• Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
  • Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
  • The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
  • This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (medscape.com)
  • Pulmonary infiltrates frequently complicate hematopoietic SCT (HSCT). (nih.gov)
  • Hematopoietic stem cell transplantation (HSCT) has been shown to be effective. (medscape.com)
  • In the prospective Autologous Stem Cell Transplantation International Scleroderma (ASTIS) trial, a phase 3 comparison of autologous HSCT with 12 successive monthly intravenous pulses of cyclophosphamide in 156 patients with early diffuse cutaneous systemic sclerosis, HCST was associated with higher treatment-related mortality than in the first year after treatment. (medscape.com)
  • BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a well-established treatment modality for a variety of diseases. (koreamed.org)
  • PURPOSE: To identify the symptoms and signs of patients with dry eye disease (DED) after allogenic hematopoietic stem cell transplantation (HSCT) and analyze the correlations between these signs and symptoms. (koreamed.org)
  • BACKGROUND AND OBJECTIVES: Cells of innate immunity normally recover in the first weeks to months after allogenenic hematopoietic stem cell transplantation (allo-HSCT). (koreamed.org)
  • BACKGROUND: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can cure leukaemia. (koreamed.org)
  • Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). (hindawi.com)
  • Allogeneic hematopoietic stem cell transplantation (HSCT) offers the only curative modality for many hematological disorders. (hindawi.com)
  • Body iron disorders have been reported after myeloablative conditioning in patients undergoing hematopoietic stem cell transplantation (HSCT). (karger.com)
  • There is a concern that labile plasma iron (LPI), the redox-active form of iron, can be involved in the occurrence of toxicity and other complications commonly observed in the early post-HSCT period. (karger.com)
  • Hematopoietic stem cell transplantation (HSCT) is a broad term that covers the transplantation of blood progenitor/stem cells from any source. (drugdiscoverynews.com)
  • Among the conditions HSCT can treat are: acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, chronic lymphocytic leukemia, myeloproliferative disorders, myelodysplastic syndromes, multiple myeloma, non-Hodgkin lymphoma, Hodgkin disease, aplastic anemia and pure red-cell aplasia-but this list is not exhaustive. (drugdiscoverynews.com)
  • Other groups are also working on cell therapies for the treatment of poor graft function after HSCT. (drugdiscoverynews.com)
  • Their ongoing Phase 2 study is evaluating whether infusion of mesenchymal stem cells (MSCs) can treat steroid-resistant acute graft-versus-host disease (GVHD) or poor graft function after HSCT. (drugdiscoverynews.com)
  • Cardiac complications have been described in HSCT with the majority of reported cardiac complications during HSCT attributed to the use of high-dose cyclophosphamide [30]. (slideshare.net)
  • Researchers at Baylor College of Medicine and collaborating institutions have engineered immune cells to control two major life-threatening complications, namely graft-vs-host disease (GvHD) and cancer relapse, which typically emerge after treating leukemia with allogeneic hematopoietic stem cell transplantation (allo-HSCT). (texaschildrens.org)
  • Acute Graft-versus-host disease (GvHD), one of the major complications of HSCT, is correlated to conditioning-induced gut barrier damage and may be predicted by pre-transplant serum citrulline level (Rashidi, BBMT 2018). (confex.com)
  • Tuberculosis (TB) is a rare but potentially devastating complication in hematopoietic stem cell transplantation (HSCT) recipients. (bvsalud.org)
  • Hematopoietic stem cell transplantation (HSCT) is the only curative treatment to date and as outcomes improve its use has increased. (abstractarchives.com)
  • Complications of HSCT are frequent and some literature suggests there is a higher incidence in the SCD population. (abstractarchives.com)
  • This comprehensive course will enhance your understanding of hematopoietic stem cell transplant (HSCT) and provide concepts to apply to your care of HSCT patients. (ons.org)
  • The learner will apply evidence-based care concepts of hematopoietic stem cell translant into nursing care to improve outcomes for HSCT patients. (ons.org)
  • Chronic graft- versus -host disease (cGvHD) is a major cause of morbidity after hematopoietic stem cell transplantation (HSCT). (haematologica.org)
  • Hematopoietic stem cell transplantation (HSCT) is an important therapeutic option for patients with non-malignant diseases as well as high-risk and refractory hematopoietic malignancies. (haematologica.org)
