Compounds cytotoxic. Medical search. Frequent questions

Therefore, the exploitation of this undervalued part of the plant can be a source of valuable bioactive compounds for food and/or pharmaceutical industries. (mdpi.com)
Medicinal plant species, especially those applied in traditional medicine, have attracted significant attention because they include bioactive compounds that could develop legal or approved drugs against several diseases with no or minimal side effects (Iteku et al. (springeropen.com)
Bioactive compounds from E. arvense and their pharmacological activities are shown in Table 4. (researchgate.net)
The 3 main bioactive compounds (vitamin E, β -sitosterol, and ALA) in kenaf seed oil are known to contribute greatly as chemopreventive agents [ 3 - 5 ]. (hindawi.com)

MTT assay was used to evaluate cytotoxicity of the compounds against three human adenocarcinoma cells, using methotrexate and dimethyl sulfoxide (DMSO) as positive and negative controls, respectively. (hud.ac.uk)
This paper describes, for the very first time, a cytotoxicity assay-guided isolation of the major active compound from the methanol extract of the leaves of A. pavarii, and its identification as ursolic acid (1) by comprehensive spectroscopic analyses. (ljmu.ac.uk)
In this work, we report the synthesis of a new 1,3-thiazolium-5-thiolate derivative of a mesoionic compound (MIH 2.4Bl) and the characterization of its selective cytotoxicity on a panel of breast cancer cells lines. (lsu.edu)
Cytotoxicity of extracts and compounds isolated from Croton echioides in animal tumor cell (HTC). (scielo.br)
Up to 92% of failures for these new compounds at the clinical level are related to cytotoxicity, which often onl manifests during the costly and time consuming process of whole animal testing. (inknowvation.com)
The concentration of the chemicals tested as anti-biofilm agents was chosen based on cytotoxicity assays: the highest non-cytotoxic chemical concentration was used for biofilm inhibition assays, with dendrimer concentration 10-fold higher than polyamino-phenolic ligands. (frontiersin.org)
The compounds showed moderate cytotoxicity (approximately 70 μg/mL), but are not responsible for the leishmanicidal effect of the extract. (lu.se)

The latter do not adequately address the types of effects potentially produced by pharmaceuticals, especially highly potent compounds. (cdc.gov)

All isolated compounds were evaluated for their cytotoxic activity against A-549 human lung carcinoma cells. (unboundmedicine.com)

This study was aimed to specify the cytotoxic effect of C. sativa -derived extracts on colon cancer cells and adenomatous polyps by identification of active compound(s) and characterization of their interaction. (nih.gov)
The cytotoxic effect of MIH 2.4Bl on breast cancer cell lines was determined by XTT and crystal violet assays, flow cytometry analysis, electron microscopy characterization, and terminal deoxynucleotidyl transferase (TdT) deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL) apoptosis assays. (lsu.edu)

It has been reported that the antibacterial and cytotoxic properties of silver are affected by the assay conditions, particularly the type of growth media used in vitro. (bath.ac.uk)
Mulley, G , Jenkins, ATA & Waterfield, NR 2014, ' Inactivation of the antibacterial and cytotoxic properties of silver ions by biologically relevant compounds ', PLoS ONE , vol. 9, no. 4. (bath.ac.uk)
All the compounds were screened for their tuberculostatic, antibacterial, and anticancer activities. (springer.com)
Preliminary results indicated that target compounds exhibited weak tuberculostatic and antibacterial activities. (springer.com)
The synthesized compounds were evaluated for their biological activity in vitro: tuberculostatic, antibacterial, cytotoxic, and anticancer. (springer.com)

