Compounds human cells. Medical search. Frequent questions

We identified six mitochondria-affecting compounds (PS compounds) that exhibit selective cytotoxicity against AML cells in vitro. (nature.com)
Fig. 5: PS compounds induced synergistic cytotoxicity when combined with other anti-cancer drugs in AML cell lines and primary AML samples. (nature.com)
Cytotoxicity testing of drug compounds using human colon organoids. (sigmaaldrich.com)
The mechanism of 6‑OAP cytotoxicity in all cell lines was associated with the induction of apoptosis with the presence of cleaved caspase‑3 and PARP. (spandidos-publications.com)
These compounds exhibited potent inhibitory effects against methicillin-resistant Staphylococcus aureus (MRSA), brine shrimp larvae (test for compound cytotoxicity and pesticide-ability) and the human lung tumor line A-549. (wikipedia.org)
The results from our previously published cytotoxicity assay were helpful, but very little is known about these small-molecule compounds. (sciencedaily.com)
Extraction from 9 parameters of KSO-SFE was screened for cytotoxicity towards human colorectal cancer cell lines (HT29) and mouse embryonic fibroblast (NIH/3T3) cell lines using MTS assay. (hindawi.com)
Therefore, this study determined the cytotoxicity of KSO-SFE on colon cancer cells. (hindawi.com)
The activity is determined by the dose-dependent cytotoxicity of the human TF-1 cell line (human erythroleukemic indicator cell line)) ≤ 0.4. (sigmaaldrich.com)
The initial structure and activity relationship (SAR) analysis revealed that the length of the side chain at C-3 for isocoumarin-type compounds 1-3 could affect the cytotoxicity against HeLa cells. (bvsalud.org)

Here we demonstrate the use of highly-characterized human iPS cell-derived colon organoids as an alternative cell model for traditional Caco-2 cell drug toxicity assays for drug screening applications. (sigmaaldrich.com)
In addition, a normal cell line (lung fibroblast) was used as toxicity control. (frontiersin.org)
Toxicity, and IL-1beta production were attenuated in exposed NLRP3 knockout THP-1 cells. (cdc.gov)
The team started by testing the toxicity of its mitophagy-inducing compounds and combinations against acute myeloid leukemia (AML) cells, the most commonly diagnosed form of the disease. (sciencedaily.com)
The acute toxicity of these compounds is generally low and may not pose a direct health hazard during exposure [ 2 ]. (springer.com)
Synthesis and toxicity evaluation in breast cancer cell lines. (lu.se)
In addition, two other spiro-bicyclic compounds, lacking the paclitaxel side chain, showed toxicity. (lu.se)
The protective effect on SH-SY5Y cells against Aß toxicity was also evaluated, and compounds 6 and 10 significantly alleviated Aß toxicity. (bvsalud.org)
Studies of human exposure to petroleum (crude oil and fuel) often involve monitoring volatile monoaromatic compounds because of their toxicity and prevalence. (cdc.gov)

The results of our preliminary study demonstrated that 6-OAP inhibits the proliferation of human MM cells by inducing the arrest of mitosis and inhibiting specific key pathways ( 5 ). (spandidos-publications.com)
This compound also inhibits the growth of MRSA in vitro. (wikipedia.org)
By coupling efficient chemical synthesis routes to multiple upfront in parallel phenotypic screens, we identify that KBU2046 inhibits cell motility and cell invasion in vitro. (nature.com)
Across three different murine models of human prostate and breast cancer, KBU2046 inhibits metastasis, decreases bone destruction, and prolongs survival at nanomolar blood concentrations after oral administration. (nature.com)
The psychoactive compound of Cannabis sativa, Δ9-tetrahydrocannabinol (THC) inhibits the human trophoblast cell turnover. (medscape.com)
β-D-N 4-hydroxycytidine (NHC) Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells. (cdc.gov)

