 . (ersjournals.com)
Fulvestrant (Faslodex) was approved by the FDA for hormone receptor (HR)-positive, HER2-negative locally-advanced or metastatic breast cancer in postmenopausal women not previously treated with endocrine therapy. (medscape.com)
Palbociclib and ribociclib are cyclin-dependent kinases (CDK) 4, 6 inhibitors indicated in combination with an aromatase inhibitor as initial endocrine-based therapy for postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer. (medscape.com)

BACKGROUND: Growth factor receptors such as epidermal growth factor receptor 1 and human epidermal growth receptor 2 (HER2) are overexpressed in certain cancer cells. (ncue.edu.tw)
METHODS: The authors examined HER2 expression using the monoclonal antibody trastuzumab as a targeting ligand to test their system. (ncue.edu.tw)
RESULTS: The 2 conjugates bound to the HER2-expressing tumor competitively in a receptor-specific fashion, but they failed to bind to a similar cell tumor that did not express HER2. (ncue.edu.tw)
The concentration of the conjugate present in the tumor as determined by 2-photon optical fiber fluorescence was shown to serve as an index of the HER2 expression levels. (ncue.edu.tw)

ErbB4 ligands include the neuregulins, beta-cellulin and heparin-binding EGF-like growth factor (HB-EGF). (bio-techne.com)

Typically, heterodimerization with ErbB2 forms the high affinity receptor complex. (bio-techne.com)

Here we review the interactions of metabolism, galectins and glycoprotein ligands as well as the utility of this model to predict and treat inflammation and autoimmunity. (gr.jp)

Here, we present a mathematical model of receptor sorting into alternative pathways that explains the EGF-concentration dependent response of CIE. (biomedcentral.com)
Further, we describe extensibility of the model to more than two pathways which might play a role in contexts other than receptor internalization. (biomedcentral.com)
This is especially important since a receptor modification discriminating between the pathways has not been found experimentally. (biomedcentral.com)
the distribution of receptors into the two pathways was shown to be EGF-concentration dependent. (biomedcentral.com)
Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
The opening of transient receptor potential vanilloid 1 (TRPV1) ligand-gated ion channels facilitates transmembrane Ca 2+ and Na + entry, which modifies the delicate balance between apoptotic and proliferative signaling pathways. (encyclopedia.pub)
This Part 2 post is concerned with anti-cancer drug and other interventions that simultaneously address multiple growth pathways. (anti-agingfirewalls.com)

The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. (thermofisher.com)
The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. (thearabidopsisbook.org)

Monocarboxylate transporters (MCTs) play an immense role in metabolically active solid tumors by regulating concentration-dependent transport of different important monocarboxylates including pyruvate and lactate and are encoded by the SLC16A family of genes. (bvsalud.org)
The existing methods for the quantification of these receptors in tumors involve immunohistochemistry or DNA quantification, both in extracted tissue samples. (ncue.edu.tw)
These results show that while BaF3 BCR ABL xenograft tumors are resistant to imatinib, their growth can be significantly inhibited by bortezomib. (mi-rna.com)

The term microdosing, which was introduced through the work of such pioneers as Garner and Lappin ( 1 - 3 ), indicates the potential to assay the plasma pharmacokinetics of a very low administered mass in humans using a highly sensitive means of recording the concentration-time profile. (snmjournals.org)

CIMAvax-EGF is composed of recombinant human epidermal growth factor (EGF) conjugated to a protein carrier. (wikipedia.org)
Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (bio-techne.com)

Description: This MHN1-519 monoclonal antibody reacts with human Notch1, one of four members of the Notch family of receptors. (thermofisher.com)
We use a monoclonal antibody, PY20, 2 coupled at a concentration of 10 mg antibody/ml Affi-Gel (Bio-Rad, Richmond, CA).] PY20 I j. (docksci.com)

The TRPV1-apoptosis pathway involves Ca 2+ influx and efflux between the cytosol, mitochondria, and endoplasmic reticulum (ER), the release of apoptosis-inducing factor (AIF) and cytochrome c from the mitochondria, caspase activation, and DNA fragmentation and condensation. (encyclopedia.pub)
Consistent with increase in serum T, piperine increased Leydig cell number, cell size, and multiple steroidogenic pathway proteins, including steroidogenic acute regulatory protein, cholesterol side-chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase 1, 17α-hydroxylase/20-lyase, and steroidogenic factor 1 expression levels. (frontiersin.org)
The Part 1 post was concerned principally with interventions that address the mTOR pathway, a growth pathway also of great interest from the viewpoint of longevity. (anti-agingfirewalls.com)

