AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Transplantation, HomologousPostoperative ComplicationsBone Marrow TransplantationGraft vs Host DiseaseHematopoietic Stem Cell TransplantationTreatment OutcomeTransplantation ConditioningRetrospective StudiesIsoantigensHematologic NeoplasmsIntraoperative ComplicationsLymphocyte Culture Test, MixedGraft SurvivalTransplantation ChimeraGraft vs Tumor EffectTime FactorsT-LymphocytesRecurrenceTissue DonorsFollow-Up StudiesTransplantation, IsogeneicWhole-Body IrradiationGraft vs Leukemia EffectStem Cell TransplantationLeukemiaSkin TransplantationTransplantation, AutologousGraft RejectionHistocompatibility TestingHistocompatibilityProspective StudiesRisk FactorsAcute DiseaseGraft vs Host ReactionImmunosuppressive AgentsDiabetes ComplicationsBusulfanLymphocyte ActivationTransplantation ImmunologyMice, Inbred C57BLImmunosuppressionMice, Inbred BALB CCytotoxicity, ImmunologicPregnancy ComplicationsLymphocyte DepletionRemission InductionSurvival RateSpleenLeukemia, Myeloid, AcuteSurvival AnalysisMyeloablative AgonistsBlood TransfusionLeukemia, Myelogenous, Chronic, BCR-ABL PositiveReoperationPeripheral Blood Stem Cell TransplantationVidarabineLeukocyte TransfusionBlood Transfusion, AutologousRadiation ChimeraDendritic CellsPrecursor Cell Lymphoblastic Leukemia-LymphomaAnemia, AplasticCombined Modality TherapyImmune ToleranceIncidenceHLA AntigensLymphocytesCytomegalovirus InfectionsMyelodysplastic SyndromesChimerismFatal OutcomeTransplantation ToleranceT-Lymphocytes, CytotoxicLength of StayHemorrhageMice, Inbred StrainsHistocompatibility AntigensInfectionMice, Inbred C3HHematologic DiseasesTomography, X-Ray ComputedHepatic Veno-Occlusive DiseasePrognosisObstetric Labor ComplicationsCyclophosphamideCells, CulturedLaparoscopyH-2 AntigensSurgical Wound InfectionBlood Loss, SurgicalCyclosporineRisk AssessmentAllograftsPostoperative HemorrhagePregnancyCytotoxicity Tests, ImmunologicCD4-Positive T-LymphocytesAntilymphocyte SerumFlow CytometryChronic Disease
TransplantationTransplantHSCTGvHDTransplantsDonor cellsMortalityGraftAGVHDAutologous stemRelapsePulmonary complicationsIncidence of these complicationsPatientsTransfusion associatedStem cellThromboticRecipientsPotentiallyMyelomaCommonAllogenicInfectionClinicalPatientRisksTissueRiskTreatmentsPhysicianStudy
Transplantation39
Transplant21
  • Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
  • Allogeneic bone marrow transplant -- The term allo means other. (medlineplus.gov)
  • Umbilical cord blood transplant -- This is a type of allogeneic transplant. (medlineplus.gov)
  • Haploidentical transplant -- This is a type of allogeneic transplant, in which the donor is not completely matched with the recipient. (medlineplus.gov)
  • The Hematopoietic Cell Transplant Comorbidity Index predicts survival after allogeneic transplant for nonmalignant diseases. (duke.edu)
  • ECIL-6 guidelines recommend quantitative PCR of whole blood, plasma, or serum to screen for EBV DNA in allogeneic hematopoietic stem cell transplant (HSCT) recipients and to monitor EBV DNA-emia. (medscape.com)
  • [11] About one-third to one-half of allogeneic transplant recipients will develop acute GvHD. (wikipedia.org)
  • A team of hematology marrow transplant department of the Saint-Louis Hospital AP-HP, the Paris University and INSERM (U976 unit) in collaboration with the Pasteur Institute, led the work on graft against host disease (GVHD) using liquid chromatography coupled with mass spectrometry to study the metabolome of allogeneic patients at Saint-Louis hospital AP-HP. (pasteur.fr)
  • In this project, the team of Dr. David Michonneau and Professor Gérard Socié (INSERM U976 / Saint Louis Hospital AP-HP / University of Paris) was interested in the study of the metabolome of allogeneic patients in the hospital Saint- Louis AP-HP in the hematology-transplant adult service. (pasteur.fr)
  • The purpose of this study is to assess the effect your disease and the treatment of allogeneic stem cell transplant has upon you before and after your treatment process through questionnaires at certain time points. (mayo.edu)
  • the disease is a side effect that is common after an allogeneic bone marrow transplant. (researchandmarkets.com)
  • Before undergoing an allogeneic stem cell transplant, the patient will receive high doses of chemotherapy or radiation to destroy the diseased cells and prepare the body for the donor cells. (researchandmarkets.com)
  • As an allogeneic transplant recipient, the patient might experience either form of Graft vs. Host Disease, either form, or neither. (researchandmarkets.com)
  • Since July 2016, Dr He has been appointed as the medical lead in Bone Marrow Transplant at the Olivia Newton-John Centre in Austin Hospital after the successful establishment of Victoria's third adult allogeneic transplant unit. (epworth.org.au)
  • Familiarize trainees with important clinical aspects of stem cell transplant and cellular therapy, including pharmacology, patient monitoring, and recognition and basic management of complications. (ebmt.org)
  • An allogeneic stem cell transplant is similar, but we take cells from someone other than the patient. (mdanderson.org)
  • Where do allogeneic stem cell transplant donor cells come from? (mdanderson.org)
