Complexes nuclear localization sequence nuclear localization signals. Medical search. Frequent questions

Understanding the functional biology of CSCs - especially the signaling pathways that are involved in their self-renewal mechanisms - is crucial for discovering new forms of treatment. (docksci.com)
HIPKs are regulators of various signaling pathways and involved in the pathology of cancer, chronic fibrosis, diabetes, and multiple neurodegenerative diseases. (nature.com)
Reactive oxygen species (ROS), generated as consequence of oxidative metabolism, activate signal transduction pathways, which contribute to cellular homeostasis [ 1 ]. (hindawi.com)
Instead, we propose that mutual inhibition by Kaiso/TCF3 of their DNA-binding functions may be important in developmental or cancer contexts and acts as a regulatory node that integrates epigenetic and Wnt signalling pathways. (biologists.com)
Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways. (embl.de)

This separation requires a continuous traffic of molecules: new RNA molecules must be transported out of the nucleus and nuclear proteins, such as newly-synthesized histones or polymerases, must be transported back into the nucleus. (rcsb.org)
Instead, many nuclear proteins are built with a special tag-a short sequence called the nuclear localization signal-that tells the transport machinery to carry the protein into the nucleus. (rcsb.org)
The importin complex shown here (built from three separate PDB entries) transports proteins with nuclear localization signals. (rcsb.org)
The thousands of proteins that make up the nuclear pore are covered with special amino acid sequences that are flexible and that contain many phenylalanines. (rcsb.org)
The structure shown here includes the full importin-beta (in rainbow-colored cylinders) and a few short pieces from the nuclear pore proteins (shown in spheres at the bottom, with the phenylalanine amino acids in red). (rcsb.org)
Raver-1 also modulates focal adhesion assembly by binding to the cytoskeletal proteins, including alpha-actinin, vinculin, and metavinculin (an alternatively spliced isoform of vinculin) at adhesion complexes, particularly in differentiated muscle tissue. (nih.gov)
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. (antibodies-online.cn)
Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). (antibodies-online.cn)
cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. (nih.gov)
Furthermore, three OsS40 proteins were identified as nuclear located proteins by transient protoplast transformation assay. (biomedcentral.com)
Transcriptional regulators or transcription factors (TFs) are proteins that bind to specific sequences of the DNA, i.e. promoters, and hereby facilitate or inhibit the binding of RNA polymerase (RNAP). (hormonessignaling.com)
However, the absence of genome sequence remains a limiting factor for the identification of proteins in the non sequenced strains. (hormonessignaling.com)
By using fluorescent fusion proteins, we show that TAF10 does not have an intrinsic nuclear localization signal (NLS) and needs one of its three interaction partners to be transported into the nucleus. (hal.science)
If the nuclear exclusion of truncated BRCA2 proteins is also observed in primary tumour samples, then individuals with truncating mutations in BRCA2 could be screened by immunostaining. (biomedcentral.com)
Domain commonly found in eukaryotic signalling proteins. (embl.de)
Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)

One side of importin-beta binds to these special sequences. (rcsb.org)
Raver1 binds to PTB through the PTB-binding motifs at its C-terminal half, and binds to other partners, such as RNA having the sequence UCAUGCAGUCUG, through its N-terminal RRMs. (nih.gov)
Then the raver1/vinculin tail (Vt) complex binds to vinculin mRNA, which is permissive for vinculin binding to F-actin. (nih.gov)
The DNA-binding domain (DBD) of the hGRα corresponds to amino acids 420-480 and contains 2 zinc finger motifs through which the hGRα binds to specific DNA sequences, the glucocorticoid-response elements (GREs) in the promoter region(s) of target genes. (medscape.com)
Rab40c is a SOCS box-containing protein which binds Cullin5 to form a ubiquitin E3 ligase complex (Rab40c/CRL5) to regulate protein ubiquitylation. (life-science-alliance.org)
Mechanistically, we found that Rab40c binds the protein phosphatase 6 (PP6) complex and ubiquitylates one of its subunits, ankyrin repeat domain 28 (ANKRD28), thus leading to its lysosomal degradation. (life-science-alliance.org)
Experiments using fluorescence recovery after photobleaching show that TAF10 does not associate with any cytoplasmic partner but that once transported into the nucleus it binds to nuclear structures. (hal.science)
PAPbeta, a protein that binds to and is phosphorylated by the non-receptor tyrosine kinase PYK2, contains several modular signaling domains including a pleckstrin homology domain, an SH3 domain, ankyrin repeats and an ARF-GAP domain. (embl.de)
Injected intravenously into adult Xenopus females, the protein-DNA complex is rapidly transported through the bloodstream and, within the ovary, the vitellogenin ligand present in the protein binds to the receptors at the surface of the oocytes. (biologists.com)

