Microvascular complicationsNephropathyCardiovascularPathogenesisInsulinVascular complicationsHyperglycemiaGlycemic controlHypertensionEndothelialRegulateGenome2019DiagnosticMetabolicExamineDiseaseMethodsSevereGlucosePresentCellsLevelsAnimal modelsAssociationSignificantlyProteinRoleCasesStudySearchRESULTSIndividualsYearsEditionFactorsTreatmentLevelLaboratoryDataStudiesTherapyAdditionFactorLower
Microvascular complications6
- [ 5 ] Benefits of tight glycemic control include not only continued reductions in the rates of microvascular complications but also significant differences in cardiovascular events and overall mortality. (medscape.com)
- Although diabetic nephropathy, neuropathy and retinopathy are the most common microvascular complications of hyperglycemia, it also affects choroid plexus. (scialert.net)
- In vivo Corneal Confocal Microscopy and Nerve Growth Factor in Diabetic Microvascular Complications. (e-dmj.org)
- Moreover, NGFs and receptors are also expressed in retina and renal mesangial cells, suggesting their possible role in the common pathogenesis of diabetic microvascular complications. (e-dmj.org)
- Interestingly, similar changes were seen in other microvascular complications as well. (e-dmj.org)
- CONCLUSION: Our results provide a possibility of using novel tools, IVCCM and NGF, as common diagnostic tools for diabetic microvascular complications, but it should be followed by a large population study. (e-dmj.org)
Nephropathy6
- Since miR-192 was shown to regulate extracellular matrix proteins Collagen, type I, α1 and α2 (Col1α1 and 2) that accumulate during diabetic nephropathy, miR-192 may play a role in kidney diseases as well. (wikipedia.org)
- A correlation between elevated Notch signaling pathway gene expression, which is important for cell to cell communication, and diabetic nephropathy has also been shown. (wikipedia.org)
- Protective Effects of Lithospermic Acid B on Diabetic Nephropathy in OLETF Rats Comparing with Amlodipine and Losartan. (e-dmj.org)
- We examined the effects of LAB on the prevention of diabetic nephropathy compared with amlodipine, a calcium channel blocker, and losartan, an angiotensin receptor blocker, in Otsuka Long-Evans-Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. (e-dmj.org)
- CONCLUSION: These results suggest that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by decreasing oxidative stress and inflammation as potent as losartan. (e-dmj.org)
- Activation of NF-kappaB and AP-1 in Peripheral Blood Mononuclear Cells Isolated from Patients with Diabetic Nephropathy. (e-dmj.org)
Cardiovascular4
- The most pronounced deterioration of diurnal arterial stiffness indicators in the group of comorbid patients with EAH and SН, as well as the excess of vascular age over chronological and reliable correlation with the comorbidity index, revealed during the study, suggests an assessment of these indicators in patients with cardioendocrine pathology to assess the true risk cardiovascular complications and the selection of adequate therapy. (orscience.ru)
- Cardiovascular complications, along with the levels of cTnI, creatine kinase (CK), and creatine kinase MB (CK-MB) in hospitalized PCR-confirmed COVID-19 patients were extracted. (nutrition-evidence.com)
- BACKGROUND AND AIM Occasionally, children with COVID-19 may develop arrhythmia, myocarditis, and cardiogenic shock involving multisystemic inflammatory syndrome in children (MIS-C). This study aimed to identify the laboratory parameters that may predict early cardiovascular involvement in these patients. (nutrition-evidence.com)
- They offer utility in the assessment of hypertensive phenotypes, in cardiovascular risk prediction, and as surrogate endpoints in clinical trials. (biomedcentral.com)
Pathogenesis2
- Connective Tissue Growth Factor (CTGF) has recently been shown to be over-expressed in kidney, myocardium and aorta in diabetic animals, implicating CTGF role in the pathogenesis of both microvascular and macrovascular diabetic complications ( Brownlee, 2001 ). (scialert.net)
