• Low levels of high-density lipoprotein cholesterol (HDL), or hypoalphalipoproteinemia (HA), includes a variety of conditions, ranging from mild to severe, in which concentrations of alpha lipoproteins or high-density lipoprotein (HDL) are reduced. (medscape.com)
  • Alterations in plasma lipid and lipoprotein composition including a tendency toward an increase in total cholesterol (TC) and triglyceride (TG) and decrease in high-density lipoprotein cholesterol (HDL-C) levels suggest that psoriasis may associate with the disorders of lipid metabolism [ 25 , 26 ]. (hindawi.com)
  • Concomitantly, there was strong interest in high-density lipoprotein cholesterol (HDL-C) as a protective risk factor, supported by extensive epidemiological evidence (4) . (eas-society.org)
  • Similarly, decreased levels of high density lipoprotein cholesterol (HDL-C) and its transport complex, apolipoprotein A (apo AI and apo AII) are associated with the development of atherosclerosis. (nih.gov)
  • The handling of lipoprotein particles in the body is referred to as lipoprotein particle metabolism. (wikipedia.org)
  • The plasma protein N-glycome is implicated in both lipid metabolism and T2DM risk. (biomedcentral.com)
  • Hence, we first investigate the relationship between the N-glycome and postprandial metabolism and then explore the mediatory role of the plasma N-glycome in the relationship between postprandial lipaemia and T2DM. (biomedcentral.com)
  • The proteins, termed apolipoproteins, play an important role in lipoprotein metabolism. (medscape.com)
  • These effects on lipoprotein metabolism may be exerted through specific modulation of the expression of the LDL receptor and apolipoprotein B genes. (cambridge.org)
  • Citations to Plasma cholesterol metabolism in end-stage renal disease. (jci.org)
  • Plasma cholesterol metabolism in end-stage renal disease. (jci.org)
  • Plasma cholesterol metabolism was investigated in normotriglyceridemic patients with end-stage renal disease treated by hemo- or continuous ambulatory peritoneal dialysis (CAPD), and compared with that in a control group with normal renal function. (jci.org)
  • Chylomicron-like lipid emulsions, resembling chylomicrons in composition, size and metabolism were prepared in the presence of [125 I]Aβ1-40. (iospress.com)
  • Therefore, this latest EAS Statement reviewed what is known about the structure, function, metabolism, and atherogenicity of TG-rich lipoproteins and their remnants, with the ultimate aim of identifying targeted therapeutic approaches to address residual cardiovascular risk associated with elevated TG levels (9) . (eas-society.org)
  • Effect of dairy fat and milk product supplementation on plasma lipids and low-density lipoprotein metabolism in the guinea pig. (arizona.edu)
  • Effects of dairy fat composition on LDL metabolism were measured in male guinea pigs fed 15% (w/w) fat diets, either butterfat (BF) or a synthetic butter-like fat mix (SBF). (arizona.edu)
  • however, a diet supplemented with liquid milk products providing up to 46% of the daily energy intake, with higher total fat (1.4-fold) and dietary cholesterol (2.3-fold) did not increase plasma cholesterol and triacylglycerol levels or alter LDL metabolism in the guinea pig. (arizona.edu)
  • Van Leeuwen H, Heezius E, Dallinga G, van Strijp J, Verhoef J. Lipoprotein metabolism in patients with severe sepsis. (spmi.pt)
  • PURPOSE:Proprotein convertase subtilisin-kexin type 9 (PCSK9) promotes low density lipoprotein (LDL) receptor degradation, thereby providing a key pathway for LDL metabolism. (shengsci.com)
  • Lipoproteins are complex molecular assemblies that are key participants in the intricate cascade of extracellular lipid metabolism with important consequences in the formation of atherosclerotic lesions and the development of cardiovascular disease. (cdc.gov)
  • Subgroups of these plasma particles are primary drivers or modulators of atherosclerosis. (wikipedia.org)
  • they are not related to the lipoprotein particles that this article is about. (wikipedia.org)
  • The role of lipoprotein particles is to transport fat molecules, such as triglycerides, phospholipids, and cholesterol within the extracellular water of the body to all the cells and tissues of the body. (wikipedia.org)
  • The outer shell of lipoprotein particles have the hydrophilic groups of phospholipids, cholesterol, and apolipoproteins directed outward. (wikipedia.org)
  • The kind of apolipoproteins contained in the outer shell determines the functional identity of the lipoprotein particles. (wikipedia.org)
  • The interaction of these apolipoproteins with enzymes in the blood, with each other, or with specific proteins on the surfaces of cells, determines whether triglycerides and cholesterol will be added to or removed from the lipoprotein transport particles. (wikipedia.org)