NFAT2, as an important transcriptional promoter, regulates expression of TNF-α, myc proto-oncogene protein (c-myc), cyclooxygenase-2 (COX-2), Fas ligand (FasL) and also generates crosstalks with ERK/MAPK pathway and AKT/GSK3b signaling, which achieves its control of the cell fate [7-12]. (researchsquare.com)
Notch signaling is highly conserved cell signaling pathway, which is involved in diverse embryonic organs or tissue development as well as regeneration ( 1 - 10 ). (frontiersin.org)
Thus, we propose a model where Rab40c/CRL5 regulates ANKRD28 ubiquitylation and degradation, leading to a decrease in PP6 activity, which ultimately affects FAK and Hippo pathway signaling to alter focal adhesion dynamics. (life-science-alliance.org)
We demonstrate that a direct interaction between the methyl-CpG-dependent transcription repressor Kaiso and xTcf3, a transducer of the Wnt signalling pathway, results in their mutual disengagement from their respective DNA-binding sites. (biologists.com)

It is believed that TGF-β1 signalling is involved in controlling epithelial cell proliferation, to drive epithelial-mesenchymal transition (EMT) and it plays a major role in lung fibrosis and emphysema. (springer.com)
Single - cell RNA-sequencing analysis revealed that CREB3L1 expression gradually increased during the neoplastic progression of a thyroid follicular epithelial cell to an ATC cell, accompanied by the activation of the extracellular matrix (ECM) signaling. (biomedcentral.com)

Amino acid sequence predictions and immunohistochemical staining support the localization of C5orf22 to cytoplasm and nucleus. (wikipedia.org)
It also contains a nuclear localization sequence (NLS) that targets the hRad9 protein into the nucleus [ 11 ]. (biomedcentral.com)
Presumably the C-terminal domain is essential for transport of the 9-1-1 complex from the cytoplasm into the nucleus, for activation of the G2 checkpoint signalling cascade [ 12 ]. (biomedcentral.com)
Huge tube-shaped nuclear pores act as the highway connecting the nucleus and the cytoplasm, and importins and exportins (collectively known as karyopherins) ferry molecules back and forth through the pore. (rcsb.org)
Once the importin-beta/importin-alpha/cargo complex gets inside the nucleus, the cargo must be released and the importins must be recycled back to the cytoplasm. (rcsb.org)
Upon phosphorylation, R-SMADs recruit the co-SMAD SMAD-4 to form protein complexes that translocate into the nucleus and exhibit transcriptional activity. (springer.com)
It shuttles between the cytoplasm and the nucleus and can accumulate in the perinucleolar compartment, a dynamic nuclear substructure that harbors PTB. (nih.gov)
When the NLS sequences of either TAF8 or SPT7L are mutated, TAF10 remains cytoplasmic, but a heterologous NLS can drive TAF10 into the nucleus. (hal.science)
Thus, here we describe a novel role of the three mammalian interacting partners in the nuclear localization of TAF10, and our data suggest that a complex network of regulated cytoplasmic associations may exist among these factors and that this network is important for the composition of different TFIID and TFTC-type complexes in the nucleus. (hal.science)
BRCA2 is localised to the nucleus and the functions ascribed to it are nuclear functions. (biomedcentral.com)
The bound complex is internalized and translocates into the oocyte nucleus thanks to an SV40 nuclear localization signal, enhanced by an adjacent casein kinase phosphorylation site. (biologists.com)
From the hippocampus, signals are relayed via the fornix to the mammillary bodies and via the mammillothalamic tract to the anterior nucleus of the thalamus. (medscape.com)