- This review aimed to elucidate the potential role of leukotrienes (LTs) in the pathogenesis and clinical presentation of SARS-CoV-2 infection, and to reveal the critical role of LT pathway receptor antagonists and inhibitors in Covid-19 management. (nutrition-evidence.com)
Insulin11
- Since Type 2 diabetes is characterized by chronic hyperglycaemia as a result of impaired pancreatic beta cell function and insulin resistance in peripheral tissues, it was thought that the gene might be downregulated in type 2 diabetes patients through DNA methylation. (wikipedia.org)
- Further testing revealed that the more PPARGC1A was expressed, the more insulin was released from the islets, and as expected, in diabetic patients there was less PPARGC1A expressed and also less insulin secreted. (wikipedia.org)
- This data supports the idea that PPARGC1A expression is reduced in animal models of diabetes and human diabetes and is associated with impaired insulin secretion. (wikipedia.org)
- PGC-1α, the protein encoded by the gene PPARGC1A, can modulate glucose-mediated insulin secretion in human islets, most likely through an effect on ATP production. (wikipedia.org)
- In human type 2 diabetic islets, reduced PPARGC1A mRNA levels were associated with impaired glucose-mediated insulin secretion. (wikipedia.org)
- Type 1 diabetes is a chronic illness characterized by the body's inability to produce insulin due to the autoimmune destruction of the beta cells in the pancreas. (medscape.com)
- Optimal diabetic control requires frequent self-monitoring of blood glucose levels, which allows rational adjustments in insulin doses. (medscape.com)
- All patients with type 1 diabetes should learn how to self-monitor and record their blood glucose levels with home analyzers and adjust their insulin doses accordingly. (medscape.com)
- Patients with type 1 diabetes require lifelong insulin therapy. (medscape.com)
- Most require 2 or more injections of insulin daily, with doses adjusted on the basis of self-monitoring of blood glucose levels. (medscape.com)
- To evaluate fitness of Contour® TS glucometer (Contour® TS, Bayer/Ascensia*) - a system for blood glycemia level control, and its characteristics in everyday use for Russian patients with insulin dependent diabetes mellitus (DM) types 1 and 2 and endocrinologists. (orscience.ru)
Vascular complications2
- Epigenetics may play a role in a wide array of vascular complications and in diabetes. (wikipedia.org)
- Advanced glycation end-products (AGEs) contribute to vascular complications and organ damage in diabetes. (bvsalud.org)
Hyperglycemia2
- Diabetes is a methabolic disease characterized by hyperglycemia, with high morbidity and mortility worldwide. (scialert.net)
- Diabetic microvasular complications, which are considered as an important group of hyperglycemia imperfections, caused by increased endothelial permeability and can progress to severe impairments in several organs. (scialert.net)
Glycemic control2
- Real-time continuous monitoring of glucose-using continuous glucose monitors (CGMs)-can help patients improve glycemic control. (medscape.com)
- Long term diabetes and poor glycemic control are the most important risk factors for DN development ( DCCT Research Group, 1993 ). (scialert.net)
Hypertension2
- To identify the features of the daily dynamics of arterial stiffness in patients with essential arterial hypertension (EАH) and subclinical hypothyroidism (SH). (orscience.ru)
- Hypertension was the most common in 161 (48.8%) patients, followed by diabetes (16.7%, n = 55) and coronary heart disease (13.3%, n = 44). (nutrition-evidence.com)
Endothelial2
- From IVCCM, we measured corneal nerve density, branch, and tortuosity, total corneal/epithelial thickness, and the number of endothelial/keratocyte cells, and we checked patients' biochemical profiles and serum and tear NGF levels. (e-dmj.org)