  • Characterization in human plasma Lipoproteins are complex particles that have a central hydrophobic core of non-polar lipids, primarily cholesteryl esters and triglycerides. (wikipedia.org)
  • It is divided into two pathways, exogenous and endogenous, depending in large part on whether the lipoprotein particles in question are composed chiefly of dietary (exogenous) lipids or whether they originated in the liver (endogenous), through de novo synthesis of triglycerides. (wikipedia.org)
  • When the chylomicrons are reduced in TG content, they become remnants that are rapidly cleared by the liver (apoprotein E binds to the LDL receptor [LDL-R]). At this time, apoprotein C-II is passed to high-density lipoprotein (HDL) particles in the circulation. (medscape.com)
  • In insulin-resistant and homozygous carriers, PNPLA3-I148M exerted a distinct antihyperlipidemic effect with decreased very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) particles and their constituents, and increased high-density lipoprotein particles and their constituents, compared with noncarriers. (lu.se)
  • Many studies have reported the association of Aβ with lipoproteins from plasma suggesting an involvement of lipoprotein particles in Aβ transport. (iospress.com)
  • It was observed that there was no difference in the plasma clearance of [125 I]Aβ and that of the 3 H-cholesteryl ester, a marker of the emulsion particles, demonstrating that Aβ remains associated with these particles throughout both their lipolysis and tissue uptake. (iospress.com)
  • There is also exploration of the relative atherogenicity of TG-rich lipoproteins and their remnants versus LDL, with the caveat that precise definition of the nature of remnant particles is currently uncertain. (eas-society.org)
  • Emerging approaches include measuring the cholesterol content of remnant particles, or TG-rich lipoprotein particle number or composition, although none of these is fully validated for their association with ASCVD risk. (eas-society.org)
  • Through this mechanism, fenofibrate increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III (an inhibitor of lipoprotein lipase activity). (nih.gov)
  • The resulting fall in triglycerides produces an alteration in the size and composition of LDL from small, dense particles (which are thought to be atherogenic due to their susceptibility to oxidation), to large buoyant particles. (nih.gov)
  • Lipoproteins are complex particles with a central core containing cholesterol esters and triglycerides surrounded by free cholesterol , phospholipids , and apolipoproteins , which facilitate lipoprotein formation and function. (healthmatters.io)
  • As with other lipoproteins, IDL particles are primarily composed of triacylglycerols and cholesterol esters and are responsible for carrying fatty acids before their eventual release at the target membrane. (healthmatters.io)
  • This group showed reduction in plasma LDL-cholesterol and triglycerides and elevations in HDL-cholesterol as well as reductions in large and medium VLDL particles and increases in LDL particle size. (biomedcentral.com)
  • However, these advanced MS techniques are limited by traditional pre-analytical fractionation techniques that compromise the structural integrity of lipoprotein particles during separation from serum or plasma. (cdc.gov)
  • Indeed, beyond the lipoprotein lipase cofactor apolipoprotein (apo) CII, recent studies have identified the relevance of apoCIII in controlling the efficiency of TG clearance, and angiopoietin-like protein 3 (ANGPTL3) in modulating lipoprotein lipase activity, suggesting potential as therapeutic targets (14,15) . (eas-society.org)
  • Short-term effects of anti-TNF on plasma lipid concentrations seemed beneficial and anti-atherogenic. (bmj.com)
  • However, these changes did not persist: plasma concentrations of total and LDL-cholesterol and the atherogenic index increased after 6 months and 1 year from the start of therapy. (bmj.com)
  • We conclude that one-year therapy with infliximab is likely to lead to a more pro-atherogenic pattern of the plasma lipids concentrations. (bmj.com)
  • 1 Among the traditional cardiovascular risk factors, the lipid profile in RA has often been described as "pro-atherogenic", 2 based on decreased HDL-cholesterol (HDL-C) and increased LDL:HDL-C ratio and lipoprotein (a) plasma concentrations in both active and treated RA. (bmj.com)
  • While it is well established that the fatty acid composition of dietary fat is important in determining plasma lipoprotein cholesterol concentrations, the effects of changing the absolute quantities of the individual fatty acids are less clear. (cambridge.org)
  • IE vs. non-IE] on changes in plasma triacylglycerol (TAG), glucose, glucose-dependent insulinotropic polypeptide (GIP), peptide YY (PYY), insulin, gastric emptying (paracetamol concentrations) and satiety (visual analogue scales). (springer.com)
  • at 4-h plasma TAG concentrations declined following the IE fat but continued to rise following the non-IE fat. (springer.com)
