• One of the hypotheses being investigated is that aberrant vascular stiffness changes are involved in the genesis of certain cardiovascular pathologies (e.g., preeclampsia, isolated systolic hypertension in elderly). (pitt.edu)
  • Computational models and simulations are used to predict the relationship between parameters that are otherwise challenging to test experimentally, or used to design more relevant experiments reducing the time and costs of experiments. (wikipedia.org)
  • Computational biomechanics is an essential ingredient in surgical simulation, which is used for surgical planning, assistance and training. (wikipedia.org)
  • In various engineering scenarios, the computational cost of simulating intricate and large systems is considerable and frequently exceeds the present computer capabilities. (stanford.edu)
  • Therefore, the Darve research group is working on innovative numerical strategies to lower this computational cost and facilitate the simulation of complex systems over realistic timescales. (stanford.edu)
  • Biophysical computational models of the heart provide a quantitative framework for mapping changes in anatomy to whole heart function. (plos.org)
  • In this review, we introduce the concept of computational fluid dynamics (CFD) modeling with a clinical perspective and we review the CFD models used to study RE from the fluid mechanics point of view. (unav.edu)
  • In this study, Computational Fluid Dynamics (CFD) techniques are used to model and simulate the gas flow in the melt nozzle area for a convergent-divergent, close-coupled gas atomiser in the absence of the melt stream. (unav.edu)
  • A rabbit ventricular computational model was used to simulate 9-V battery stimulation for different durations at varying onset times during sinus rhythm. (ox.ac.uk)
  • Predictive computational biomedicine involves applications that are comprised of multiple components, arranged as far as possible into automated workflows in which data is taken, from an individual patient, processed, and combined into a model which produces predicted health outcomes. (bsc.es)
  • Dr. Shroff has been serving as the Principal Investigator on a NIH-NHLBI pre-doctoral training grant (Cardiovascular Bioengineering Training Program) since 2005 and the Coulter Translational Research Partnership II Program since 2013, and Co-Director on a NIH-NHLBI post-doctoral training grant (Training Program in Imaging Sciences in Translational Cardiovascular Research) since 2016. (pitt.edu)
  • Mechanical modeling using finite element analysis has been used to interpret the experimental observation of plant cell growth to understand how they differentiate, for instance. (wikipedia.org)
  • Under certain mathematical circumstances, blood flow can be modeled by the Navier-Stokes equations. (wikipedia.org)
  • In addition to basic and translational research, Dr. Shroff and colleagues have developed and continue to develop novel, simulation-based material (i.e., mathematical models of biological systems and associated "virtual experiments") for education and engineering design. (pitt.edu)
  • DC application to diastolic tissue induced anodal and cathodal make excitations in both simulations and experiments. (ox.ac.uk)
  • An often studied liquid biofluid problem is that of blood flow in the human cardiovascular system. (wikipedia.org)
  • It is well known that the modern understanding of the cardiovascular system undoubtedly starts with the work of William Harvey (1578-1657) who published his discovery of the circulation of blood in 1628. (scirp.org)
  • Artificial Intelligence (AI) plays an integral role in enhancing the quality of surgical simulation, which is increasingly becoming a popular tool for enriching the training experience of a surgeon. (frontiersin.org)
  • As AI technology is key to driving the future of surgical simulation, this paper will review the literature delineating its current state, challenges, and prospects. (frontiersin.org)
  • In addition, a consolidated list of FDA/CE approved AI-powered medical devices for surgical simulation is presented, in order to shed light on the existing gap between academic achievements and the universal commercialisation of AI-enabled simulators. (frontiersin.org)
  • In this review, we aim to discuss the current state of AI technology in surgical simulation. (frontiersin.org)
  • 2) The role of pulsatile arterial load (vascular stiffness in particular) in cardiovascular function. (pitt.edu)
  • We used a combined experimental and modelling approach to understand how the interaction of direct current (DC) from a battery may induce reentrant activity within rabbit ventricles and its dependence on battery application timing and duration. (ox.ac.uk)
  • The research interests of Professor Darve span across several domains, including machine learning for engineering, surrogate and reduced order modeling, stochastic inversing, anomaly detection for engineering processes and manufacturing, numerical linear algebra, high-performance and parallel computing, and GPGPU. (stanford.edu)
  • Then, the influence of both the inlet gas pressure and this design parameter are investigated, comparing the numerical results provided by simulations varying the inlet pressure from 5 to 80 bar and modelling different convergent-divergent gas nozzles with throat widths of 0.29¿Lo, 0.5¿Lo, 0.77¿Lo and 2¿Lo respectively. (unav.edu)
  • In this work, we test the hypothesis that in a statistical shape model (SSM), the modes that are most relevant for describing anatomy are also most important for determining the output of cardiac electromechanics simulations. (plos.org)
  • As a result, in cardiac models, representing patient anatomy using a limited number of modes of anatomical variation can cause a loss in accuracy of simulated electromechanical function. (plos.org)
  • Simulations of cardiac electrical activation and mechanical pump function in hearts with shapes described by different combinations of shape components were performed. (plos.org)
  • This highlights the need to have high fidelity anatomical models in cardiac simulations and demonstrates that subtle changes in cardiac anatomy can have a large impact on cardiac function. (plos.org)
  • Finally, we show what CFD simulations have taught us about the hemodynamics during RE, the current capabilities of CFD simulations of RE, and we suggest some future perspectives. (unav.edu)
