Complexes can induce. Medical search. Frequent questions

Priming the udder of cows with LPS was shown to induce ET in mammary epithelial cells (MEC), thereby protecting the udder against reinfection for some time. (uni-muenchen.de)
Yurt overexpression thus induces apical constriction in epithelial cells. (elifesciences.org)

We previously reported how the NLRP3 Goal2 and RIG-I inflammasomes are triggered in nasopharyngeal carcinoma (NPC)2 (2) which end-binding proteins 1 (EB1) can be a novel element of these triggered inflammasome complexes (9). (cancer-pictures.org)
NLRP1 (NACHT and leucine-rich repeat-containing protein family, pyrin domain-containing protein 1) is an innate immune sensor that is involved in the formation of inflammasome complexes. (frontiersin.org)
NLRP1 is known to be activated by various stimuli to form NLRP1 inflammasome complexes ( 7 ). (frontiersin.org)

In glioma cells, the effects of TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) have been shown to induce DISC-mediated apoptosis. (wikipedia.org)
Cu3G is a Cu(II) complex of a photoactive tetradentate ligand that is cleaved upon UV irradiation to release Cu. Here we show that the cytotoxicity of Cu3G increases in response to brief UV stimulation to result in extensive cytoplasmic vacuolization that is indicative of nonapoptotic cell death. (duke.edu)
Reported in this review are the photochemical and photophysical properties of a group of symmetric, multinuclear complexes of the general form [L′(CN) 4 M(CN)-(PtL 4 )-(NC)-M(CN) 4 L′] n- (where M is a Group 8 metal, L is an amine, and L′ is a σ-donor ligand) that provide for apparent photoinduced multielectron charge transfer. (princeton.edu)
Of the complexes, 1 and 3 are purely metal hydrazone complexes whereas 2 and 4 incorporate coordinated pseudohalides in their crystal structures, and 4 shows different coordination modes of the hydrazone ligand. (uea.ac.uk)
Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation. (baistructurelab.org)
wp-content/uploads/2019/10/clear.png 0 0 Academic Web Pages /wp-content/uploads/2019/10/clear.png Academic Web Pages 2020-04-23 18:56:50 2021-09-21 18:58:06 Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation. (baistructurelab.org)

The death-inducing signaling complex or DISC is a multi-protein complex formed by members of the death receptor family of apoptosis-inducing cellular receptors. (wikipedia.org)
In this review we describe the cellular and molecular mechanisms underlying complex-learning-induced long-lasting modifications in GABA A -receptors and GABA B -receptor-mediated synaptic inhibition. (haifa.ac.il)
Inflammasomes are multi-protein complexes that comprise Ginsenoside Rf receptors (NLPR3 Goal2 and NLRC4) an adaptive proteins ASC and procaspase 1. (cancer-pictures.org)

Pre-treating MEC with various inhibitors of histone H3 modifiers (for demethylation, acetylation or deacetylation) all failed to induce any of the protective factors and only resulted in some dampening of cytokine gene expression after the re-challenge. (uni-muenchen.de)
We demonstrate in cultured cells and a patient-derived xenograft model that small-molecule inhibitors of lactate dehydrogenase selectively induce an ATP crisis and cell death in HTC. (figshare.com)
Administration of CCN1 protein or soluble JAG1 induced cholangiocyte proliferation in mice, which was blocked by inhibitors of NF-κB or NOTCH signaling. (jci.org)

We generated Nlrp1b (the mouse homologue of human NLRP1 ) gain-of-function knock-in ( Nlrp1b KI) mice with UVB irradiation-induced autoinflammatory skin lesions. (frontiersin.org)
We demonstrated that UVB irradiation induces IL-1β upregulation and IL-1β-dependent inflammation via caspase-1 activation in these Nlrp1b KI mice. (frontiersin.org)