  • As a result, HSCT is often attributed to an increased risk of health complications, the most severe being chronic graft- versus -host disease (cGvHD). (haematologica.org)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
  • This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
  • Allo-hSCT is estimated to reduce the risk of leukemia relapse to half, but with significant risk for treatment-related complications. (cancercentrum.se)
  • of graft-versus-host disease, which is observed as a major complication of hematopoietic stem cell transplantation. (karger.com)
  • BACKGROUND: This study aimed to assess the outcome of stem cell transplantation (SCT), including overall survival (OS), failure-free survival (FFS) and graft-versus-host disease (GvHD)-free/failure-free survival (GFFS), and to analyze prognostic. (koreamed.org)
  • Graft versus host disease is a major complication of allogeneic haematopoietic stem cell transplantation with a wide spectrum of clinical manifestations. (ausmed.com.au)
  • Despite advances in post-transplant care, the morbidity and mortality of complications such as graft versus host disease (GVHD) and infections remain significant limitations, and hinder the application of this life-saving procedure. (damonrunyon.org)
  • Acute graft versus host disease (aGVHD) is a common complication following allogeneic hematopoietic stem cell transplantation (AHSCT) caused by cellular and inflammatory factors, including those arising from monocytes and dendritic cells as integral parts of the immune system. (magiran.com)
  • Novice nurses with limited pediatric clinical experience and no stem cell transplant experience. (aphon.org)
  • These nurses may know adult stem cell transplant, but have not cared for pediatric patients. (aphon.org)
  • Related transplant donors must be proven not to have Fanconi anemia in order for a transplantation to succeed. (medscape.com)
  • The study involved targeted mutational analysis of samples obtained before stem cell transplant from 1,514 MDS patients enrolled at the Center for International Blood and Marrow Transplant Research Repository between 2005 and 2014. (ascopost.com)
  • The researchers then evaluated the animals' behavior and found that memory loss and neurocognitive impairment were completely prevented in mice that received the stem cell transplant. (scitechdaily.com)
  • Donor Killer Cell Immunoglobulin-Like Receptor Genotype Does Not Improve Graft-versus-Leukemia Responses in Chronic Lymphocytic Leukemia after Unrelated Donor Transplant: A Center for International Blood and Marrow Transplant Research Analysis. (anthonynolan.org)
  • Up to 4.25 ILNA points may be applied to Basic Concepts for Transplantation OR Early Post-Transplant Management OR Pre-Transplant Care OR Types of Transplants and Sources of Stem Cells. (ons.org)
  • Viral infection can lead to fatal complications in patients with weakened immune systems resulting from chemotherapy, bone marrow or cord blood transplant, and other forms of inherited or acquired disorders. (ca.gov)
  • Hematopoietic cell transplantation is, to date, the only curative therapy for SCD, but its application is limited by availability of a suitable HLA-matched donor and lack of awareness of the benefits of transplant. (duke.edu)
  • Included in this study are 1000 recipients of HLA-identical sibling transplants performed between 1986 and 2013 and reported to the European Society for Blood and Marrow Transplantation, Eurocord, and the Center for International Blood and Marrow Transplant Research. (duke.edu)
  • Peripherally inserted central catheters in allogeneic hematopoietic stem cell transplant recipients. (uff.br)
  • Under immunosuppression conditions, all infectious foci can be activated and, for this reason, all active infections in hematopoietic stem cell pre-transplant patients must be eradicated prior to transplant so as to prevent or reduce the risk of systemic complications in these patients. (bvsalud.org)
  • Aim: Present a case report of dental care provided to a non-Hodgkin lymphoma patient with an urgent need for hematopoietic stem cell transplant. (bvsalud.org)
  • The aim of the academic journal is to provide a platform for researchers, scientists, physicians, and other health professionals to find latest research information in the areas of stem cell research, transplantations such as stem cell transplantation, transplantation immunology, kidney transplantation and its treatment. (slideshare.net)
  • For example, in developing and developed countries alike, kidney transplantation not only yields survival rates and quality-of-life that are far superior to those obtained with other treatments for end-stage renal disease, such as haemodialysis, but is also less costly in the long run. (who.int)
