Complexes membrane differentiation of cells. Medical search. Frequent questions

Psoriasis lesions are characterized by hyper-proliferation with incomplete differentiation of epidermal keratinocytes and decreased keratinocyte apoptosis, associated with inflammatory cellular infiltrate in both dermis and epidermis [ 12 ]. (springer.com)
Ceramides are typically found within the membranes that surround cells and play a role in regulating cell maturation (differentiation), growth and division of cells (proliferation), and controlled cell death (apoptosis). (medlineplus.gov)
TGF-β1 expression is reduced in Vohwinkel syndrome with GJB2 mutations, and the in vitro study showed increased keratinocyte proliferation and cellular repair in Vohwinkel syndrome cells when TGF-β1 was introduced. (medscape.com)
The framework will allow to label for up to 10 markers to visualize at the same time ANXA1, centrosomes, chromosomes, cell-cell adhesion molecules, differentiation markers, proliferation, and apoptosis. (southampton.ac.uk)
The present work introduces a computational implementation of some principles of a theory of organism development, namely that the default state of cells is proliferation and motility, and includes the principle of variation and organization by closure of constraints. (nature.com)
In the present model, the bioelectric context of cells and tissue is the field responsible for organization, as it regulates cell proliferation and the level of communication driving the system's evolution. (nature.com)
Starting from a depolarized (proliferative) cell, the organism grows to a certain size, limited by the increasingly polarized state after successive proliferation events. (nature.com)
Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
Here, we identified tranylcypromine, which is used to treat refractory depression, caused human-induced pluripotent stem cell-derived brain organoids neurotoxicity, leading to decreased proliferation activity and apoptosis induction. (frontiersin.org)
In vitro studies have shown that the active form of vitamin D, calcitriol, acts in myocytes through genomic effects involving VDR activation in the cell nucleus to drive cellular differentiation and proliferation. (hindawi.com)
These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. (senescence.info)
These drugs, called GGTIs, inhibit proliferation of various human cancer cells and inhibit tumor growth in animal model systems. (uclahealth.org)
The cell experiments indicated that the proliferation, migration, and invasion of the HCT-116, DLD-1, and RKO cell lines were considerably increased after LRRC59 knockdown. (bvsalud.org)
In vitro TNFa induces proliferation and migration but suppresses differentiation of myoblasts. (cdc.gov)
Effects of chloroplast DNA content on the cell proliferation and aging in Chlamydomonas reinhardtii. (bio.net)
In response to mito- pendence between the key mecha- gens, cell proliferation is triggered by nistic characteristics. (who.int)
H - Ras cell proliferation are also linked with haematopoietic cel s. (who.int)

Functional proteomics is aimed to understand proteins' biological function and their regulation by studying protein-protein interactions within and among multiprotein complexes through affinity purification and mass spectrometric analysis. (mdanderson.org)
Because of the low abundance of most native ion channel proteins in mammalian cells, the purified native ion channel complexes are commonly contaminated by an overwhelming number and/or amount of non-specifically co-purified proteins, which makes the downstream mass-spectrometric and functional analyses very difficult. (mdanderson.org)
We explore how molecular interactions between proteins and small molecules, defined at atomic resolution, govern biochemical output and in turn control cell behaviour. (southampton.ac.uk)
Members of the Rho family of small G proteins transduce signals from plasma-membrane receptors and control cell adhesion, motility and shape by actin cytoskeleton formation. (embl-heidelberg.de)
These EV contain a lipid bilayer associated to membrane proteins. (frontiersin.org)
Pigment cell-specific transmembrane proteins SLC45A2 and OCA2 are a transporter and channel, respectively, that modulate melanosome pH at different stages of melanosome maturation and that are targets of mutation in different forms of oculocutaneous albinism. (chop.edu)
An Illustration of the Laminin-111 complex depicting the domain organization Laminins are high-molecular weight (~400 to ~900 kDa) proteins of the extracellular matrix. (pearltrees.com)
Salk Institute scientists have discovered that an interaction between two key proteins helps regulate and maintain the cells that produce neurons. (neurosciencenews.com)
Another Salk professor and a coauthor on the paper, Martin Hetzer, previously found that proteins in the nuclear membrane influence gene expression in different kinds of cancer cells. (neurosciencenews.com)
Gage's team conducted screens in cells from mice and rats to see which genes were being transcribed into proteins in precursor cells, immature neurons and astrocytes. (neurosciencenews.com)
AKT proteins are recruited to the cell membrane by phosphatidylinositol 3,4,5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by PI3K. (senescence.info)
AKT proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway, in addition to responding to extracellular signals from growth factors and cytokines, is disregulated in many cancers. (senescence.info)
The Ras-superfamily G-proteins play critical roles in cell growth and differentiation. (uclahealth.org)
Tamanoi's laboratory has developed anti-cancer drugs against Ras proteins aimed at inhibiting their posttranslational modification and membrane association. (uclahealth.org)
Biological membranes are complex and highly dynamic environments composed of proteins and lipids which are required for numerous cellular functions including signal transduction, cell differentiation and morphogenesis. (limes-institut-bonn.de)
Lipids serve as structural building blocks of membrane and interact with lipid binding proteins or with integral membrane proteins. (limes-institut-bonn.de)
Mechanistically, DNAJA3 deficiency significantly increases dysfunctional mitochondria activity and decreases mitochondrial mass, membrane potential, and mitochondria respiratory complex proteins. (bvsalud.org)

