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ThiophenesFuransEchinops PlantChemistry Techniques, SyntheticMolecular StructureAnisolesCyclizationHeterocyclic CompoundsSulfur CompoundsPalladiumCombinatorial Chemistry TechniquesStructure-Activity RelationshipStereoisomerismCatalysisModels, MolecularOxidation-ReductionAntineoplastic AgentsSocieties, PharmaceuticalEducation, Pharmacy, GraduateDrug IndustryTechnology, PharmaceuticalChemistry, PharmaceuticalEducation, PharmacyPharmaceutical Preparations
AliphaticBioactive compoundsAromaticBenzeneAromaticitySynthesisAldehydesMolybdenum disulfideMoleculesOrganicSulfurDerivativesAntibacterial activityExhibitIntermediatesProteinsSulfidesAnticancerCharacteristicInorganicBiologicalStrainsMolecularWidelyReactionInteractionsOxideProteinStructuralFormulaChemicalActualHighRecognitionGroupFormLiquidActiveDifferenceDataTablesImportantDrugs
Aliphatic2
  • Heating at high temperature (500° to 820 °C) of lacustrine mudstone samples by the Sample Analysis at Mars (SAM) instrument allowed gas chromatography-mass spectrometry (GC-MS) analyses of the evolved gases and the detection of aromatic and aliphatic molecules including several thiophene compounds. (wikipedia.org)
  • But terpenes and benzenoid substances do have a chemical characteristic in common, namely higher unsaturation indexes than many aliphatic compounds , and Hofmann may not have been making a distinction between the two categories. (newworldencyclopedia.org)
Bioactive compounds1
  • Dicarboxylic acids, which are appealing structural motifs in organic synthesis and exist widely in bioactive compounds, have been widely used as important monomers in the polymer industry to construct valuable materials. (nso-journal.org)
Aromatic8
  • Thiophene is considered to be aromatic, although theoretical calculations suggest that the degree of aromaticity is less than that of benzene. (wikipedia.org)
  • A modern depiction of a molecule of benzene, the prototypical aromatic compound. (newworldencyclopedia.org)
  • Many of the earliest-known examples of aromatic compounds, such as benzene and toluene , have distinctive pleasant smells. (newworldencyclopedia.org)
  • This property led to the term "aromatic" for this class of compounds, and hence to "aromaticity" being the eventually discovered electronic property of them. (newworldencyclopedia.org)
  • The first known use of the word "aromatic" as a chemical term-namely, to apply to compounds that contain the phenyl radical-occurs in an article by August Wilhelm Hofmann in 1855. (newworldencyclopedia.org)
  • A group of compounds with three aromatic rings joined in linear arrangement. (lookformedical.com)
  • Norris and Sanders, 1901 ) Carbocations have been identified as key intermediates in many organic reactions, including electrophilic aromatic substitutions, unimolecular nucleophilic substitutions, addition-eliminations, and many rearrangements ( Olah, 2004 ). (frontiersin.org)
  • Friedel, R. A. and M. Orchin (1951) Ultraviolet Spectra of Aromatic Compounds. (photochemcad.com)
Benzene4
  • Thiophene was discovered as a contaminant in benzene. (wikipedia.org)
  • These reagents are contacted with an oxide catalyst at 500-550 °C. At room temperature, thiophene is a colorless liquid with a mildly pleasant odor reminiscent of benzene,[citation needed] with which thiophene shares some similarities. (wikipedia.org)
  • The high reactivity of thiophene toward sulfonation is the basis for the separation of thiophene from benzene, which are difficult to separate by distillation due to their similar boiling points (4 °C difference at ambient pressure). (wikipedia.org)
  • Like benzene, thiophene forms an azeotrope with ethanol. (wikipedia.org)
Aromaticity1
  • As a consequence of its aromaticity, thiophene does not exhibit the properties seen for conventional sulfides. (wikipedia.org)
Synthesis4
  • The first synthesis of thiophene by Meyer, reported the same year that he made his discovery, involves acetylene and elemental sulfur. (wikipedia.org)
  • Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. (wikipedia.org)
  • Analogous outcomes were acquired with FR(Shape 1S) and GARFTase (Shape 2S) and offer considerable support for the synthesis and natural evaluation of 5 and 7 as FRand FRtransport substrates so when GARFTase inhibitors. (crispr-reagents.com)
  • Amonafide (AS1413) CHEMISTRY As demonstrated in Structure 1 synthesis of the prospective compounds 5-8 began having a palladium-catalyzed Sonogashira coupling of 4-bromo-thiophene-2-carboxylic acidity methyl ester or 5-bromo-thiophene-3-carboxylic acidity methyl ester with but-3-yn-1-ol 9 to cover the thiophenebutynyl alcohols 10-11. (crispr-reagents.com)
Aldehydes1