- RESULTS: Patients with more severe neuropathy had less corneal endothelial cells (3105 +/- 218 vs. 2537 +/- 142 vs. 2350 +/- 73/mm3 vs. 1914 +/- 465/mm3, P = 0.02), higher serum NGF (36 +/- 15 vs. 60 +/- 57.66 vs. 80 +/- 57.63 vs. 109 +/- 60.81 pg/mL, P = 0.39) and tear NGF levels (135.00 +/- 11.94 vs. 304.29 +/- 242.44 vs. 538.50 +/- 251.92 vs. 719.50 +/- 92.63 pg/mL, P = 0.01). (e-dmj.org)
Regulate3
- MiR-143 has also been experimentally shown to regulate genes that are crucial for adipocyte differentiation, (including GLUT4, Hormone-sensitive lipase, the fatty acid-binding protein, aP2 and PPAR-γ2), demonstrating that miRNAs are also involved in fat metabolism and endocrine function in humans. (wikipedia.org)
- Although all diabetic cells are exposed to elevated levels of plasma glucose, hyperglycemic damage is limited to those cell types that are unable to down regulate glucose transport into the cell (e.g., endothelial cells), leading to intra-cellular hyperglycemia ( Brownlee, 2001 ). (scialert.net)
- Nerve growth factors (NGF) are believed to regulate peripheral and central nervous system, neuronal differentiation, and regeneration of damaged nerves, and their role in diabetic neuropathy is being emphasized these days. (e-dmj.org)
Genome2
- In recent years it has become apparent that the environment and underlying mechanisms affect gene expression and the genome outside of the central dogma of biology. (wikipedia.org)
- single nucleotide polymorphism-DNA sequence variations with a single nucleotide (adenine, thymine, cytosine, or guanine) in the genome sequence altered. (biomedcentral.com)
20191
- Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the responsible agent for the coronavirus disease 2019 (Covid-19), has its entry point through interaction with angiotensin converting enzyme 2 (ACE2) receptors, highly expressed in lung type II alveolar cells and other tissues, like heart, pancreas, brain, and vascular endothelium. (nutrition-evidence.com)
Diagnostic1
- In vivo corneal confocal microscopy (IVCCM) is being recognized as a non-invasive, early diagnostic tool for diabetic neuropathy, for it provides a clear image of corneal subbasal nerve plexus in detail. (e-dmj.org)
Metabolic4
- A subset of miRNAs has been shown to be involved in metabolic regulation of glucose homeostasis and in epigenetics of diabetes type 2. (wikipedia.org)
- OBJECTIVES: The objective of this study was to assess glucose-mediated albumin modification that yields non-standard epitopes of AGEs (AGE-1) in diabetes and in associated metabolic abnormalities. (bvsalud.org)
- MATERIAL AND METHODS: The AGE-1, expressed as median AGE-1 level and AGE-1 positivity, was determined in 246 individuals (198 with prediabetes/diabetes) using a new slot-dot-blot method (allowing for detection of barely traceable analytes) and related to the presence of diabetes-associated metabolic abnormalities and complications, and treatment. (bvsalud.org)
- Its elevation was associated with metabolic syndrome (MetS), obesity, hyperlipidemia, and non-alcoholic fatty liver disease (NAFLD) but not with diabetic control or microand macroangiopathy, except for atherosclerotic plaques formation in carotid arteries. (bvsalud.org)
Examine3
- We plan to examine corneal structures of diabetic patients and compare IVCCM with conventional tools and analyze their serum and tear NGF levels. (e-dmj.org)
- We furthermore examine genes and polymorphisms relevant to each technique. (biomedcentral.com)
- method of using measured variation in genes of known function to examine the causal effect of a modifiable exposure on disease. (biomedcentral.com)
Disease1
- An understanding of the epigenome of Diabetes patients may help to elucidate otherwise hidden causes of this disease. (wikipedia.org)
Methods2
- METHODS: IVCCM, nerve conduction velocity (NCV), and serum, urine, and tear samplings were done to 42 diabetic patients. (e-dmj.org)
- METHODS The study was designed based on severe and critically ill patients with COVID-19. (nutrition-evidence.com)
Severe3
- Thirty-four cases were considered mild (64%), 17 moderate (32%), and 2 (4%) severe. (nutrition-evidence.com)