Researchers from Oregon State University 's Global Hemp Innovation Center have discovered that Cannabis sativa is loaded with healing compounds that ward off the Wuhan coronavirus (Covid-19). (newstarget.com)
Study lead Richard van Breemen, who also works at the Linus Pauling Institute, determined that these and other cannabis compounds "show the ability to prevent the virus that causes COVID-19 from entering human cells. (newstarget.com)
Van Breeman made sure to remind the world that cannabis compounds taken orally "have a long history of safe use in humans. (newstarget.com)
A review of the published literature into cannabis withdrawal symptoms in human users. (medscape.com)
Therefore, in assessing petroleum exposure, it is essential to identify exposure to tobacco smoke as well as other types of smoke exposure (e.g., cannabis, wood) because many smoke volatile organic compounds are also found in petroleum products such as crude oil, and fuel. (cdc.gov)

We hypothesize that the pure compounds (3beta-hydroxy-lanosta-8,24-dien-21-al, inotodiol and lanosterol, respectively) separated from I. obliquus would inhibit tumor growth in Balbc/c mice bearing Sarcoma-180 cells (S-180) in vivo and growth of human carcinoma cells in vitro. (nih.gov)
6‑O‑angeloylplenolin (6‑OAP) is a sesquiterpene lactone agent that has been previously demonstrated to inhibit the growth of multiple myeloma (MM) cells through mitotic arrest with accumulated cyclin B1. (spandidos-publications.com)

"There is recent evidence that some bioactive compounds, in particular polyphenols, phenolic acids and tannins (PPTs), can affect the shape of the blood glucose curve … Some studies have shown that these compounds may result in an altered pattern of intestinal glucose uptake, possibly due to interactions between compounds and sugar transporters," said the authors. (nutraingredients.com)
The 3 main bioactive compounds (vitamin E, β -sitosterol, and ALA) in kenaf seed oil are known to contribute greatly as chemopreventive agents [ 3 - 5 ]. (hindawi.com)

Scientific Methods: In vitro growth inhibition assays were completed with AHCC alone and in combination with PLD in panel of human cancer cell lines and findings confirmed in vivo in an ovarian cancer xenograft mouse model. (researchgate.net)
Successive assays revealed that some compounds were endowed with a promising anti-proliferative effect against HCT116 cells, alone or stimulated by serotonin as a pro-inflammatory factor in order to mimick an inflamed model of cancer cell microenvironment. (amrita.edu)

A new study in mice concludes that light-sensitive proteins on fat cells can detect sunlight. (medicalnewstoday.com)
For the first time, a new study has investigated whether or not certain proteins on fat cells that lie beneath the skin might also detect light. (medicalnewstoday.com)
In tests, they found that the extracts had antioxidant properties and could prevent amyloid beta proteins from clumping in human nerve cells. (acs.org)
Two key compounds in particular, cannabigerolic acid (CBGA) and cannabidiolic acid (CBDA), were found to block covid spike proteins from entering cells and causing infection. (newstarget.com)
They bind to the spike proteins so those proteins can't bind to the ACE2 enzyme, which is abundant on the outer membrane of endothelial cells in the lungs and other organs. (newstarget.com)
IFN-α 2A enhances the expression of MHC proteins by increasing the presentation of antigen peptides and activates cytotoxic T cells. (sigmaaldrich.com)
HAMLET (Human Alpha-lactalbumin Made Lethal to Tumour cells) is a compound of proteins and lipids (fats and fat-like substances) from breast milk. (lu.se)