Proteomic research implicated the protein product as a novel component of the WBP11/PQBP1 splicing complex which regulates expression of genes involved in a spectrum of processes ranging from DNA repair to immunomodulation. (wikipedia.org)
PB2 genes (viral ribonucleoproteins [RNPs]) and are most- encoded protein sequences have not been extensively ly located in the functional domains related to RNP-RNP reported. (cdc.gov)
At the cellular level, the actions of glucocorticoids are mediated by a 94-kd protein, the glucocorticoid receptor (GR). The human (h) GR belongs to the steroid/thyroid/retinoic acid superfamily of nuclear receptors and functions as a ligand-dependent transcription factor that regulates the expression of glucocorticoid-responsive genes positively or negatively. (medscape.com)
Lastly, we elucidated that these nanoparticles could upregulate the downstream genes of Notch signaling, indicating that the payload was viable and successfully altered the genetic downstream effects. (frontiersin.org)
There is no longer a need for signals to activate these genes. (cancerquest.org)
Many of these genes are responsible for providing the positive signals that lead to cell division. (cancerquest.org)
TFIID, comprising the TATA box binding protein (TBP) and 13 TBP-associated factors (TAFs), plays a role in nucleation in the assembly of the RNA polymerase II preinitiation complexes on protein-encoding genes. (hal.science)
Our data rule out a model suggesting that xKaiso is a direct repressor of Wnt signalling target genes in early Xenopus development via binding to promoter-proximal CTGCNA sequences as part of a xTcf3 repressor complex. (biologists.com)
We use these engineered Cas9 activation complexes to investigate sgRNA targeting rules for effective transcriptional activation, demonstrate multiplexed activation of 10 genes simultaneously, and upregulate long intergenic non-coding RNA (lincRNA) transcripts. (cdc.gov)

Raver-1 contains three N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), two putative nuclear localization signals (NLS) at the N- and C-termini, a central leucine-rich region, and a C-terminal region harboring two PTB-binding [SG][IL]LGxxP motifs. (nih.gov)

Once NFAT2 is activated, it exposes nuclear localization sequences, promoting its cytoplasm-to-nuclear translocation and then NFAT2 forms heterodimers with other transcription factors to exert its transcriptional functions [6]. (researchsquare.com)
RAD51, a nuclear protein, has been shown to interact with the 6174delT form of BRCA2, which lacks the NLSs and is localised to the cytoplasm. (biomedcentral.com)

These are as follows: sustained proliferative signalling, cell death resistance, replicative immortality, genome instability and increased mutations, tumour-promoted inflammation, insensibility to growth repressors, deregulation of cellular energetics, evasion of immune destruction, induction of metastasis, and promotion of angiogenesis. (hindawi.com)
Conclusions At present, the complete L. sakei genome sequence of strain23K is available [16], and the genome sequence of strain DSM 15831 is currently under assembly http://www. (hormonessignaling.com)
METHODS: We reviewed medical records, laboratory results, and autopsy findings, and performed whole genome sequencing (WGS) to compare patient and bat virus sequences. (cdc.gov)

Notch signaling is a highly conserved signaling system that is required for embryonic development and regeneration of organs. (frontiersin.org)

Notch signaling regulates cell-fate determination during activation by signal sending and receiving, affected through ligand-receptor crosstalk. (frontiersin.org)
The splicing factor PQBP1 regulates mesodermal and neural development through FGF signaling. (xenbase.org)

TGF-β1 binding to either subunit initiates their assembly into a heteromeric protein complex that consists of two type I and two type II subunits. (springer.com)
A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). (nih.gov)

Moreover, KPNA2 mediated the nuclear translocation of CREB3L1, thus allowing it to activate downstream ECM signaling. (biomedcentral.com)
Immunofluorescence of 293T cells, transfected with plasmids expressing GFP-tagged BRCA2 fragments, suggests that the C terminus of BRCA2 is responsible for nuclear translocation. (biomedcentral.com)

In addition, this region is the most frequent site of alternative splicing and secondary start sites and contains a variety of kinase recognition sequences. (indigobiosciences.com)
Within the HIPK family, HIPK1 and HIPK2 are the most closely related members, sharing about 93% sequence identity in their kinase domains, while HIPK3 is slightly less conserved with 87% identity. (nature.com)
Integrin-linked kinase (ILK) is a major structural adaptor protein governing signaling complex formation and cytoskeletal dynamics. (jneurosci.org)

Notch receptors are processed in the endoplasmic reticulum and Golgi apparatus within the signal-receiving cell, through cleavage and glycosylation, generating a Ca 2+ -stabilized heterodimer composed of NECD non-covalently attached to the transmembrane NICD inserted in the membrane called S1 cleavage. (frontiersin.org)

Thus, activated, type I subunits recruit and phosphorylate receptor SMADs (R-smad), which are the first intracellular mediators of TGF-β signalling. (springer.com)
Understand Nuclear Receptors through our introduction to this family of intracellular transcription factors that regulate gene expression. (indigobiosciences.com)