  • Stem and progenitor cells can be taken from the pelvis, at the iliac crest, using a needle and syringe. (wikipedia.org)
  • It was used extensively in early studies, but is now considered to measure more mature progenitor or transit-amplifying cells rather than stem cells[citation needed]. (wikipedia.org)
  • Systemic transplantation of wild-type hematopoietic stem and progenitor cells (green) led to their differentiation into microglia-like cells (red), which reduced the amount of beta amyloid plaques (magenta) in the brain. (scitechdaily.com)
  • In the study, recently published in Cell Reports , the researchers demonstrate that transplanting hematopoietic stem and progenitor cells was effective in rescuing multiple signs and symptoms of Alzheimer's in a mouse model of the disease. (scitechdaily.com)
  • Our work shows that hematopoietic stem and progenitor cell transplantation has the potential to prevent complications from Alzheimer's and could be a promising therapeutic avenue for this disease. (scitechdaily.com)
  • Mishra and her colleagues performed systemic transplantations of healthy wild-type hematopoietic stem and progenitor cells into Alzheimer's mice and found that the transplanted cells did differentiate into microglia-like cells in the brain. (scitechdaily.com)
  • Altogether, the transplantation of healthy hematopoietic stem and progenitor cells led to enhanced microglia health, which in turn protected against multiple levels of Alzheimer's pathology. (scitechdaily.com)
  • Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
  • [ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (medscape.com)
  • A study from UC San Diego indicates that transplants of hematopoietic stem cells can shield mice with Alzheimer's from memory decline, neuroinflammation, and accumulation of β-amyloid. (scitechdaily.com)
  • A recent study conducted by scientists at the University of California San Diego suggests that stem cell transplants could be a promising therapeutic against Alzheimer's. (scitechdaily.com)
  • The Cherqui lab had already found success using similar stem cell transplants to treat mouse models of cystinosis, a lysosomal storage disease, and Friedreich's ataxia, a neurodegenerative disease. (scitechdaily.com)
  • Balassa K, Danby R, Rocha V. Haematopoietic stem cell transplants: principles and indications. (anthonynolan.org)
  • Angiocrine is developing a cell therapy aimed to improve the availability and engraftment of blood stem cell transplants for cancer patients who have had their cancerous bone marrow removed by chemotherapy. (ca.gov)
  • The number of human tissue transplants is increasing in both developed and developing countries, but global data on this form of transplantation are less complete. (who.int)
  • Access to transplantation is limited in low- and many medium-income countries, where the rate of transplants remains far below that of richer nations. (who.int)
  • Front Cell Infect Microbiol;13: 1258561, 2023. (bvsalud.org)
  • In recent years, different studies have reported thromboembolic complications with increased morbidity and bleeding complications with higher mortality in patients undergoing AHSCT. (isth.org)
  • The study, which involved 130 patients, also found that adding fludarabine to conditioning caused three-fold enhancement of hematopoietic cell engraftment. (medscape.com)
  • Incomplete engraftment (poor graft function) requires the patient to undergo more transfusions of red cells or platelets. (drugdiscoverynews.com)
  • One trial is testing whether MSCs with or without peripheral blood stem cells could treat poor graft function and delayed platelet engraftment. (drugdiscoverynews.com)
  • Research Objective We will use integrated gene editing techniques to develop a new CAR-T cell therapy for multiple myeloma treatment Impact Develop an improved CAR-T cell therapy for patients with refractory multiple myeloma and a new manufacturing strategy that circumvents the costs and inefficiencies of viral production. (ca.gov)
  • Of all the other cancers, multiple myeloma causes this complication the most. (webmd.com)
  • Multiple myeloma (MM) is a debilitating malignancy that is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance ( MGUS ) to plasma cell leukemia. (medscape.com)
  • Bone marrow aspirate demonstrating plasma cells of multiple myeloma. (medscape.com)
  • Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells. (wikipedia.org)
  • In vertebrates, the very first definitive HSCs arise from the ventral endothelial wall of the embryonic aorta within the (midgestational) aorta-gonad-mesonephros region, through a process known as endothelial-to-hematopoietic transition. (wikipedia.org)
  • Rebar N. Mohammed Hematopoietic stem cells (HSCs) are a rare population of cells that reside mainly in the bone marrow and are capable of generating and fulfilling the entire hematopoietic system upon differentiation. (karger.com)