- Montelukast (MK) is a safe asthma controller drug, which is considered as a potential antiviral drug for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (nutrition-evidence.com)
- CONCLUSIONS Cardiac injury was associated with elevated levels of inflammatory cytokines among severe and critically ill patients with COVID-19, suggesting that hyper-inflammatory response may involve in cardiac injury. (nutrition-evidence.com)
Glucose1
- A fingerstick glucose test is appropriate for virtually all patients with diabetes. (medscape.com)
Present3
- It is not unusual for patients with type 1 diabetes to present with diabetic ketoacidosis (DKA). (medscape.com)
- We aimed at developing ELISA for AGE10 quantification, determining whether AGE10 is present in diabetic patients (n = 82), and evaluating its association with diabetic complications. (bvsalud.org)
- complete set of exons present in an organism which accounts for all the coding regions of genes present. (biomedcentral.com)
Cells2
- Using bisulfite testing, it was also found that there was an approximately twofold increase in DNA methylation of the PPARGC1A promoter of human islet cells from diabetics as compared to non-diabetic human islet cells. (wikipedia.org)
- in a study, it was found that there was increased DNA methylation in the LBW patients' muscle cells. (wikipedia.org)
Levels3
- Also miR-192 levels have been shown to be increased in glomeruli isolated from diabetic mice when compared to non-diabetic mice, suggesting that it is involved as well. (wikipedia.org)
- The ADA recommends using patient age as one consideration in the establishment of glycemic goals, with different targets for preprandial, bedtime/overnight, and hemoglobin A 1c (HbA 1c ) levels in patients aged 0-6, 6-12, and 13-19 years. (medscape.com)
- The age, sex, COVID-19-associated symptoms, pro-brain natriuretic peptide (proBNP), CK-MB, and troponin I levels of the patients were recorded. (nutrition-evidence.com)
Animal models1
- Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 and type 2 diabetic animal models. (e-dmj.org)
Association4
- An international expert committee appointed by the ADA, the European Association for the Study of Diabetes (EASD), and the International Diabetes Association recommended the HbA 1c assay for diagnosing type 1 diabetes only when the condition is suspected but the classic symptoms are absent. (medscape.com)
- The American Diabetes Association has released condensed recommendations for Standards of Medical Care in Diabetes: Abridged for Primary Care Providers, highlighting recommendations most relevant to primary care. (medscape.com)
- The recommendations can be accessed at American Diabetes Association DiabetesPro Professional Resources Online, Clinical Practice Recommendations - 2015. (medscape.com)
- However, data are relatively scarce on the association between hyper-inflammatory response and cardiac injury among COVID-19 patients. (nutrition-evidence.com)
Significantly3
- Analysis of the daily dynamics of arterial stiffness in patients with EAH and the presence of endocrine pathology showed that SН have a negative effect on elastic properties of the arteries, which is confirmed by significantly higher values of PWVao and arterial stiffness index, ASI, including at night, as well as lower PTIN indices compared with patients with isolated EAH. (orscience.ru)
- It can also be assumed that the worsening of arterial stiffness in the group of patients with AG+SН is more pronounced, given the significantly higher vascular age in this group of patients, associated with an increase in the number of comorbid pathology, compared with the AН group. (orscience.ru)
- AGE10 was significantly higher in patients with microangiopathy, in whom it depended on treatment, being lower in patients treated with aspirin. (bvsalud.org)
Protein1
- In patients untreated with aspirin, AGE-1 positivity was associated with higher C-reactive protein (CRP) level. (bvsalud.org)
Role1