However, it is difficult to capture the complexity of transcript isoform variance using these libraries, and large cDNA sequences are often difficult to clone into size-limited viral expression vectors. (cdc.gov)

Expression and subcellular localization of USH1C/harmonin in human retina provides insights into pathomechanisms and therapy. (nih.gov)

Localisation of hRad9 protein were performed on paired tumor and normal breast tissues. (biomedcentral.com)
There are considerable data indicating that CSCs could be responsible for complex tumor biology, including initiation, growth, and regeneration. (docksci.com)
These results demonstrate that CREB3L1 maintains the CAF - like property of ATC cells by activating the ECM signaling, which remodels the tumor stromal microenvironment and drives the malignancy of ATC. (biomedcentral.com)
Once an adrenal or extra-adrenal tumor is detected, CT scanning or MRI of the region may be performed for anatomic localization prior to surgical removal. (medscape.com)

We describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. (cdc.gov)

Unlike receptors found on the cell surface, members of the nuclear hormone receptor (NR) superfamily are restricted to metazoan organisms such as nematodes, insects, and vertebrates. (indigobiosciences.com)
The A/B domain's sequence and length are highly variable between receptors (i.e. (indigobiosciences.com)

Delivering exogenous genetic materials encoding Notch into cells can reestablish downstream signaling and rescue cellular functions. (frontiersin.org)
This study identifies two nuclear localisation signals (NLSs) within BRCA2 and makes the important observation that they are downstream of all known cancer-associated truncating mutations in BRCA2 . (biomedcentral.com)

Furthermore, amino acid sequence analysis indicated a predicted partial nuclear localization signal (NLS) from AA 175-185. (wikipedia.org)
C) Enlargement of part of the DBD showing the amino acid sequence (single letter codes) of the 2 zinc fingers and the dimerization loop (in bold). (medscape.com)

This gene encodes a scaffold protein that functions in the assembly of Usher protein complexes. (nih.gov)
Mutations in this gene cause Carney complex (CNC). (nih.gov)

TAFs are shared among other transcription regulatory complexes (e.g. (hal.science)
However, while the role of the super elongation complex (SEC) in enhancing transcription activation of HIV is well established, the function of SEC in modulating viral latency is less defined and its cell partners are yet to be identified. (biomedcentral.com)

Cell localization evidence and the presence of a NLS further support this hypothesized function. (wikipedia.org)
Nuclear factor of activated T cells 2 (NFAT2, also known as NFATc and NFATc1) is an important member of NFAT family which plays a vital role in T cell activation and differentiation [4]. (researchsquare.com)
For these reasons, it is thought that the variable N- terminal sequences may be responsible for the receptor-, species-, and cell type-specific effects as well as promoter context-dependent properties of NR transactivation. (indigobiosciences.com)
In endothelium, Delta-like ligand 4 (DLL4) is one of main ligands to send a signal to Notch in the adjacent cell ( 4 , 6 ) ( Figure 1A ). (frontiersin.org)
This in turn signals the surrounding cells to determine the cell-fate ( 4 ). (frontiersin.org)
The cell division process is dependent on a tightly controlled sequence of events. (cancerquest.org)
But if this is not possible, oxidative stress finally activates signals that will lead to cell death. (hindawi.com)
An infection is established in the basal layer of the epithelium, and a complex viral life cycle is carried out, dependent on the differentiation state of the host cell [ 1 - 3 ]. (biomedcentral.com)
Live cell imaging demonstrates that FUS co-localizes with AFF4 within nuclear punctuated condensates, which are disrupted upon treating cells with aliphatic alcohol. (biomedcentral.com)
CONCLUSIONS These results suggest that activation of VEGFR-1 by VEGF-A within the carcinoma, and activation of lymphatic endothelial cell VEGFR-3 by VEGF-D within the adjacent benign stroma may be important see more signaling mechanisms involved in the progression and subsequent metastatic spread of prostate cancer. (cdk-receptor.com)
Cell polarization involving the Par-complex in situ is linked to various other processes. (elifesciences.org)
Because of such association between Par-dependent polarization and other processes, the Par-complex exhibits different behavioral characteristics in an individual context, making it difficult to determine general features of the dynamic process taking place during cell polarization by the Par-complex. (elifesciences.org)
To understand the general and dynamic characteristics of the cell polarization process induced by the Par-complex, we attempted to reconstruct Par-complex-dependent cell polarization system in a cell-autonomous manner using non-polar cells. (elifesciences.org)