Fig. 6: Flow cytometry evaluation of viable cell number and apoptosis induction in primary AML samples and healthy bone marrow cells. (nature.com)
The pharmacological NFkappaB inhibitors BAY117082 and MG132 induce cell arrest and apoptosis in leukemia cells through ROS-mitochondria pathway activation. (nature.com)
Resveratrol-induced apoptosis is enhanced in acute lymphoblastic leukemia cells by modulation of the mitochondrial permeability transition pore. (nature.com)
In the present study, the levels of apoptosis were analyzed in dexamethasone‑sensitive (MM.1S), dexamethasone‑resistant (U266) and chemotherapy‑sensitive (RPMI 8226) myeloma cell lines. (spandidos-publications.com)
The incompletely differentiated plasma cells are characterized by deregulated apoptosis ( 1 ). (spandidos-publications.com)
6-OAP induces apoptosis in multiple myeloma (MM) cells, as detected by DNA fragmentation assay. (spandidos-publications.com)
Cell cycle analysis showed a significant increase in the accumulation of KSO-SFE-treated cells at sub-G1 phase, indicating the induction of apoptosis by KSO-SFE. (hindawi.com)
We now report an alternate mechanism of GAS-mediated apoptosis of primary human keratinocytes, initiated by extracellular GAS and involving dysregulation of intracellular calcium to produce endoplasmic reticulum stress. (lu.se)
Induction of keratinocyte apoptosis by wild-type GAS was accompanied by cell detachment and loss of epithelial integrity, a phenomenon not observed with GAS deficient in capsule or SLO. (lu.se)
We propose that cell signalling initiated by extracellular GAS compromises the epithelial barrier by inducing premature keratinocyte differentiation and apoptosis, thereby facilitating GAS invasion of deeper tissues. (lu.se)

In this study, we demonstrated that triptolide significantly inhibited the proliferation, migration and invasion of prostate cancer cells in a time- and dose-dependent manner. (nih.gov)
This issue is of particular relevance since changes in NO release could play an important role in endothelial function maintenance, in addition to regulating proliferation of smooth muscle cells, leukocyte adhesion, platelet aggregation, angiogenesis, thrombosis, vascular tone, and hemodynamics. (hindawi.com)

Researchers at Oregon State University discovered hemp chemicals that have the capacity to block the virus that causes COVID-19 from entering human cells. (scrubsmag.com)
This dark brown colouration is unique to the species and has caused some researchers to include it in the dematiaceous fungi, a group of unrelated, darkly coloured moulds that includes some serious opportunistic pathogens of humans. (wikipedia.org)
Researchers have discovered potential new drugs that target mitochondria in cancer cells. (sciencedaily.com)
A new method to predict human mobility -- which can be used to chart the potential spread of disease or determine rush hour bottlenecks -- has been developed by a team of researchers, including one from Arizona State University. (sciencedaily.com)
The researchers found that, based on empirical data from cell phones and GPS records, people are most inclined to travel to "attractive" locations they've visited before, and these movements are independent of the size of a region. (sciencedaily.com)
9, 2019 Researchers have developed a new method for identifying compounds that prevent aging. (sciencedaily.com)
To identify these compounds, the researchers created and characterized extracts of four common varieties of hops using a method similar to that used in the brewing process. (acs.org)
The researchers say that although this work may not justify drinking more bitter brews, it shows that hop compounds could serve as the basis for nutraceuticals that combat the development of AD. (acs.org)
Graphene is said to be an effective material to help boost nerve cell signaling in the human brain, and the researchers who found out about this did so completely by accident. (naturalnews.com)
And now, in an attempt to use it as a potential biosensor , the researchers inadvertently ended up finding out about its effect on enhancing nerve cell signaling. (naturalnews.com)
Considering that they only managed to realize their discovery after setting up their initial experiment, which consisted of growing neurons or nerve cells on a sheet of graphene, the researchers were quick to adapt to the circumstances. (naturalnews.com)
The puzzling speed has made researchers to conclude the possibility of a transporter, which facilitates cell fuel delivery. (articlecity.com)
To overcome these hurdles, a team of SKI researchers has designed an entirely new type of CAR T cell that acts as a "micropharmacy": It can deliver a toxic drug payload directly to a tumor, killing both tumor cells that contain the cancer marker as well as those cancer cells nearby that do not. (worldhealth.net)

In previous studies, the research groups of Rice biochemist Natasha Kirienko and MD Anderson physician-scientist Marina Konopleva screened some 45,000 small-molecule compounds to find a few that targeted mitochondria. (sciencedaily.com)
And indeed, we found that six of the eight small-molecule compounds were deadly to leukemia cells. (sciencedaily.com)
But getting CAR T cells to produce a small-molecule cancer drug is a trickier prospect. (worldhealth.net)
In contrast to small-molecule drugs, human cells are very good at making enzymes, so CAR T cells are able to produce it effectively," Dr. Tan adds. (worldhealth.net)