When only 1 or a few of antipicornavirus drugs for their ability to inhibit PV rep- compounds had been described for a particular target (for lication in vitro. (cdc.gov)
Increased incidence of chromosomal aberration were observed at cytotoxic concentrations of methyl isothiocynate in tests with mammalian cells, precluding any conclusion on its in vitro clastogenic potential. (europa.eu)
With current in vitro screening assays now representing a $1.4B market with a predicted 12% annual growth rate, we believe we possess a product capable of significantly impacting the chemical/drug screening market and, here in particular, advancing our understanding of cytotoxic chemical biotransformations as they pertain to public health and consumer safety. (inknowvation.com)
The drug discovery process requires that upwards of 10,000 molecules be screened for each new lead compound developed and relies upon an expensive and time consuming combination of in vitro cell culture-based and in vivo whole animal-based models to identify, validate, and ensure the safety of any resulting potential therapeutic agents. (inknowvation.com)
This process is frustratingly exacerbated by an unfortunate dichotomy whereby the inexpensive in vitro cell culture systems used for tier 1 screening contribute to failures due to their inabiliy to model the complexity and parallel systems interaction inherent in whole animal models (which are responsible for up to 92% of new compound failures at the clinical level) and because they are not capable of demonstrating species-specific effects. (inknowvation.com)
As the crude extract possessed anti-leishmanial properties, the compounds were assayed for cytotoxic and anti-parasitic activities in vitro in murine macrophages cells (Raw 264.7) and leishmania promastigotes (L. amazoniensis and L. braziliensis), respectively. (lu.se)

Among the heterocyclic compounds, 4,7-dichloroquinoline is a hydroxychloroquine intermediate for the treatment of different types of malaria 23 . (nature.com)

In search of new natural products with respect to pharmaceutical lead discovery of antifungal and anticancer agents, bioassay-guided fractionation and chemical investigation of the methanol extract of the dried fruit of Piper retrofractum led to the isolation of three new amides, namely (2 E ,14 Z )-N-isobutyleicosa-2,14-dienamide ( 1 ), dipiperamides F and G ( 2 and 3 ), together with 30 known compounds. (thieme-connect.com)
Separation science plays a crucial role in the isolation of novel compounds contained in complex matrices. (bvsalud.org)

Seven compounds inhibited the growth of some cancer cell lines, whereas one of the 2-quinoline derivatives displayed favorable activity against all tested cancer cells with GI 50 values of 0.92-13 μM. (springer.com)
These findings prompted us to extend our search for biologically active compounds among nitrogen heterocyclic derivatives. (springer.com)
Podophyllotoxin and its derivatives are potent cytotoxic agents that inhibit cell mitosis and deoxyribonucleic acid (DNA). (medscape.com)

We demonstrate that biologically relevant compounds such as glutathione, cysteine and human blood components significantly reduce the toxicity of silver ions to clinically relevant pathogenic bacteria and primary human dermal fibroblasts (skin cells). (bath.ac.uk)

To overcome these detractions and develop an improved tier 1 screening system that reduces the cost and time required for new compound evaluation, 490 BioTech proposes to develop a panel of multiple continuously bioluminescent human cell lines that will permit the simultaneous monitoring of each line to ascertain both the individual effects of compound treatment as well as the downstream effects of a compound's biotransformed metabolic breakdown products in real-time. (inknowvation.com)
In the evaluation of compounds of the plant species Zanthoxylum chiloperone (Rutaceae), it was shown that isolated compounds of the extract had leishmanicidal, trypanocidal and antifungal in vivo activities. (bvsalud.org)

All isolated compounds were screened for their antifungal and cytotoxic activities. (thieme-connect.com)

Results: Four new cytotoxic compounds, benthamianoate (2), benthamiacone (3), benthamianin (5) and benthamianol (6), and two known compounds, methyl gallate (1) and 2-methoxyacrylic acid (4) were identified. (hud.ac.uk)

Estrogen Alfa (ERα) is a receptor used as the main marker to identify the presence of tumors in the breast.compounds Gendarusin A-E have anticancer activity by inhibiting the poliferation of cancer cells and inducing apoptosis. (simulations-plus.com)
Samples of commonly utilized anticancer plants obtained from the chosen areas using physical and virtual oral seminars were studied for physiochemical composition and a possible antioxidant and cytotoxic potential to validate the basis for the use of the selected anticancer plants. (who.int)