Each of the cell lines also reacted with antibodies against neural cell adhesion molecules, but none of them were positive for antibodies against glial fibrillary acidic protein, keratin, microtubule-associated protein tau and microtubule-associated protein 2, human lymphocyte antigen-DR, epidermal growth factor receptor, and T-cell antigen. (duke.edu)
Anti-human lymphocyte antigen-A,B and anti-beta 2-microglobulin antibodies reacted with xenografts of D384 Med and D425 Med and were weakly positive for a small population of D384 Med cultured cells. (duke.edu)
On the basis of these data, it is proposed that T-cell survival and effector responses are driven by antigen-independent, cytokine-dependent mechanisms, and that therapeutic strategies that seek to restore T-cell homeostasis rather than further depress T-cell function should be explored in the future. (biomedcentral.com)
However, the results of detailed phenotypic and functional analyses of chronically activated T cells derived from inflamed joints are difficult to reconcile with traditional models of cartilage-antigen-driven inflammatory disease in patients with RA. (biomedcentral.com)
SIV antigen has been demonstrated by immunohistochemical methods in lymph node sinus histiocytes, macrophages, and giant cells (14) as well as in macrophage-derived cells in brain tissue from diseased monkeys (8). (cdc.gov)

Ion channels are membrane protein complexes that translocate ions across cell or organelle membranes, underlying a broad range of the most basic physiological processes from nerve and muscle excitability, to membrane potential setting, pH/cell volume regulation, secretion and absorption. (mdanderson.org)
The lab employs a variety of approaches to probe how BLOC-1 interacts with membranes and with other HPS-encoded protein complexes to better understand its mechanism of action. (chop.edu)
DNAJA3 and OXPHOS protein complexes in sorted B cells between mice groups were compared using immunoblot techniques. (bvsalud.org)
Electron microscopy reveals loss of desmosomes (epithelial intercellular junctions formed by membrane and submembrane protein complexes), breakdown of desmosome-keratin intermediate filament attachment, and perinuclear aggregates of keratin intermediate filaments. (medscape.com)

Tissue factor (TF) is a 47-kDa membrane-bound protein that serves as a receptor and co-factor for the enzyme factor VIIa (FVIIa), with subsequent formation of the extrinsic tenase complex that converts factor X (FX) to FXa (2). (scielo.br)
CD19 forms a complex with CD21 (CR2) and CD81 (TAPA-1), and functions as a BCR co-receptor. (biolegend.com)
Predicted to be part of receptor complex. (zfin.org)
The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. (novusbio.com)
The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. (novusbio.com)
Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. (novusbio.com)
Additionally, the lab has identified defects in innate immunity to bacterial infection from a mouse HPS2 model, partly explaining the recurrent bacterial infections observed in HPS2 patients, and is uncovering mechanisms by which the endosomal adaptor AP-3 influences toll-like receptor recruitment to phagosomes, inflammasome signaling from phagosomes, and autophagy activation in dendritic cells. (chop.edu)
A putative transmembrane receptor may be responsible for nongenomic effects leading to rapid influx of calcium within muscle cells. (hindawi.com)
AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. (senescence.info)
This complex of mb-1, B29 polypeptides, immunoglobulin constitute the B cell Ag receptor. (enquirebio.com)
Project Section A 'Biological and chemical modulation of membrane molecule function and dynamics' was devoted to the analyses of plasma membrane receptor dynamics, oligomerization and signal transduction in fundamental biological resposes, such as cell growth, cell fate decisions, metabolic signalling and motility. (limes-institut-bonn.de)
To this end, the projects assembled in this section employ state-of-the art molecular genetics and furthermore feature interdisciplinary approaches such as combinatorial chemistry, innovative visualization of membrane receptor dynamics and computer-assisted modelling of membranes. (limes-institut-bonn.de)