This review focuses on an emerging topic, the functional involvement of AQPs in ROS membrane transport, with specific regard to the movement of hydrogen peroxide and NO into and out of cells, in both health and oxidative stress-induced diseases. (hindawi.com)

Structure-activity relationship studies identified six analogs from two original scaffolds that had over an order of magnitude difference between LD50 in AML and healthy peripheral blood mononuclear cells. (nature.com)
CD138 + cells from a single patient with MM were isolated with informed consent from bone marrow (BM) mononuclear cells using positive immunomagnetic column separation (Miltenyi Biotec GmbH, Bergisch Gladbach, Germany). (spandidos-publications.com)

Depending on the fire's specific conditions, many diverse chemical compounds are produced in varying amounts. (springer.com)
So, Cristina Airoldi, Alessandro Palmioli and colleagues wanted to investigate which chemical compounds in hops had this effect. (acs.org)

The smoke may contain ultra-fine particles, toxic compounds (e.g., benzene, toluene, hydrogen cyanide), viruses (e.g., human papilloma virus [HPV]), and cancer cells (Guideline for Surgical Smoke Safety). (cdc.gov)
Monoaromatic compounds such as benzene, toluene, ethylbenzene, and xylenes (BTEX) associated with these sources have been well studied and have established reference concentrations (RfC) and reference doses (RfD). (cdc.gov)

The objective was to define the mechanism of the growth inhibition of active hexose correlated compound (AHCC) alone and evaluate its activity in combination with pegylated liposomal doxorubicin (PLD). (researchgate.net)

The team's experiments showed several mitophagy-inducing compounds were significantly more synergistic with doxorubicin. (sciencedaily.com)
The most synergistic, a compound called PS127B, had a coefficient of 29. (sciencedaily.com)

Prepare selected test compounds in their desired concentrations. (sigmaaldrich.com)
B) U266 and MM.1S cells were treated with 6-OAP at the indicated concentrations for 48 h and DNA fragmentation was analyzed. (spandidos-publications.com)
But administering those same concentrations in combination can kill a considerable amount of cancer cells and still not affect healthy cells. (sciencedaily.com)
BTEX concentrations are commonly measured in environmental and biomonitoring samples to assess exposure levels associated with petroleum sources because they are (1) prominent components in petroleum, (2) carried over from crude oil into consumer products or fortified in fuels for their anti-knock properties, (3) chemically stable, and (4) persist as intact compounds in the environment and in the body. (cdc.gov)
However, in the case of reactive VOCs such as acrolein, acrylonitrile, 1,3-butadiene, and isoprene, VOC concentrations should be measured using the metabolite as these compounds are not stable in blood on the order of days, even if stored at refrigerator temperatures. (cdc.gov)

Isolated from Spodoptera frugiperda (Sf9) cells infected with recombinant baculovirus carrying truncated human furin. (neb.com)

One depsidone showed significant anti-proliferatory activity on human cancer cells. (wikipedia.org)
However, the effect of triptolide on migration and invasion of human prostate cancer cells is still poorly understood. (nih.gov)
One of the big challenges was to establish optimal conditions and doses for testing on both cancer cells and healthy cells," said study lead author Svetlana Panina, a researcher at the University of Texas at Austin who conducted the research during her postdoctoral studies at Rice. (sciencedaily.com)
There is no death of healthy cells or cancer cells. (sciencedaily.com)
Interestingly, P-Tex cells expressed CDK4 genes as high as cancer cells, which could be simultaneously inhibited by CDK4 inhibitors and might be a potential reason for the ineffectiveness of CDK4 inhibitors in treating HPV-positive HNSCC. (elifesciences.org)
Standard-issue CAR T cells are designed in the lab to recognize specific markers on cancer cells. (worldhealth.net)
One is that the CAR T cells can only kill cancer cells that contain the marker they are designed to recognize. (worldhealth.net)
But it is not uncommon for cancer cells to stop making this marker and thus to "escape" from the therapy. (worldhealth.net)
A second problem is that CAR T cells can become "exhausted" -- and even inhibited by the cancer cells themselves. (worldhealth.net)
But when it is produced locally just at the site of a tumor, it is effective at safely killing cancer cells in mice. (worldhealth.net)