- A literature search was done in PubMed, Scopus, Web of Science and Google Scholar databases to find the potential role of montelukast and other LT inhibitors in the management of pulmonary and extra-pulmonary manifestations triggered by SARS-CoV-2. (nutrition-evidence.com)
Cases1
- To investigate patient outcomes, 53 consecutive COVID-19 test (+) cases (ages 3-90) from a well-established, single-center practice in Boston, Massachusetts, between March - November 2020, were treated with levocetirizine and montelukast in addition to then existing protocols [2]. (nutrition-evidence.com)
Study2
- In a different study where transcriptional changes due to a risk factors for diabetes, were examined, changes in the methylation patterns of the PPARGC1A gene were also found. (wikipedia.org)
- In the study done on physical inactivity, where subjects were required to have a sustained bed-rest of 10 days and were then examined, it was also found that there was significant downregulation of the PPARGC1A gene. (wikipedia.org)
Search1
- The search was conducted in PubMed, Web of Science, and Scopus databases and yielded 35 studies containing the influence of MK on SARS-CoV-2. (nutrition-evidence.com)
RESULTS3
- RESULTS: The AGE-1 level was higher in patients with prediabetes/diabetes than in controls. (bvsalud.org)
- RESULTS Out of 1094 obtained records, 22 studies on a total of 4,157 patients were included. (nutrition-evidence.com)
- RESULTS There were 32.4% (n = 107) of patients with cardiac injury. (nutrition-evidence.com)
Individuals1
- Screening for type 1 diabetes in asymptomatic low-risk individuals is not recommended. (medscape.com)
Years2
- [ 2 ] However, in patients at high risk (eg, those who have first-degree relatives with type 1 diabetes), it may be appropriate to perform annual screening for anti-islet antibodies before the age of 10 years, along with 1 additional screening during adolescence. (medscape.com)
- The median age was 67 years, and 48.8% (n = 161) of patients were men. (nutrition-evidence.com)
Edition1
- Updated clinical guidelines "Standards of specialized diabetes care", 9th Edition. (orscience.ru)
Factors1
- Logistic regression analysis showed that hs-CRP, TNF-α and IL-6 were independent risk factors for cardiac injury. (nutrition-evidence.com)
Treatment1
- Montelukast can be effective in the treatment of SARS-CoV-2 infection. (nutrition-evidence.com)
Level2
- Secondarily, we compared the cardiac troponin I (cTnI) level between the surviving and expired patients. (nutrition-evidence.com)
- The pooled incidences of the extracted data were calculated, and the unadjusted cTnI level was compared between the surviving and expired patients. (nutrition-evidence.com)
Laboratory1
- FDA has approved a multicenter, randomized, placebo-controlled, Phase 2 clinical trial design, replete with electronic diaries and laboratory metrics to explore scientific questions not addressed herein. (nutrition-evidence.com)
Data1
- Data obtained so far underline that pulmonary and extra-pulmonary manifestations in Covid-19 are attributed to a direct effect of SARS-CoV-2 in expressed ACE2 receptors or indirectly through NF-κB dependent induction of a cytokine storm. (nutrition-evidence.com)
Studies2
- Recent studies have shown that miRNAs have pivotal roles in many different gene regulatory pathways. (wikipedia.org)
- We explore the relative influence of participant genetics, with reference to large-scale genomic studies, population-based cohorts, and candidate gene studies. (biomedcentral.com)
Therapy1
- We evaluate the efficacy of antimicrobial Photodynamic Therapy (APDT) for inactivating a variety of antibiotic-resistant clinical strains from diabetic foot ulcers. (bvsalud.org)
Addition1
- In addition, it was shown that after the bed rest, there was a marked increase in DNA methylation of the PPARGC1A gene along with a decrease in mRNA expression. (wikipedia.org)
Factor1
- These epigenetic mechanisms are believed to be a contributing factor to pathological diseases such as type 2 diabetes. (wikipedia.org)
Lower1
- The AGE-1-positive patients had higher triglycerides and lower high-density lipoprotein (HDL)-cholesterol. (bvsalud.org)