Ethanol extracts of C. sativa were analyzed by high-performance liquid chromatography and gas chromatograph/mass spectrometry and their cytotoxic activity was determined using alamarBlue-based assay (Resazurin) and tetrazolium dye-based assay (XTT) on cancer and normal colon cell lines and on dysplastic adenomatous polyp cells. (nih.gov)
The unheated cannabis extracts (C2F), fraction 7 (F7), and fraction 3 (F3) had cytotoxic activity on colon cancer cells, but reduced activity on normal colon cell lines. (nih.gov)
The F7 and F7+F3 cytotoxic activity involved cell apoptosis and cell cycle arrest in S or G0/G1 phases, respectively. (nih.gov)
C. sativa compounds interact synergistically for cytotoxic activity against colon cancer cells and induce cell cycle arrest, apoptotic cell death, and distinct gene expression. (nih.gov)
The purpose of this research are to predict the cytotoxic activity, physicochemical properties, and toxicity of the gendarusin A-E compound. (simulations-plus.com)
Prediction of cytotoxic activity using Molegro Virtual Docker (MVD) by validating receptors and molecular docking. (simulations-plus.com)
This study investigates the cytotoxic activity of Caesalpinia benthamiana. (hud.ac.uk)
All the compounds were active with the new monoterpenoid characterized as benthamiacone exhibiting the highest activity (IC50 13.23-21.97 μg/ml) across cancer cell lines investigated. (hud.ac.uk)
This study investigates the cytotoxic activity of Caesalpinia benthamiana.Materials and Methods: Column chromatography (CC) and preparative thin layer chromatography (PTLC) were used to isolate compounds. (hud.ac.uk)
2-8) let us hypothesize that the cytotoxic activity is related to the mol. (unisa.it)
Natural carboxylic acids are plant-derived compounds that are known to possess biological activity. (edu.pl)
The aim of this review was to compare the effect of structural differences of the selected carboxylic acids (benzoic acid (BA), cinnamic acid (CinA), p-coumaric acid (p-CA), caffeic acid (CFA), rosmarinic acid (RA), and chicoric acid (ChA)) on the antioxidant, antimicrobial, and cytotoxic activity. (edu.pl)
Cytotoxic Activity of the Mesoionic Compound MIH 2.4Bl in Breast Cance" by Luciana Amaral de Mascena Costa, Ashlyn C. Harmon et al. (lsu.edu)
The study aim was to evaluate the cytotoxic activity, using the MTT test [3-(4,5-Dimethilthiazol-2-yl)-2,5-diphenil tetrazolium bromide], from the crude extract of Picrasma crenata (Pau Tenente) and its isolated compounds, quassin and parain, in culture of rat liver tumor cells (HTC). (scielo.br)
Thus, the results demonstrate a first indication of the cytotoxic activity of compounds quassin and parain, adding an important social and economic value to them, and may have application in future research and in pharmaceutical industry. (scielo.br)
The objective was to define the mechanism of the growth inhibition of active hexose correlated compound (AHCC) alone and evaluate its activity in combination with pegylated liposomal doxorubicin (PLD). (researchgate.net)
The quinoline compound showed significant activity against the viral pathogen serotype 2 (DENV-2). (nature.com)
Sulfonamides are compounds with diverse pharmacological activity. (springer.com)
The amidine functional group is an important structural element of compounds with established pharmacological activity. (springer.com)

This study was thus designed to identify new natural compounds from Malagasy medicinal plants traditionally used to treat cancer. (springeropen.com)
This study aimed to examine the interaction of four cytotoxic compounds isolated from Madagascar endemic medicinal plants Diospyros quercina and Salacia leptoclada with both angiogenesis target protein HIF-1α and human androgen receptor (HAR) by evaluating binding affinity energy of formed complex and defining the amino residues involved in such interaction. (springeropen.com)
Using cytotoxic and antioxidant studies, the study attempted to assess some of the commonly used medicinal plants used to cure cancer among Yoruba people in Ogun, Oyo, Osun, and Lagos (South-West, Nigeria). (who.int)

At Biogen Idec, we are continuing to invest and apply our expertise in MS with new research into novel compounds such as BG-12 to further improve the lives of people with this disease," said Michael Panzara, MD, MPH, Vice President, Chief Medical Officer of Neurology, Biogen Idec. (medindia.net)

Since 2011, several quinoline compounds have shown Epidermal Growth Factor Receptor (EGFR) inhibition 22 . (nature.com)
Inhibition of Mps1 led to a potent cytotoxic effect indicating its potential use as a treatment against neuroblastoma. (lu.se)

Identifying novel and potent antiviral compounds is critical to successful drug development targeting poxviruses. (cdc.gov)
Here we tested two compounds, nucleoside trifluridine, and nucleotide adefovir dipivoxil, for antiviral activities against vaccinia virus (VACV), mpox virus (MPXV), and cowpox virus (CPXV) in physiologically relevant primary human fibroblasts. (cdc.gov)
Our results characterized trifluridine and adefovir dipivoxil as strong poxvirus antiviral compounds and further validate the VACV Gaussia luciferase assay as a highly efficient and reliable reporter tool for identifying poxvirus inhibitors. (cdc.gov)