  • The authors discuss the genetic, hematologic, and clinical features of SCD and describe the major associated health complications. (thalassaemia.org.cy)
  • The cells are also being evaluated in a variety of other hematologic indications. (drugdiscoverynews.com)
  • The insertion site is the main risk factor for central venous catheter‐related complications in patients with hematologic malignancies. (uff.br)
  • The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. (wikipedia.org)
  • Viral-antigen detection is one of the new tests, but the results are generally less sensitive and less specific than those of conventional cell cultures. (medscape.com)
  • Stem cell infusion is a relatively simple process that is performed at the bedside. (medscape.com)
  • Infusion of haematopoietic cells and complications. (uff.br)
  • Umbilical cord hematopoietic stem cell transplantation has been restricted mainly to children because there are too few stem cells in umbilical cord blood for an adult. (msdmanuals.com)
  • Because cord blood contains immature stem cells, HLA matching appears less crucial than for the other types of hematopoietic stem cell transplantation. (msdmanuals.com)
  • One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
  • Angiocrine Bioscience Inc. will use genetically engineered cells, derived from cord blood, to see if they can help alleviate or accelerate recovery from the toxic side effects of chemotherapy for people undergoing treatment for lymphoma and other aggressive cancers of the blood or lymph system. (ca.gov)
  • 1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)
  • CheckMate -67T is a Phase 3 randomized, open-label trial evaluating subcutaneous administration of Opdivo co-formulated with Halozyme's proprietary recombinant human hyaluronidase, rHuPH20, or subcutaneous nivolumab (nivolumab and hyaluronidase) compared to intravenous (IV) Opdivo , in patients with advanced or metastatic clear cell renal cell carcinoma (ccRCC) who have received prior systemic therapy. (businesswire.com)
  • Current treatment of systemic sclerosis is directed toward managing complications and providing symptomatic relief. (medscape.com)
  • A study by MacMillan et al reported that alternative donor hematopoietic cell transplantation had a high success rate in patients with Fanconi anemia who did not have a history of opportunistic infections or transfusions and who underwent conditioning with single fraction total body irradiation 300 cGy, cyclophosphamide, fludarabine, and antithymocyte globulin. (medscape.com)
  • The histocompatibility differences between the donor and the recipient, the presence of donor's immunocompetent cells, and the inability of the recipient to reject these cells were defined as the basic pathogenic prerequisites for GVHD development by Billingham in 1966 [ 10 ]. (hindawi.com)
  • 2 cGvHD is a multisystemic disorder that occurs due to foreign donor immune cells attacking the recipient's tissues. (haematologica.org)
  • KEYTRUDA is an anti-PD-1 therapy that works by increasing the ability of the body's immune system to help detect and fight tumor cells. (merck.com)
  • Epstein-Barr virus (EBV) is usually maintained in an asymptomatic and latent form by the host immune system, and primarily by EBV-specific cytotoxic T cells (CTLs). (researchgate.net)
  • In healthy T-cells, PD-1 acts as a brake that prevents the cells from creating an out-of-control immune response, but in tumors, PD-1 can make T-cells inactive preventing them from killing cancer cells. (drugs.com)
  • Both the innate immune response (especially NK cells) and the acquired immune response (virus-specific CD4 and CD8 cells) have a critical role in clearing the infection ( 2 ). (frontiersin.org)
  • Dr. Turtle will test the hypotheses that alterations in the bacterial composition of the human gastrointestinal tract regulate the reconstitution of a specialized bacteria-responsive subset of immune cells after HCT, and that impaired regulation of this immune cell subset is associated with an increased risk of infection or GVHD. (damonrunyon.org)
  • As an intergenic lncRNA, the lncDC was shown to regulate the human monocytes differentiation and antigen presenting cells (APCs) activation during immune responses. (magiran.com)
  • Stem cell treatments, which have been successfully applied to a range of cancers and blood and immune system disorders, are now being investigated for their potential against Alzheimer's. (scitechdaily.com)
  • The success of the therapy stems from its effects on microglia, a type of immune cell in the brain. (scitechdaily.com)
  • A team at Children's Hospital of Los Angeles is testing the feasibility of providing these immune suppressed patients with engineered T-cells to fight these viruses. (ca.gov)
