• The conically shaped, interior-bottom vial has several advantages over a standard, flat-bottom vial, especially for removal of radioactive compounds or radiopharmaceuticals. (snmjournals.org)
  • Therefore, the corresponding radiopharmaceuticals have been a major focus, and some of them like 99m Tc-Annexin V, 18 F-ML-10, 18 F-CP18, and 18 F-ICMT-11 are currently under clinical investigations in Phase I/II or Phase II/III clinical trials on a wide scope of diseases. (oncotarget.com)
  • Single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) with technetium-99m ( 99m Tc)-labelled radiotracers. (cadth.ca)
  • Here we report the results of our studies on the possibility to detect in vivo and non-invasively malignant tumors that will become resistant to subsequent therapy using single-photon emission tomography and 99mTc-Sestamibi, a tumor-seeking agent currently used in clinical practice. (cnr.it)
  • In 1937, technetium (specifically the technetium-97 isotope) became the first predominantly artificial element to be produced, hence its name (from the Greek τεχνητός , technetos , from techne , as in "craft", "art" and having the meaning of "artificial", + -ium ). (knowpia.com)
  • Because even the longest-lived isotope of technetium has a relatively short half-life (4.21 million years), the 1952 detection of technetium in red giants helped to prove that stars can produce heavier elements . (knowpia.com)
  • 7 Viable myocardial cells take up the radionuclide tracer (either thallium isotope [ 201 TI] or isotope 99m Tc-labelled radiotracer) in proportion to blood flow. (cadth.ca)
  • The history of nuclear cardiology began in 1927 when Dr. Herrmann Blumgart developed the first method for measuring cardiac strength by injecting subjects with a radioactive compound known as Radium C (214Bi). (wikipedia.org)
  • One short-lived gamma ray -emitting nuclear isomer , technetium-99m , is used in nuclear medicine for a wide variety of tests, such as bone cancer diagnoses. (knowpia.com)
  • Can an appropriate compound be labeled with a suitable radionuclide? (docslib.org)
  • 99m Tc-sestimibi imaging using planar imaging, SPECT, or SPECT/CT is useful, particularly when 18 F-FDG PET/CT is not available ( 4 - 6 ). (snmjournals.org)
  • This time interval, however, depends on the dose administered and is based on physical decay of Tc-99m. (studylib.net)
  • Technetium is a chemical element with the symbol Tc and atomic number 43. (knowpia.com)
  • The chemical compound calcium acetate is the calcium salt of acetic acid. (drugbank.com)
  • A sestamibi or tetrofosmin nuclear scan thus can identify cancer patients in whom certain drugs are unlikely to be effective. (axisimagingnews.com)
  • Our studies showed that both the uptake and efflux mechanisms of 99mTc-Sestamibi can be helpful for the non-invasive assessment of drug resistance in cancer. (cnr.it)
  • In light of the European Directive 97/43/Euratom and current practice throughout Europe, the above activities for Tc-99m sestamibi should be considered only as a general indication. (studylib.net)
  • Naturally occurring technetium is a spontaneous fission product in uranium ore and thorium ore, the most common source, or the product of neutron capture in molybdenum ores. (knowpia.com)
  • This tumor-induced diffuse bone loss compounds the treatment-induced bone loss from frequent use of high-dose glucocorticoid medications (typically dexamethasone), leading to severe osteoporosis. (snmjournals.org)
  • This will promote rapid hepatobiliary clearance of technetium Tc-99m sestamibi resulting in less liver activity in the image. (studylib.net)
  • Longer delays are required for resting images and for stress with vasodilators alone because of the risk of higher subdiaphragmatic Tc-99m activity. (studylib.net)
  • In this paper, molecular topology was used to develop a mathematical model capable of classifying compounds according to their antibacterial activity. (eurekaselect.com)
  • The topological model of activity obtained included two discriminant functions, selected by a combination of various statistical paremeters such as Fisher-Snedecor F and Wilk's lambda, and allows the reliable prediction of antibacterial activity in any organic compound. (eurekaselect.com)
  • After a virtual pharmacological screening on a library of 6375 compounds, the model has selected 263 as active compounds, from which 40% have proven antibacterial activity. (eurekaselect.com)
  • For intravenous injection after radiolabelling with sodium (Tc-99m) pertechnetate solution and is indicated for: - adjunct for diagnosis of ischaemic heart disease. (studylib.net)
  • The vial is reconstituted with a maximum of 11 GBq of oxidant-free sodium (Tc-99m) pertechnetate solution for injection in 1 - 5 ml. (studylib.net)
  • This graph shows the total number of publications written about "Technetium Tc 99m Exametazime" by people in this website by year, and whether "Technetium Tc 99m Exametazime" was a major or minor topic of these publications. (umassmed.edu)
  • The most commonly used tracers are thallium-201 thallous chloride (thallium), technetium-99m-2-methoxy-isobutyl-isonitrile ( 99m Tc MIBI) and 99m Tc 1,2-bis [bis(2-ethoxyethyl)phosphino] ethane (tetrofosmin). (medscape.com)
  • Thallium-201 and the 2 technetium-labeled radiopharmaceuticals (MIBI and tetrofosmin) are commercially available. (medscape.com)
  • Technetium-99m sestamibi, a lipophilic cationic compound, and Tc-99m tetrofosmin, a diphosphine agent, are the Tc-99m labeled radiotracers. (medscape.com)
  • Delayed views of up to 3 hr postinjection were also obtained.Technetium-99m-pertechnetate was used for thyroid delineation.The tetrofosmin/99mTc-pertechnetate subtraction scan (TF/TC), thesingle-tracer washout technique and the thallium/technetium subtraction (TL/TC) were compared. (fdocuments.net)