Cellular respiration - The metabolic reactions and processes that take place in a cell or across the cell membrane to convert biochemical energy from fuel molecules into adenosine triphosphate (ATP) and then release the cell's waste products. (wikipedia.org)
Cellular differentiation - A concept in developmental biology whereby less specialized cells become a more specialized cell type in multicellular organisms. (wikipedia.org)
When a cell switches state from one cell type to another, it undergoes cellular differentiation. (wikipedia.org)
Then, we demonstrate how the inner wall of the capsules can be decorated with a continuous ECM layer that is anchored to the alginate gel and mimics the basal membrane of a cellular niche. (rsc.org)
It is strongly recommended that when using a reagent for the first time, users compare the spillover on cells and BD® CompBeads to ensure that BD® CompBeads are appropriate for your specific cellular application. (bdbiosciences.com)
This paradigm proposes that genetic and environmental factors shape a complex series of molecular and cellular interactions leading to a chronic inflammatory response. (biomedcentral.com)
The new work sought to understand how neural precursor cells maintain their own cellular identity as they divide and create neurons or astrocytes. (neurosciencenews.com)
The lipid composition of cellular membranes is tightly regulated and highly specific for different cell types, organelles, and the different leaflets of the lipid bilayer. (limes-institut-bonn.de)
Project Section C 'Membrane Trafficking' investigated membrane trafficking events in various cellular contexts. (limes-institut-bonn.de)
Pathogenesis and sporulation are complex processes that are governed by cellular signalling networks including G-protein and phospholipid signalling. (wur.nl)
Together, our work demonstrates ILK as necessary for normal oligodendrocyte development, reinforces its role as a bridge between the actin cytoskeleton and cell membrane, and highlights the overarching compensatory capacity of oligodendrocytes in response to cellular milieu. (jneurosci.org)
Taming the fierce roller: an 'enhanced' understanding of cellular differentiation in Volvox. (bio.net)

Apoptosis induction potential of each compound determined by mitochondrial membrane potential analysis (Rho123), cleaved caspase-3 expression analysis by flow cytometry and immunofluorescent staining and cell morphology analysis by giemza, hematoxylin and eosin and Papanicolaou protocols. (ijpsonline.com)
In the cell morphology analyzes, chromatin condensation and marginalization, changes in the cell membrane, ghost cells and apoptotic bodies were observed as evidence of apoptosis formation. (ijpsonline.com)
In a different study, in which researchers systematically analyzed mutations identical to those found in patients with Darier disease, mutant SERCA2 protein aggregates were found to cause stress to the endoplasmic reticulum, subsequently inducing cell apoptosis. (medscape.com)

However, the applicability of such traditional chemotherapeutic approaches is primarily limited due to acquired Multi-Drug Resistance (MDR) in cells, which is acquired through the production of anti-apoptotic cascades and the overexpression of cell membrane-based drug efflux pumps, such as P-glycoprotein, for self-defense. (ijpsonline.com)
and the synaptic vesicle membrane glycoprotein synaptophysin. (duke.edu)

Finally, we used this approach to encapsulate human Neural Stem Cells (hNSC) derived from human Induced Pluripotent Stem Cells (hIPSC), which were further differentiated into neurons within the capsules with negligible loss of viability. (rsc.org)
Moreover, tranylcypromine treatment affects neurons and astrocytes, which impairs cell density and arrangement. (frontiersin.org)
In the latter part of his career, Sueoka became interested in the differentiation of mammalian neurons and developed a system based on neuronal cancer cells to approach this complex subject. (colorado.edu)
The work, published in Cell Stem Cell on September 14, 2017, offers insight into why an imbalance between these precursor cells and neurons might contribute to mental illness or age-related brain disease. (neurosciencenews.com)
During development, oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes (OLs) that extend processes to contact multiple axons of CNS neurons. (jneurosci.org)

These studies have served to highlight the role of AND-34/BCAR3 and p130Cas in cell adhesion and migration signaling pathways. (molvis.org)
Such activation is known to affect cell migration and outgrowth of axons and dendrites in vivo. (embl-heidelberg.de)
The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion. (pearltrees.com)

The stem cells within the basal layer, which contact the basement membrane, continually divide during the lifetime of the organism, providing a source of cells which progressively migrate upwards through the epidermis, differentiating and stratifying to form the barrier layer of the skin [ 11 , 14 ]. (springer.com)
They are a major component of the basal lamina (one of the layers of the basement membrane), a protein network foundation for most cells and organs. (pearltrees.com)
Basal cell carcinoma (BCC) is a nonmelanocytic skin cancer (ie, an epithelial tumor) that arises from basal cells (ie, small, round cells found in the lower layer of the epidermis). (medscape.com)
Basal cell carcinoma of the right lower lid. (medscape.com)
In the oral mucosa, melanocytes are observed in a ratio of about 1 melanocyte to 10 basal cells. (medscape.com)

Asthma is a reversible airway obstruction that is characterized by constriction of airway smooth muscle, Abstract hyper secretion of mucus, edema and airway hyper responsiveness (AHR), mucus secretion and thickening of the basement membrane underlying the airway epithelium. (cdc.gov)
Modulating the cytokine network in thickening of the basement membrane underlying the respiratory diseases such as asthma, with expected airway epithelium. (cdc.gov)

