Compounds endophytes. Medical search. Frequent questions

Phytochemical analysis revealed the presence phenolic compounds and anthraquinones. (creamjournal.org)
Ascorbic acid content ranged from 0.42-0.49 mg/100g, β-carotene 0.08-0.22 μg/100g, lycopene content 0.032-0.086 μg/100g, phenolic compounds 6.39-20.11 mg/100g of gallic acid. (creamjournal.org)
The ethyl acetate extracts of each fungal endophyte show the presence of phenolic compounds and have inhibition against Gram-positive and Gram-negative bacteria. (kemdikbud.go.id)

We compared the diversity of fungal endophytes isolated from a wild-harvested A. californica population, and those from plants cultivated for one year in a greenhouse environment. (uncg.edu)

Hence, several recent investigations have shown considerable production of plant secondary metabolites by fungal endophytes, raising the prospect of exploiting them as bioactive metabolite sources [ 8 ]. (degruyter.com)
AR1 endophyte produces secondary metabolites that are simple indole diterpenes, including paxilline and paxilline-like compounds. (waikato.ac.nz)
This study aims to isolate bioactive secondary metabolites from endophytic Aspergillus tubenginses with study the biological activity of the isolated bioactive compounds. (phcogj.com)

Both of these compounds are major alkaloids that are found in bulbus Fritillariae cirrhosae (BFC), which is an herb sourced from FUW. (wikipedia.org)
Most of that fescue is infected with endophyte fungus, which is beneficial to the grass, but produces ergot alkaloids, organic compounds in plants that are toxic to grazing animals. (stuttgartdailyleader.com)
Fescue growth and concentrations of ergot alkaloids, the toxic compounds in endophyte fungus, peak twice a year, Littlejohn said. (stuttgartdailyleader.com)
The class of chemical compounds to which quinine belongs is called the cinchona alkaloids. (labonline.com.au)
Perennial ryegrass endophyte (Neotyphodium lolii) alkaloids are frequently present in pastures containing the neurotoxin lolitrem B, together with the vaso-constrictor ergovaline, at levels associated with ryegrass staggers, heat stress, ill-thrift and lowered milk production. (thebeefsite.com)

Biotechnological processes using microorganisms have been increasing in recent years since the discovery of Paclitaxel, an important antimitotic produced by the endophyte Taxomyces andreanae. (intechopen.com)
Also, microorganisms can have the ability to favor plant growth and convert toxic compounds present in the soil. (intechopen.com)
The TLC-bioautography assay, used to screen the plant extracts for antimicrobial activity and localization of the active compounds indicated the presence of a number of inhibitory compounds with activity against tested microorganisms. (creamjournal.org)
Jessica Dominguez provided early evidence that microorganisms called endophytes could be used for disease management in citrus greening. (agropages.com)

Endophytes are abundant in plants and studies are continuously emanating on their ability to protect plants from pathogens that cause diseases especially in the field of agriculture. (frontiersin.org)
We isolated and screened the bacterial endophytes from mountain-cultivated ginseng plants to use as them as biocontrol agents against ginseng pathogens. (kist.re.kr)
Since the past decade, no significant innovations have been made, so the search for new compounds that face multidrug-resistant pathogens is critically important. (intechopen.com)
The dark septate endophytes (DSE) are endophytic and non-mycorrhizal fungi with the ability to impact and control some plant pathogens and promote plant growth. (springeropen.com)

This study elucidates the mechanisms employed by endophytes in protecting the plant from diseases and different bioactivities of importance to humans with a focus on endophytic bacteria and fungi. (frontiersin.org)
This review aimed to present the various mechanisms of action used by endophytes in protecting a plant and report some bioactivities of importance to people with special emphasis on endophytic bacteria and fungi. (frontiersin.org)
This study provides new insights into the identity and chemistry of A. californica fungal endophytes, and demonstrates the importance of considering growing conditions when pursuing natural product drug discovery from endophytic fungi. (uncg.edu)
Endophytic fungi are very rich sources of natural antibacterial and antifungal compounds. (biomedcentral.com)
This study aims to isolate endophytic fungi from gambier leaves and test the antibacterial activity of ethyl acetate extracts of fungal endophytes from gambir leaves. (kemdikbud.go.id)