  • Many aldehydes are volatile compounds with distinct and characteristic olfactory properties. (tuwien.ac.at)
Molybdenum disulfide2
  • Sulfide powder is an organic compound powder that includes many different organic and inorganic substances like zinc sulfide, copper molybdenum disulfide disulfide of tungsten. (guangyinpump.com)
  • Because sulfur-containing organic substances like thiophene can be poisonous of hydrogenation catalysts that are commonly used, molybdenum disulfide could be utilized to trigger the hydrogenation reaction in organic compounds that contain sulfur. (guangyinpump.com)
Molecules3
  • The origin and the mode of formation of these molecules are still unknown whether biotic or abiotic, but their discovery put forward the puzzling question of thiophenic compounds as possible ancient biosignature on Mars. (wikipedia.org)
  • The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (lookformedical.com)
  • Thus, ligand-based methods extract chemical features of molecules using fingerprint algorithms to compare the similarities between the query compounds and the ligands with known activities [ 8 ]. (biomedcentral.com)
Organic6
  • Organic compounds containing the carboxy group (-COOH). (lookformedical.com)
  • Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. (lookformedical.com)
  • Organic compounds containing a carbonyl group in the form -CHO. (lookformedical.com)
  • Hirayama, K. (1967) Handbook of Ultraviolet and Visible Absorption Spectra of Organic Compounds. (photochemcad.com)
  • DMS, UV Atlas of Organic Compounds. (photochemcad.com)
  • CRC Atlas of Spectral Data and Physical Constants for Organic Compounds. (photochemcad.com)
Sulfur3
  • Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. (wikipedia.org)
  • Specialized thiophenes can be synthesized similarly using Lawesson's reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. (wikipedia.org)
  • Oxidation can occur both at sulfur, giving a thiophene S-oxide, as well as at the 2,3-double bond, giving the thiophene 2,3-epoxide, followed by subsequent NIH shift rearrangement. (wikipedia.org)
Derivatives1
  • Thiophene derivatives have been detected at nanomole levels in 3.5 billions year old Martian soil sediments (Murray Formation, Pahrump Hills) by the rover Curiosity at Gale crater (Mars) between 2012 and 2017. (wikipedia.org)
Antibacterial activity2
  • The antimicrobial studies revealed that compounds 3a, 3b, 3c and 3d showed promising antibacterial activity against both the bacterial strains, while compound 3c and 3d exhibited good antifungal activity against both the fungal strains. (rjptonline.org)
  • The antibacterial activity of all compounds was also evaluated against both Gram negative and Gram positive strains, and some compounds in the series showed potent antibacterial activity against Staphylococcus aureus strains, including the methicillin-resistant MRSA strains. (bvsalud.org)
Exhibit1
  • The central notion of ligand-based approaches is that chemically similar compounds exhibit analogous biological activities [ 8 ]. (biomedcentral.com)
Intermediates1
  • The increased stability of the intermediates (such as compounds of formula (III)) against competing hydrolysis reactions, removes the need to work under anhydrous conditions. (allindianpatents.com)
Proteins2
  • Acetylases are now known to modify a variety of proteins, including transcription factors, nuclear import factors and alpha-tubulin. (embl-heidelberg.de)
  • Here, we introduce LigTMap, an online server with a fully automated workflow that can identify protein targets of chemical compounds among 17 classes of therapeutic proteins extracted from the PDBbind database. (biomedcentral.com)
Sulfides1
  • Sulfides and the analogous compounds are a collection of semimetal and metallic elements in combination with S Se, Te As, Sb as well as Bi minerals. (guangyinpump.com)
Anticancer2
  • Subbarajuc V. Kuttana R. Anticancer and Antioxidant Activity of Synthetic Chalcones and Related Compounds. (rjptonline.org)
  • The anticancer activity of all compounds was evaluated in sensitive and multidrug-resistant counterpart cell lines from human colorectal cancer (Colo 205 and Colo 320) and non-small cell lung cancer NSCLC (A549, NCI-H460 versus NCI-H460/R) as well. (bvsalud.org)
Characteristic1
  • The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound. (lookformedical.com)
Inorganic1
  • Zinc sulfide is an inorganic compound with the chemical formula ZnS, which is white to off-white or light yellow powder in appearance. (saco-indonesia.com)
Biological1
  • The relationship between the chemical structure of a compound and its biological or pharmacological activity. (lookformedical.com)
Strains1
