It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor for entry into respiratory epithelium. (wikipedia.org)
Ceramide further recruited the complement receptor 3 (CD11b/CD18) and CD36 into proximity of CD14. (unideb.hu)
Here, we show that the blood protein fibrinogen induces spine elimination and promotes cognitive deficits mediated by CD11b-CD18 microglia activation. (stanford.edu)
Three CD11 alpha chains and a common CD18 beta chain form heterodimer transmembrane complexes (CD11a/CD18, CD11b/CD18, CD11c/CD18). (medscape.com)
CD11a/CD18 is also known as leukocyte factor antigen-1 (LFA-1), CD11b/CD18 is known as CR3, and CD11c/CD18 is known as CR4. (medscape.com)
Ligands for CD11a/CD18 are intercellular adhesion molecules (ICAMs), ligands for CD11b/CD18 are complement C3bi and ICAMs, and ligands for CD11c/CD18 are C3bi and ICAMs. (medscape.com)
CD18 deficiency results in loss of expression of LFA-1, CR3 (CD11b/CD18), and CR4 (CD11c/CD18) (see Table 3). (medscape.com)
The increased adherence of activated heterophils can be partially blocked by either anti-alpha M (CD11b) or anti-beta 2 (CD18) antibodies in a dose dependent manner. (tamu.edu)
However, antibodies to the Mac-1 complex (CD11b/CD18) block only the adherence of SE-ILK-stimulated heterophils. (tamu.edu)
Thus, the CD11b/CD18 heterodimer is apparently up regulated in response to the injected SE-ILK and plays a major role in the adherence of activated heterophils. (tamu.edu)
Galectin-3 interacts with carbohydrates, such as N-acetyllactosamine, certain cell surface receptors (such as macrophage CD11b/CD18) and extracellular receptors (such as collagen). (healthmatters.io)
Neutrophils were freshly isolated from blood of 10 male healthy volunteers, stimulated the same way as endothelial cells and analyzed for surface expression of L-selectin, CD11b and CD18. (biomedcentral.com)
Generation of recombinant fragments of CD11b expressing the functional β-glucan-binding lectin site of CR3 (CD11b/CD18). (southernbiotech.com)
CD11a3
In association with CD18, the CD11a/CD18 complex forms LFA-1. (biolegend.com)
The interaction of CD54 and the corresponding ligand CD11a/CD18 expressed on γδ T cells is responsible for triggering effector function in γδ T cells. (aacrjournals.org)
CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
Integrin5
The CD11/CD18 complex is part of the beta-2 integrin family and is important in adhesion and phagocytosis (see Table 1). (medscape.com)
We examined the mechanism of adherence within the avian heterophil system using an in vitro bovine serum albumin (BSA) matrix in which neutrophil adherence is primarily CD11/CD18 integrin mediated in mammalian systems. (tamu.edu)
Background: It recognizes a transmembrane glycoprotein of 95kDa, identified as CD18 or integrin -2 (Workshop III). (m-entrepreneurship.com)
The deficiency of leukocyte integrin CD18-β subunit is caused by an autosomal recessive mutation in the integrin β-2 subunit ( ITBG2 ) gene. (basepaws.com)
While CD18 null mice have been used to investigate the function of CD18 in allergic asthma, studies on four integrins have been previously restricted to these employing monoclonal antibodies or other inhibitors of four integrin. (sodiumchannel-signal.com)
Integrins2
Together, CD11 and CD18 form CD11/CD18 integrins, which are expressed on all leukocytes' surface membranes. (basepaws.com)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
Antigens1
The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
Heterodimer1
This subunit of the CD18 protein forms a heterodimer (a complex composed of two different proteins) with one of 4 different α-subunits of the CD11 protein. (basepaws.com)
Subunit1
Cats affected with LAD1 suffer from a deficiency of the β subunit of CD18. (basepaws.com)
Receptor1
The different receptor complexes may be linked to ligand-specific cellular responses initiated by CD14. (unideb.hu)
Leukocyte adhesion d3
Of the 8 plasma membrane receptors for complement, only deficiencies of CR3 and CR4 due to CD18 deficiency have been described, known as leukocyte adhesion deficiency (LAD) type 1. (medscape.com)
This 3-year-old girl had leukocyte adhesion deficiency type I (LAD I) with complete absence of CD18 expression. (medscape.com)