Based on the significant antibacterial activity, the sorting of bacterial cells against the compounds (MID6 and MID9) was analyzed by flow cytometry. (degruyter.com)
Since discovering the life-supporting drug, Penicillin, the first β -lactam antibiotic, by Sir Alexander Fleming in the 1920s, lots of progress have been developed in the antibacterial compounds production, process development and characterization of active molecules. (nature.com)
The highest antibacterial activity is shown by ethyl acetate extracts of the fungal endophytes of Neopestalotiopsis sp at a concentration of 7.5% on P. aeruginosa ATCC 27853 23±3.9 mm and S. aureus ATCC 25923 14±2.5 mm. (kemdikbud.go.id)

Brittni Littlejohn, assistant professor of animal science, is investigating the use of melatonin to mitigate the ill effects on growth performance of calves born to cows grazed on endophyte-infected pastures during gestation. (stuttgartdailyleader.com)
An animal scientist at the Arkansas Agricultural Experiment Station has shown that a common and inexpensive hormone additive may mitigate the ill effects on growth performance of calves born to cows grazed on endophyte-infected fescue pastures during gestation. (stuttgartdailyleader.com)
Brittni Littlejohn, assistant professor of animal science for the Agricultural Experiment Station, has shown that a common and inexpensive hormone additive may mitigate the ill effects on growth performance of calves born to cows grazed on endophyte-infected fescue pastures during gestation. (stuttgartdailyleader.com)
lolii strain AR1 endophyte does not produce ergovaline, the alkaloid known to deter African black beetle (H. arator), yet pastures infected with this endophyte have moderate resistance to adult African black beetle (H. arator). (waikato.ac.nz)
Research into AR1 is of importance, as to date there have been no reports of toxicity in livestock brought about by consumption of from AR1-infected pastures and in the absence of African black beetle (H. arator) this 'novel' endophyte can provide highly productive pastures. (waikato.ac.nz)

Perennial ryegrass endophytes (Neotyphodium lolii) together with the neurotoxin lolitrem B and the vasoconstrictor ergovaline are responsible for, among others, hypersensitivity in ruminants, impaired heat stress recognition, and vasoconstriction. (thebeefsite.com)
Resistance to African black beetle (Heteronychus arator) in perennial ryegrass (Lolium perenne L.) infected with AR1 endophyte (Thesis, Doctor of Philosophy (PhD)). University of Waikato, Hamilton, New Zealand. (waikato.ac.nz)
nov. endophyte-perennial ryegrass (Lolium perenne L.) associations which do not cause toxicity to livestock and with strong resistance to African black beetle (H. arator), would be of significant value to farmers in regions where this pest is a problem. (waikato.ac.nz)

It is important to distinguish epiphytes and endophytes among seed-associated microbes, as the two often differ from one another in their mode of transmission (horizontal vs. vertical transmission) and sources of origin (environmental sources and seed tissues) ( Nelson, 2018 ). (ppjonline.org)

The bacterial endophyte Burkholderia stabilis EB159 (PG159, GenBank accession no. (kist.re.kr)
The main aim of this study is to isolate the fungal endophytes from the medicinal plant Corchorus olitorius seeds (F. Malvaceae ), followed by antimicrobial screening against various bacterial and fungal strains. (biomedcentral.com)
FIU Institute of Environment researcher Kateel Shetty is leading this search for an antimicrobial compound that could help citrus growers gain control over this bacterial scourge. (agropages.com)

Taxomyces andreanae, a fungal endophyte, was isolated from the phloem (inner bark) of the Pacific yew, Taxus brevifolia. (scienceopen.com)

In contrast to the epiphytes that are more likely to show fluctuation in their composition and abundance from one seed to the next in a stochastic and environment-dependent manner, the seed endophytes tend to show relatively stable existence owing to their ability to interact with seeds as well as other microbes. (ppjonline.org)

The action of endophytes in controlling phytopathogens, insects, and weeds that harm agriculture may be the result of microbial interactions with other organisms or the production of bioactive metabolites. (intechopen.com)

These chemicals may be produced by the plants themselves or by endophytes (symbiotic bacteria or fungi) that live in the plants (Sudakin, 2003). (psychosocialsomatic.com)

Despite this attributes, a deep understanding of the mechanism employed by endophytes in protecting the plant from diseases is still required for both effectiveness and commercialization. (frontiersin.org)
Fusarium redolens is capable of producing alkaline compounds that are similar to its host plant. (wikipedia.org)
Their tiny size, rapid growth by clonal propagation, and facile uptake of labeled compounds from the media were attractive features that made them a well-known model for plant biology from 1950 to 1990. (osti.gov)
was isolated as an endophyte from a medicinal plant, Ginkgo biloba . (creamjournal.org)
Although plant tissue culture has been a successful method to propagate many species, V. aestivalis has not yet been reliably grown as pure callus culture due to a fungal endophyte that exists within the plant. (scirp.org)