The algorithm used to distinguish changes in expression from changes in splicing was calibrated using internal non-spliced control sequences. (biomedcentral.com)
The results indicated that elevated Par3 expression induces cortical localization of the Par-complex at the interphase. (elifesciences.org)

The PAP activities of the lipins depend on a conserved C-terminus domain with sequence homology to the haloacid dehalogenase or HAD-like domain [1]. (aocs.org)
All members of transforming growth factor superfamily are synthesized as pre-pro-peptides that consist of a short N-terminal signalling peptide, a latency-associated protein (LAP) domain and the mature TGF domain [ 42 ]. (springer.com)
Within this complex, type II subunits phosphorylate type I subunits at their N-terminal domain. (springer.com)
Human raver-1 RRM1 domain in complex with human vinculin tail domain Vt, contacts at 4A. (nih.gov)
The sequence of the ligand binding domain (LBD) or E/F domain varies substantially between NRs, but they all share a common structure of 11-13 a-helices organized around a hydrophobic binding pocket. (indigobiosciences.com)
In accordance with the close relationship between HIPKs and other DYRK subfamily members, DYRK1A, a class I DYRK member, shares a sequence identity with HIPK3 of 38% within the catalytic domain. (nature.com)
The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners. (hal.science)

The protein contains PDZ domains, a coiled-coil region with a bipartite nuclear localization signal and a PEST degradation sequence. (nih.gov)

Defects in Notch signaling also cause inherited cardiovascular diseases, such as Left Ventricular Non-compaction and Alagille syndrome ( 4 , 7 , 22 ). (frontiersin.org)

The DxDxT catalytic motif is present in all HAD-like domains, along with a characteristic and conserved sequence of α-helices and β-sheets [3]. (aocs.org)
The most divergent member of the family is HIPK4, which shares only 50% sequence identity with the catalytic domains of the three other HIPKs. (nature.com)
Sequences of ARF-GAP domains show no recognizable similarity to those of other GAPs, and contain a characteristic Cys-X(2)-Cys-X(16-17)-Cys-X(2)-Cys motif. (embl.de)

Interestingly, the 12-nucleotide RNA having the sequence UCAUGCAGUCUG with micromolar affinity is found in vinculin mRNA. (nih.gov)

In light of these findings, precisely how β1 integrin transduces ECM cues via signaling intermediates, and the mechanism by which this translates to cellular responses, need to be addressed. (jneurosci.org)

Complex of importin-beta (blue), importin-alpha (green), and the cargo nucleoplasmin (yellow). (rcsb.org)
Then, the complex of importin-beta and Ran (shown on the left, PDB entry 2bku) travels back through the pore. (rcsb.org)
CAS is similar to importin-beta, but moves through the nuclear pore in the opposite direction. (rcsb.org)
Importin-beta may jump from site to site through the nuclear pore, guided by these special sequences. (rcsb.org)

cAMP is a signaling molecule important for a variety of cellular functions. (nih.gov)

While the LAP peptides confer latency, LTBP is needed to release active TGF-β1 ligand from the L-TGF-β1 complex upon appropriate stimuli [ 4 ]. (springer.com)

The actual mechanisms that importins use to pull molecules through the nuclear pore are still a subject of active debate, but PDB entry 2bpt gives some hints of how it might be done. (rcsb.org)

M. Stewart (2006) Structural basis of the nuclear protein import cycle. (rcsb.org)

Leaf senescence is an integral part of the final stages of plant development, and is controlled by a fine-tuned complex regulatory network [ 1 ]. (biomedcentral.com)

Lipin-1 and -2 have a second function as transcriptional co-activators acting in a complex with transcriptional regulators called peroxisome proliferator-activated receptor-coactivator-1α (PGC-1α) and peroxisome proliferator-activated receptor-α (PPARα) [1,3] (Fig. 1). (aocs.org)

We subse- the mechanism of influenza viral infection and replication quently used 15,785 protein sequences from the National in different host species. (cdc.gov)

Regulation of arteriovenous specification and differentiation in both endothelial cells and vascular smooth muscle cells are also involved in Notch signaling including regulation of blood vessel sprouting, branching during normal and pathological angiogenesis, and the physiological responses of vascular smooth muscle cells ( 4 , 6 , 7 , 21 - 23 ). (frontiersin.org)

A false-negative diagnosis of eosinophilic granuloma is exceptional when plain radiographic findings are used, although difficulty may be encountered with lesions in areas with more complex anatomy, such as the posterior elements of the vertebral bodies. (medscape.com)

Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion, larger molecules are transported by an active process. (antibodies-online.cn)
Maps also chart the connectivity between these molecules, elucidating the circuits and signaling processes that give rise to function. (stanford.edu)

Gβ2 was associated with GR/glucocorticoid response elements (GREs) in vivo and suppressed activation function-2-directed transcriptional activity of the GR. We conclude that the Gβγ complex interacts with the GR and suppresses its transcriptional activity by associating with the transcriptional complex formed on GR-responsive promoters. (rupress.org)

METHODS The localization of VEGF-A, VEGF-C, VEGF-D, VEGF receptor (VEGFR)-1, VEGFR-2, and VEGFR-3 was examined in cancerous and adjacent benign prostate tissue from 52 subjects representing various grades of prostate cancer. (cdk-receptor.com)

Papillomaviruses undergo a complex life cycle requiring regulated DNA replication. (biomedcentral.com)

This subgroup corresponds to the RRM1 of raver-1, a ubiquitously expressed heterogeneous nuclear ribonucleoprotein (hnRNP) that serves as a co-repressor of the nucleoplasmic splicing repressor polypyrimidine tract-binding protein (PTB)-directed splicing of select mRNAs. (nih.gov)
However, the three dimensional structure of the RXR heterodimer complex produces different DNA binding affinities. (indigobiosciences.com)
RFX forms cooperative DNA binding complexes with x2bp and cbf/nf-y. (lu.se)

Global sequence chose this entropy threshold on the basis of the entropy comparison that yielded pairwise sequence identities used value -0.379, calculated at position 627 of PB2 for the 95 in histogram analysis was done with the program Needle in avian viruses. (cdc.gov)
Mass spectrometry and in silico sequence analysis were used to identify phosphate sites on the BPV E1 protein and kinases that may recognize these sites. (biomedcentral.com)
A number of kinases were identified by sequence analysis that could potentially phosphorylate E1 at the identified positions. (biomedcentral.com)
Sequence analysis of BRCA2 revealed the presence of four potential nuclear localisation signals (NLSs), three near the C terminus. (biomedcentral.com)
The Emerging Field of Medicines Authentication by Nuclear Quadrupole Resonance Spectroscopy (Counterfeit Medicines Volume II: Detection, Identification and Analysis, ILM Publications, 2013). (lu.se)

In human cells, exogenously expressed TAF10 remains rather cytoplasmic and leptomycin B does not affect this localization. (hal.science)
The cytoplasmic-nuclear transport of TAF10 is naturally observed during the differentiation of adult male germ cells. (hal.science)
Western blots of nuclear and cytoplasmic fractions of BRCA2 mutant cells. (biomedcentral.com)

Importins recognize this signal, bind to the protein, and transport it through the nuclear pore. (rcsb.org)

A more systematic classification has been proposed, based on sequence similarity, much like that employed for cytochrome P450s. (indigobiosciences.com)

Nuclear factor of activated T cells 2 (NFAT2) has been reported to regulate the development and malignancy of few tumors. (researchsquare.com)
however, nuclear accumulations of pSMAD2-C and CLDN3 redistribution were observed with similar time course in ciliated and non-ciliated cells. (springer.com)
In normal cells, both internal and external signals control the activity of the oncogenes. (cancerquest.org)
What this means for cells is that they divide continuously even in the absence of any signals telling them to divide. (cancerquest.org)
However, since this has been demonstrated by co-immunoprecipitation, the complex may form after lysis of the cells. (biomedcentral.com)

Anatomy22

Organisms12

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Psychiatry and Psychology1

Phenomena and Processes52

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Pathways5

Proteins16

Binds9

Pathway4

Epithelial cell2

Nucleus12

Genes9

Putative1

Cytoplasm2

Genome3

Highly conserved1

Regulates2

Subunit2

Translocation2

Kinase3

Endoplasmic reticulum1

Intracellular2

CDNA1

Subcellular1

Tumor4

Genomic1

Receptors2

Downstream2

Amino acid seq2

Gene2

Transcription2

Cell13

Expression2

Domain7

Degradation1

Defects1

Domains3

Vinculin1

Transduces1

Importin-beta4

Cellular functions1

Ligand1

Mechanisms1

Structural1

Regulatory1

Regulators1

Viral1

Regulation1

Lesions1

Molecules2

Transcriptional activity1

Adjacent1

Replication1

Binding3

Analysis5

Cytoplasmic3

Bind1

Similarity1

Cells5