Plasma concentrationsMetabolic disordersInsulinSerumBiologicalSelectivityProcessesExtractionOxygenMagneticDemonstrateSamplesRangeDaysPatientsHighActivityProvideEarlySpecificChemicalWaterMembranesAssaysProteinsSalt concentrationDeterminePeakPlasmaDoseProteinTherapeuticPreparationReactionBloodImpactTotalRatesTestModelPatientsColumnActivityLocations
Plasma concentrations2
- contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events. (medscape.com)
- Note that normal concentration of glucose in CSF samples is 45-80 mg/dL or 60-80% of that in the plasma (for glucose plasma concentrations less than 400 mg/dL). (medscape.com)
Metabolic disorders1
- Importantly, metabolic disease-derived G972R mutation results in a reduced ability of LLPS, potentially implicating the involvement of aberrant IRS-1 phase separation in various metabolic disorders. (nature.com)
Insulin3
- Since these intrinsically disordered regions, which are conformationally dynamic and do not adopt stable secondary or tertiary structures, are often essential for mediating the phase transition of proteins 9 , it is therefore of interest to consider if the C-terminus of IRS-1 is involved in phase separation and to further delineate such implications upon insulin/IGF signaling. (nature.com)
- IGF-1 stimulation enhanced IRS-1 phase separation which then recruited downstream effectors to form insulin/IGF signalosomes. (nature.com)
- high concentrations of insulin thus lower serum potassium concentration. (msdmanuals.com)
Serum5
- Thus, relatively small alterations in serum potassium concentration can have significant clinical manifestations. (msdmanuals.com)
- In the absence of factors that shift potassium in or out of cells, the serum potassium concentration correlates closely with total body potassium content. (msdmanuals.com)
- Once intracellular and extracellular concentrations are stable, a decrease in serum potassium concentration of about 1 mEq/L (1 mmol/L) indicates a total potassium deficit of about 200 to 400 mEq (200 to 400 mmol). (msdmanuals.com)
- Multiple conditions are associated with xantochromia: traumatic tap, presence of carotene, melanoma and increased bilirubin concentration (bilirubin concentration will also be elevated in serum and patients are often jaundiced) due to liver diseases, hemolytic diseases (also increased free hemoglobin concentration) and inborn errors of metabolism. (medscape.com)
- For accurate interpretation of CSF glucose concentration, serum glucose should be evaluated in serum samples collected about 2 hours prior to spinal tapping (allow time for equilibrium) and all specimens (CSF and serum) should be tested immediately to avoid glycolysis. (medscape.com)
Biological4
- First Responders should use a NIOSH-certified Chemical, Biological, Radiological, Nuclear (CBRN) Self Contained Breathing Apparatus (SCBA) with a Level A protective suit when entering an area with an unknown contaminant or when entering an area where the concentration of the contaminant is unknown. (cdc.gov)
- Conclusions: This easy to automate technology allows an efficient separation of AD molecular biomarkers from volumes of biological solutions complying with the current clinical protocols and, ultimately, leads to accurate measurements of biomarkers. (brighton.ac.uk)
- Contemporary cnidarian-algae symbioses are challenged by increasing CO 2 concentrations (ocean warming and acidification) affecting organisms' biological performance. (nature.com)
- A variety of analytical methods can be used to determine trace concentrations (sub-ppb to ppb) of tungsten in biological tissues. (cdc.gov)
Selectivity2
- GC/HS) ensure sensitivity and selectivity for the detection and quantification of nanomolar concentrations of analytes in a variety of research materials. (mdpi.com)
- They have the solubility, purity and range of molecular weight needed to make hollow fiber, flat sheet and tubular membranes with the pore size and separation selectivity you need. (solvay.com)
Processes3
- Membrane separation processes can help increase the recovery of valuable food products while reducing the volume of waste streams generated. (solvay.com)
- In this study, a combination of physical and chemical separation processes was used to recover the metallic components of red mud. (researchgate.net)
- The ratio between potassium concentration in the intracellular fluid (ICF) and concentration in the extracellular fluid (ECF) strongly influences cell membrane polarization, which in turn influences important cell processes, such as the conduction of nerve impulses and muscle (including myocardial) cell contraction. (msdmanuals.com)
Extraction1
- The present invention relates to field of pharmaceutical equipment, in particular to a kind of heavy concentration systems of water and traditional Chinese medicine extraction system. (google.com)
Oxygen1
- Footnote 4 The rate of biodegradation is largely influenced by acclimatization of the microorganisms, Footnote 8 , Footnote 9 temperature, Footnote 10 , Footnote 11 dissolved oxygen concentration in water, Footnote 12 NTA concentration Footnote 13 and water hardness. (canada.ca)
Magnetic2
- At first, the impact of carbothermal reduction on magnetic separation of iron was studied. (researchgate.net)
- Low magnetic properties of iron minerals resulted in insignificant separation of iron from other components in the non-carbothermally reduced sample. (researchgate.net)
Demonstrate2
