• Quantification of interactions between cytochrome P450 2B4 and cytochrome b5 in a functional membrane complex. (nel.edu)
  • Ječmen T, Ptáčková R, Kavan D, Cerná V, Hodek P, Stiborová M, Hudeček J, Sulc M. Quantification of interactions between cytochrome P450 2B4 and cytochrome b5 in a functional membrane complex. (nel.edu)
  • The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with tramadol are complex. (nih.gov)
  • Paroxetine is an established perpetrator of drug-drug interactions (DDIs) when coadministered with agents whose clearance is largely dependent on the activity of cytochrome P450 2D6 (CYP2D6). (aspetjournals.org)
  • Whereas in vitro-in vivo scaling approaches for reversible inhibition of P450 enzymes have been extensively described over the last decade and applied in the prediction of drug-drug interactions, mathematical models for scaling interactions resulting from mechanism-based inhibition have only recently been described, with relatively fewer reported examples illustrating their predictive utility. (aspetjournals.org)
  • We found that the cytochrome P450 isoform CYP4F11 is significantly overexpressed in patients with lung squamous cell carcinoma. (qxmd.com)
  • An inhibition of 20-HETE-generating cytochrome P450 enzymes has been implicated as novel cancer therapy for more than a decade. (qxmd.com)
  • Stiripentol (STP), an antiepileptic agent, causes drug-drug interactions by inhibiting cytochrome P450 (P450) enzymes. (qxmd.com)
  • STP contains a methylenedioxyphenyl (MDP) group, which could form inhibitory metabolic intermediate complexes (MICs) with P450. (qxmd.com)
  • Concurrent flavin-containing monooxygenase down regulation and cytochrome P450 induction by dietary indoles in the rat: implication for drug-drug interactions. (oregonstate.edu)
  • Water Extract Shows Low Potential for Cytochrome P450-Mediated Drug Interactions. (oregonstate.edu)
  • Both artemether and lumefantrine are metabolized by hepatic cytochrome P450 (CYP450) enzymes which metabolize the protease inhibitors (PIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) used for HIV treatment. (bvsalud.org)
  • It is a prodrug that is metabolized by cytochrome P450 (CYP) enzymes CYP2D6 and CYP3A4 to its more potent opioid analgesic metabolites, particularly the O -demethylation product M1. (medscape.com)
  • This interaction can lead to destabilization of the heme-Met80 bond and peroxidase activity [Basova, L. V., et al. (essex.ac.uk)
  • We show that under these conditions carbon monoxide (CO) binds to cyt c, with very high affinity (similar to 5 x 10(7) M(-1)), in contrast to the native cyt c protein involved in respiratory electron shuttling that does not bind CO. Binding of CO to the cyt c-CL complex inhibits its peroxidase activity. (essex.ac.uk)
  • The affinity of CO for the complex is high enough to envisage an antiapoptotic effect of nanomolar CO concentrations via inhibition of the cyt c peroxidase activity. (essex.ac.uk)
  • Cytochrome c peroxidase, or CCP, is a water-soluble heme-containing enzyme of the peroxidase family that takes reducing equivalents from cytochrome c and reduces hydrogen peroxide to water: CCP + H2O2 + 2 ferrocytochrome c + 2H+ → CCP + 2H2O + 2 ferricytochrome c CCP can be derived from aerobically grown yeast strains and can be isolated in both native and recombinant forms with high yield from Saccharomyces cerevisiae. (wikipedia.org)
  • The negative charge transfer process is carried out by a complex formed between cytochrome c and cytochrome c peroxidase which occurs in the inter-membrane space of mitochondria. (wikipedia.org)
  • Cytochrome c peroxidase can react with hydroperoxides other than hydrogen peroxide, but the reaction rate is much slower than with hydrogen peroxide. (wikipedia.org)
  • Herein, we demonstrate that cytochrome c (Cyt c ) showed peroxidase activity on IGA as a component of complexes III and IV. (biologists.com)
  • The interaction of mitochondrial cytochrome (cyt) c with cardiolipin (CL) is involved in the initial stages of apoptosis. (essex.ac.uk)
  • Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid-liquid phase separation. (us.es)
  • Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus. (us.es)
  • However, if patients are receiving antiretroviral therapy (ART), rifabutin is preferred because it is less likely to induce cytochrome P-450 metabolic enzymes that lower serum levels of protease inhibitors and non-nucleoside reverse transcriptase inhibitors. (msdmanuals.com)