  • MNO subjects had lower fasting plasma glucose and insulin concentrations and lower insulin levels during the oral glucose tolerance test (P: values ranging between 0.01-0.001). (nih.gov)
  • Plasma concentrations of fenofibric acid after administration of three 48 mg or one 145 mg tablets are equivalent under fed conditions to one 200 mg capsule. (nih.gov)
  • In examining the evidence concerning the influence of maternal nutrition on human milk composition, the subcommittee considered the broad spectrum of constituents of milk, the normal variation in their concentrations, and factors in addition to maternal nutrition that influence those variations. (nationalacademies.org)
  • We investigated the effects of energy-restricted diet containing EVOO on body composition and metabolic disruptions related to obesity. (researchgate.net)
  • however, the therapy also has benefits related to improved body composition, especially in children with conditions like PWS. (ajmc.com)
  • Treatment of adult GHD primarily targets improvements in body composition, quality of life, and surrogate markers for cardiovascular disease. (ajmc.com)
  • To elucidate longitudinal changes of complex body composition phenotypes and their association with incident type 2 diabetes mellitus. (e-dmj.org)
  • Therefore, proper evaluation and early interventional management of body composition in younger and middle-aged individuals are required to prevent the development of sarcopenia or sarcopenic obesity in the elderly. (e-dmj.org)
  • In vivo mitochondrial function [maximal ATP synthesis rate (ATPmax), ATPflux/O 2 (P/O)] was determined by 31 P-magnetic resonance spectroscopy and optical spectroscopy, and body composition was determined by dual-energy X-ray absorptiometry. (medscape.com)
  • MAIN OUTCOME MEASURES: Nuclear magnetic resonance profiling of plasma lipids, lipoprotein particle subclasses and their composition. (lu.se)
  • Measuring all major lipids and apolipoproteins in each size fraction and in the whole serum, using total of 0.1 ml, allowed the volumetric calculation of lipoprotein particle numbers and expression of composition in molar analyte per particle number ratios. (cdc.gov)
  • Objective: To test how different types and amounts of SFAs will affect body weight, plasma lipids and lipoprotein profile when replacing carbohydrate (CHO). (wayne.edu)
  • Because fats are insoluble in water, they cannot be transported on their own in extracellular water, including blood plasma. (wikipedia.org)
  • Interesterification of fats, which may be carried out by random and directed, chemical or enzymatic processes, rearranges fatty acids on their glycerol moiety within the triacylglycerols (TAG) species, thereby changing their TAG structure [stereospecific ( sn )-positional composition] and their melting properties [ 1 ]. (springer.com)
  • However, whilst the total fatty acid composition of IE fats is identical to their non-IE fat, the sn -positional composition and physical characteristics are different, making direct comparisons to non-IE fats invalid. (springer.com)
  • Indeed, it is believed that differences in sn -positional composition between some animal and plant fats may explain their divergent effects on atherogenicity despite similar fatty acid compositions. (springer.com)
  • More saturated fats thus protected the lipoproteins from damage. (biomedcentral.com)
  • Elevated plasma levels of the cholesteryl-ester rich lipoprotein (a) [Lp(a)] increase the risk for development of cardiovascular disease through both proatherogenic and prothrombotic properties [ 4 ]. (biomedcentral.com)
  • The active ingredient comprises plasma proteins such as albumin , immunoglobulins, other globulins, coagulation factors, complement proteins and protease inhibitors. (rxlist.com)
  • The content and distribution of plasma proteins in Octaplas are comparable to reference ranges for healthy blood donors, except for Protein S and alpha2-antiplasmin. (rxlist.com)
  • However, these lipids can be transported throughout the bloodstream as lipoproteins when packaged with phospholipids and proteins (apoproteins). (medscape.com)
  • Plasma lipoproteins are macromolecular complexes of lipids and proteins that are classified by density and electrophoretic mobility. (medscape.com)
  • Because of the amino acid composition of the muscle proteins, their destruction stimulates the formation of additional cortisol, to accelerate the movement of amino acids from the less important tissues to the essential ones. (180degreehealth.com)
  • Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)
  • Plasma lipid profile may be abnormal. (medscape.com)
  • CONCLUSIONS: PNPLA3-I148M confers an antiatherogenic plasma lipid profile particularly in insulin-resistant individuals. (lu.se)
