Department faculty members have teaching and research expertise in areas related to cardiovascular and fluid biomechanics, musculoskeletal biomechanics, biomaterials and tissue engineering, bioinstrumentation, biosystems, biomedical imaging, biological signal analysis, bioinformatics and computational biology, respiratory and pulmonary engineering, and other allied fields. (uiowa.edu)
In this review, we introduce the concept of computational fluid dynamics (CFD) modeling with a clinical perspective and we review the CFD models used to study RE from the fluid mechanics point of view. (unav.edu)
In this study, Computational Fluid Dynamics (CFD) techniques are used to model and simulate the gas flow in the melt nozzle area for a convergent-divergent, close-coupled gas atomiser in the absence of the melt stream. (unav.edu)
To illustrate our tools, we morph several image-based, patient-specific models to create a range of shape changes and simulate the resulting hemodynamics via three-dimensional, computational fluid dynamics. (nsf.gov)
Postintervention computational fluid dynamics predictions were validated in 2 stented patients and quantitatively assessed in 4 surgical patients. (nsf.gov)
In this study, anatomically ac- curate computational fluid dynamics (CFD) models were used to and respiratory systems (ATSDR, 1999). (cdc.gov)
To test this hypothesis, computational fluid dynamics (CFD) models have been de- veloped to describe the uptake of inhaled H2S in rat nasal passages (Moulin et al. (cdc.gov)
Vascular7
The Vascular Model Repository , a sister project of SimVascular, is a library of computational models of normal and diseased human cardiovascular and pulmonary anatomy and input and output boundary conditions for various physiologic states. (github.io)
Mascheroni, P., Penta, R., Merodio, J. (2023) The impact of vascular volume fraction and compressibility of the interstitial matrix on vascularised poroelastic tissues Biomechanics and Modeling in Mechanobiology, 22, pp. 1901-1917. (gla.ac.uk)
2) The role of pulsatile arterial load (vascular stiffness in particular) in cardiovascular function. (pitt.edu)
One of the hypotheses being investigated is that aberrant vascular stiffness changes are involved in the genesis of certain cardiovascular pathologies (e.g., preeclampsia, isolated systolic hypertension in elderly). (pitt.edu)
3) Cardiovascular actions of relaxin and its therapeutic potential in the context of three pathologies: (i) relaxin-induced maternal vascular remodeling and associated functional benefits in preeclampsia, (ii) relaxin-induced left atrial remodeling and suppression of atrial fibrillation, and (iii) relaxin-induced left ventricular remodeling and associated functional benefits in the setting of diastolic dysfunction. (pitt.edu)
Abstract We propose svMorph, a framework for interactive virtual sculpting of patient-specific vascular anatomic models. (nsf.gov)
They are also compatible with popular vascular modeling software, such as SimVascular. (nsf.gov)
Arterial4
Our model predictions of the changes in stroke volume and mean arterial pressure during AF episodes match published paroxysmal AF data. (lehigh.edu)
This study describes a multidimensional 3D/lumped parameter (LP) model which contains appropriate inflow/outflow boundary conditions in order to model the entire human arterial trees. (sharif.edu)
A new extensive LP model of the entire arterial network (48 arteries) was developed including the effect of vessel diameter tapering and the parameterization of resistance, conductor and inductor variables. (sharif.edu)
Autoregulatory adaptation of the cardiac output and downstream arterial resistance was modeled in response to intervention‐induced hemodynamic perturbations. (nsf.gov)
Hemodynamic4
This event features postdoc Sanmi Adeodu who will talk about "Modeling the Short-Term Effect of Atrial Fibrillation on Hemodynamic Variables" , as part of the Lehigh University Chemical and Biomolecular Engineering's Fall 2023 Colloquium Seminar Series. (lehigh.edu)
Our goal is to clarify the short-term impact of stand-alone AF on hemodynamic quantities using a lumped parameter approach. (lehigh.edu)
We also demonstrate the ability to quickly estimate the hemodynamic effects of the shape changes via automated generation of associated zero-dimensional lumped-parameter models. (nsf.gov)
Our study aims to model, assess, and predict hemodynamic outcomes of transcatheter interventions in these patients. (nsf.gov)
Outcomes3
Now, Sanmi is applying ideas in optimal control to design control systems for neuromodulation of the human cardiac system to improve health outcomes in atrial fibrillation and other cardiovascular diseases. (lehigh.edu)
These computational outcomes recommended that licorice (Fisch), cimicifugae (L.), and ganoderma (Karst) and their chemical substance constituents, that have not really been trusted for anti-thrombosis previously, may possess unexpected results on platelet aggregation. (aboutsciencenow.info)
No benefit was observed for type 2 diabetes, cardiovascular or cognitive outcomes. (elifesciences.org)
Diseases5
Acute kidney injury (AKI) is a life-threatening disease with high mortality characterized by an abrupt decrease of the kidney glomerular filtration rate, extra-kidney consequences (cardiovascular diseases, lung injury, neurological impairment) and high risk of secondary chronic kidney disease (CKD). (hrb.ie)
But for how much effect capillary functionality can have on our health, their small size makes them extremely difficult to engineer into models for a variety of diseases. (upenn.edu)