  • All the synthesized compounds were evaluated for their in vitro antimicrobial activity against two bacterial strains, Escherichia coli and Staphylococcus aureus and two fungal strains, Penicillium italicum and Fusarium oxysporum using the well-diffusion method. (rjptonline.org)
Molecular3
  • Another aspect is a compound of formula I for use in a molecular layer. (justia.com)
  • Further aspects of the invention relate to compounds for use in the molecular layer, to the use of the molecular layer and to processes for the production and operation of the electronic switching element and components based thereon. (justia.com)
  • All compounds were fully characterized by means of several spectroscopic and analytical techniques, and the molecular structures of [Ru(η5-C5H5)(PPh2(C6H4COOH))2Cl], 1, 3 and 4 have been additionally studied by single-crystal X-ray diffraction. (bvsalud.org)
Widely1
Reaction1
  • Viktor Meyer was able to isolate thiophene as the actual substance responsible for this reaction. (wikipedia.org)
Interactions2
  • These models will help chemists understand the orbital interactions involved in these compounds so that they can approach their synthetic goals most effectively. (frontiersin.org)
  • Parkin, 2007 ) to define 2-center metal-ligand interactions of organometallic compounds as ML l X x Z z , where the ligand atoms are classified as L, X, and Z ligands ( Figure 1A ). (frontiersin.org)
Oxide1
Protein2
  • Acetylation regulates many diverse functions, including DNA recognition, protein-protein interaction and protein stability. (embl-heidelberg.de)
  • They either apply docking to estimate the structural and chemical fitness of the query compound to the target or extract a set of pharmacophores from protein-ligand complexes and check whether the query compound matches well with the pharmacophores. (biomedcentral.com)
Structural1
  • Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. (lookformedical.com)
Formula1
  • Thiophene is a heterocyclic compound with the formula C4H4S. (wikipedia.org)
Chemical1
  • Furthermore, it is not straightforward to define cutoffs for chemical similarity measures, as they strongly depend on the fingerprints used and classes of the compounds under study [ 10 ]. (biomedcentral.com)
Actual1
  • Neither structure is an adequate representation of the actual compound, and the double-headed arrow indicates that the molecule is best represented by a hybrid (average) of these two structures. (newworldencyclopedia.org)
High1
  • Notably, compounds 6 and 7 (R CH2CH2OH and (N,N) = bipy or Me2bipy, respectively) showed antiproliferative effect against both cell lines with high intrinsic selectivity towards cancer cells. (bvsalud.org)
Recognition1
  • Crossbar arrays of memristors may be used in a variety of applications, including non-volatile solid state memory, programmable logic, signal processing, control systems, pattern recognition, and other applications. (justia.com)
Group1
Form2
  • Thiophenes undergo hydrogenolysis to form hydrocarbons and hydrogen sulfide. (wikipedia.org)
  • A memristive cross-bar array includes a number of row lines, a number of column lines intersecting the row lines to form a number of junctions, and a number of resistive memory devices coupled between the row lines and the column lines at the junctions. (justia.com)
Liquid1
  • The mixed Si-N-O compound 2a was obtained when liquid ammonia was not dried over sodium prior to use. (kobv.de)
Active3
  • In one or more embodiments, the acceptor with an active layer of an OPV includes is a non-fullerene acceptor. (justia.com)
  • The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. (lookformedical.com)
  • Similar components based on redox-active bipyridinium compounds are proposed in US 2005/0099209 A1. (justia.com)
Difference1
  • While all compounds are lipophilic, the difference in the distribution coefficient for neutral and charged complexes is around one order of magnitude. (bvsalud.org)
Data2
  • Crystallographic data (CIF) Experimental procedures and compound characterization data (PDF) Notes: The authors declare no competing financial interest. (docksci.com)
  • 1963) Tables of Spectrophotometric Absorption Data of Compounds Used for the Colorimetric Determination of Elements. (photochemcad.com)
Tables1
  • No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. (mdpi.com)
Important1
  • They are extracted from complex mixtures obtained by the refining of oil or by distillation of coal tar, and are used to produce a range of important chemicals and polymers, including styrene, phenol , aniline , polyester , and nylon . (newworldencyclopedia.org)
Drugs1
  • Results for 5 and 7 were compared to those for 4 and to classical antifolate drugs including MTX PMX PDX and LMTX (Table 1). (crispr-reagents.com)