  • IDLs are either cleared from the plasma by the liver through receptor-mediated endocytosis (RME) or are further degraded to LDLs. (healthmatters.io)
  • The agreement with previous studies indirectly validates the AF4-LC-MS/MS approach and demonstrates the potential of this workflow for characterization of lipoprotein composition in clinical studies using small volumes of archived frozen samples. (cdc.gov)
  • In this study we report on the effect of this intervention with and without fiber supplementation on plasma homocysteine, lipoprotein (a) [Lp(a)], C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α). (biomedcentral.com)
  • The fatty acid compositions of ultracentrifugally isolated LDL, HDL 2 and HDL 3 fractions were analyzed by gas liquid chromatography (Table 2 ). (biomedcentral.com)
  • In the test, the RPR antigen is mixed with unheated or heated serum or with unheated plasma on a plastic-coated card. (cdc.gov)
  • Plasma levels of TG-rich lipoproteins depend on the rate of production, the efficiency of removal of TG content by lipolysis, and hepatic clearance. (eas-society.org)
  • Plasma total cholesterol (3.0 ± 1.4 versus 2.6 ± 0.1 mmol/L) and hepatic cholesterol (8.1 ± 0.6 versus 9.0 ± 1.2 μmol/g) were not different between WE and milk product treated diets. (arizona.edu)
  • During therapy, the changes in disease activity and inflammatory status were inversely correlated with changes in plasma total and HDL cholesterol levels and positively correlated with the variation of atherogenic index. (bmj.com)
  • Therefore, MUFA-enriched diets are a suitable alternative to low-fat, high-carbohydrate diets as a means of reducing plasma cholesterol levels and CHD risk. (bl.uk)
  • [ 2 ] The purpose of this article is to discuss the basic biology of lipoproteins, the pathophysiology of dyslipidemias, the interpretation of lipid levels in pediatric patients, dyslipidemia screening, and the management of pediatric lipid abnormalities. (medscape.com)
  • In abetalipoproteinemia, plasma cholesterol levels are very low, less than 50 mg/dL. (medscape.com)
  • Plasma sphingomyelin levels are relatively increased at the expense of lecithin. (medscape.com)
  • We are currently studying the regulation of lipoprotein levels and composition to identify therapeutic targets for their manipulation with a particular interest in the Lp(a) and HDL lipoproteins which have opposing risk associations with heart disease. (otago.ac.nz)
  • however, the contribution to the overall plasma HDL levels is minimal. (jci.org)
  • The TP-rich diets increased plasma LDL- and HDL-cholesterol levels in a concentration-dependent manner. (cambridge.org)
  • Peak plasma levels of fenofibric acid occur within 6 to 8 hours after administration. (nih.gov)
  • Here we examined effects of exogenous hyperinsulinemia on plasma PCSK9 levels in humans without and with type 2 diabetes mellitus. (shengsci.com)
  • Plasma PCSK9 levels remained unchanged in healthy subjects (median (interquartile range) change, -23 (-63 to 25) %, P = 0.50) and in diabetic patients (change, 4 (-17 to 44) %, P = 0.20). (shengsci.com)
  • CONCLUSION:Plasma PCSK9 levels are not increased by exposure to moderate 24h hyperinsulinemia in healthy and type 2 diabetic individuals. (shengsci.com)
  • Insufficient vitamin B 12 and folate correlate with plasma homocysteine levels, and supplemental B vitamins and folate can be part of an effective dietary treatment [ 4 ]. (biomedcentral.com)
  • The contradictory findings on the role of HDL on LDL oxidation in vitro may be due to rather small study populations, and the reported heterogeneity of oxidation kinetics between lipoprotein preparations in vitro [ 9 ] which might be due to individual intrinsic properties of the lipoproteins. (biomedcentral.com)
  • Oxidative modification of low-density lipoprotein (LDL) is a key event in the oxidation hypothesis of atherogenesis. (biomedcentral.com)
  • TS-containing diets did not increase the cholesterol content of any of the major lipoprotein fractions. (cambridge.org)
  • Lipoprotein composition within size fractions was expressed in molar ratios of analytes (A-I/A-II, C-II/C-I, C-II/C-III. (cdc.gov)
  • A low HDL cholesterol level is thought to accelerate the development of atherosclerosis because of impaired reverse cholesterol transport and possibly because of the absence of other protective effects of HDL, such as decreased oxidation of other lipoproteins. (medscape.com)
  • Some in vitro experiments have previously suggested that high-density lipoprotein (HDL) co-incubated with LDL prevents Cu 2+ -induced oxidation of LDL, while some other studies have observed an opposite effect. (biomedcentral.com)
  • Oxidation rate was positively associated with polyunsaturated fatty acid content of the lipoproteins in that it was positively related to the content of linoleate and negatively related to oleate. (biomedcentral.com)