  • The cancer cells use that protein to evade the component of our immune system that routinely destroys tumors. (ca.gov)
  • Various immune-suppressive cell populations appear to associate with suppression of cGvHD, including T reg cells, B reg cells, M2 macrophages, dendritic cells, and CD56 bright natural killer (NK) cells. (haematologica.org)
  • There are complications of serial transfusions of either of these cell types, and a patient needs intense prophylactic treatments to protect from infections if his or her white counts are low. (drugdiscoverynews.com)
  • Vascular access and bloodstream infections associated with tunneled, non-trialysis and non-tunneled, trialysis catheters in patients undergoing hematopoietic stem cell transplantation. (uff.br)
  • Also, myeloma complications like kidney damage, frequent infections, high blood calcium, and more may change how well your brain works. (webmd.com)
  • Lesions on a significant proportion of the total body surface area, which may be associated with edema and secondary bacterial or fungal infections among other complications. (cdc.gov)
  • The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
  • Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
  • Bristol Myers Squibb (NYSE: BMY) today announced six-year results from Part 1 of the Phase 3 CheckMate -227 trial, which continues to demonstrate long-term, durable survival benefits of Opdivo (nivolumab) plus Yervoy (ipilimumab) compared to chemotherapy in the first-line treatment of patients with metastatic non-small cell lung cancer (mNSCLC), regardless of PD-L1 expression levels. (advfn.com)
  • We are ecstatic to see Opdivo plus Yervoy continue to demonstrate almost double the overall survival rates as chemotherapy after six years of follow-up - the longest-ever for a Phase 3 trial with immunotherapy in metastatic non-small cell lung cancer. (advfn.com)
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • The current gold standard of care for first-line therapy in patients with nonsmall cell lung cancer (NSCLC) is a platinum-based doublet chemotherapy, which is recommended for a maximum of six cycles. (deepdyve.com)
  • OPDIVO ® (nivolumab), in combination with platinum-doublet chemotherapy, is indicated as neoadjuvant treatment of adult patients with resectable (tumors ≥4 cm or node positive) non-small cell lung cancer (NSCLC). (opdivohcp.com)
  • CD40 ligand (CD40L) is mainly expressed on activated platelets and CD4+T cells, and it can be cleaved from the cell surface, releasing a soluble CD40L (sCD40L). (researchgate.net)
  • Research Objective Our research will determine how aging of human blood stem cells leads to dramatic increases in disorders of platelets, cells that normally prevent bleeding but form harmful clots when dysregulated. (ca.gov)
  • Supportive care for patients with symptomatic Fanconi anemia includes transfusions of packed RBCs that have been leukodepleted (and are not from family members, to avoid sensitization in case of a future transplantation). (medscape.com)
  • The presentation of MM can range from asymptomatic to severely symptomatic, with complications requiring emergent treatment. (medscape.com)
  • Cells Tissues Organs (2019) 207 (1): 15-20. (karger.com)
  • Together with providing current indications on genetic diagnosis, modern risk-adapted front-line therapy and salvage treatment, the review contains specific recommendations for the identification and management of most important complications such as the bleeding disorder, APL differentiation syndrome, QT prolongation and other ATRA- and ATO-related toxicities, as well as for molecular assessment of response to treatment. (nih.gov)
  • PKC is an important signaling molecule in numerous cell pathways, including cell differentiation, proliferation and apoptosis. (medscape.com)
  • Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults, accounting for more than 431,000 new cases and 179,000 deaths worldwide each year. (businesswire.com)
  • Clear cell renal carcinoma (ccRCC) is the most common form of RCC, affecting about 7 out of 10 people with RCC. (businesswire.com)
  • KEYTRUDA plus LENVIMA is approved in the U.S., the EU, Japan and other countries for the treatment of advanced renal cell carcinoma (RCC) and certain types of advanced endometrial carcinoma. (streetinsider.com)
  • Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)
  • LICs give rise to drug-resistance and relapse and remain unsolved clinical problems in B cell tumors. (ca.gov)
  • Cytotoxic T lymphocytes were determined as the cellular effectors of GVHD, and the key role of antigen-presenting cells (APCs) in T-lymphocyte activation was established during the following years [ 11 , 12 ]. (hindawi.com)
  • The resulting β-amyloid build-up also puts stress on other brain cells, including endothelial cells that affect blood flow to the brain. (scitechdaily.com)