Natural products from plants and microbial sources, either as pure compounds or as standardized extracts, provide unlimited opportunities for new drugs discoveries due to unmatched chemical diversity 1 . (nature.com)
GC-MS characterization of the extracts revealed several compounds with antioxidant activity. (uni-mysore.ac.in)

The advantage that endophytes have over other biocontrol agents is the ability to colonize plant's internal tissues. (frontiersin.org)

Molecular phylogenetic analysis, tests on growth characteristics, enzyme assays, and comparative analysis of volatile compounds, were carried out for this purpose. (springer.com)

Then the laboratory experiments were conducted to investigate the effects of endophyte on the growth of four pathogen species as well as the brown patch of the host and its neighbor plants. (plant-ecology.com)
The two species of endophytes could reduce lesion area of detached host leaves. (plant-ecology.com)

The fungus is hyphomyceteous and, when grown in a semi-synthetic liquid medium, produced taxol and related compounds. (scienceopen.com)
The fungal endophytes were isolated by inoculating the fungus obtained from gambir leaves on potato dextrose agar (PDA) media. (kemdikbud.go.id)

However, few studies have been reported on the effects of endophyte infection on non-symbiotic neighbours. (plant-ecology.com)
Endophyte infection can confer protective benefits to its host through the production of bioprotective compounds. (edu.au)

Seed endophytes are probably the first microbes that can interact with plants during the germination of seeds and development into seedlings before other microbes in the soil do. (ppjonline.org)

An additional 14 known compounds were identified using LC-MS dereplication of the various fungal endophytes. (uncg.edu)
Ar 6) crude extract was performed using LC-HR-ESI-MS and led to the dereplication of sixteen compounds of various classes (1-16). (biomedcentral.com)

The present study aims at the production optimization, purification, and characterization of a potent broad-spectrum antimicrobial compound (AMC) produced by Aspergillus fumigatus nHF-01 (GenBank Ac. (nature.com)
Even when plants themselves don't produce a useful compound, they often have chemicals that inspire more potent synthetic drugs. (labonline.com.au)
The Amazon is home to unique wildlife that contains potent compounds that scientists can use to synthesise new drugs. (labonline.com.au)
Representative compound C34 showed potent inhibitory activity against EGFRL858R/T790M/C797S with an IC50 of 5.1 nM and significantly inhibited the proliferation of the H1975-TM cell line harboring EGFRL858R/T790M/C797S with an IC50 of 0.05 µM. (bvsalud.org)

A time-course study using a deep RNA-sequencing approach was performed at six stages of germination, using seeds infected with one of three endophyte strains belonging to different representative taxa. (edu.au)
Furthermore, comparisons of the tran-scriptomes from three endophyte strains in planta identified genes unique to each strain, including genes predicted to be associated with secondary metabolism. (edu.au)
Findings from this study highlight the importance of better understanding the unique properties of individual endophyte strains and will serve as an excellent resource for future studies of host-endophyte interactions. (edu.au)

endophytes: diversity and functional roles.New Phytologist 182:314-330. (sfnordica.com)

In the last 20 years, endophytes isolated from most plants have shown themselves to be a rich source of natural products for industrial and agricultural use amongst several other applications. (frontiersin.org)
Endophytes are generally isolated from the internal tissues of plants after surface sterilization. (frontiersin.org)
Background: Rare plants that contain corrinoid compounds mostly comprise cobalamin analogues, which may compete with cobalamin (vitamin B 12 (B 12 )) metabolism. (mdpi.com)
S. globosus, S. hypolithicus, P. citrea and P. minatonensis are reported as endophytes for the first time in the ethnomedicinal plants. (uni-mysore.ac.in)
Inversely, plants provide nourishment and shelter to the resident endophyte in return. (edu.au)
The results from this study suggest that in order to obtain endophyte-free callus tissue, vine explants are to be taken from plants grown in a growth chamber simulating springtime conditions, sterilized in a combination of alcohol, bleach, and chlorine dioxide, and plated on selection media containing an antifungal agent, such as chlorothalonil. (scirp.org)
This technique could potentially be used with plants that have associated endophytes or other contamination problems to establish callus tissue for research and/or commercial propagation efforts. (scirp.org)
Phytochemicals include compounds with various biological properties (i.e. antioxidant, antiproliferative, DNA repair) which have presumably evolved, in part, to allow plants to cope with environmental challenges including exposure to radiation and toxins, and defense against pests and infectious agents (Tuteja et al. (psychosocialsomatic.com)