  • Identification of protein-protein interactions (PPIs) is important for understanding how proteins work together in a coordinated fashion in a cell to perform cellular functions. (nature.com)
  • Even for Arabidopsis , known PPI data cover interactions with only about 34.55% of proteins. (nature.com)
  • Top-Down Characterization of Denatured Proteins and Native Protein Complexes Using Electron Capture Dissociation Implemented within a Modified Ion Mobility-Mass Spectrometer. (oregonstate.edu)
  • The intrinsic apoptotic pathway is initiated in response to a variety of stress signals ( Willis and Adams, 2005 ), and a complex interplay of Bcl-2 proteins relays this signal to the mitochondrial outer membrane (OM) to initiate Bak and Bax activation, oligomerisation and OM damage ( Fig. 1 ). (biologists.com)
  • The genomic DNA of tick species was extracted, and cytochrome oxidase subunit 1 (cox1) and 16S ribosomal RNA (rRNA) genes were amplified and sequenced. (bvsalud.org)
  • Conflicting drug-drug interaction (DDI) studies with the HIV protease inhibitors (PIs) suggest net induction or inhibition of intestinal or hepatic CYP3A. (aspetjournals.org)
  • Attempts at predicting drug-drug interactions perpetrated by paroxetine from in vitro data have utilized reversible enzyme inhibition models and have been unsuccessful to date, grossly underpredicting interaction magnitude. (aspetjournals.org)
  • The enzyme contains a 68-residue sequence at the N-terminus of its monomeric protein, which targets it to the inter-membrane space of the mitochondria where it can the complex with cytochrome c and where it carries out its sensor, signaling and catalytic roles. (wikipedia.org)
  • Atovaquone (ATQ) exerts its action by inhibiting plasmodial mitochondria electron transport at the level of the cytochrome bc1 complex. (unl.pt)
  • The photons from the laser penetrate cells and interact with the mitochondria, specifically the cytochrome c complex. (southbaychiro.com)
  • Stimulation of cytochrome c in the mitochondria is the main target of light therapy. (southbaychiro.com)
  • Incubation of racemic methylenedioxyamphetamine (MDA) or methylenedioxymethamphetamine (MDMA) with rat hepatic microsomes, in the presence of NADPH, generated a spectrally observed inhibitory complex with cytochrome P-450. (erowid.org)
  • Tramadol's simultaneous opioid agonist action and serotonin (5-HT) and norepinephrine reuptake inhibitory effects result in a unique side effect profile and important drug interactions that must be considered. (medscape.com)
  • The mechanism involves ferrous cytochrome c (Cc) providing electrons for the Cc-CcP system to reduce hydrogen peroxide to water. (wikipedia.org)
  • Letermovir is an antiviral active against CMV without associated myelotoxicity, does not require dose adjustment for kidney impairment, has a unique mechanism of action as an inhibitor of the CMV DNA terminase complex, and is not associated with cross-resistance to other anti-CMV agents," Dr Limaye's team explained. (renalandurologynews.com)
  • The general mechanism of herb-warfarin interaction almost remains unknown, yet several pharmacokinetic and pharmacodynamic factors were estimated to influence the effectiveness of warfarin. (hindawi.com)
  • however, the pore complexes that are formed by Bak and Bax remain poorly defined in terms of their composition, size, number and structure, as well as the mechanism by which they are regulated by other Bcl-2 family members. (biologists.com)
  • The bifunctional CODH ( cdhAB-2 ) is predicted to play an ubiquitous role in the metabolism of CO, and a novel nitrate reductase-associated respiratory complex was induced specifically in the presence of sulfate. (hindawi.com)
  • Overall, carboxidotrophic growth seems as an intrinsic capacity of A. fulgidus with little need for novel resistance or respiratory complexes. (hindawi.com)
  • Fqo can be hypothesized to be operative during sulfate reduction with CO. The Fqo complex receives electrons from the reduced coenzyme F 420 (F 420 H 2 ), generated from the oxidative acetyl-CoA pathway, and transfers electrons to the membrane-bound respiratory chain by the reduction of menaquinone [ 16 - 18 ]. (hindawi.com)
  • A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III. (nih.gov)
  • Also, more atten- tion should be devoted to sensitive groups, toxicological mechanisms and interactions as most workplace exposures are mixtures. (cdc.gov)
  • Its probable major substrate, the light-harvesting complex of PSII, once phosphorylated, dissociates from PSII and docks to PSI, thereby restoring the balance of absorbed light excitation energy between the two photosystems. (unige.ch)