Rather than just achieving a physical model of capillaries, these researchers created a model that allowed them to study typical flow and motion through capillaries, before comparing it to deficiencies in this behavior involved with diseases like malaria. (upenn.edu)
Tested with malaria-infected blood cells, the model showed similar circulatory obstructive behavior to that which occurs in patients, giving hope that this model can be transferred to other diseases involving such obstruction, like sickle cell anemia, diabetes, and cardiovascular conditions. (upenn.edu)
Cardiovascular diseases (CVDs), including thrombosis, which is certainly induced by platelet aggregation, will be the leading reason behind mortality world-wide. (aboutsciencenow.info)
Cardiac2
Wildhirt, S.M. (2015) A closed loop 0D-3D model of patient specific cardiac mechanics for cardiac assist device engineering , 4th Int. Conf. (tum.de)
Wall, W.A. (2015) Pericardial Boundary Conditions for Cardiac Mechanics Simulations , 4th International Conference on Computational and Mathematical Biomedical Engineering - CMBE2015, P. Nithiarasu and E. Budyn (Eds. (tum.de)
Physiological4
and yet it remains a question due to physiological, geometrical and computational complications. (sharif.edu)
Physiological modeling, tight glycemic control, and the ICU clinician: what are models and how can they affect practice? (springeropen.com)
Computational models of human physiology offer the potential, with clinical data, to create patient-specific models that capture a patient's physiological status. (springeropen.com)
Such models can provide new insights into patient condition by turning a series of sometimes confusing clinical data into a clear physiological picture. (springeropen.com)
Mathematical3
Mathematical Biology is the application of mathematical modelling to solve problems in biology and physiology. (gla.ac.uk)
In addition to basic and translational research, Dr. Shroff and colleagues have developed and continue to develop novel, simulation-based material (i.e., mathematical models of biological systems and associated "virtual experiments") for education and engineering design. (pitt.edu)
Biological models include the use of mathematical equations, computers, and other electronic equipment. (lookformedical.com)
20161
Dr. Shroff has been serving as the Principal Investigator on a NIH-NHLBI pre-doctoral training grant (Cardiovascular Bioengineering Training Program) since 2005 and the Coulter Translational Research Partnership II Program since 2013, and Co-Director on a NIH-NHLBI post-doctoral training grant (Training Program in Imaging Sciences in Translational Cardiovascular Research) since 2016. (pitt.edu)
Biomechanics3
The Biomechanics and Biomaterials Laboratory is equipped to perform experiments relating to the cardiovascular and human musculoskeletal systems as well as the various properties of biomaterials. (uiowa.edu)
The lab is used for the course BME:2500 Biomaterials and Biomechanics , elective courses in cardiovascular and musculoskeletal biomechanics, and senior design projects. (uiowa.edu)
Miller, L., Penta, R. (2023) Investigating the effects of microstructural changes induced by myocardial infarction on the elastic parameters of the heart Biomechanics and Modeling in Mechanobiology, 22, pp. 1019-1033. (gla.ac.uk)
Neurological1
Human exposure to H2S results in dose-related human exposure to low levels of H2S is widespread due to its neurological, respiratory, and cardiovascular effects. (cdc.gov)
System8
We developed a paroxysmal AF model by making three modifications to a computational model of the human cardiovascular-baroreflex system. (lehigh.edu)
His teaching and research interests focus on development and application of multi-disciplinary dynamic system modeling, vehicle system dynamics and controls, electromechanical system modeling and simulation, and application of machine learning and AI for smart hand tools. (utexas.edu)
Conventional models of cardiovascular system frequently lack required detail and focus primarily on the overall relationship between pressure, flow and volume. (sharif.edu)
This study proposes a localized and regional model of the cardiovascular system. (sharif.edu)
It is well known that the modern understanding of the cardiovascular system undoubtedly starts with the work of William Harvey (1578-1657) who published his discovery of the circulation of blood in 1628. (scirp.org)
A quasidynamic model of the blood buffer system. (physiome.cz)
The stable download Windows для профессионалов (программирование в Win32 API position simulation electromagnetic was in its active modern set in 1998 maintained for choosing the possible and cardiovascular diesel of sonar multimedia from system trees, mock as after an metric in a new length page. (taido-hannover.de)
Biology1
Systems biology combines mechanistic modelling with quantitative experimentation in studies of networks and better understanding of the interaction of multiple components in disease processes. (biomedcentral.com)
Simulation results1
The simulation results show how similarly these two parameters modify gas mass flow rates, gas velocity fields, aspiration pressures in the melt delivery tube or the size of the recirculation zones below the melt nozzle. (unav.edu)
Methods3
A focus of this paper is that the model-based methods discussed here can provide patient-specific care that is robust to these intra- and inter-patient variabilities. (springeropen.com)
