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  • folate
  • Lower maternal vitamin B12 and higher folate concentrations were associated with higher offspring insulin resistance. (springer.com)
  • Higher maternal folate concentrations were associated with higher HOMA-IR in the children at 9.5 ( p = 0.03) and 13.5 years of age ( p = 0.03). (springer.com)
  • However, associations of maternal homocysteine and folate concentrations with birth size, and with childhood insulin resistance and glycaemia in the offspring, suggest a role for nutritionally driven disturbances in one-carbon metabolism in fetal programming of diabetes. (springer.com)
  • In the current analysis we aimed to replicate the Pune analysis, to examine whether low maternal vitamin B12 and high plasma folate concentrations predicted higher insulin resistance and other cardiometabolic risk factors in children. (springer.com)
  • Plasma Hcy was measured by fluorescence polarization immunoassay, folate and vitamin B(12) by RIA, vitamin B(6) by HPLC, and eNOS and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms by PCR with restriction fragment length polymorphism analysis. (unifi.it)
  • drug concentrations
  • However, a significant drawback in the use of aminoglycosides is their narrow therapeutic index, the potential for ototoxicity and nephrotoxicity and the need for monitoring of drug concentrations. (biomedcentral.com)
  • The site and technique for collecting the hair specimens are important because considerable differences in trace element and drug concentrations have been reported for hair samples collected from different sites (Chatt and Katz 1988, pp. 14-16). (druglibrary.org)
  • phenobarbital
  • Phenobarbital serum concentrations were measured using a fluorescence polarization immunoassay. (eur.nl)
  • Only 50% of the first measured phenobarbital serum concentrations in each patient were within the therapeutic range of 10-40 mg/L, in comparison with 88.6% concentration measured after TDM implementation. (eur.nl)
  • Simulations were performed to predict the optimum dosage regimen that would maintain plasma phenobarbital concentrations between 15 and 20 mg l(-1) for 72 h. (ox.ac.uk)
  • Simulations suggested that a loading dose of 15 mg kg(-1) followed by two maintenance doses of 2.5 mg kg(-1) at 24 h and 48 h would maintain plasma phenobarbital concentrations between 16.4 and 20 mg l(-1) for 72 h. (ox.ac.uk)
  • CONCLUSIONS: Phenobarbital, given as an i.v. loading dose, 15 mg kg(-1), achieves maximum plasma concentrations of greater than 15 mg l(-1) with good clinical effect and no significant adverse events in children with severe falciparum malaria. (ox.ac.uk)
  • analytes
  • Typically, each procedure includes the following steps: specimen collection, sample washing, digestion or extraction of the hair sample, Immunoassay screening, and confirmation or quantitation of the various analytes. (druglibrary.org)
  • HPLC
  • In addition, empirical models derived from this in vitro data are applied to fosphenytoin and phenytoin concentrations determined via HPLC only from actual patients. (thefreelibrary.com)
  • dose
  • In the present study, we determined the serum concentrations of acetaminophen attained with a regimen of an initial dose of 40 mg/kg followed by doses of 20 mg/kg every 6 h. (asahq.org)
  • Concentration measurements required for dose-adjustments are however complex and are therefore only performed at specialized facilities. (epfl.ch)
  • Dose adjustments should be made in transplant patients to minimize possible organ rejection due to low concentrations. (drugs.com)
  • A maintenance dose of 2.5 mg kg(-1) at 24 h and 48 h was predicted to be sufficient to maintain concentrations of 15-20 mg l(-1) for 72 h, and may be a suitable regimen for treatment of convulsions in these children. (ox.ac.uk)
  • The addition of voriconazole to chronic treatment with carbamazepine 400 mg twice a day was associated with increased carbamazepine serum levels (14.1 mg/l) and serum concentration dose ratios. (clinmedjournals.org)
  • Carbamazepine concentration as well as serum concentration dose ratio gradually decreased after treatment with voriconazole was discontinued, suggesting a probable interaction between the two drugs, according to the drug interaction probability scale. (clinmedjournals.org)
  • We report a case in which the addition of voriconazole to chronic treatment with carbamazepine was associated with increased carbamazepine serum levels and serum concentration dose ratios (SCD ratios). (clinmedjournals.org)
  • parameters
  • In addition, we evaluated whether the pharmacokinetic parameters that we determined previously from acetaminophen doses of 10-30 mg/kg predict the serum concentrations of acetaminophen attained with that regimen. (asahq.org)
  • In the routine practice, in addition of classic parameters, it will be useful to measure the concentration of apo E and that of Homocysteine and if possible to determine the APO E gene polymorphism. (beds.ac.uk)
  • Polarization parameters as a discriminating benchmark. (bioportfolio.com)
  • toxicity
  • This study corroborated the contention that epoxyscillirosidine concentration in yellow tulp fluctuates and may explain I the variability in toxicity. (scielo.org.za)
  • Laboratory
  • Many laboratories, including our own, have replaced immunoassays for other immunosuppressants, which can also suffer from interferences, with laboratory-developed tests that use LC-MS/ MS (4). (thefreelibrary.com)
  • antibiotics
  • Addressing the elimination of both antibiotics, the concentrations in 15 ml elution medium (simulating the volume of the orbit in a newborn) were measured after 0.25, 1, 2, 6, 24, 48 and 72 hours of eluation. (arvojournals.org)
  • circulates
  • Following intravenous injection of fluorescein sodium in an aqueous solution, the unbound fraction of the fluorescein can be excited with a blue light flash from a fundus camera as it circulates through the ocular vasculature, and the yellowish green fluorescence of the dye is captured by the camera. (sgpharma.com)
  • The circulating IGF-I concentration is under control of growth hormone (GH) and circulates largely bound in a ternary complex of IGF-I, IGF-Binding Protein 3 (IGFBP-3) and a protein referred to as the Acid-Labile Subunit (ALS). (biomedcentral.com)
  • Monitoring
  • 5. A method of monitoring compliance of a patient that has been placed on a methadone maintenance program in accordance with claim 3 and wherein step (b) the concentration of methadone is measured. (google.com)
  • Monitoring serum concentrations for once-daily netilmicin dosing regimens. (uzh.ch)
  • attain
  • The invention provides a method of potentiating the activity of antibacterial agents that act on bacterial cell walls, comprising the step of administering to a subject an antibacterial agent and an aminoglycoside to attain a peak concentration of at least 4 mg/l of aminoglycoside and thereafter maintaining. (google.com)
  • samples
  • Next, attempts were undertaken to adapt the immunoassay for analysis in whole blood samples. (epfl.ch)
  • However, samples obtained from the north-eastern part of the sampling I region tended to have higher epoxyscillirosidine concentrations compared to samples obtained from the south-western part of the sampling region. (scielo.org.za)