In the current study, the antiproliferative activity of raw extracts and fractions of D. tertiolecta (clone CCMP 1320) was evaluated against four different human cancer cell lines: melanoma, hepatocellular liver carcinoma, and two lung adenocarcinoma cell lines. (frontiersin.org)
To test this hypothesis, the growth inhibition of each subfraction isolated from I. obliquus on human carcinoma cell lines (lung carcinoma A-549 cells, stomach adenocarcinoma AGS cells, breast adenocarcinoma MCF-7 cells, and cervical adenocarcinoma HeLa cells) was tested in vitro. (nih.gov)

3 Human epithelial colon organoids are thought to be considered more physiologically relevant for drug screening applications. (sigmaaldrich.com)
The compound slows the transmission of information in the epithelial cells lining the intestines. (genengnews.com)

This newly discovered compound decreases the formation of ever-present cellular messenger molecules, cyclic guanosine monophosphate and cyclic adenosine monophosphate, caused by various bacterial toxins and might prevent or attenuate the intestinal fluid secretion, diarrhea, and dehydration," said Dr. Murad, the senior author of the research paper that appears in the June 16 online edition of PNAS . (genengnews.com)

Synthesis and biological evaluation of new 3(2)-pyridazinone derivatives as non-toxic anti-proliferative compounds against human colon carcinoma HCT116 cells. (amrita.edu)
In the new study, they chose eight of the most promising compounds, identified between five and 30 closely related analogs for each and conducted tens of thousands of tests to systematically determine how toxic each analog was to leukemia cells, both when administered individually or in combination with existing chemotherapy drugs like doxorubicin. (sciencedaily.com)
We hypothesized that if they activate mitophagy, they may be particularly toxic to leukemia cells," said Kirienko, the corresponding author of the new study. (sciencedaily.com)
Therefore, measures of fire safety and the assessment of toxic effects of fires on humans, which are the key factors to assess fire hazards, have been researched in the last decades. (springer.com)
However, it is more and more recognized that there is also a need to assess the environmental impact of toxic compounds within fire effluents. (springer.com)
Progress in the field of ecotoxicological studies is important because long-term exposure from the environment and bioaccumulation of toxic compounds in the human food chain may cause indirect health effects on humans. (springer.com)
Many of these released substances are not only potentially toxic to humans but also to flora and fauna, which renders fire and fire effluent not only able to cause incapacitation, injury or death in people but also a potentially potent environmental hazard [ 3 ]. (springer.com)
3) monitoring the degradation of polyethylene terephthalate powder and its effect on adsorbing toxic organic compounds. (calstatela.edu)

1 Monolayers of Caco‐2 cells, a transformed cell line derived from human colorectal carcinoma, have been widely used by pharmaceutical companies as a standard intestinal barrier model for the prediction of intestinal permeability for drug candidates. (sigmaaldrich.com)
2 Despite their convenience and accessibility, Caco-2 cells have a single homogeneous phenotype, and therefore fail to recapitulate lineage development into the diverse cell phenotypes that constitute the physiology of the native intestinal epithelium, leading to inconclusive experimental results. (sigmaaldrich.com)
Using human colonic organoids as an intestinal tissue model could decrease the time and cost of drug development and provide new insights into drug absorption and drug discovery. (sigmaaldrich.com)
During preclinical tests, the compound was associated with a significant reduction in intestinal fluid secretion in an animal model of bacterial diarrhea. (genengnews.com)
Polyphenols and phenolic acids from strawberry and apple may decrease glucose uptake by blocking transport through human intestinal cells, according to a new study. (nutraingredients.com)

Compounds derived from PS127 significantly upregulated production of reactive oxygen species (ROS) in AML cells and triggered ferroptotic, necroptotic, and/or apoptotic cell death in AML cell lines and refractory/relapsed AML primary samples. (nature.com)
According to human and animal research, AHCC may significantly increase natural killer (NK) cell activity. (allstarhealth.com)