  • We conclude that in vitro HDL does not protect LDL from oxidation, but is in fact oxidized fastest of all lipoproteins due to its fatty acid composition, which is oxidation promoting. (biomedcentral.com)
  • In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII. (nih.gov)
  • Exposure to fenofibric acid in plasma, as measured by Cmax and AUC, is not significantly different when a single 145 mg dose of fenofibrate is administered under fasting or nonfasting conditions. (nih.gov)
  • Lipoproteins are derived from the exogenous and the endogenous pathways. (medscape.com)
  • Epidemiological studies show an inverse correlation between high-density lipoprotein (HDL) concentration and the risk of developing coronary artery disease [ 1 ]. (biomedcentral.com)
  • However, available information on quantitative PP intake is incomplete and comprehensive reference food composition tables are not available, because of the wide range of PPs and the considerable number of factors that modify their concentration in foods 58 . (bvsalud.org)
  • Plasma TG is, however, merely a surrogate for estimating the critical lipoproteins - TG-rich lipoproteins and their remnants. (eas-society.org)
  • First, there is clarification of what is meant by TG, TG-rich lipoproteins, and remnants. (eas-society.org)
  • Second, this EAS Statement provides a framework for understanding how remnants of TG-rich lipoproteins are generated and cleared from the circulation. (eas-society.org)
  • This EAS Statement provides a state-of-the art review of current thinking on how TG-rich lipoproteins and their remnants are retained in the arterial wall and promote maladaptive responses central to plaque initiation and progression. (eas-society.org)
  • Two key gaps in knowledge about TG-rich lipoproteins and remnants are highlighted. (eas-society.org)
  • The Panel concludes that clinicians should continue to use plasma TG (either fasting or nonfasting) as a surrogate for quantitating TG-rich lipoproteins and remnants, as recommended by the 2019 European Society of Cardiology/EAS dyslipidaemia guidelines (12,16) . (eas-society.org)
  • The study explores the hypothesis by investigating effects of consumption of 1000 mg of PSO on total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), systolic (SBP) and diastolic (DBP) blood pressure ((BP). (scielo.br)
  • Multiplexed mass spectrometry (MS) techniques have substantially improved the ability to characterize the composition of lipoproteins. (cdc.gov)
  • With the increasing popularity of nSLB systems there is a growing need for a standardized workflow to accurately characterize their quality, composition, and structure to aid in their development and expand their utility. (lu.se)
  • A lipoprotein is a biochemical assembly whose primary function is to transport hydrophobic lipid (also known as fat) molecules in water, as in blood plasma or other extracellular fluids. (wikipedia.org)
  • Each class had the same chemical and immunochemical composition and seemed to be interconvertible in vitro, presumably as a result of aggregation/disaggregation. (bmj.com)
  • In some reports this finding could not be confirmed, and in fact it has been demonstrated that in vitro HDL is oxidized faster than other lipoproteins [ 4 ]. (biomedcentral.com)
  • These findings support the use of fatty acid-modified foods as a suitable vehicle through which to achieve changes in dietary composition. (bl.uk)
  • The effect of different dietary fatty acids on lipoprotein. (cambridge.org)
  • Dietary groups were: whole milk powder (WM), skim milk powder-SBF (SM/S), casein-SBF (C/S), and skim milk powder-BF (SM/B). A hypocholesterolemic effect was observed in guinea pigs fed the WM (plasma cholesterol, 1.5 mmol/L) diet compared to all other diet groups (3. (arizona.edu)
  • Trans fatty acid intake was significantly reduced (-38.6%) while dietary folate was unchanged, as was plasma homocysteine. (biomedcentral.com)
  • The extent and duration of this postprandial response is regulated by lipoprotein lipase (LPL). (bl.uk)
  • Linear mixed models were used to investigate the associations between plasma protein N-glycosylation and metabolic response (fasting, postprandial ( C max ), or change from fasting). (biomedcentral.com)
  • This study provides a comprehensive overview of the interconnections between plasma protein N-glycosylation and postprandial responses, demonstrating the incremental predictive benefit of N-glycans. (biomedcentral.com)
  • The postprandial increase in plasma TAG was higher following the IE PSt/PK versus the non-IE PSt/PK, with a 51 % greater incremental area under the curve [mean difference with 95 % CI 41 (23, 58) mmol/L min P = 0.001]. (springer.com)
  • Our Octaplas, Pooled Plasma (human), Solvent/Detergent Treated Solution for Intravenous Infusion Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • Abetalipoproteinaemic plasma lipoproteins were fractionated by molecular sieve chromatography into two classes on the basis of size. (bmj.com)