  • GVHD is a potentially fatal complication that occurs following a transplant of stem cells from either a related or allogeneic donor. (pregnancy-info.net)
  • Graft-versus-host disease (GVHD) is a common complication after a stem cell transplant with donor cells (allogeneic transplant). (bmtinfonet.org)
  • A complication of allogeneic hematopoietic stem cell transplant, aGVHD occurs in approximately 50% of patients who undergo this procedure. (onclive.com)
  • In addition, engraftment kinetics, supportive treatment, transplant-related complications, and hospital length of stay were derived from medical records. (bvsalud.org)
HSCT4
  • Despite the improvement in the management of patients, allogeneic HSCT remains associated with severe immunological complications. (pasteur.fr)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
  • Allo-hSCT is estimated to reduce the risk of leukemia relapse to half, but with significant risk for treatment-related complications. (cancercentrum.se)
GvHD5
  • Graft against the host (GVHD) is a major complication that may occur after a allograft, and is characterized by tissue damage induced by donor immune cells which react against those of the recipient. (pasteur.fr)
  • Indoles derivatives are ligands of the receptor Aryl Hydrocarbon (AhR), which regulates the activation and differentiation of immune cells and could therefore contribute to limiting the risk of immune reaction to allogeneic origin of GVHD. (pasteur.fr)
  • Acute GvHD contributes significantly to non-relapse morbidity and mortality (NRM), thus prevention or control of this severe complication is necessary. (frontiersin.org)
  • Patient underwent allogeneic BTM and two days later developed acute GVHD on intestine. (bvsalud.org)
  • GVHD disease is the most common consequence of allogeneic BMT and the skin is the most commonly affected organ [5, 13]. (bvsalud.org)
Transplants7
  • [ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (medscape.com)
  • Stem cell transplants fall into two categories: autologous and allogeneic. (mdanderson.org)
  • One big improvement has occurred in the realm of allogeneic transplants (in which donor cells are used). (managedhealthcareexecutive.com)
  • We've managed to be able to reduce the rates of severe graft-versus-host disease-that's the major complication of transplants," says Devine. (managedhealthcareexecutive.com)
  • Ten to 15 years ago we never sought them for donor transplants (what we call allogeneic transplants). (managedhealthcareexecutive.com)
  • In terms of allogeneic transplants, the most common indication is acute myeloid leukemia and myelodysplastic syndrome, which is a blood disorder that affects blood formation in older patients. (managedhealthcareexecutive.com)
  • Patients were directly matched for the number of previous allogeneic hematopoietic stem cell transplants (alloHCT), disease and refined Disease Risk Index. (bvsalud.org)
Donor cells1
Mortality2
  • In recent years, different studies have reported thromboembolic complications with increased morbidity and bleeding complications with higher mortality in patients undergoing AHSCT. (isth.org)
  • While the overall survival rate among children with SCD has improved in recent years, pediatric rates of hospitalization, ED use, and mortality from complications of SCD remain high. (thalassaemia.org.cy)
Graft1
  • Chronic graft-vs-host disease (cGVHD) is the most common complication following allogeneic BMT [10]. (bvsalud.org)
AGVHD1
  • CD34-selection of stem cells reduces the risk of aGvHD, but also leads to increased infectious complications and relapse. (frontiersin.org)
Autologous stem1
  • What's the difference between allogeneic and autologous stem cell transplantations? (clevelandclinic.org)
Relapse1
  • Since approximately 30% of leukemia patients relapse after allogeneic BMT using total body irradiation (TBI)-based preparative regimens, treatment intensity may be suboptimal. (nature.com)
Pulmonary complications1
  • This study is designed to determine if point-of-care washing of allogeneic Leukocyte-Reduced Red Blood Cells reduces pulmonary complications when compared to standard-of-care Leukocyte-Reduced Red Blood Cells in a cardiac surgical population. (mayo.edu)
Incidence of these complications1
  • The incidence of these complications has been reduced by prophylaxis against Pneumocystis carinii pneumonia, preemptive therapy in patients at high risk for cytomegalovirus (CMV) reactivation, and, more recently, screening for serum CMV antigen. (nih.gov)
Patients12
  • To analyze the thrombotic and hemorrhagic complications in patients undergoing AHSCT. (isth.org)
  • Post-AHSCT bleeding complications were detected in 41 patients, mainly gastrointestinal (n = 14) and genitourinary (n = 13). (isth.org)
  • The main thrombotic complications were DVT, mostly in patients with a CVC. (isth.org)
  • The study enrolled 413 patients who were randomized to receive either KEYTRUDA (200 mg fixed dose every three weeks for up to 35 cycles of treatment [up to approximately two years]) plus best supportive care (including pain management and management of other potential complications including ascites per local standards of care) or placebo plus best supportive care. (merck.com)