This protein has no ligand binding domain of its own and therefore cannot bind growth factors. (origene.com)
When the ability of CR2093 to bind to EGF receptors was assessed in a ligand binding assay, it was found that the antagonist displaced up to 23% of labeled EGF. (dundee.ac.uk)

Via direct or indirect binding, adaptors recruit the receptor to special membrane regions which are characterized by a particular composition of cage-proteins and/or -lipids [ 8 , 9 ]. (biomedcentral.com)
Upon binding its membrane-bound ligand (either Delta or Jagged), the Notch receptor undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. (thermofisher.com)

MA5-14485 targets Epidermal Growth Factor Receptor in IHC (P) applications and shows reactivity with Human samples. (thermofisher.com)
Components and Strategies Cell lines and major Millimeter growth cells Human being Millimeter cell lines (U266, ARH-77, IM-9, Millimeter.1S and RPMI8226) were purchased from the American Type Tradition Collection (Manassas, Veterans administration). (researchensemble.com)
Besides functioning as an antioxidant and anthelmintic , many isoflavones have been shown to interact with animal and human estrogen receptors , causing effects in the body similar to those caused by the hormone estrogen . (wikipedia.org)

This protein is a receptor for members of the epidermal growth factor family. (genetex.com)

Notably, addition of extracellular ENO1 protein in cancer cell culture enhanced glycolytic activity, hypoxia-inducible factor 1-α (HIF-1α) expression, glycolysis-related gene (GRG) expression and pro-cancer activities, such as cell migration, cell viability and tumor-promoting cytokine secretion. (bvsalud.org)
Interestingly, one gene that we studied, keratinocyte growth factor, that was up-regulated by P (peak E levels vs. PcDNA) was more highly expressed in IcDNA. (umassmed.edu)

Thus CimaVax does not target the cancer cells directly, but is expected to work against these cancers by denying the cancers the growth stimulus they require. (wikipedia.org)
Tumor cells are influenced by both genetic factors and environmental elements in the microenvironment, resulting in a complex regulation process ( 1 ). (spandidos-publications.com)
These cells are then forced to compete for growth and nutrients ( 2 ). (spandidos-publications.com)
However, rather than actively modifying the environment, multiple mechanisms guide the evolution of tumor cells through the selection of subclones with the most adaptive phenotype by environmental factors ( 1 ). (spandidos-publications.com)
PD153035 and ZD1839 inhibited the growth of NPC cells with IC 50 S around 10 and 20 μM, respectively. (tmu.edu.tw)
Proliferation is involved in structural development and renewal, while programmed cell death is necessary to eliminate defective cells and prevent uncontrolled growth. (encyclopedia.pub)
Brain-derived neurotrophic factor also enhanced cell survival, indicating that in differentiated cells, NGF acts through the p75 receptor to prevent apoptosis. (umassmed.edu)
Starting with basics: "All cancers arise as a result of the acquisition of a series of fixed DNA sequence abnormalities, mutations, many of which ultimately confer a growth advantage upon the cells in which they have occurred. (anti-agingfirewalls.com)
In this study, we have investigated the ability of epidermal growth factor conjugated fluorescein (EGF-FL) to accumulate within GBM cells in vitro and its ability to delineate tumor boundaries in vivo. (cns.org)
We have used this procedure with good success for isolating PY proteins from chronic myelogenous leukemia cells and, with minor modifications, for isolating PY proteins from growth factor-stimulated adherent cells. (docksci.com)
This vertical growth phase represents a key event for the cell spread, since it allows the cells to migrate deeply in the dermis, in the lymphatics, and the bloodstream. (hindawi.com)
In the case of melanoma, circulating cells may find a suitable microenvironment in the first draining lymph node, known as the sentinel lymph node, in other lymphnodes or in distant organs, leading to secondary tumor growth (Figure 1 ). (hindawi.com)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)

CimaVax is an active vaccine with which patients are immunized with epidermal growth factor (EGF), thus raising antibodies targeting EGF itself. (wikipedia.org)
By raising antibodies against EGF, which is EGFR's major ligand, the concentrations of EGF in the blood are reduced. (wikipedia.org)
Antibodies against these receptors (eg. (ncue.edu.tw)

Calcium entry through transient receptor potential vanilloid 1 (TRPV1) ion channels modulates the delicate balance between proliferation and apoptosis. (encyclopedia.pub)

Two major mechanisms of apoptosis are an extrinsic, death-receptor mediated mechanism, and an intrinsic, mitochondria-mediated mechanism [ 4 ] . (encyclopedia.pub)

Thirty-day treatment of rats with piperine significantly increased serum T levels without affecting LH concentrations. (frontiersin.org)