We routinely specialize in formulating highly toxic compounds, suchas cytotoxics, hormones, potent substances, controlled substances and steroids into safe and effective oral solids, liquid or lyophilized drug products. (piramalpharmasolutions.com)

PORT WASHINGTON, New York, Aug. 24, 2021 /PRNewswire/ - Equashield (equashield.com), a leading provider of Closed System Transfer Devices (CSTDs) for hazardous drugs, today announced the publication of a peer-reviewed study proving the effectiveness of its CSTD in eliminating leakage of hazardous materials when compounding antineoplastic drugs. (aagato.com)
The European study, Effectiveness of Closed System Drug Transfer Devices in Reducing Leakage during Antineoplastic Drugs Compounding, was published in the International Journal of Environmental Research and Public Health. (aagato.com)
No detectable levels of GEM were found in any sample using the Equashield CSTD, suggesting it effectively eliminates spills and leaks when compounding antineoplastic drugs, as well as surface contaminations in the drug unit. (aagato.com)
Equashield is a leading provider of manual and automated solutions for the compounding and administration of hazardous drugs. (aagato.com)
Chemotherapy refers to the use of cytotoxic drugs in the treatment of cancer. (medindia.net)
Given that both compounds are FDA-approved drugs, and trifluridine is already used to treat ocular vaccinia, further development of trifluridine and adefovir dipivoxil holds great promise in treating poxvirus infections, including mpox. (cdc.gov)

Taking into account anti-cancer properties of studied NCA, it seems that the presence of hydroxyl groups had an influence on intermolecular interactions and the cytotoxic potential of the molecules, whereas the carboxyl group participated in the chelation of endogenous transition metal ions. (edu.pl)
With an average of 10,000 novel molecules that must be screened for each new lead compound developed, and an average of 10 to 15 years of research and development at a cost of up to $1B to manufacture one new drug, pharmaceutical companies must develop new testing regimens that provide more data at a lower cost in order to achieve the economics necessary to remain profitable. (inknowvation.com)
ADCs are complex compounds resulting from the coupling of cytotoxic small molecules to a monoclonal antibody. (brighttalk.com)
These data suggest that the studied compounds, especially dendrimers, could be considered as novel molecules in the design of research projects aimed at the development of efficacious anti-biofilm disinfection treatments of water systems in order to minimize legionellosis outbreaks. (frontiersin.org)
Based on these results, the genotoxic and cytotoxic effects of canthin-6-one and 5-methoxycanthin-6-one, molecules isolated from the plant, on bone marrow cells of treated mice were evaluated in the present study. (bvsalud.org)

Ethylene glycol is a very useful industrial compound because of its low freezing point and high boiling point. (cdc.gov)

Previous study has shown that kenaf seed oil extracted by SFE (KSO-SFE) is cytotoxic towards human cervical cancer cell line [ 7 ]. (hindawi.com)

Endocrine disruptors (EDs) are exogenous compounds that act like hormones in the endocrine system and disrupt the physiologic function of endogenous hormones. (mdpi.com)

The present study investigates two species of freshwater sponges, Eunapius fragilis and Ephydatia muelleri, for possible cytotoxic compounds as determined by brine shrimp microassay. (carroll.edu)
Results show that both species have cytotoxic compounds extractable in methanol and at least two cytotoxic compounds may be present in Eunapiusfragilis, both of which are extractable in hexane. (carroll.edu)
While Macrophen and Double Macrophen were the most active substances among polyamino-phenolic ligands, dendrimers were overall twofold more effective than all other compounds with a reduction up to 85 and 73% of legionella and multi-species biofilms, respectively. (frontiersin.org)

Potential synergistic effects of various combinations including these compounds were tested by measuring cancer cell proliferation and apoptosis. (frontiersin.org)

A variety of VOCs and SVOCs were measured in the emission cloud and included suspected carcinogens, hazardous air pollutants, suspected endocrine disrupting compounds, and other unidentified compounds. (cdc.gov)

