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  • vitro
  • Previous studies have indicated that QBP1 (polyQ binding peptide 1) binds to the expanded polyQ stretch and inhibits aggregate formation of the expanded polyQ protein in vitro [ 5 , 6 ]. (hindawi.com)
  • Protein (ovotransferrin, α-lactalbumin and insulin) can be denatured and aggregated in vitro by adding DTT (reducing agent). (ukessays.com)
  • angiotensin
  • Lately TRPC6 and TRPC6/7 have already been identified as important parts of the α1-adrenoceptor-activated cation currents in smooth muscle cells (27) while in the heart TRPC3 and TRPC6 proteins are essential for angiotensin II-induced hypertrophy (28 29 and TRPC3 is essential to the potentiated insulin-induced current (30). (plant-finder.com)
  • The angiotensin II receptor antagonist, losartan, enhances regulator of G protein signaling 2 mRNA expression in vascular smooth muscle cells of Wistar rats. (gopubmed.org)
  • Humans
  • Effective at lowering low-density lipoprotein-cholesterol (LDL-C), these inhibitors also elevate liver enzymes and induce hepatic steatosis in animals and humans. (aspetjournals.org)
  • With change in the biochemical compounds of humans body such as PH, temperature or bodys chemical condition in protein structure change as well and these changes can cause denaturation of protein. (ukessays.com)
  • pathway
  • The pan-caspase inhibitor, Z-VAD-FMK, could reverse dicitrinone B-induced apoptosis, suggesting that it is a caspase-dependent pathway. (mdpi.com)
  • Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. (genetex.com)
  • Objective- Tissue factor pathway inhibitor (TFPI) is produced in 2 isoforms: TFPIα, a soluble protein in plasma, platelets, and endothelial cells, and TFPIβ, a glycosylphosphatidylinositol-anchored protein on endothelium. (ahajournals.org)
  • Of the 56 up-regulated genes, 17 were direct target genes for transcription factors sterol regulatory element-binding protein (SREBP) 1 or SREBP2, which activate genes in the sterol biosynthesis pathway. (aspetjournals.org)
  • chemical
  • The underlying frameworks of natural products represent the evolutionarily selected fractions of chemical space explored by nature so far and meet the criteria of relevance to nature and biological prevalidation most crucial to inhibitor development. (pnas.org)
  • The underlying frameworks of natural products (NPs) provide evolutionarily selected chemical structures encoding the properties required for binding to proteins, and their structural scaffolds represent the biologically relevant and prevalidated fractions of chemical space explored by nature so far ( 7 - 9 ). (pnas.org)
  • vivo
  • The investigators expect to determine the stability of the concentration of vancomycin, teicoplanin, linezolid, daptomycin and tigecycline used in lock solutions, and thus to assay the optimal timeframe that the concentration of antibiotic used in lock solution keeps its in vivo antimicrobial activity. (clinicaltrials.gov)
  • Study Hypothesis: An antibiotic lock solution maintains in vivo concentration and antimicrobial activity for at least 10 days after its infusion inside a subcutaneous port catheter. (clinicaltrials.gov)
  • I am interested in finding protocols for inhibiting protein and RNA synthesis in vivo in Arabidopsis. (bio.net)
  • compound
  • Here we show the crystal structures of the prefusion MeV-F alone and in complex with the small compound AS-48 or a fusion inhibitor peptide. (pnas.org)
  • CETP
  • Potentially important differences are emerging in the mechanisms by which CETP inhibitors operate, which may lead to variation in their anti-atherogenicity unrelated to the changes in HDL-cholesterol they induce. (bjcardio.co.uk)
  • 1 2 The ability of CETP to facilitate the remodeling of lipoprotein composition endows an important role to this protein in the intravascular metabolism of lipoproteins. (ahajournals.org)
  • We and others have suggested that the function of CETP, that is, its capacity to affect changes in the composition of individual lipoprotein fractions, is modulated by a second plasma protein, lipid transfer inhibitor protein (LTIP). (ahajournals.org)