We call them SEAKER cells," says physician-scientist David A. Scheinberg, Chair of the Molecular Pharmacology Program in SKI who also directs the Center for Experimental Therapeutics. (worldhealth.net)

Phosphatidylserine is a phospholipid that is present in cell membranes and is involved in signal transmission as well as brain protection. (naspcenter.org)
However, when they began conducting their tests, they soon found out that it enabled nerve cell membranes to pull in more cholesterol, which in turn increased the vesicles that packaged neurotransmitters. (naturalnews.com)
To better understand the mechanism, our group uses surface plasmon resonance microscopy (SPRM) to study the kinetics of interaction etween α-synuclein (monomers and aggregates) and living cell membranes and scanning ion conductance microscopy (SICM) to determine α-synuclein-induced morphological and mechanical changes and possible membrane disruption in real time on living cell membranes. (calstatela.edu)
C. Feng, M. Flores, C. Dhoj, A. Garcia, S. Belleca, D. Abou Abbas, J. Parres-Gold, A. Anguiano, E. Porter, and Y. Wang* " Observation of Alpha-Synuclein Pre-Formed Fibrils Interacting with SH-SY5Y Neuroblastoma Cells Membranes Using Scanning Ion Conductance microscopy " ACS Chem. (calstatela.edu)
The sphingomyelin that accumulates in the lysosomes of Niemann-Pick disease-affected cells is thought to arise from the degradation of the cells and their organelles because it is a major component of all mammalian cell membranes. (medscape.com)

Fig. 1: Parental PINK-1 stabilizing (PS) compounds and their analogs as potential anti-AML agents. (nature.com)

Authors showed that a fraction from D. tertiolecta CCMP364 containing 95% of violaxanthin displayed 50% growth inhibition on the MCF7 breast cancer cell line at a concentration of 11.7 μg/mL. (frontiersin.org)

Inconclusive or adverse screening results of the effects of drugs and their metabolites on relevant human tissues have negatively impacted the ability to introduce new drug candidates. (sigmaaldrich.com)

Fig. 4: PS molecules induce different cell death pathways. (nature.com)
The eight compounds induce mitophagy, the housekeeping routine cells use to decommission and recycle mitochondria that are past their prime. (sciencedaily.com)
Human genetic risk of treatment with antiviral nucleoside analog drugs that induce lethal mutagenesis - the special case of molnupiravir. (cdc.gov)

Transplantation in Parkinson's disease using human embryonic stem cell (hESC)-derived dopaminergic (DA) neurons is a promising future treatment option. (lu.se)

It has therefore not been possible to identify regulators of cell motility possessing the selective capacity to support targeted manipulation. (nature.com)
We hypothesized that we could use them to identify novel and selective sites that regulate cancer cell motility and that such sites would constitute high-value therapeutic targets. (nature.com)

These compounds exhibited synergy with several anti-leukemia agents in AML, acute lymphoblastic leukemia (ALL), or chronic myelogenous leukemia (CML). (nature.com)
They then tested the six most effective AML-killing compounds against other forms of leukemia and found five were also effective at killing acute lymphoblastic leukemia (ALL) cells and chronic myelogenous leukemia (CML) cells. (sciencedaily.com)

While many pathways have been shown to regulate cell motility, they constitute pathways whose regulatory effects are pleiotropic 5 . (nature.com)
P-Tex cells could aggregate in the antigen-presenting cell niches and activate certain signaling pathways. (elifesciences.org)

Within this work, and considering the discussed background, another D. tertiolecta clone (CCMP 1320) was selected and tested against several cancer cell lines, and a bioactivity-guided fractionation approach allowed to identify the source of the biological activity observed within the extracts of this green alga. (frontiersin.org)

AHCC is a proprietary compound produced by cultivation and enzymatic modification of several species of mushroom mycelia, including shiitake, grown in rice bran extract. (allstarhealth.com)