MCF-7 cells displayed both time- and dose-dependent decreases in cell growth and survival, with a maximum cytotoxic effect observed at 72 and 96 hours. (lsu.edu)
However, bortezomib is cytotoxic against nonimmune cells, which limits its use for autoimmune diseases. (rcsb.org)
hmm, the last poster said what i have suspected for some time and never see mentioned…all of these herbs that are supposedly "anti-viral, or anti-fungal, anti-bacterial, etc" - if they are all of those things aren't they killing our own cells as well and who can say if they body knows how to use the compounds in these herbs to kill viruses, bacteria anyway? (metaefficient.com)
A study by White et al (2009) found that psychosine's cytotoxic effects on oligodendroglia and Schwann cells was mediated through disruption of the architecture and composition of lipid rafts (cell membrane regions characterized by high cholesterol and sphingolipid concentration), followed by altered protein kinase C (PKC) function. (medscape.com)

However, the active compounds from Cannabis sativa flowers and their interactions remain elusive. (nih.gov)
In silico analyses by molecular docking to model ligand-protein interactions, and by SwissADME and ADMET webservers to establish the pharmacokinetic profile of the four investigated compounds in interaction with the angiogenesis target protein HIF-1α/breast cancer (PDB ID: 3KCX) and human androgen receptor/prostate cancer (PDB ID: 1E3G) were performed. (springeropen.com)
In contrast, our substrate-free, autobioluminescent reporter cell lines emit light continuously and can modulate the output level of this signal in real time in response to cytotoxic interactions. (inknowvation.com)
Common among these 10 interactions of organic compounds, their power to detect excess cancer agents is the electrophilic nature of or their metabolites, with DNA and R 1 risk at particular sites. (who.int)

This compound has a chlorine atom in its structure linked to the quinoxaline ring (C-5) substituted at the C-2 position with a sulfanilamide moiety. (springer.com)

For quassin, the concentrations of 80 and 100 μg/mL were cytotoxic, after 72 hours of treatment. (scielo.br)
Control banding is a process of assigning a compound to a hazard category that corresponds to a range of airborne concentrations - and the engineering controls, administrative controls, and personal protective equipment - needed to ensure safe handling. (cdc.gov)

The parent compound tetrachloroethylene is also a likely contributing factor to neurotoxicity, particularly central nervous system (CNS) effects [Boyes et al. (cdc.gov)
Biogen Idec, which announced the publication of Phase IIb data showing the effectiveness of the company's novel oral compound, said that an ad hoc analysis conducted during the study showed a decrease in the likelihood of Gd+ lesions evolving into T1-hypointense lesions (black holes), warranting further clinical study into the potential neuroprotective and anti-inflammatory effects of BG-12. (medindia.net)
Resveratrol has shown the ability to interfere with cell growth and multiplication without any cytotoxic effects. (nutraingredients.com)
The study of genotoxic effects was made through the test of modifications in the frequency of micronuclei and the cytotoxic effects by modifications in the relationship between polychromatic erythrocytes and normochromic erythrocytes. (bvsalud.org)
Statistical analysis showed that both compounds had neither genotoxic nor cytotoxic effects. (bvsalud.org)
However, with an adeq battery of necf expsre blmarkers, prospective studies of en- vironmental effects on pregnancy outcomes might be possible. (cdc.gov)

TRE-Luc assay into a 1536-wells plate format for assaying potential agonistic antagonistic and cytotoxic activities of the compounds tested. (researchatlanta.org)

The pharmacokinetic profile of these phyto-compounds revealed that they are orally active and safe. (springeropen.com)
GROUP I: negative control that received 200 µL of water and 2.1% of DMSO, orally, GROUP II: compound to be evaluated (canthin-6 -one or 5-methoxycanthin-6-one) with 2.1% DMSO, and GROUP III: positive control that received cyclophosphamide 50mg /kg animal weight, intraperitoneal. (bvsalud.org)

Conclusion: This study revealed potential cytotoxic compounds which are here reported for the first time from C. benthamiana. (hud.ac.uk)

Materials and Methods: Column chromatography (CC) and preparative thin layer chromatography (PTLC) were used to isolate compounds. (hud.ac.uk)

Both compounds potently inhibited the replication of VACV, CPXV, and MPXV (MA001 2022 isolate) in plaque assays. (cdc.gov)

