• Due to the great influence the concentration of hemoglobin S has on the kinetics of gelation, we hypothesized that cetiedil might inhibit sickling by modifying erythrocyte Na+ or K+ movements in a manner which would prevent a rise in the concentration of intracellular hemoglobin. (unboundmedicine.com)
  • Cetiedil, a drug reported to relieve painful crises in sickle cell anemia, has direct antisickling properties in vitro. (unboundmedicine.com)
  • AU - Berkowitz,L R, AU - Orringer,E P, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 283 EP - 8 JF - Blood cells JO - Blood Cells VL - 8 IS - 2 N2 - Cetiedil, a drug reported to relieve painful crises in sickle cell anemia, has direct antisickling properties in vitro. (unboundmedicine.com)
  • In the treatment of sickle-cell disease, hydroxycarbamide increases the concentration of fetal hemoglobin. (wikipedia.org)
  • 3] So that the higher antioxidant property of an antisickling agent enables it to reduce oxidative stress that contributes to sickle cell crisis. (researchsquare.com)
  • Due to its chemical properties hydroxyurea was explored as an antisickling agent in the treatment of hematological conditions. (wikipedia.org)
  • The effects of oral administration of different doses ofCaricapapayaseed extracts on hematological parameters specifically red blood cells (RBC), packed cell volume (PCV), and hemoglobin concentration in male and female Wistar rats were examined. (researchwap.com)
  • 1969). The red blood cell count, white blood cell counts, packed cell volume and hemoglobin concentration are regularly measured hematological parameters but this study is concerned with red blood cells, packed cell volume, and haemoglobin. (researchwap.com)
  • Some of medicinal plants are thought to be responsible for observed antisickling action for their high contain of phenolic compounds and antioxidant nutrients. (researchsquare.com)
  • In addition, increase scientific research has been focused on identifying and isolating bioactive agents in medicinal plants [5]. (austinpublishinggroup.com)
  • This could possibly mean that the phytomolecules present in Millettia aboensis possess stimulatory effect on red blood cell production and could probably be used as a therapeutic agent in the treatment of anaemia. (soapboxscience.org)
  • Focusing on testing and evaluating of herbal therapies will be of great value in finding of potent alternative medicine to face resistant bacterial infections and to provide sufficient therapeutic agent to disband the problem. (microbiologyjournal.org)
  • Cetiedil then may represent an alternate type of antisickling agent, exerting its effect through changes in erythrocyte membrane cation permeability rather than directly modifying hemoglobin S. (unboundmedicine.com)
  • The red blood cell mass, hemoglobin concentration, and packed cell volume of the rats were determined by routine methods. (researchwap.com)
  • Cetiedil has two such effects: It causes a rise in passive Na+ movements and it inhibits a specific increase in K+ permeability secondary to a rise in cytoplasmic Ca2+ concentration. (unboundmedicine.com)
  • Previous studies have shown that Carica papaya has antisickling effects (Sofoworaet al. (researchwap.com)
  • The extracts of Hyphaene thebaica was used in treatment of hypertension, bilharzias and as a haematinic agent. (researchsquare.com)
  • Generally, treatment depends on causative agent and course of disease accordingly, because that tonsillitis may occur in the form of chronic or acute condition. (microbiologyjournal.org)
  • was observed after incubation of RBCs with 2% sodium metabisulfite in the presence of three different concentration (1000, 500 and 250) μg/ml of Hyphened thebaica for two type of extraction (aqueous and methanol) extract. (researchsquare.com)
  • Antioxidants (scavengers of free radicals) are thought to be major components of these antisickling action thus different antisickling agents have different degrees of effect according to amount of antioxidant. (researchsquare.com)
  • i] It has the ability to retain high concentrations of electrolyte minerals, allowing it to stay internally hydrated in the driest of conditions. (weebly.com)
  • These plants have also been reported to possess antisickling, antiparasitic and antiseptic activities and have been known to be used to treat other ailments including toothache, sexual impotence, gonorrhoea, malaria, dysmenorrhoea, urinary and venereal diseases and abdominal pain. (islamicteachings.org)
  • 2018 ). It occurs due to irregular intestinal absorptive and secretory activities of fluid and electrolytes caused by infectious agents, toxicants, diet, allergic substances and GIT disorders including inflammatory bowel syndrome, dysmotility and drugs (Ezeja et al. (springeropen.com)
  • Following ethanol plant extract administration of 2000 mg/kg, the level of haemoglobin concentration and its related indices were appreciably improved. (soapboxscience.org)
  • For both doses, serum crizanlizumab concentrations rose to a near maximum level shortly after infusion. (thalassaemia.org.cy)
  • All in all, enzymatically active and bioavailable Moringa oleifera provides 36 natural anti-inflammatory agents. (weebly.com)
  • With an increase in tooth decay and gum diseases all over the world, there is need to produce oral cleaning agents that will better control caries-causing bacteria. (islamicteachings.org)
  • Hydroxyurea has been reported as endogenous in human blood plasma at concentrations of approximately 30 to 200 ng/ml. (wikipedia.org)
  • Due to its chemical properties hydroxyurea was explored as an antisickling agent in the treatment of hematological conditions. (wikipedia.org)
  • Current management strategies include prophylactic penicillin and immunizations to decrease the occurrence of pneumococcal infections, hydroxyurea (a disease-modifying agent), blood transfusions (for symptomatic acute anemia, stroke management, preoperative optimization), and bone marrow transplant. (ccjm.org)
  • Jean-Antoine Ribeil, MD, PhD, from the Reference Centre for Sickle Cell Disease, Necker Children's Hospital, Paris, France, and colleagues introduced a lentiviral vector bearing an antisickling variant of HbA into a boy when he was 13 years old. (medscape.com)
  • The purpose of this RFA is to fund the development and adaptation of biological assays for automated, high throughput screening of compounds that can potentially be used to improve the understanding of the biology of Sickle Cell Disease (SCD) and provide inroads toward new agents for SCD treatments. (nih.gov)
  • Not only will the compounds provide further insight on the sickling mechanisms, but those that show therapeutically significant effects at concentrations known to be non-toxic can be very rapidly approved for clinical trials as these agents are either already FDA-approved or under clinical development for other diseases. (nih.gov)
  • Clinical utility of a myelosuppressive 'switching' agent. (nih.gov)
  • In conclusion, G6PD(202A,376G) may be associated with lower haemoglobin concentration in sickle cell anaemia by a mechanism other than increased haemolysis. (nih.gov)
  • One potential contrast agent is intracellular methemoglobin, a paramagnetic molecule that is normally present in small amounts in red blood cells. (bvsalud.org)