Much of the remainder of the discussion focuses on the different ways in which, in the longer term, the chronic inflammatory process influences maturation, differentiation, and function of effector T cells at sites of inflammation. (biomedcentral.com)
CD79a first appears at pre B cell stage, early in maturation,, persists until the plasma cell stage where it is found as an intracellular component. (enquirebio.com)

The primary goal of the Marks Lab is to understand the molecular basis of intracellular membrane trafficking underlying the formation of cell type-specific lysosome-related organelles (LROs). (chop.edu)
The common interest of the projects of this section was the functional elucidation of novel protein players and/or mechanisms of intracellular membrane transport in immune defense, development and metabolic control. (limes-institut-bonn.de)

Histologically, the dermatosis is characterized by hyperproliferation of keratinocytes, impaired epidermal barrier function at the sites of skin lesions, and skin infiltration by activated inflammatory cells [ 5 ]. (springer.com)
The Epidermal Differentiation Complex (EDC) is a co-ordinately regulated locus that is evolutionarily conserved within mammals. (bl.uk)

This simplified model of embryogenesis, tissue organization and carcinogenesis, based on non-excitable cells' bioelectric properties, can be made more realistic with the introduction of other components, like biochemical fields and mechanical interactions, which are fundamental for a more faithful representation of reality. (nature.com)
The lab is using biochemical and cell biological approaches to dissect the mechanism by which it functions. (chop.edu)
Project Section B 'Genetic and biochemical manipulation of the lipid metabolism for the analysis of membrane protein function' used different model systems to study the role of the lipid metabolism in membrane and membrane protein function. (limes-institut-bonn.de)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)

Lipid bilayer - A membrane composed of two layers of lipid molecules (usually phospholipids). (wikipedia.org)
The lipid bilayer is a critical component of the cell membrane. (wikipedia.org)
The exosome vesicles are a type of extracellular vesicles (EV), which are defined as lipid-bilayer spheroid structures, without replicating capacity, that are released from cells, including both prokaryotes and eukaryotes. (frontiersin.org)

A vesicle trafficking protein αSNAP regulates Paneth cell differentiation in vivo. (nih.gov)
Expression of AND-34 regulates epithelial cell growth pattern, motility, and growth factor dependence. (molvis.org)
We recently used a proteomic-based screen to identify a novel mitotic complex including the membrane-associated Annexin A1 (ANXA1) protein that interacts with and regulates cortical recruitment of the LGN spindle orientation complex in mitotic mammary epithelial cells. (southampton.ac.uk)
Protein phosphorylation regulates actomyosin-driven vesicle movement in cell extracts isolated from the green algae, Chara corallina. (bio.net)

Polarised epithelial cell divisions represent a critical mechanism for correct partitioning of fate determinants and genomic material into the daughter cells during tissue homeostasis and morphogenesis, and their disruption can lead to severe developmental disorders and diseases such as cancer. (southampton.ac.uk)
The system reaches homeostasis, with a depolarized core (proliferative cells) surrounded by a rim of polarized cells (non-proliferative in this condition). (nature.com)
This theory would deal with the way an organism spontaneously grows from a single cell to a complete and complex organism, introducing organization at the different development stages and homeostasis for a mature organism. (nature.com)
As cells migrate and experience forces from their surroundings, they constantly undergo mechanical deformations which reshape their plasma membrane (PM). To maintain homeostasis, cells need to detect and restore such changes, not only in terms of overall PM area and tension as previously described, but also in terms of local, nano-scale topography. (elifesciences.org)

the team and its collaborators have shown that the products of HPS-associated genes in skin melanocytes regulate two pathways of membrane protein transport from endosomes to newly forming melanosomes and a retrograde pathway from melanosomes. (chop.edu)
Studies reveal that chronic exposure of T cells to TNF uncouples TCR signal transduction pathways by impairing the assembly and stability of the TCR/CD3 complex at the cell surface. (biomedcentral.com)
Despite this membrane-proximal effect, TNF selectively uncouples downstream signalling pathways, as is shown by the dramatic suppression of calcium signalling responses, while Ras/ERK activation is spared. (biomedcentral.com)

Mitochondrial membrane potential was found at low levels in cells treated with Schiff base compounds and doxorubicin. (ijpsonline.com)
METHODS: We characterized B cell populations in various developmental stages and examined mitochondrial content and function between control and DNAJA3 KO using flow cytometry analysis. (bvsalud.org)

The activity of G-protein-coupled receptors is not limited to the cell surface. (natureasia.com)
They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein. (bvsalud.org)
TNFa delivers its signals to target cells by binding to specific cell surface membrane receptors (TNFR1 and TNFR2). (cdc.gov)
Secreted IFN-α/β and IFN-λ bind to their specific receptors (IFNAR and IFNLR) in infected and neighboring cells. (cdc.gov)