  • However, no IGA has been established for complex III because of the difficulty of access by ubiquinol, a substrate for complex III. (biologists.com)
  • However, unlike valganciclovir, letermovir has potential drug interactions (moderate cytochrome P3450 3A inhibitor, substrate for organic anion transporting polypeptide 1B1/3) and does not have activity against herpes simplex virus (HSV) or varicella zoster virus (VZV). (renalandurologynews.com)
  • Environmental carcinogens and certain other endogenous factor (genetic alteration and mutation) interacting in a complex manner can give rise to development of cancer. (bvsalud.org)
  • This CYP1A1 induction pattern reversal is a unique example of complex biological interactions between coplanar (PCB 126) and noncoplanar (PCB 153) halogenated aromatic hydrocarbons. (cdc.gov)
  • The recommended dose of Zithromax for the prevention of disseminated Mycobacterium avium complex (MAC) disease is: 1200 mg taken once weekly. (buysumamed.com)
  • Although imidazole ligand binding to cytochrome c is not directly related to its physiological function, it has the potential to provide valuable information on the molecular and electronic structure of the protein. (rcsb.org)
  • The central nervous system (CNS) depends on a complex and intricate network of molecular and cellular interactions to maintain appropriate function and homeostasis. (frontiersin.org)
  • We then describe the evolution of genomic organisation across lineages, how this process has been shaped by interactions with the nuclear genome and population genetics dynamics. (nature.com)
  • Genetics of maize microbe interactions special issue. (usda.gov)
  • Magnitudes of interactions produced by paroxetine (20-30 mg/day) with desipramine, risperidone, perphenazine, atomoxetine, ( S )-metoprolol, and ( R )-metoprolol were predicted, considering the contribution of CYP2D6 to their oral clearance. (aspetjournals.org)
  • Simulation of the sensitivities of these predictions to model inputs suggests a 2-fold underprediction of interaction magnitude when a CYP2D6 degradation half-life of 14 h (reported for rat CYP3A) is used. (aspetjournals.org)
  • ii) to examine conformationally-modulated ET through a tightly integrated program comprised of kinetic measurements of the variations of ET with solvent, structural characterization of dynamic complexes (NMR), and computational (Brownian Dynamics/MD/Smoluchowski equation) approaches. (northwestern.edu)
  • Enzootic strains (subtype I, varieties D and E, as well as related species in the VEE complex comprising subtypes II-VI) have been regularly isolated in lowland tropical forests and swamps in Florida, Mexico, and Central and South America. (cdc.gov)
  • Electric field-induced functional changes in electrode-immobilized mutant species of human cytochrome c. (us.es)
  • A better understanding of reservoir biology and of pathogen-reservoir interactions, particularly their mechanisms of disease resistance, could also facilitate the development of treatment and control strategies for humans and domestic animals ( 3 , 4 ). (cdc.gov)
  • However, rifabutin is preferred over rifampin for disseminated MAC infections because of its superior activity in vitro and reduced drug interaction potential. (msdmanuals.com)
  • Lastly, we observed differential rod and core pigment responses to nitrogen deprivation, suggesting that PBS complexes undergo a stepwise degradation process. (osti.gov)
  • Protein-protein interactions (PPIs) play essential roles in many biological processes. (nature.com)
  • The goal of understanding protein-protein interactions and interprotein ET has led us to recent, highly successful efforts at their control through a charge-reversal strategy for redesign of the docking interface, one result being the discovery of an interprotein singlet ET photocycle on ps-ns timescales. (northwestern.edu)
  • Cyanobacterial phycobilisome (PBS) pigment-protein complexes harvest light and transfer the energy to reaction centers. (osti.gov)
  • This paper presents an update overview of clinical findings regarding herb-warfarin interaction, highlighting clinical outcomes, severity of documented interactions, and quality of clinical evidence. (hindawi.com)
  • Structural and functional insights into lysine acetylation of cytochrome c using mimetic point mutants. (us.es)
  • Identifying the membrane components needed for protection against this peptide type can therefore clarify how a complex vulnerable structure can be modified to be fit for a different functional scenario. (lu.se)
