• These findings support the possibility that under pathological conditions, gangliosides serve as cytotoxic factors in the central nervous system (CNS). (biomedcentral.com)
  • The prediction models were trained on influenza protein sequences isolated from both avian and human samples, which were transformed into amino acid physicochemical properties feature vectors. (springer.com)
  • An analogue containing the paramagnetic amino acid TOAC (N-TOAC-StII11-30) was also studied. (bvsalud.org)
  • Rescue of synaptic and cognitive functions in polysialic acid-deficient mice and dementia models by short polysialic acid fragments. (mhh.de)
  • Exposure of cells to either octanoic acid (C8:0), a C8-ceramide hydrolysis product, or oleic acid (C18:1) did not affect MDR1 expression. (sphingolipidclub.com)
  • One crucial determinant of host tropism is hemagglutinin (HA) receptor specificity, in particular, preference of specific species of sialic acid on host cells. (springer.com)
  • A cell culture model for investigation of synapse influence-ability: epigenetics, expression and function of gene targets important for synapse formation and preservation in SH-SY5Y neuroblastoma cells differentiated by retinoic acid. (mhh.de)
  • The trisialoganglioside (GT1b) is one of the major brain gangliosides and acts as an endogenous regulator in the brain. (biomedcentral.com)
  • News and views on polysialic acid: From tumor progression and brain development to psychiatric disorders, neurodegeneration, myelin repair and immunomodulation. (mhh.de)
  • Neuroimmunomodulatory properties of polysialic acid. (mhh.de)
  • Prebiotics, such as poly-d-3-hydroxybutyric acid (PHB), have gained attention for their potential to alter the gut microbiota, promote beneficial bacterial growth, and alleviate obesity. (bvsalud.org)
  • Conjugated linoleic acid (CLA) has received increased attention recently as a fat-reducing fatty acid to control fat deposition in mammals. (anti-cancers.com)
  • The existing paradigm is that 'sialidase-sensitive' animal rotavirus strains bind to glycans with terminal sialic acid (Sia), whereas 'sialidase-insensitive' human rotavirus strains bind to glycans with internal Sia such as GM1 (ref. 3). (nih.gov)
  • NEU1 is part of the sialidase family that are exoglycosidases removing terminal sialic acid residues from glycoproteins, glycolipids and oligosaccharides. (biomedcentral.com)
  • On the other hand, non-reducing end sugars and amino acids to which O-glycans are attached differ greatly between plants and animals, and it is known that arabinose and galactose are added to hydroxyproline (Hyp) in plants. (thers.ac.jp)
  • Note: The amino acid numbering for glucocerebrosidase used in this GeneReview follows the HGVS-recommended nomenclature, which includes the first 39 amino acids, and differs from the traditional numbering system, which does not include the first 39 amino acids. (nih.gov)
  • Gobburi ALP, Zhang R, Willard B, Inman D, Anderson DJ (2015) Heterogeneous Ganglioside Standards in LC-MS/MS: Sensitive Method for Quantifying the Major Molecular Components in Mono-Sialo Ganglioside Standards. (omicsonline.org)
  • A commercially-available mono-sialo (GM1) ganglioside standard consists of three major components with different ceramide structures: C18:0 fatty acid/C18-sphingosine, C18:0 fatty acid/C20-sphingosine and C20:0 fatty acid/C18-sphingosine. (omicsonline.org)
  • The usual multiple reaction monitoring (MRM) liquid chromatography-tandem mass spectrometry (LC-MS/MS) of gangliosides, which monitors the dehydrated sialic acid fragment (m/z 290), cannot differentiate between the individual iso-molecular weight components C18:0 fatty acid/C20-sphingosine and C20:0 fatty acid/C18-sphingosine. (omicsonline.org)
  • Present characterization of ganglioside standards quantifies only the fatty acid content by gas chromatography-flame ionization detection (GC-FID) analysis of the ganglioside mixture and does not parse out the percentages of the individual mono-sialo ganglioside components. (omicsonline.org)
  • In the present work analyzing a heterogeneous GM1 standard, results from a dehydrated sialic acid daughter ion MRM LC-MS/MS determination employing hydrophilic interaction liquid chromatography were combined with results of the fatty acid content determined by GC-FID analysis to sensitively quantify the three predominant individual molecular GM1 components in standards at concentrations as low as 50 ng/mL (Method 1). (omicsonline.org)
  • These dehydrated sialic acid MRM results (Method 1) were confirmed by a less sensitive fatty acid daughter ion MRM LC-MS/MS technique (Method 2) which could only determine molecular GM1 components in standards at high concentrations (1 μg/mL-10 μg/mL). (omicsonline.org)
  • In multivariate regression models, levels of C-reactive protein, uric acid, and interleukine-6 were consistently associated with MetS components, although the impacts of single markers differed. (bvsalud.org)
  • NEU3 was able to modify the sialic acid content of purified LFA-1 in vitro . (frontiersin.org)
  • Sialic acid (also known as neuraminic acid, or Neu5Ac) has long been recognized to participate in the regulation of immune cell function. (frontiersin.org)
  • DIFFERENTIAL MODULATION OF GLUTAMATERGIC SYNAPTIC TRANSMISSION BY POLYSIALIC ACID Except where reference is made to the work of others, the work described in this dissertation is my own or was done in collaboration with my advisory committee. (auburn.edu)
  • Although the involvement of Sia in the animal strains is firmly supported by crystallographic studies, it is not yet known how VP8* of human rotaviruses interacts with Sia and whether their cell attachment necessarily involves sialoglycans. (nih.gov)
  • The production of ammonia and consequent buffering of the acid environment of the human stomach are essential for H. pylori pathogenesis. (medscape.com)
  • Early reports dubbed increases in B cell antigen sensitivity a "neuraminidase effect," ( Cowing and Chapdelaine, 1983 ) and recent evidence has ascribed this phenomenon to sialic acid acting as a negative regulator of immune cell interactions ( Bagriacik and Miller, 1999 ). (frontiersin.org)
  • [ 19 ] However, there is no evidence that this extracellular urease contributes to the acid resistance of H. pylori . (medscape.com)
  • Percentages for the individual mono-sialo gangliosides in the standard differed by at most 2% (absolute difference in the percentages) in comparing the results obtained by the two methods. (omicsonline.org)
  • These results establish that NEU3 can modulate glycoconjugate composition and contribute to the regulation of integrin activity. (frontiersin.org)