CMMs usually progress from an in situ proliferation to a radial growth pattern, and then to a vertical growth phase. (hindawi.com)

AR42J, a rat pancreatic cell line expressing receptors for both gastrin and epidermal growth factor (EGF), has been used to examine the effect of the gastrin receptor antagonist CR2093 on basal, gastrin-17 (G17), EGF and transforming growth factor (TGF)-alpha stimulated growth in vitro. (dundee.ac.uk)

Receptor Activator of NF-kB Ligand (RANKL), its receptor RANK and the natural antagonist osteoprotegerin (OPG) are essential regulators of bone resorption. (oncotarget.com)

The goal of the study was to evaluate whether an optical fiber-based technique can be used to quantify the expression of multiple growth factor receptors simultaneously. (ncue.edu.tw)
Design of a ligand that can be simultaneously applied as an efficient light-harvesting antenna for Tb surface ions and a strong binder of biomolecules to LnNPs surfaces. (poly-dtech.com)

Check serum testosterone concentrations mail as a tool control your diabetes while on steroids. (opensourcesports.com)

This article discusses the consequences of the facilitated regulations, the impact of performing studies at very low pharmacologic concentrations, and the differences in regulation and pharmacology between smaller (organic) molecules and larger (protein biologic) molecules. (snmjournals.org)

Intracellular calcium (Ca 2+ ) concentration ([Ca 2+ ] i ) is a key determinant of cell fate and is implicated in carcinogenesis. (encyclopedia.pub)
effective reduced amount of epidermal thickness from 10 to 3 practical cell levels and counteracted EGF\induced epidermal tension. (thebiotechdictionary.com)
The galectin lattice (i) regulates flow of receptors and solute transporters to coated-pit endocytosis and/or caveolin domains, and (ii) promotes turnover of cell-cell contacts such as immune synapses and focal adhesion complexes. (gr.jp)

However, for extrapolation to therapeutically relevant doses and plasma concentrations, there are specific aspects of the use of these low doses and low plasma concentrations that require special attention. (snmjournals.org)
modulation of CFTR channel, potentiating its opening at low concentration and inhibiting it a higher doses. (wikipedia.org)
For example, the half-life Saracatinib AZD0530 of enoxaparin sodium 4 h after a single subcutaneous dose and 7 hours after repeated doses, significant anti-factor Xa activity t in the plasma consists of 12 hours after a 40-mg sc single dose, w During the station re state is reached, the second day of treatment. (syksignaling.com)

Pan-Cancer Analysis of Ligand-Receptor Cross-talk in the Tumor Microenvironment. (nccs.com.sg)

Optimal dilutions/concentrations should be determined by the researcher. (genetex.com)
The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. (promab.com)

Notch receptors are 300-kDa single-pass transmembrane proteins. (thermofisher.com)

As CED suffers from a variety of limitations including the procedural invasiveness, and unequal and unpredictable intratumoral agent distribution, the creation of easily administered and tumor-specific drugs via conjugation to ligands such as EGF provides an increasingly attractive therapeutic strategy. (cns.org)
In conclusion, we believe that this study has demonstrated EGF-FL to be a clinically useful agent for fluorescence-guided resections and has highlighted the potential for ligands to serve as carriers for therapeutic agents. (cns.org)

Several mechanisms to generate this behaviour have been described theoretically, the underlying assumptions of which, however, have not been experimentally demonstrated for the EGF receptor internalization network. (biomedcentral.com)
It can also inhibit type 1 growth factor-stimulated growth, but although this action may in part be related to the antagonist's ability to inhibit binding to the EGF receptor, other mechanisms may be involved. (dundee.ac.uk)

Anatomy20

Organisms9

Diseases15

Chemicals and Drugs129

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes52

Disciplines and Occupations1

Information Science3

EGFR33

Tyrosine kinases3

ErbB2

Kinase10

Extracellular domain1

Induces3

Inhibition2

Binds2

Plays a pivotal role1

Phosphorylation1

Differentiation2

Metastatic breast cancer3

HER24

Heparin-bindin1

Affinity1

Glycoprotein1

Pathways7

Repeats2

Tumors3

Humans1

Recombinant2

Antibody2

Pathway3

Bind2

Membrane2

Human3

Family1

Gene2

Cells13

Antibodies3

Modulates1

Apoptosis1

Rats1

Proliferation1

Pancreatic1

Antagonist1

Simultaneously2

Serum1

Pharmacology1

Cell3

Doses3

Microenvironment1

Optimal2

Proteins1

Therapeutic2

Mechanisms2