  • Nurses who care for patients with SCD have an opportunity to improve health outcomes and quality of life for these patients by recognizing the major SCD-associated complications and providing patients and their caregivers with appropriate educational information. (thalassaemia.org.cy)
  • In addition, they review the nursing implications of each complication and provide online links to resources for clinicians, patients, and caregivers. (thalassaemia.org.cy)
  • New research in clustered regularly interspaced short palindromic repeats (CRISPR) technology suggests that base-edited T cells could be useful in patients with relapsed leukemia and could help anticipate the risks of immunotherapy -related complications. (ajmc.com)
  • Degenerative lumbar scoliosis (DLS) patients undergoing posterior long-segment spinal fusion surgery often require perioperative blood transfusions, and previous studies have reported that increased complications and additional costs accompany these transfusions. (medscimonit.com)
  • Rethymic ( allogeneic processed thymus tissue-agdc) is processed thymus tissue indicated for immune reconstitution in pediatric patients with congenital athymia. (rxlist.com)
  • With better management, patients usually require fewer transfusions of donated blood components, which avoids transfusion-associated complications. (nba.gov.au)
  • This complication may be present in as many as 30% of patients with MM at presentation. (medscape.com)
  • Occasionally, patients may have such a high volume of monoclonal protein that their blood viscosity increases, resulting in complications such as stroke, myocardial ischemia, or infarction. (medscape.com)
Transfusion associated1
  • Everhart JS, Sojka JH, Mayerson JL et al (2018) Perioperative allogeneic red blood-cell transfusion associated with surgical site infection after total hip and knee arthroplasty. (springermedicine.com)
Stem cell1
  • Allogeneic hematopoietic stem cell (HSC) is a curative treatment used for many hematologic malignancies and congenital or acquired anomalies of hematopoiesis. (pasteur.fr)
Thrombotic1
  • The incidence of thrombotic and hemorrhagic complications is similar to that previously published. (isth.org)
Recipients1
  • Strikingly, 12 cases occurred in 1997 with the majority in recipients of allogeneic matched sibling donor stem cells. (nih.gov)
Potentially1
  • Anemia caused by MDS must be carefully managed, as it can cause potentially serious complications. (healthline.com)
Myeloma1
  • Carpal tunnel syndrome is a common complication of myeloma. (medscape.com)
Common1
  • Postpartum fatigue is not only a common complication after childbirth, but also an important factor in maternal postpartum recovery and breastfeeding. (scirp.org)
Allogenic1
  • Additionally, the relation of allogenic RBC transfusion to the risk of complications in THA remains controversial. (springermedicine.com)
Infection2
  • In 1971, hepatitis B surface antigen testing heralded the advent of screening to minimize infection transmission complicating allogeneic transfusion. (medscape.com)
  • Progressive lung complications from overlapping Aspergillus niger infection resulted in death on day 33. (ajmc.com)
Clinical2
  • The authors discuss the genetic, hematologic, and clinical features of SCD and describe the major associated health complications. (thalassaemia.org.cy)
  • Adicet Bio, Inc is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer. (stradanove.net)
Patient1
  • The patient very often blames the surgeon for this result while the surgeon tends to call it a complication. (egms.de)
Risks3
  • Besides of postoperative deformities many other risks and complications have to be considered. (egms.de)
  • The risks for rhinoplasty-complications can be reduced with increasing experience. (egms.de)
  • Where appropriate medical care is available, the risks associated with live kidney donation are low but not negligible - in addition to operative complications, they include such long-term risks as failure of the remaining kidney. (who.int)
Tissue2
  • Our Rethymic (allogeneic processed thymus tissue-agdc) for Surgical Implantation Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • RETHYMIC consists of yellow to brown slices of allogeneic processed thymus tissue for administration by surgical implantation. (rxlist.com)
Risk3
  • This study found that allogeneic RBC transfusion in THA was not associated with the increased risk of complications and any-cause readmission. (springermedicine.com)
  • If indeed there is a real increase in the incidence of this complication, then efforts need to be directed towards elucidating a possible cause or risk factors. (nih.gov)
  • These data, while not establishing a cause, suggest a markedly augmented risk of DAH in allogeneic BMT. (nih.gov)
Treatments1
  • Special treatments are performed to decrease the chance of complications due to the incomplete match. (medlineplus.gov)
Physician1
  • In this case the physician has to identify the complication early enough and react adequately. (egms.de)
Study1
  • Using the Chinese national inpatient database, the current study aimed to examine trends, complications, charges, and readmission patterns of allogeneic RBC transfusion in THA. (springermedicine.com)