  • Three related user communities lie at the heart of the CoE: academic, industrial and clinical researchers who all wish to build, develop and extend such capabilities in line with the increasing power of high performance computers. (bsc.es)
  • Using an interdisciplinary approach and maintaining close links with clinical practice, the institute combines state-of-the-art imaging, data science and data modeling methods to lay the foundations for improvements in diagnostics, treatment planning and the clinical decision-making process. (charite.de)
  • The idea is to support device validation along the entire research and development pathway - from in silico modeling to virtual animal and clinical studies. (charite.de)
  • Although arguably still in its early stages of widespread clinical application, AI technology enables personal evaluation and provides personalised feedback in surgical training simulations. (frontiersin.org)
  • We shall work with them to advance the exploitation of HPC and will engage closely with medical professionals through our partner hospitals in order to establish modeling and simulation as an integral part of clinical decision making. (bsc.es)
  • The newly funded SIMCor project aims to establish a computer platform which will serve as a joint, open research and development resource for device manufacturers, medical institutes, and regulatory authorities. (charite.de)
  • We are firmly convinced that, through the use of computer simulation and virtual studies, SIMCor will speed up the development, validation and regulatory approval of cardiovascular medical devices," says project coordinator Prof. Dr. Titus Kühne, Director of Charité's Institute of Cardiovascular Modeling and Image-Guided Cardiovascular Interventions (ICM) and Research Group Lead at the German Heart Center Berlin (DHZB). (charite.de)
  • Three distinct exemplar research areas will be pursued: cardiovascular, molecularly-based and neuro-musculoskeletal medicine. (bsc.es)
  • The simulation results show how similarly these two parameters modify gas mass flow rates, gas velocity fields, aspiration pressures in the melt delivery tube or the size of the recirculation zones below the melt nozzle. (unav.edu)
  • Cardiovascular implantable medical devices are some of the most advanced, commonly used and life-sustaining implants. (charite.de)
  • SIMCor will also deliver device-specific models which are capable of predicting the safety, efficacy, and user-friendliness of medical devices. (charite.de)
  • risk levels (MRLs) from the Agency for Toxic Sub- output of the simulation or dose metric was the maxi- stances and Disease Registry (ATSDR), serve to protect mum value of the sum of the concentration of trichlo- the target human population and also permit cost-effec- roethylene in blood and the concentration of trichloro- tive use of a chemical within regulatory constraints. (cdc.gov)
  • Hence, all probabilistic parame- its for hazardous chemicals is protection of human ters used in the model are based on actual human data. (cdc.gov)
  • At the microscopic scale, the effects of individual red blood cells become significant, and whole blood can no longer be modeled as a continuum. (wikipedia.org)
  • In fact, although in the introduction to the problem (paragraphs 1-8), Euler focuses on the discussion on blood flow through arteries, to such a degree to even proposing adhoc models for the behavior of their elastic cross-sections, surprisingly, and also somehow disappointing, is that the main body of the manuscript (paragraphs 9-34) is devoted to the modeling of flows through rigid tubes, driven by a piston pump. (scirp.org)
  • The main types of cardiovascular drugs market are anti-hypertensive drugs, hypolipidemics, anti thrombotics, and other drugs for cardiovascular diseases (congestive heart failure, anti-arrhythmic and anti-anginal drugs). (thebusinessresearchcompany.com)
  • Many of the models are multiscale, requiring the coupling of two or more high performance codes. (bsc.es)
  • 5) Development of novel, physiology-based cardiovascular monitoring technologies. (pitt.edu)
  • Age-adjusted logistic regression models explored the association between obesity, socioeconomic status, and region. (bvsalud.org)
  • This Centre of Excellence will advance the role of computationally based modelling and simulation within biomedicine. (bsc.es)
  • Computer-based (in silico) methods for the testing and validation of these devices - such as virtual animal models and computer modeling - can help to improve their quality, efficacy and safety while also reducing cost and time-to-market. (charite.de)
  • The aim of the project is to create a platform for the testing, development, and regulatory approval of cardiovascular implants. (charite.de)
  • New methods such as computer simulations and virtual animal models are used, which contribute to an even better quality and safety of such implants. (charite.de)
  • Long working hours, less physical activity, and unhealthy eating and drinking habits are major causes of cardiovascular diseases including hypertension. (thebusinessresearchcompany.com)
  • These factors are expected to increase the patient pool globally, thereby driving the cardiovascular drugs market during the forecast period. (thebusinessresearchcompany.com)
  • He was previously a student at the Ecole Normale Supérieure, rue d'Ulm, Paris, in Mathematics and Computer Science. (stanford.edu)
  • Received May 14, 1997 variability and to use this measure of variability to Using the Monte Carlo method and physiologically derive a safe exposure limit or guidance value for inha- based pharmacokinetic modeling, an occupational in- lation of trichloroethylene (TRI) in an occupational set- halation exposure to trichloroethylene consisting of ting. (cdc.gov)
  • This has led FE modeling (or other discretization techniques) to the point of becoming ubiquitous in several fields of Biomechanics while several projects have even adopted an open source philosophy (e.g. (wikipedia.org)
  • Comparative biomechanics is often applied in medicine (with regards to common model organisms such as mice and rats) as well as in biomimetics, which looks to nature for solutions to engineering problems. (wikipedia.org)