  • 19 20 21 22 23 24 LTIP is a LDL-associated protein of ∼30 kd that preferentially reduces the action of CETP on LDL, probably through its capacity to prevent CETP binding to lipoproteins. (ahajournals.org)
  • 1 26 In normolipidemic individuals, VLDL TG, not CETP concentration, is rate limiting for these net lipid transfers. (ahajournals.org)
  • Mammalian
  • It is now widely recognized that mammalian cells use mitogen-activated protein kinases (MAPKs) as distal effectors for many extracellular growth factors, stress detectors, and drug sensors. (aspetjournals.org)
  • buffer
  • In the present article it was hypothesized that creatine at a relatively high concentration would serve as a buffer for the sudden release of ATP and UTP during the early phase of ischemia in association with previously RTA 402 described arrhythmic events. (plant-finder.com)
  • activity
  • Under normal circumstance, the plasmid numbers are above the threshold, the inhibitor concentration is high enough to completely repress the activity of in-promoter. (igem.org)
  • In our project, when the plasmid numbers are below the threshold, the decrease of inhibitor proteins will lead to the increase of in-promoter activity. (igem.org)
  • In this study, we have explored the potential for chaperone activity of α B-crystallin to suppress the formation of protein aggregates. (hindawi.com)
  • We have identified GSK923295, an allosteric inhibitor of CENP-E kinesin motor ATPase activity, and mapped the inhibitor binding site to a region similar to that bound by loop-5 inhibitors of the kinesin KSP/Eg5. (pnas.org)
  • Decreased AKT activity occurs many hours before the HSP90-dependent decline of AKT protein but is correlated with loss of AKT phosphorylation. (aacrjournals.org)
  • However, in plasma deficient in lipid transfer inhibitor protein (LTIP) activity, HDL and LDL are equivalent donors of CE to VLDL ( Arterioscler Thromb Vasc Biol . (ahajournals.org)
  • bound
  • Other HDL-bound proteins associated with functions related to lipid metabolism/cholesterol homeostasis, oxidation, coagulation, complement activation and immunity were unchanged after consumption of the MedDiet for 5 weeks. (karger.com)
  • Here we show the crystal structures of MeV-F alone and bound to inhibitors. (pnas.org)
  • extracellular
  • Activation of AKT involves both conformational change and phosphorylation of the protein and is usually preceded by up-regulation of receptor kinases induced by extracellular stimuli. (aacrjournals.org)
  • gene
  • The inhibitor can repress the in-promoter and control the expression of downstream killer gene. (igem.org)
  • expression
  • 1) Part:BBa_K808000 AraC -P BAD is used to control the expression of inhibitor proteins, The concentration of inducer arabinose is regarded as an input signal, and the red fluorescence intensity controlled by in-promoter is the output. (igem.org)
  • diseases
  • The formation of intranuclear inclusions of polyQ-containing proteins in the brain is one of the pathological features of these diseases. (hindawi.com)
  • The α B-crystallin protein is found to be overexpressed in many neurological diseases, and mutations in α A- or α B-crystallin can cause cataracts and myopathy [ 11 ]. (hindawi.com)
  • Some diseases can let of significant change in the protein structure. (ukessays.com)
  • Amyloidoses are diseases characterized by abnormal protein folding and self-assembly, for which no cure is available. (nih.gov)
  • decrease
  • Fig.2 With the decrease of plasmid numbers, the concentration of repressor will reduce to a threshold. (igem.org)
  • Note the decrease in Gγ 1 Coomassie staining in the presence of 300 mM imidazole during protein elution. (nih.gov)
  • Increase of malonic dialdehyde (MDA) by 89% and protein carbonyl groups (PCG) by 60% and decrease of superoxide dismutase (SOD) by 40% were also observed. (hindawi.com)
  • function
  • Centromere-associated protein-E (CENP-E) is a kinetochore-associated mitotic kinesin that is thought to function as the key receptor responsible for mitotic checkpoint signal transduction after interaction with spindle microtubules. (pnas.org)
  • There is direct relation between proteins structure and their function. (ukessays.com)