Na(+) influx via Orai1 inhibits intracellular ATP-induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation. (nih.gov)
Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. (novusbio.com)
The fact that we were able to connect transcription factors, which are mobile switches, to the pore complex, which is a very stable structure, offers a clue as to how cells maintain their identity through regulated gene expression," says Tomohisa Toda, a Salk research associate and first author of the paper. (neurosciencenews.com)
Molecular characterization and gene expression of lhcb5 gene encoding CP26 in the light-harvesting complex II of Chlamydomonas reinhardtii. (bio.net)

Ion channels have long been key therapeutic targets in disease intervention and pharmaceutical drug development because of their direct involvement in diverse diseases, vulnerability to small molecular modulation, and accessibility for direct activity measurement on cell membranes by patch-clamp recording from whole cell to single molecule levels. (mdanderson.org)
Facilitated diffusion is a type of passive transport where a "helper" molecule assists in the movement of solute across a cell membrane. (proprofs.com)

It was observed that tumor cells strongly accelerate plasma coagulation as a result of: i) expression of the blood clotting initiator protein, a tissue factor, as shown by flow cytometry and functional assays (factor Xa formation in the presence of cells and factor VIIa), and ii) direct activation of prothrombin to thrombin by cells, as evidenced by hydrolysis of the synthetic substrate, S-2238, and the natural substrate, fibrinogen. (scielo.br)
Carcinogenesis is introduced through a localized event (a spot of depolarized cells) or by random depolarization of cells in the tissue, which returns cells to their initial proliferative state. (nature.com)
An organism's growth and transformation during its life cycle is a tremendously complex succession of processes and events but even a simplistic and limited theory, dealing with only the general trend and generating a broad vision of tissue organization, can drive specific studies and experiments to further inform this field of research. (nature.com)
Given MSCs differentiation directions, adipose tissue was considered another valid source of MSCs (AT-MSCs). (biomedcentral.com)
An intense signal was observed in cells in the white pulp in spleen, germinal center cells in the lymph node, lymphoid tissue in appendix and non-germinal center cells in the tonsil. (enquirebio.com)
More moderate antibody staining intensity was present in cells in the white pulp in spleen, germinal center cells in the lymph node, lymphoid tissue in appendix and non-germinal center cells in the tonsil. (enquirebio.com)
Yet, it is still largely unclear how a specific membrane composition is generated and stabilized and how altered membrane organization and shapes (e.g. curvature) translate to cell and tissue differentiation and morphogenesis. (limes-institut-bonn.de)
of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)

MCP-1) and adhesion molecules (VCAM-1), in proliferating or differentiating C2C12 cells and primary myoblasts. (cdc.gov)
Deficiencies are highly variable with regard to symptoms, phenotype, genotype, severity, etc, because many cells and molecules are required for both natural and adaptive immunity . (lu.se)

Latest proteomic research shows that native ion channels commonly exist as a large functional unit of "signaling complex" consisting of the ion-conducting pore subunits, variable peripheral auxiliary subunits, and interacting protein partners. (mdanderson.org)
Filaments composed of ESCRT-III subunits constrict membranes of the intercellular bridge midbody to the abscission point. (elifesciences.org)
HPS types 7, 8 and 9 are due to mutations in genes encoding subunits of BLOC-1, a complex required for the generation of tubular cargo carriers destined for melanosomes. (chop.edu)
HPS types 3, 5 and 6 are due to mutations in genes encoding subunits of BLOC-2, a complex that directs BLOC-1-dependent cargo carriers with melanosomes. (chop.edu)
Forms heteromultimeric complex with alpha subunits. (ucsc.edu)

It consists of a large number of genes, organised into clusters of gene families, which mainly encode structural constituents of the cornified envelope which replaces the plasma membrane of fully differentiated keratinocytes. (bl.uk)
They include endothelial cells, fibroblasts, and keratinocytes. (frontiersin.org)

The metal complexes of the compounds had stronger cytotoxic effects and cleaved caspase-3 expression than their ligands. (ijpsonline.com)
Targeting to cancer by attaching ligands specific to cancer cells is currently being investigated. (uclahealth.org)

Its localization suggested involvement in cell differentiation and elongation and its 7-TM domain showed a canonical GPCR membrane topology. (wur.nl)

Located in neuronal cell body and plasma membrane bounded cell projection. (wormbase.org)

Vital functions of an organism occur within cells. (wikipedia.org)
Tissues - A collection of interconnected cells that perform a similar function within an organism. (wikipedia.org)

On the other hand, the "exosome vesicle " is an extracellular particle released from the endosomal compartment of most eukaryotic cells. (frontiersin.org)

The large-conductance, Ca 2+ and voltage-activated K + channel (BK, also termed as BK Ca , Maxi-K, K Ca1.1 or Slo1) is a unique member of the mammalian K + channel family, which has the largest single channel conductance and is dually activated by membrane voltage and intracellular Ca 2+ . (mdanderson.org)