  • Those that had received the stem cell therapy had less cortical expression of genes associated with diseased microglia, and less hippocampal expression of genes associated with diseased endothelial cells. (scitechdaily.com)
  • To analyze the thrombotic and hemorrhagic complications in patients undergoing AHSCT. (isth.org)
  • Post-AHSCT bleeding complications were detected in 41 patients, mainly gastrointestinal (n = 14) and genitourinary (n = 13). (isth.org)
  • Hematopoietic stem cells constitute 1:10,000 of cells in myeloid tissue. (wikipedia.org)
  • We used the CliniMACS Plus system located in our Cell and Tissue. (karger.com)
  • The easy accessibility of hematopoietic cells, which are not tightly embedded in tissue, has supported. (karger.com)
  • The excellent outcome of a cohort transplanted over the course of 3 decades confirms the role of HLA-identical sibling transplantation for children and adults with SCD. (duke.edu)
  • Acute myeloid leukemia (AML) is a disease with diverse genetic features of the leukemic cells and with variable outcome. (cancercentrum.se)
  • Peripheral blood mononuclear cells (PBMCs) were isolated by Ficoll-Hypaque gradient from the blood samples collected at days 0, 7, 14, 28, and final day of transplantation. (magiran.com)
  • Wharton's jelly mesenchymal stem cells (WJ-MSCs) are a class of stem cells with high differentiative potential, an immuno-privileged status and easy access for collection, which raise no legal or ethical. (koreamed.org)
  • Cells Tissues Organs (2021) 209 (4-6): 209-214. (karger.com)
  • While the overall survival rate among children with SCD has improved in recent years, pediatric rates of hospitalization, ED use, and mortality from complications of SCD remain high. (thalassaemia.org.cy)
  • The survival rate after transplantation from alternative donors is improving, depending on the completeness of the HLA-matching. (medscape.com)
  • Access to transplantation entails more than the surgery itself, because success is measured by longer survival of the patient and a long-term improvement in the quality of life. (who.int)
  • Cure of APL patients, however, is also dependent on peculiar aspects related to the management and supportive measures that are crucial to counteract life-threatening complications associated with the disease biology and molecularly targeted treatment. (nih.gov)
  • The study enrolled 413 patients who were randomized to receive either KEYTRUDA (200 mg fixed dose every three weeks for up to 35 cycles of treatment [up to approximately two years]) plus best supportive care (including pain management and management of other potential complications including ascites per local standards of care) or placebo plus best supportive care. (merck.com)
  • The only proven effective treatment for the disease is hematopoietic stem cell transplantation. (frontiersin.org)
  • The current treatment for incomplete hematopoietic recovery includes administration of factors stimulating white and red blood cell growth, such as granulocyte-colony stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin. (drugdiscoverynews.com)
  • however, 5-15 % of patients die from treatment-related complications. (deepdyve.com)
  • OPDIVO, in combination with YERVOY ® (ipilimumab), is indicated for the first-line treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors express PD-L1 (≥1%) as determined by an FDA-approved test, with no EGFR or ALK genomic tumor aberrations. (opdivohcp.com)
  • Impact Treatment of the cancer stem cell driven disease Acute Myelogenous Leukemia (AML) will be impacted. (ca.gov)
  • Hematopoietic stem cell transplantation is an established treatment for patients with a wide range of malignant and nonmalignant conditions. (ankara.edu.tr)
  • Moreover, for patients who have kidney failure, access to transplantation is reduced when funds are spent on other forms of treatment that are less cost-effective. (who.int)
  • Yet the expense of immunosuppressive therapy or treatment of the resulting complications can be catastrophic for individuals, even in rich countries. (who.int)
  • PD-1 and its ligands, PD-L1 and PD-L2, thereby activating T lymphocytes which may affect both tumor cells and healthy cells. (merck.com)
  • Microsatellite instability (or MSI) is defined by the National Cancer Institute as a change that occurs in the DNA of certain cells, such as tumor cells, in which the number of repeats of microsatellites (short, repeated sequences of DNA) is different from the number of repeats that was in the DNA when it was inherited. (merck.com)
  • KEYTRUDA is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2, thereby activating T lymphocytes which may affect both tumor cells and healthy cells. (merck.com)
  • Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)