- Here, we demonstrate that the C-terminus of IRS-1 undergoes phase separation. (nature.com)
- The high separation power and short analysis time obtained demonstrate for the first time that supercritical fluid chromatography is a fast and reliable technique for the analysis of lignin-derived phenols in complex environmental samples. (lu.se)
Samples2
- These advancements are expected to provide efficient protocols for the concentration and manipulation of molecular biomarkers from clinical samples, enhancing the accuracy and the sensitivity of diagnostic technologies. (brighton.ac.uk)
- 0.2 to 33.5 µg/L). Concentrations of NTA in raw and treated water samples exceeded 10 µg/L in only 14% of the locations. (canada.ca)
Range2
- Results: Here we describe a novel technology to extract one of the most important molecular biomarkers of AD (Aβ 1−42 ) from a clinically-relevant volume − 100 µl - therein dispersed in a range of concentrations critical for AD early diagnosis. (brighton.ac.uk)
- The concentration range included two logarithmic decades. (europa.eu)
Days1
Patients1
- Patients with stable potassium concentration 3 mEq/L ( 3 mmol/L) typically have a significant potassium deficit. (msdmanuals.com)
High1
- High-performance polymers may also have a good fit with emerging polymer membrane applications including carbon dioxide removal (e.g., from natural gas), natural gas liquids removal and dehydration, hydrogen recovery from refinery wet gas and fuel gas streams, olefin/paraffin separations (e.g., propane/propylene) and carbon dioxide sequestration from flue gases. (solvay.com)
Activity1
- Separation and Identification of Four New Compounds with Antibacterial Activity from Portulaca oleracea L. (mdpi.com)
Provide1
- the odor does not provide adequate warning of hazardous concentrations. (cdc.gov)
Early1
- Udel® PSU was used in the early 1980's to make the world's first commercial gas separation membrane able to separate hydrogen from ammonia purge-gas streams. (solvay.com)
Specific1
- In addition to maintaining specific organelle structures, phase separation enables hub proteins to assemble signalosomes which promote the speed of signaling outputs 11 , 12 . (nature.com)
Chemical1
- Hyflon® AD amorphous perfluoropolymers are suitable for polymeric gas separation membranes used in the separation of gases or vapors, the recovery of gases and the enrichment of air in pharmaceutical or chemical processing applications. (solvay.com)
Water3
- The invention provides a kind of heavy concentration systems of water, it is intended to improves the problem of heavy cold-storage jar deslagging of existing water is difficult. (google.com)
- Footnote 4 Based on one model of NTA metal ion speciation, it is predicted that at a concentration of 25 ppb in river water, 50% of the NTA is complexed with Cu 2+ ions, 34% with Ni 2+ , 9% with Ca 2+ and 5% with Zn 2+ . (canada.ca)
- Based on the mean concentration of NTA reported in the Canadian national survey (2.82 µg/L), Footnote 20 and assuming average daily water consumption of 1.5 L, average daily intake of NTA from drinking water is 4.23 µg. (canada.ca)
Membranes1
- To achieve control over NP distribution, this project proposes the use of asymmetric membranes: Membranes with lateral asymmetries or domains that form through the phase separation of membrane lipids, and membranes with transversal asymmetries due to the asymmetric distribution of lipids in the two leaflets that constitute the bilayer membrane. (europa.eu)
Assays3
- Detergents play an important role in membrane protein (MP) solubilization, purification and post-purification processing, i.e., concentration for subsequent characterization assays. (aiche.org)
- Numerous assays are being developed to measure blood concentrations of cyclosporine. (nih.gov)
- Comparison of concentrations in published literature to patient concentrations using current assays must be done with detailed knowledge of the assay methods employed. (nih.gov)
Proteins2
- Here, we discuss two methods of obtaining high concentration of MPs without increasing detergent concentration using light-driven sodium and chloride transporters, KR2 and halorhodopsin (pHR), as model proteins. (aiche.org)
- One of the key techniques employed in protein purification is chromatography, which involves the separation of proteins based on their physicochemical properties. (pswc2010.org)
Salt concentration4
- Alternately, increasing the extraction of MPs from lipid bilayers using longer alkyl chain detergents and higher salt concentration is another means of improving yield. (aiche.org)
- 0.001) between the decreased community phylogenetic distance and increased salt concentration. (researchgate.net)
- Despite significant differences in composition, communities in locations with a similar salt concentration had a similar phylogenetic distance. (researchgate.net)
- Factors such as pH, temperature, salt concentration, flow rates, and column dimensions need to be carefully optimized to maximize the efficiency of each step. (pswc2010.org)
Determine3
- We used the Community Multiscale Air Quality model employing the decoupled direct method to quantify changes in air quality and epidemiological evidence to determine concentration-response functions to calculate associated health impacts. (nih.gov)