The mesenchymal stromal cells (MSC) have immunomodulatory properties and a high regenerative capacity. (frontiersin.org)
There is a growing body of evidence that multipotent mesenchymal stromal cells' (MSCs') remarkable therapeutic potential is attributed not only to their differentiation and regenerative capacity, but also to the paracrine effect, underlying their immunomodulatory properties. (biomedcentral.com)

MSCs are reported to contribute both to the inflammation initiation and to its resolution via complex cross talk with immune cells, most importantly macrophages [ 1 ]. (biomedcentral.com)
This chapter aims to explore this theme in more depth, beginning with an outline of the molecular events that dictate the differentiation of T helper (Th) cells at the outset of adaptive immune responses in regional lymph nodes. (biomedcentral.com)
However, the role of DNAJA3 in B cell development and immune function remains unknown. (bvsalud.org)
DNAJA3flx/flx) to investigate the physiological function of DNAJA3 in B cell development and immune function. (bvsalud.org)
These factors could have influenced B cell differentiation during development, differentiation to antibody-secreting cells, and immune activation. (bvsalud.org)
During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
2) T cell deficiencies affect the function in killing infected cells or helping other immune cells. (lu.se)

This was supported by the fact that disrupting Nup153's function in the precursor cells triggered differentiation. (neurosciencenews.com)

Ceramides influence various cell functions, and it is likely that abnormal regulation of these processes also contributes to the features of this condition. (medlineplus.gov)
This process is essential for maintaining concentration gradients across cell membranes and is crucial for various physiological processes in living organisms. (proprofs.com)
Our research is focussed on understanding these complex processes using a variety of complementary models and systems to better inform antibody selection, design and clinical application. (southampton.ac.uk)

More recently, a number of studies have focused on the procoagulant mechanisms exhibited by tumor cells. (scielo.br)
Moreover, a monoclonal antibody against bovine factor Xa reduced the prothrombin-converting activity of tumor cells. (scielo.br)
The PI3K/AKT signalling pathway is crucial for tumor cell survival. (senescence.info)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)

Scholars@Duke publication: Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts. (duke.edu)
Although the different membrane compartments show distinct lipid characteristics they are not strictly separated but are in a complex and dynamically regulated interchange. (limes-institut-bonn.de)

The Pathology Department conducts research into anatomical and clinical correlations in human pathology, and in the fields of cell biology, general immunology and immunopathology. (unige.ch)

Forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells and interacts with VAV and LYN. (biolegend.com)

In the present study, we dissected the molecular mechanisms responsible for the procoagulant activity of MV3, a highly aggressive human melanoma cell line. (scielo.br)
Our work will lay the foundation for a more ambitious, collaborative project bringing together expertise in cell and molecular biology, cancer biology, physics, and mathematics, to investigate the causal relationship between ANXA1-mediated defects in cell divisions and tumour heterogeneity, and the underlying mechanisms. (southampton.ac.uk)
There is now good evidence that there exists a coordinated programme of molecular events initiated at the outset of T-cell differentiation that leads to the generation of CD4 + Th effector cells [ 1 ]. (biomedcentral.com)
3) the molecular mechanisms that control the asymmetric distribution of membrane constituents and the impact of lipid metabolites in cell signalling and (4) to generate novel tools for the analysis of membrane function. (limes-institut-bonn.de)
Reviews in Cell Biology and Molecular Medicine articles are self-contained treatments of a given topic, usually with over 100 references and 10 to 20 figures and tables, making this an authoritative reference source for undergraduate and graduate students, faculty, librarians and researchers. (lu.se)

ILK forms an obligate heterotrimeric complex with particularly interesting Cys-His-rich protein (PINCH) and parvin, which together lend stability to the actin cytoskeleton at focal adhesions ( Brakebusch and Fässler, 2003 ). (jneurosci.org)

Cell biology research extends to both the great diversities of single-celled organisms like bacteria and the complex specialized cells in multicellular organisms like humans. (wikipedia.org)
Cell biology can be described as all of the following: Branch of science - A systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe. (wikipedia.org)
Cell biology - (formerly cytology) The study of cells. (wikipedia.org)
Dr. Mukhopadhyay did his doctoral studies in Biochemistry at the Department of Biochemistry from Calcutta University and received the postdoctoral training in the Department of Cell Biology, Cleveland Clinic Foundation, USA. (jnu.ac.in)

Mesoglea, also known as mesohyl, is the translucent, non-living, jelly-like substance found between the two epithelial cell layers (i.e., between the ectoderm and endoderm) in the bodies of cnidarians and sponges. (pearltrees.com)

Recent breakthroughs in human pluripotent stem cells (hPSCs)-derived cerebral organoids offer a promising approach for investigating the mystery of human brain ( 19 ). (frontiersin.org)
Leukocytes are produced in stem cells in bone marrow. (lu.se)