In-silico analysis of the dereplicated metabolites led to highlighting the compounds responsible for the antimicrobial activity of Aspergillus sp. (biomedcentral.com)

Similarly, both the compounds showed significant activity against urease with IC 50 values equal to 45 ± 1.45 and 67 ± 6.23 µM, respectively, while thiourea was used as standard for urease inhibition assay with IC 50 value of 21 ± 0.12 µM. (innspub.net)

Furthermore, the fungal endophytes were cultivated using rice media : aquades (100 : 110). (kemdikbud.go.id)

Therefore, good agricultural practices that limit contamination along with feeding compounds that have the capacity to bind these toxins are needed to reduce or eliminate the harmful effects. (thebeefsite.com)

These results will expand the knowledge of endophytes and provide us with new approaches to face the global antibiotic resistance problem and the future production of undiscovered compounds different from the antibiotics classes. (biomedcentral.com)
Earlier work suggested that these paxilline-like compounds could be the bioactive, or linked-marker associated with the bioactive compound(s), that provide some resistance to adult African black beetle (H. arator) feeding. (waikato.ac.nz)
Results from this research contribute towards further understanding the bioactivity of AR1 endophyte against adult African black beetle (H. arator) and will underpin further research into the chemical basis for this resistance. (waikato.ac.nz)
In the intact leaves, the endophyte reduced the disease resistance of both the host and its neighbor grasses L. chinensis to C. lunata and B. sorokiniana . (plant-ecology.com)
This study first verified that the endophytes in A. sibiricum have a positive effect on disease resistance of neighbor grasses to brown patch. (plant-ecology.com)

Several characteristics of the fungal endophyte interaction still need to be fully elucidated, but fortunately, science is advancing in the search for this understanding [ 13 ]. (biomedcentral.com)

This hypothesis was tested based on phylogenetic analysis of the rDNA ITS region, morphological characters of basidiomes and pure cultures, growth rates and optimum growth temperature experiments, mycelial confrontation tests, enzyme activity tests and volatile organic compound (VOC) production. (springer.com)
Ingestion of endophyte toxins in grasses, even at sub-clinical amounts is of concern in animal production. (thebeefsite.com)

Shetty believes they may be able to identify a natural compound because of preliminary findings from one of his current Ph.D. students while she was working on her master's degree at FIU in 2019. (agropages.com)

Thanks to improvements in biotech, scientists no longer have to exploit animals to extract these valuable compounds. (labonline.com.au)

Endophytes are the richest sources of natural compounds, showing biological varieties and pharmacological activities. (phcogj.com)

The U.S. Department of Agriculture has awarded FIU scientists $500,000 to investigate natural compounds that could suppress or even eliminate the deadly bacteria that causes citrus greening. (agropages.com)

Endophytes are important sources for the discovery of bioactive compounds. (creamjournal.org)

The paxilline ELISA could potentially be used for screening E. festucae endophyte ryegrass associations that produce unknown compounds which deter African black beetle (H. arator) and which do not cause toxicity to livestock. (waikato.ac.nz)

Bioactive compounds produced by fungal endophytes have potential benefits, such as low cost, rapid growth, facile genetic manipulation, and industrial scale-up with fewer negative effects. (degruyter.com)

Additionally, compound C34 demonstrated good pharmacokinetic properties with an oral bioavailability of 30.72% and significantly inhibited tumor growth in the H1975-TM xenograft tumor model. (bvsalud.org)

With this study, we explored the identity and chemistry of fungal endophytes from the roots of yerba mansa [Anemopsis californica (Nutt. (uncg.edu)

Molecular docking studies were performed for both the compounds using PatchDock server. (innspub.net)

Anatomy5

Organisms31

Diseases2

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes10

Disciplines and Occupations1

Technology, Industry, Agriculture4

Information Science2

Health Care4

Geographicals2

Phenolic compounds3

Fungal endophytes isolated1

Secondary metabolites3

Alkaloids5

Microorganisms4

Pathogens4

Endophytic5

Antibacterial3

Pastures5

Perennial ryegrass3

20181

Bacterial3

Andreanae1

Epiphytes1

Phytopathogens1

Fungi1

Plant5

Extracts2

Biocontrol agents1

Volatile compounds1

Species2

Fungus2

Infection2

Microbes1

Dereplication2

Potent4

Strains3

Diversity1

Plants8

Antimicrobial activity1

Inhibition1

Rice1

Contamination1

Resistance5

Interaction1

Production2

20191

Extract1

Biological1

Natural1

Sources1

Produce1

Potential1

Growth1

Study1

Studies1