  • This interaction causes several events in the cell, which increase metabolism. (southbaychiro.com)
  • Due to their overly complex pathophysiology, interdisciplinary approaches and breakthrough science are highly needed to unravel disease mechanisms, and thus developing effective new therapies. (frontiersin.org)
  • Based on limited literature and information reported, we identified corresponding mechanisms of interactions for a small amount of "interacting herbs. (hindawi.com)
  • Although these interactions remain to be further examined in humans, the physiological functions of taurine appear to be inconsistent with the adverse cardiovascular symptoms associated with excessive consumption of caffeine-taurine containing beverages. (researchgate.net)
  • A structural switch controls the architecture of Vibrio cholerae biofilms by mediating the interactions between two matrix components. (elifesciences.org)
  • It is mediated by the Stt7/STN7 protein kinase, which is activated through the cytochrome b6f complex upon reduction of the plastoquinone pool. (unige.ch)
  • Our findings indicate that IGA for Cyt c reflected the indirect activity of complexes III and IV. (biologists.com)
  • quinone oxidoreductase complex (Fqo) is crucial in energy conservation in A. fulgidus during growth with lactate [ 13 ]. (hindawi.com)
  • Vigadrone (vigabatrin powder) is an anti-epileptic medicine ( anticonvulsant ) indicated as adjunctive therapy for adults and pediatric patients 10 years of age and older with refractory complex partial seizures who have inadequately responded to several alternative treatments and for whom the potential benefits outweigh the risk of vision loss. (rxlist.com)
  • Although the effects of caffeine excess have been widely studied, little information is available on potential interactions between the other active ingredients of energy drinks and caffeine. (researchgate.net)
  • In agreement with this conclusion, the European Union's Scientific Committee on Food published a report in March 2003 summarizing its investigation into potential interactions of the ingredients in energy drinks. (researchgate.net)
  • Herb-warfarin interaction has considerable clinical significance, so it is especially necessary to identify the herbs that interact with warfarin. (hindawi.com)
  • To form the higher-order oligomers that probably constitute the apoptotic pore complex, Bak dimers then interact via regions away from the BH3 domain and groove. (biologists.com)
  • Herbal medicines and food interaction are now cited as the main cause of adverse events with warfarin. (hindawi.com)
  • Use of tramadol for chronic pain or in the perioperative period requires an awareness of its unique pharmacology and special attention to the CYP450 polymorphism status, as well as an understanding of drug-drug interactions, to ensure adequate pain relief and avoidance of adverse drug effects. (medscape.com)
  • However, RbmA dimers cross-link VPS to form a more solid complex that is anchored into the matrix. (elifesciences.org)
  • Beside utilizing CO, A. fulgidus grows with H 2 and formate and a wide variety of simple and complex organic compounds [ 4 - 7 ]. (hindawi.com)
  • When the cytochrome c component absorbs the light, it stimulates energy production in the form of ATP. (southbaychiro.com)
  • Significant interaction terms indicated that the associations between PCB levels and having ever eaten locally raised livestock and local clay were much stronger among African-Americans than among White participants. (cdc.gov)
  • Previous ensemble studies have shown that cyanobacteria respond to changes in nutrient availability by modifying the structure of PBS complexes, but this process has not been visualized for individual pigments at the single-cell level due to spectral overlap. (osti.gov)
  • In absence of good evidence, speculation has taken its place, and poor quality of available information in turn restricts future study of herb-warfarin interaction. (hindawi.com)
  • However, removing RbmA led to visually similar biofilms, despite the absence of the cross-linked protein complexes. (elifesciences.org)
  • At the cardiovascular level, they concluded that 'if there are any interactions between caffeine and taurine, taurine might reduce the cardiovascular effects of caffeine. (researchgate.net)
  • The age-adjusted incidences for simple and complex partial and generalized tonic-clonic seizures are higher for men than women. (medscape.com)