It is not present in myeloid or T cell lines. (enquirebio.com)

Blood coagulation involves a series of zymogen acti-vation reactions that are mainly performed by enzyma- tic complexes consisting of a serine protease, a protein co-factor and membranes containing anionic phospholipids (1). (scielo.br)

Eukaryote - Organisms whose cells are organized into complex structures enclosed within membranes, including plants, animals, fungi, and protists. (wikipedia.org)
During differentiation, cells acquire specific structures and functions that allow them to perform specific tasks in the body. (proprofs.com)

Here, through the use of conditional knock-out mice, we demonstrate a requirement for ILK in oligodendrocyte differentiation and axonal myelination in vivo . (jneurosci.org)

were prepared for electron microscopy so that cortical microtubules could be counted along the longitudinal walls in cell files in the endodermis, pericycle, and inner and outer cortex, and in sieve and xylem elements. (biologists.com)
The cells augment their population of cortical microtubules as they elongate and divide, showing a net increase of up to 0.6 μ m of polymerized microtubule length per min. (biologists.com)
Most cell types thus maintain a set density of cortical microtubules while they elongate and divide. (biologists.com)
The cortical cells expanded in all dimensions, and the interpolation of microtubules diminished or ceased. (biologists.com)

Glucolipotoxicity leads to mTOR-dependent inhibition of macroautophagy in β cells. (bio-rad-antibodies.com)
For TNFa induced inhibition of myoblast differentiation myogenin expression was reduced. (cdc.gov)

However, the unusual phenotype of synovial T cells, including their profound proliferative hyporesponsiveness to TCR ligation, has challenged the notion that T-cell effector responses are driven by cognate cartilage antigens in inflamed synovial joints. (biomedcentral.com)

He also made widely-known contributions to our understanding of DNA replication, particularly in the bacterium B. subtilis , with a focus on the role of membranes in replication initiation. (colorado.edu)
For cytokine genes, at least three stages are thought to be required for the acquisition of transcriptional competence in T cells: an initiation phase, a commitment phase, and a phase of acute gene transcription (Fig. 1 ). (biomedcentral.com)

Gage's team already knew that the cell nucleus-the ball-shaped membrane containing the genome-looks very different in the three cell types, with different genes active in each. (neurosciencenews.com)
A fluorescent microscopy image shows Nup153 (red) in pore complexes encircling and associating with Sox2 (green) in a precursor cell nucleus. (neurosciencenews.com)
Interestingly, Nup153 levels are also known to be high in cells with elevated levels of a mobile protein called Sox2, a transcription factor that floats around the nucleus and binds to genes and turns them on or off. (neurosciencenews.com)
After translocation in the nucleus, phosphorylated STAT1 and STAT2 form a complex with IRF9 to induce expression of ISGs, such as OAS-RNase L and PKR, and establishment of an antiviral program. (cdc.gov)

Typically tubular, multinucleated, and with a chitinous cell wall. (wikipedia.org)

Mouse anti Rat CD63 antibody 6H1 ( MCA4754GA ) used to demonstrate CD63 expressing cells by immunofluorescence. (bio-rad-antibodies.com)
a Immunofluorescence of CD63 (green) and mTOR (red) in INS1 cells treated with control (1% BSA, 11 mM glucose, "1% BSA") or glucolipotoxic (1% BSA, 33.3 mM Glucose and 0.4 mM Palmitate, "Glc/Pal") media for 20 h. (bio-rad-antibodies.com)

Recent breakthroughs in human pluripotent stem cell-derived cerebral organoids provide a valuable platform for investigating the human brain after different drugs treatments and for understanding the complex genetic background to human pathology. (frontiersin.org)
Genetic studies using fission yeast and Drosophila established that Rheb plays critical roles in both cell growth and cell cycle progression at the G1/S boundary and that this function of Rheb is mediated by its ability to activate the TOR/S6K signaling pathway. (uclahealth.org)
These antibodies are used as fluorescent markers to distinguish subsets of mouse thymic epithelial cells in genetic studies of the thymus . (wikipedia.org)

In the precursors, they discovered high numbers of a protein called Nup153, which is part of a multiprotein complex that forms a gatekeeping pore in the nuclear membrane, controlling what goes in or out. (neurosciencenews.com)

Immunoreactivities with anti-tenascin and anti-glioma-associated antibodies were variable in these cell lines. (duke.edu)
When fluorochrome conjugated antibodies are bound to BD® CompBeads, they have spectral properties very similar to cells. (bdbiosciences.com)
For example, mouse thymic epithelial cells react with antibodies for keratin 5, keratin 8, and keratin 14. (wikipedia.org)

This state is resilient to cell death (random or due to injure) and to limited depolarization (potentially carcinogenic) events. (nature.com)
KCl activates phospholipase D at two different concentration ranges: Distinguishing between hyperosmotic stress and membrane depolarization. (bio.net)