  • Comparing adenomas to hyperplasia in respect to tetrofosmin retention,a statistically significant difference was observed (p = 0.005).Conclusion: Technetium-99m-tetrofosmin is suitable for parathyroid imaging. (fdocuments.net)
  • 1. Effects of MDR1 and MDR3 P-glycoproteins, MRP1, and BCRP/MXR/ABCP on the transport of (99m)Tc-tetrofosmin. (nih.gov)
  • 12. P-glycoprotein versus MRP1 on transport kinetics of cationic lipophilic substrates: a comparative study using [99mTc]sestamibi and [99mTc]tetrofosmin. (nih.gov)
  • 13. Involvement of the glutathione S-conjugate compounds and the MRP protein in Tc-99m-tetrofosmin and Tc-99m-sestamibi uptake in glioma cell lines. (nih.gov)
  • 15. Limitations of (99m)Tc tetrofosmin in assessing reversal effects of verapamil on the function of multi-drug resistance associated protein 1. (nih.gov)
  • Thirty-six patients with chronic myocardial infarction and LV dysfunction (ejection fraction, 35% ± 6%) underwent resting technetium 99m tetrofosmin single photon emission computed tomography (SPECT) imaging under control conditions (baseline) and after sublingual administration of 10 mg isosorbide dinitrate. (cnr.it)
  • Tc 99m MIBI) as a diagnostic agent. (nih.gov)
  • We describe contrast-enhanced CT and 99m Tc-MIBI SPECT/CT findings in a patient with renal oncocytosis presenting with metachronous bilateral renal tumors. (bvsalud.org)
  • The larger tumors showed higher 99m Tc-MIBI uptake than the adjacent renal parenchyma, suggesting renal oncocytoma confirmed by biopsy. (bvsalud.org)
  • Lack of technetium-99m methoxyisobutylisonitrile ((99m) Tc-MIBI) uptake is consistently reported to predict poor response to subsequent chemotherapy in a variety of human malignant tumours. (cnr.it)
  • Since (99m) Tc-MIBI accumulates within mitochondria, which also play a central role in apoptosis through the integration of death signals by Bcl-2 family members, we tested whether early (99m) Tc-MIBI uptake is affected by alterations of the apoptotic pathway. (cnr.it)
  • Forty-two breast cancer patients were intravenously injected with 740 MBq of (99m) Tc-MIBI and planar images were obtained 10 min post injection with the patients in the prone lateral position. (cnr.it)
  • Ten carcinomas failed to accumulate (99m) Tc-MIBI and could not be visualised on scintigraphic images despite being larger than 1. (cnr.it)
  • Thirty-two of the 42 breast carcinomas showed focal uptake of (99m) Tc-MIBI (MIBI positive), and 10 min tumour-to-background ratios (T/B) varied between 1. (cnr.it)
  • By the late 1980s, two different compounds containing technetium-99m were introduced: teboroxime and sestamibi. (wikipedia.org)
  • With the introduction of technetium-99m compounds in the late 1980s, clinicians erroneously assumed that sestamibi was taken up by cardiac tissue within minutes and retained. (medscape.com)
  • When complex with indium-111, oxyquinoline forms a highly lipophilic compound that can easily cross cell membranes and enter various tissues, making it a suitable candidate for various applications. (openmedscience.com)
  • The usual isotopes for such studies are either thallium-201 or technetium-99m. (wikipedia.org)
  • Thallium-201 and technetium-99m are the two radio-labeled agents that are frequently used for the assessment of myocardial perfusion. (wikidoc.org)
  • Technetium-99m, a calcium analog with a higher photon energy and a shorter half life than thallium chloride, can be linked to a variety of agents. (wikidoc.org)
  • Technetium-99m is used as a marker of myocardial perfusion. (wikidoc.org)
  • Technetium-99m-tetrofosminhas been recently introduced as a myocardial perfusion agent(18). (fdocuments.net)
  • Tc 99m is a gamma emitter with a principal photon energy of 140 keV and a physical half-life of 6.04 hours. (nih.gov)
  • The chemical compound calcium acetate is the calcium salt of acetic acid. (drugbank.com)
  • sestamibi in thyroid and parathyroid tissues have enableddouble-phase and washout kinetic studies (7(5,77), which havebeen reported to obviate the need of a second tracer andproblems induced by subtraction. (fdocuments.net)
  • A US Nuclear Regulatory Commission subcommittee has recommended that nursing be discontinued for 24 hours after administration of all technetium Tc 99m diagnostic products to simplify guidance recommendations, although this time interval may be longer than necessary. (nih.gov)
  • Technetium-99m-sestamibi is an isonitrile compound that, like thallium, is taken up by the myocardium proportional to blood flow but in contrast to thallium does not undergo redistribution. (wikidoc.org)
  • Similarities in biodistribution and biokinetics betweenthese two technetium agents (19,20) have triggered researchtoward the same fields of application. (fdocuments.net)
  • We present a case report that illustrates the promise of sestamibi in distinguishing between viable and infarcted myocardium. (medscape.com)
  • Currently, only the Miraluma Tc-99m sestamibi compound, manufactured by DuPont Pharmaceuticals, is approved by the Food and Drug Administration (FDA) for breast imaging in the United States. (imaginis.com)
  • 9. Assessment of the in vitro and in vivo properties of a (99m)Tc-labeled inhibitor of the multidrug resistant gene product P-glycoprotein. (nih.gov)
  • For nursing mothers who work with Tc 99m substances in their workplace, there is no need to take any precautions other than those appropriate for general radiation protection. (nih.gov)
  • We compared 10-, 7-, 5-, and 3-minute acquisitions for 99m Tc and 81m Kr performed simultaneously on StarGuide CZT-SPEC. (ebsco.com)