4 We have generated a highly-qualified human iPSC-derived colonic organoid system consisting of assay-ready cryopreserved human colon organoids and specialized serum-free expansion media that was used to test the cytotoxic effects of numerous drug compounds. (sigmaaldrich.com)
CAMBRIDGE, UK - October 13, 2020 - Axol Bioscience (Axol), a biotechnology company specializing in the use of stem cell technology to manufacture disease-relevant cell-based assay systems to the drug discovery industry, today announced the expansion of its service offering, with the introduction of multi-electrode array (MEA) screening for human induced pluripotent stem cell (hiPSC)-derived cells. (labmanager.com)

The survival prognosis of human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) is largely different, and little is known about the anti-tumor mechanism of tumor-infiltrated exhausted CD8 + T cells (Tex) in HNSCC. (elifesciences.org)

Cell entry inhibitors, like the acids from hemp, could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells," Van Breemen said, adding compounds that block virus-receptor interaction have been helpful for patients with other viral infections. (scrubsmag.com)
E ) Percentage of viral reads measured in all single cells by days post infection (dpi). (elifesciences.org)
CD74 and MHCII cell-surface levels in HCMV- infected monocytes inversely-correlate with viral transcript levels. (elifesciences.org)
B and C ) Relative expression level of the viral transcripts RNA2.7 and UL138 ( B ) or MHCII and CD74 transcripts ( C ), as measured by RT-qPCR in HCMV- infected cells, sorted by either MHCII (left) or CD74 (right) cell-surface levels at 3dpi. (elifesciences.org)
Interferon α 2A (IFN-α 2A) belongs to the type I interferon protein family and is produced by many cell types in response to viral infection. (sigmaaldrich.com)
Overcoming culture restriction for SARS-CoV-2 in human cells facilitates the screening of compounds inhibiting viral replication. (cdc.gov)

Exposure of hypertensive rats to this compound produced an anti-inflammatory effect with mild edema at the injection site but without an increase in blood pressure edemas on the hypertensive rats. (wikipedia.org)

Pilot in vivo efficacy studies indicate anti-leukemic efficacy in a MOLM14/GFP/LUC xenograft model, including extended survival in mice injected with leukemic cells pre-treated with PS127B or PS127E and in mice treated with PS127E at a dose of 5 mg/kg. (nature.com)
THP-1 wild-type and NLRP3 knockout human monocytic cells were exposed to 0-100 microg/ml and male C57BL/6 mice were exposed by pharyngeal aspiration to 4 or 40 microg BNNTs and sacrificed 4 and 24 h post-exposure. (cdc.gov)

Chimeric antigen receptor (CAR) T cell therapy is a type of immunotherapy that uses genetically modified versions of a person's own immune cells to fight cancer. (worldhealth.net)
Immunotherapies called chimeric antigen receptor (CAR) T cells use genetically engineered versions of a patient's own immune cells to fight cancer. (worldhealth.net)
These cells combine the target-seeking power of immune cells with the ability to locally generate a potent anticancer drug for double effect. (worldhealth.net)
HAMLET is also promising in terms of its ability to kill tuberculosis bacteria hiding in macrophages - a type of white blood cell which is part of the immune system. (lu.se)

Check viability of organoids via microscopy before adding drug compounds. (sigmaaldrich.com)

Liam Taylor, CEO, Axol Bioscience, said: "At Axol, we have worked extremely hard to establish ourselves as the market-leading provider of neuroscience and cardio-based hiPSC-derived cells. (labmanager.com)

Occupational exposure to cadmium and cadmium compounds occurs mainly in the form of airborne dust and fume. (inchem.org)
Public health officials and others concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAELs) or exposure levels below which no adverse effects (NOAELs) have been observed. (cdc.gov)
As oil and natural gas extraction capacity grows to meet increased demand for petroleum-based products, the potential for exposure to volatile organic compounds (VOCs) from these sources increases. (cdc.gov)

In the biological activity test, compounds 1 and 3 showed cytotoxic activity against HeLa cells with IC50 values of 11.49 ± 1.64 µM and 8.70 ± 0.94 µM, respectively. (bvsalud.org)

What's the Latest in Clear Cell Ovarian Cancer? (slideshare.net)