- It is believed that dose adjustment and therapeutic monitoring data in clinical practice can provide insight about the drug dose/concentration and response relationship which may help determine which drug falls into NTI category and may need tighter review criteria. (nih.gov)
- The concentration and distribution of the nanoparticles in the bilayer determine the permeability and deformability of the GUV membrane. (europa.eu)
Peak2
- Peak concentrations (C max ) in blood and plasma are achieved at about 3.5 hours. (nih.gov)
- There was no effect on plasma lipids or uric acid, but there was a lower glucose and insulin peak concentration after consumption of the FVPD compared with the sugar-matched control. (cambridge.org)
Plasma3
- Scatterplot depicting plasma (A) and whole blood (B) taurine concentrations for Cavalier King Charles Spaniels grouped based on myxomatous mitral valve disease stage. (avma.org)
- Scatterplot depicting plasma (A) and whole blood (B) taurine concentrations for Cavalier King Charles Spaniels eating diets that met World Small Animal Veterinary Association (WSAVA) nutritional guidelines versus other diets. (avma.org)
- Violin plot showing the distribution of plasma and whole blood taurine concentrations in dogs (n = 198) used to form the reference intervals. (avma.org)
Dose2
- Narrow therapeutic index (NTI) drugs are those drugs where small differences in dose or blood concentration may cause serious adverse events or therapeutic failure. (nih.gov)
- It is recommended that patients taking cyclosporine capsules, (NON-MODIFIED) over a period of time be monitored at repeated intervals for cyclosporine blood concentrations and subsequent dose adjustments be made in order to avoid toxicity due to high concentrations and possible organ rejection due to low absorption of cyclosporine. (nih.gov)
Protein2
- This article will delve into various aspects related to protein purification including different chromatographic separation techniques, affinity tags utilized for target protein isolation, downstream processing considerations like filtration and diafiltration steps along with their optimization strategies. (pswc2010.org)
- Filtration techniques such as microfiltration and ultrafiltration aid in separating particles based on size while diafiltration helps in exchanging buffer components and adjusting protein concentration. (pswc2010.org)
Therapeutic1
- Methoxyverapamil at therapeutic concentration and 10 times that level resulted in a 12% and 21% reduction in the formation of ISCs respectively, which was statistically significant. (who.int)
Preparation2
Reaction2
- 3. Stop cross-linking reaction by adding glycine to a final concentration of 0.125 M. We use a 10X (1.25 M) stock solution. (nih.gov)
- Treating adsorption as a chemical reaction between the gas molecule and the adsorption vacant site, the classical Langmuir isotherm model expresses the reaction in terms of the species concentrations. (osti.gov)
Blood1
- These drugs were tested in pharmacological concentrations and in higher concentrations on blood obtained from patients with sickle-cell anaemia. (who.int)
Impact2
- Residential combustion (RC) and electricity generating unit (EGU) emissions adversely impact air quality and human health by increasing ambient concentrations of fine particulate matter (PM 2.5 ) and ozone (O 3 ). (nih.gov)
- Moreover, this project studies the impact of the concentration and distribution of NPs on the mechanical properties of the GUV membrane in the presence and absence of the external stimulus, which is light, at the adequate wavelength to excite the phonon modes of the membrane through plasmon-phonon energy transfer. (europa.eu)
Total1
- A number of emitting source sectors that are spatially distributed across the United States contribute to total ambient concentrations of these pollutants, including electricity generating units (EGUs), which burn fossil fuels like coal and natural gas to produce electricity, and residential combustion (RC) sources, including oil and natural gas-burning furnaces or wood-burning stoves to heat homes. (nih.gov)
Rates1
- According to this standard, the system must achieve ammonia, nitrogen and dust separation rates of at least 70 % for each of these elements. (dlg.org)
Test1
- In the test, the CleaningCubes achieved a minimum separation efficiency of 78.6 % in winter and 71.4 % in summer for PM10 fine dust. (dlg.org)
Model1
- Designed to capture the surface heterogeneity, the proposed thermodynamic Langmuir isotherm model substitutes the species concentrations with the species activities and calculates the species activity coefficients with the adsorption non-random two-liquid activity coefficient model. (osti.gov)
Patients1
- Multiple conditions are associated with xanthochromia: traumatic tap, presence of carotene, melanoma and increased bilirubin concentration (bilirubin concentration will also be elevated in serum and patients are often jaundiced) due to liver diseases, hemolytic diseases (also increased free hemoglobin concentration) and inborn errors of metabolism. (medscape.com)
Column1
- Distillation and absorption are well established separation technologies, and column performance can usually be accurately predicted by theoretical models. (sulzer.com)
Activity1
- The PAF concentrations were estimated by assessing the aggregatory activity toward washed rabbit platelets (WRP). (news-medical.net)
Locations1
- We measured area CO concentrations at Association (HIA) Can Do various locations on the upper and lower decks of the houseboats. (cdc.gov)