The results of this study indicate that the Gendarusin A-E compound didn't completed the Five Lipinski Rules. (simulations-plus.com)
In 1994, a study was carried out to isolate various chemical compounds from the seeds of Iris tectorum, it found an ester 'iristectorene B'. In 1999, a study was carried out Iris tectorum rhizomes, it found a triterpenoid chemical compound. (wikipedia.org)
In 2007, a study was carried out on cytotoxic properties of Iris tectorum, used to treat cancer. (wikipedia.org)
In May 2007, a study was carried out on the rhizomes of Iris tectorum, to find various chemical compounds. (wikipedia.org)
In 2013, a study was carried on Iris tectorum to isolate various chemical compounds. (wikipedia.org)
The study was conducted between 2016 and 2021 in the centralized cytotoxic drug preparation unit of a hospital in Genoa, Italy. (aagato.com)
Industrial Relevance: This study presents an example of the successful integration of a well- known herbal supplement, AHCC, with traditional western medicine cytotoxic agent, pegylated liposomal doxorubicin, for the treatment of recurrent ovarian cancer. (researchgate.net)

We used the optimized qHTS system to test the 1280 compounds of the LOPAC library (Library of Pharmacologically Active Compounds) [26] and the 1408 chemicals from the National Toxicology System collection (NTP) [27]. (researchatlanta.org)
These chemical collections were utilized for validation of the high-throughput display (qHTS) because of the diverse chemical family members they contain some of which are proven to be pharmacologically active and with almost all the compounds previously tested in one or more standard toxicological assays. (researchatlanta.org)
The major active constituent, podophyllotoxin, is a lipid-soluble compound that easily crosses cell membranes. (medscape.com)

This provides an uninterrupted stream of visual data over the lifetime of the reporter cell as it interacts and reacts to compound exposure at both its pre- and post-biotransformed states. (inknowvation.com)

They are generally basic compounds having a bitter taste and contained nitrogen in their structure. (novapublishers.com)

EcN was armed with HlyE, a small cytotoxic protein, under the control of the araBAD promoter (P BAD ). (nature.com)

Pursuant to section 68 or 74 of the Canadian Environmental Protection Act, 1999 (CEPA), the Minister of the Environment and the Minister of Health conducted a screening assessment of four of five substances referred to collectively under the Chemicals Management Plan as the Furan Compounds Group. (canada.ca)
The resin impregnated liner (referred to as an uncured resin tube) is typically refrigerated until use, as it may contain volatile and semi-volatile organic compounds (VOCs, SVOCs) and thermally sensitive chemicals. (cdc.gov)

The ecological risks of the substances in the Furan Compounds Group in this assessment were characterized using the ecological risk classification of organic substances (ERC). (canada.ca)

Many of the compounds extracted from marine sponges have been shown to possess useful antitumoral properties. (carroll.edu)
Studies have shown that these metabolites are cytotoxic, mutagenic, or both [Guyton et al. (cdc.gov)
Patients with relapsing-remitting multiple sclerosis (MS) have new hope after trials of a new compound called BG-12 have shown that it can reduce the number of new gadolinium enhancing (Gd+) lesions by 69 percent in such patients. (medindia.net)

The oral compound was also found to show a 53 percent reduction in the mean number of T1-hypointense lesions, and a 44 percent reduction in cumulative new Gd+ lesions in patients treated during the trial. (medindia.net)

Anatomy23

Organisms17

Diseases8

Chemicals and Drugs124

Analytical, Diagnostic and Therapeutic Techniques and Equipment39

Phenomena and Processes45

Disciplines and Occupations3

Technology, Industry, Agriculture1

Information Science3

Health Care2

Bioactive compounds4

Cytotoxicity7

Potent Compounds1

Isolated compounds were evaluated1

Characterization2

Antibacterial5

Vitro6

Heterocyclic Compounds1

Isolation2

Derivatives3

Biologically1

Evaluation2

Antifungal1

Methyl1

Anticancer2

Activity19

Medicinal plants3

Novel compounds1

Inhibition2

Antiviral3

Controlled substances1

Drugs6

Molecules5

Ethylene1

Cervical1

Hormones1

Species3

Apoptosis1

Carcinogens1

Cells4

Interactions4

Moiety1

Concentrations2

Effects6

Assay1

Orally2

Potential1

Materials and Met1

20221

Study7

Active3

Cell1

Nitrogen1

Protein1

Chemicals2

Organic1

Shown3

Reduction1