Variants of leukocyte adhesion deficiency have also been reported, including fully expressed but nonfunctional CD18 and an E selectin that is expressed but rapidly cleaved from the cell surface (only present in soluble form). (medscape.com)
Complement1
C3 cleavage may result in formation of the membrane attack complex (MAC), the cytotoxic component of the complement system. (msdmanuals.com)
Deficiency1
8] Deficiency of CD18 on phagocytic cells causes LAD type 1 (see Table 2). (medscape.com)
Lymphocytes1
However, PE-Cy5 conjugated reagents should not be used to stain splenocytes of SJL, NOD, and MRL mice as B lymphocytes and/or other leukocytes have been reported to non-specifically stain regardless of the use of Mouse BD Fc Block™ (the CD72c complex has been implicated for PE-Cy5 binding in these strains). (bdbiosciences.com)
Adhesion4
These findings support the notion that the newly uncovered properties of ALP to interfere with cytokine signalling and upregulation of adhesion molecules in endothelial cells are likely to contribute to the therapeutic potential of ALP in immune-complex-induced tissue injury. (biomedcentral.com)
CD18/CD11 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses. (m-entrepreneurship.com)
An important protein crucial for successful adhesion and cell surface signaling of neutrophils is CD18. (basepaws.com)
Structure and Function of the Leukocyte Adhesion Molecules CD11/CD18. (basepaws.com)
Molecules1
Isotype-matched control mAbs against other DC molecules including CD18, CD31, and major histocompatibility complex I did not block. (rockefeller.edu)
Cells3
Immune cells abundantly infiltrate tumors, creating a complex environment mediated by repetitive cycles of antitumor responses and immune evasion ( 1 ). (frontiersin.org)
Applications: Functional Activity (Order SAF formulation)Flow Cytometry: 0.5-1 ug/million cells in 0.1mlImmunofluorescence: 0.5-1 ug/mlOptimal dilution of the CD18 antibody should be determined by the researcher. (m-entrepreneurship.com)
We have previously reported that GRN163L could shorten telomeres and limit the lifespan of CD18/HPAF and CAPAN1 pancreatic cancer cells. (oncotarget.com)
Leukocytes1
Immunogen: Stimulated human leukocytes were used as the immunogen for the CD18 antibody. (m-entrepreneurship.com)
Associates1
CR2 associates with CD19 forming a CR2-CD19 complex when stimulated by C3d-bearing antigen engaging CR2. (medscape.com)
Proteins2
The human leukocyte antigen ( HLA ) is a gene complex that encodes the major histocompatibility complex ( MHC ) proteins . (amboss.com)
The regulation of complex and dynamic signal transduction proteins contributes to the destination of targeting proteins and the signal transduction of cell growth, and exposure to parasites can also influence signaling pathways. (biomedcentral.com)
Beta1
Although the I-like domain is located between the NTR and mid-region, its removal does not affect the folding of the beta(2) NTR/mid-region complex because this complex alone can be expressed as a soluble protein and precipitated by the appropriate mAbs. (amsterdamumc.org)
Cell1
The stability of peptide-MHC complex (pMHC) is an important factor to shape the fate of peptide-specific T cell immune response, but how it influences on T cell activation process is poorly understood. (molcells.org)
Function2
These results suggest that the NTR/mid-region complex is involved in the regulation of LFA-1 function. (amsterdamumc.org)
The telomerase inhibitory function of this complex can be enhanced by drugs that block the poly(ADP-ribosyl)ation of its TRF1 and/or TRF2 subunits. (oncotarget.com)
Intracellular1
Galectins play an important and complex role in intracellular pathways and disease mechanisms. (healthmatters.io)
Incidence1
The reasons for this high incidence are very complex. (biomedcentral.com)
Réunion Island, an overseas department of France, Processus Infectieux en Milieu Insulaire Tropical, University of La where cases emerged in 2015 ( 6 , 7 ). (cdc.gov)
Access1
The Shelterin complex is a telomere-associated complex that limits the access of telomerase to telomeres. (oncotarget.com)
Topics1
All Osmosis Notes are clearly laid-out and contain striking images, tables, and diagrams to help visual learners understand complex topics quickly and efficiently. (osmosis.org)