They are not controlled substances like THC, the psychoactive ingredient in marijuana, and they have a good safety profile in humans. (scrubsmag.com)
The substances, contained within fire effluents, can adversely affect human health. (springer.com)

Cancer represents a huge threat for human health linked to the unrestrained cellular growth of different types of tissues in the human body. (frontiersin.org)
The transplantation of organs, cells and tissues has become the treatment of choice for a wide range of both fatal and non-fatal diseases, resulting in high levels of demand for transplantation services, particularly in high- and middle-income countries. (who.int)

Seven compounds show good activity against single cell line whereas, compounds having a pyridine scaffold showed significant anti‐proliferative activity. (researchgate.net)

Hop flowers used to flavor beers contain compounds that could help prevent Alzheimer's disease. (acs.org)
Alzheimer's disease (AD) is an important human disease that mainly causes cognitive impairments. (bvsalud.org)

And our research showed the hemp compounds were equally effective against variants of SARS-CoV-2, including variant B.1.1.7, which was first detected in the United Kingdom, and variant B.1.351, first detected in South Africa. (newstarget.com)
That means cell entry inhibitors, like the acids from hemp, could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells. (newstarget.com)

These transformations tolerated a broad range of the nucleophilic reagents thus allowing the synthesis of a wide variety of hetero- and carbocyclic compounds including the derivatives of pyridine, pyrimidine, pyrazole, pyran, dioxane, and isoxazole as well as their heterofused derivatives. (researchgate.net)

The anti‐proliferative activity of all newly synthesized compounds has been assessed against six human solid tumor cell lines. (researchgate.net)
All newly synthesized compounds were screened for anti‐proliferative activity against different human tumor cell lines. (researchgate.net)

We identify a unique cell motility regulatory mechanism and synthesize a targeted therapeutic, providing a platform to pursue studies in humans. (nature.com)
One hypothesis of the cytotoxic mechanism is that the α-synuclein aggregates insert into the lipid bilayer and disrupt the cell membrane's integrity, leading to the permeabilization of lipid bilayers and eventually cell death, while many questions remain unanswered in this field. (calstatela.edu)
Using the same mechanism that HAMLET employs to initiate cell death, it can also make the bacteria react to the weakened or ineffective antibiotics so that they once again become effective. (lu.se)

Tyrosine is an amino acid that helps to build nerve cells and enhances concentration. (naspcenter.org)
Combining these two changes resulted in much stronger signals between nerve cells in the human brain. (naturalnews.com)

This compound, glycerol 1-(9 Z ,12 Z ,15 Z -octadecatrienoate)-2-(4 Z ,7 Z ,10 Z ,13 Z -hexadecatetraenoate)-3- O -β-D-galactopyranoside ( 1 ), was purified and its antiproliferative activity was confirmed. (frontiersin.org)
Compound 5 showed high antiproliferative activity against several human tumor cell lines. (researchgate.net)

Anatomy27

Organisms16

Diseases4

Chemicals and Drugs103

Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Phenomena and Processes70

Disciplines and Occupations3

Technology, Industry, Agriculture1

Information Science3

Health Care4

Cytotoxicity10

Toxicity9

Inhibits6

Cannabis5

Inhibit2

Bioactive compounds2

Assays2

Proteins7

Apoptosis10

Proliferation2

Researchers13

Small-molecule4

Oxidative Stress1

Mononuclear cells2

Chemical2

Benzene2

Active hexose c1

Synergistic2

Concentrations5

Recombinant1

Cancer Cells10

Lung2

Epithelial2

Decreases1

Toxic8

Intestinal5

Significantly2

Pharmacology1

Membranes5

Analogs1

Growth inhibition1

Metabolites1

Induce3

Neurons1

Selective2

Acute lymphobl2

Pathways2

Bioactivity1

AHCC1

Assay2

Carcinoma1

Viral6

Anti-inflammatory1

Mice2

Immune4

Microscopy1

Neuroscience1

Exposure3

Biological1

Ovarian cancer1

Substances2

Tissues2

Scaffold1

Alzheimer's2

Hemp2

Derivatives1

Newly2

Mechanism3

Nerve cells2

Antiproliferative2