Methods and Results Isolated proximal and "extensive" interventions (stenting and/or balloon angioplasty of proximal and lobar vessels) were performed in silico on 6 patient‐specific PA models. (nsf.gov)
Our computational methods accurately predicted postinterventional PA pressures, the primary indicators of success for treatment of peripheral PA stenosis. (nsf.gov)
Clinical4
This article presents the concept of model-based therapeutics, the use of computational models in clinical medicine and critical care in specific, as well as its potential clinical advantages, in a format designed for the clinical perspective. (springeropen.com)
The overall review clearly shows the concept and significant clinical potential of using computational models in critical care medicine. (springeropen.com)
In the Fall 2019 Quarter, he taught a special study course (BioE 297: Physics-Based Modeling and In Silico Clinical Trials). (ucsf.edu)
50%), better clinical models and pipelines for targeted therapies are urgently required. (hrb.ie)
Estimation1
The proposed method of parameter estimation for hydraulic electric analogy model is recursive least squares algorithm. (sharif.edu)
Human2
Although the facilities for soft tissue modeling have improved and the precise CT-imaging of human head has revealed novel details of brain, skull and the interface (the meninges), a comprehensive FEM model of TBI is still being studied. (sharif.edu)
of rats to 80 ppm resulted in full thickness necrosis of the Scaled kinetic parameters were incorporated into a human CFD model to predict H olfactory mucosa on the dorsal meatus (Brenneman et al. (cdc.gov)
Diesel2
To account for SOA formation from both diesel and gasoline sources, the parameterization has six lumped precursor species that resolve both volatility and molecular structure (aromatic versus aliphatic). (copernicus.org)
The revised model predicts all mobile sources (including on- and off-road gasoline, aircraft, and on- and off-road diesel) contribute ∼1 µg m −3 to the daily peak SOA concentration in Pasadena. (copernicus.org)
Simulations3
Then, the influence of both the inlet gas pressure and this design parameter are investigated, comparing the numerical results provided by simulations varying the inlet pressure from 5 to 80 bar and modelling different convergent-divergent gas nozzles with throat widths of 0.29¿Lo, 0.5¿Lo, 0.77¿Lo and 2¿Lo respectively. (unav.edu)
Large animal models and computer simulations indicate that adding non-contractile material to the damaged left ventricular wall can potentially reduce myofiber stress. (ucsf.edu)
We describe simulations using an updated version of the Community Multiscale Air Quality model version 5.3 (CMAQ v5.3) to investigate the contribution of intermediate-volatility organic compounds (IVOCs) to secondary organic aerosol (SOA) formation in southern California during the CalNex study. (copernicus.org)
Boundary conditions1
Realistic boundary conditions and Navier-Stokes equations in healthy and stenosed models of carotid artery bifurcation. (sharif.edu)
Study2
D., engineered a three-dimensional microvessel model with living cells to study the mechanisms of microcirculatory obstruction involved with malaria. (upenn.edu)
The shape of the engineered model is similar to that of an hourglass, allowing the researchers to study instances where red blood cell transit may encounter bottlenecks between the capillaries and other vessels. (upenn.edu)
Behavior1
In fact, although in the introduction to the problem (paragraphs 1-8), Euler focuses on the discussion on blood flow through arteries, to such a degree to even proposing adhoc models for the behavior of their elastic cross-sections, surprisingly, and also somehow disappointing, is that the main body of the manuscript (paragraphs 9-34) is devoted to the modeling of flows through rigid tubes, driven by a piston pump. (scirp.org)
Elastic1
frictional, elastic and hydraulic were considered for the prosthetic joints of the amputee and their design parameters were optimized to achieve the closest. (sharif.edu)
Molecular1
You cannot receive the percentage of a page or an modeling through molecular information but you can have the decision of tools. (ligaya-technologies.com)
Design1
A computer aided-design (CAD) algorithm was proposed to efficiently handle the coupling of two or more 3D models with the LP model, and substantially lessen the coupling processing time. (sharif.edu)
Insights1
Insights obtained from this model will aid the in-silico assessment of potential neuromodulation strategies for AF suppression and also increase the specificity of AF detection algorithms. (lehigh.edu)
Professor1
Dr. Sanmi Adeodu is a current post-doc in the Process Modeling and Control group under Professor Mayuresh Kothare . (lehigh.edu)
Normal1
A two-dimensional, seven link, nine degrees of freedom biped model was developed to investigate the dynamic characteristics of normal and transfemoral amputee locomotion during the entire gait cycle. (sharif.edu)
Care1
They thus help first jS, and because of this they care well lumped 25:42)02 services. (cypressfineart.com)
Technology1
Using multiphoton technology, Zheng and her team created 100mm capillary models with etched-in channels and a collagen base, to closely model the typical size and rigidity of the vessels. (upenn.edu)
Small1
Stage A generally starts as a small lump in the palm of the hand, often just under the digit on the palmar crease. (biomedcentral.com)