While Akt Ser 473 phosphorylation was readily detectable in AND-34 +/+ lens epithelial cells, it was markedly reduced in the AND-34 −/− lens epithelium. (molvis.org)

Initially designated 'intermediate' because their average diameter (10 nm) is between those of narrower microfilaments (actin) and wider myosin filaments found in muscle cells, the diameter of Intermediate filaments is now commonly compared to actin microfilaments (7 nm) and microtubules (25 nm). (pearltrees.com)

Is an ortholog of human MAK (male germ cell associated kinase). (wormbase.org)
N-SLIT2 amplifies reactive oxygen species production in response to the bacteria by activating p38 mitogen-activated protein kinase that in turn phosphorylates NCF1, an essential subunit of the NADPH oxidase complex. (elifesciences.org)
Integrin-linked kinase (ILK) is a major structural adaptor protein governing signaling complex formation and cytoskeletal dynamics. (jneurosci.org)
The FA2 gene of Chlamydomonas encodes a NIMA family kinase with roles in cell cycle progression and microtubule severing during deflagellation. (bio.net)

Additionally, ceramides are a component of a fatty substance called myelin that insulates and protects nerve cells. (medlineplus.gov)
In conjunction, ILK-deficient primary oligodendrocytes are defined by a failure in process extension and an inability to form myelin membrane upon axonal contact. (jneurosci.org)

Multipotent mesenchymal stromal cells (MSCs) are an extensively researched yet still understudied tool for treating a wide range of pathological conditions, one particular area of research interest being their immunomodulatory properties. (biomedcentral.com)

Structure of intermediate filament Intermediate filaments (IFs) are cytoskeletal components found in the cells of vertebrate animal species,[1][2] and perhaps also in other animals, fungi, plants, and unicellular organisms. (pearltrees.com)

It is a member of the immunoglobulin superfamily expressed on B cells (from pro-B to blastoid B cells, absent on plasma cells) and follicular dendritic cells. (biolegend.com)
B lineage (except plasma cells), follicular dendritic cells. (biolegend.com)
and plasma membrane bounded cell projection. (wormbase.org)
and plasma membrane. (zfin.org)
The cells secrete extracellular vesicles (EV) that may have an endosomal origin, or from evaginations of the plasma membrane. (frontiersin.org)
Anti-CD79a also stains more cases of plasma cell myeloma, occasionally some types of endothelial cells as well. (enquirebio.com)

Leukemia is a blood cancer that develops in the hematopoietic system and presents in the bone marrow with or without peripheral blood cell involvement[ 1 , 2 ]. (ijpsonline.com)
Human peripheral blood mononuclear cells-derived macrophages were then treated with umbilical cord-derived MSCs' conditioned media and their effect on macrophages polarization was assessed. (biomedcentral.com)
The hierarchy of T-cell dysfunction from peripheral blood to inflamed joint suggests that these defects are acquired through prolonged exposure to proinflammatory cytokines such as tumour necrosis factor (TNF)-α. (biomedcentral.com)

With other collaborators, the lab has extended its analyses of LRO biogenesis to dense and alpha granules in platelets and megakaryocytes, lamellar bodies in lung epithelial type II cells, and phagosomes in dendritic cells. (chop.edu)

This enzyme is found in lysosomes, which are cell compartments that digest and recycle materials. (medlineplus.gov)

Anatomy69

Organisms12

Diseases2

Chemicals and Drugs72

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes67

Disciplines and Occupations1

Technology, Industry, Agriculture5

Information Science3

Health Care1

Proliferation17

Proteins17

Antigen5

Protein complexes4

Receptor12

Cellular12

Apoptosis3

Glycoprotein2

Neurons5

Migration3

Basal5

Basement membrane2

Maturation2

Intracellular membrane2

Epidermal2

Biochemical4

Lipid bilayer3

Regulates4

Homeostasis4

Pathways3

Mitochondrial2

Receptors4

Gene expression4

Molecule2

Tissue8

Molecules2

Subunits5

Keratinocytes2

Ligands2

Elongation1

Neuronal cell1

Organism2

Vesicle1

Mammalian1

Regenerative capacity2

Immune7

Precursor cells1

Processes3

Tumor4

Characteristics2

Immunology1

Interacts1

Molecular5

Cytoskeleton1

Biology4

Epithelial cell1

Stem cells2

Myeloid1

Phospholipids1

Structures2

Vivo1

Cortical4

Inhibition2

Antigens1

Initiation2

Nucleus4

Tubular1

Immunofluorescence2

Genetic3

Multiprotein1

Antibodies3

Depolarization2

Phosphorylation1

Actin1

Kinase4

Myelin2

Mesenchymal stromal cells1

Filaments1

Plasma6

Peripheral3

Analyses1

Compartments1