The protein Yurt limits the ability of Crumbs to promote apical membrane growth, thereby defining proper apical/lateral membrane ratio that is crucial for forming and maintaining complex epithelial structures such as tubes or acini. (elifesciences.org)
The protein product of C15orf48 is structurally related to NDUFA 4, and replaces NDUFA 4 in the CcO complex. (ox.ac.uk)

We report here that Hürthle cell carcinoma of the thyroid (HTC) models harboring mitochondrial DNA-encoded defects in complex I of the mitochondrial electron transport chain exhibit impaired respiration and alterations in glucose metabolism. (figshare.com)

Biochemical analyses demonstrated that poly(dA-dT)-triggered Goal2 inflammasomes induce autophagy and IL-1β secretion within an LC3-reliant fashion. (cancer-pictures.org)

The CAP proteins associate only with the oligomerized version of APO-1 when forming the complex. (wikipedia.org)
Finally we discovered that the 5′-AMP triggered proteins kinase may regulate this EB1-mediated autophagy-based inflammasome-induced secretion of IL-1β. (cancer-pictures.org)

CRISPR-Cas9 pooled screening identified glycolytic enzymes as selectively essential in complex I-mutant HTC cells. (figshare.com)

Some of the induced genes, such as CREM, CHOP, and MAP kinase phosphatase-1, may be components of a homeostatic response to excessive stimulation. (jneurosci.org)

This is the first time to our knowledge that substantial RH5-specific responses have been induced by immunization in humans, with levels greatly exceeding the serum antibody responses observed in African adults following years of natural malaria exposure. (jci.org)
Immunization is a more inclusive term denoting the process of inducing or providing immunity artificially by administering an immunobiologic. (cdc.gov)

One example is dynorphin gene expression, which is progressively induced in dorsal striatum by cocaine. (jneurosci.org)
Isolation of 10 differentially expressed cDNAs in differentiated Neuro2a cells induced through controlled expression of the GD3 synthase gene. (nih.gov)
The C15orf48 gene is consistently induced by pro-inflammatory stimuli in many cell types, but has been little studied, and its systematic name provides little clue to its function. (ox.ac.uk)
Tuberous sclerosis complex (TSC) is an autosomal-dominant tumor suppressor gene syndrome that is characterized by the development of distinctive benign tumors and malformations in multiple organ systems (N Eng J Med 3551345-1356, 2006). (bvsalud.org)

Kume, S, Kuroiwa, K & Kimizuka, N 2006, ' Photoresponsive molecular wires of Fe II triazole complexes in organic media and light-induced morphological transformations ', Chemical Communications , no. 23, pp. 2442-2444. (elsevierpure.com)
The dispersion of STPN in P(MMA-co-IA) was highly improved in comparison with the rare earth organic complex of Sm(TTA)3Phen without hydrogen bonding. (edu.au)

The corresponding Ni II -dimethyl complexes exhibit accessible oxidation potentials, and their oxidation generates Ni III species that were characterized by EPR and X-ray crystallography. (illinois.edu)
Moreover, the Ni II -dimethyl complexes exhibit selective ethane formation upon oxidatively induced reductive elimination using various oxidants - including O 2 and H 2 O 2 , without the generation of any C-heteroatom products. (illinois.edu)
Moreover, the NiII-dimethyl complexes exhibit selective ethane formation upon oxidatively induced reductive elimination using various oxidants - including O2 and H2O2, without the generation of any C-heteroatom products. (illinois.edu)
These complexes exhibit intense intervalence charge transfer (IVCT) bands in the blue portion of the optical spectrum (350-450 nm). (princeton.edu)

Here, we report that PSMA is localized to a membrane compartment in the vicinity of mitotic spindle poles and associates with the anaphase-promoting complex (APC). (nih.gov)
Silencing of the SAC during metaphase activates the ubiquitin ligase APC/C (anaphase-promoting complex, also known as the cyclosome) and results in the proteasomal destruction of the separase inhibitor securin 1 . (nature.com)

Procaspase-8 activation is thought to occur through a dimerization process with other procaspase-8 molecules, known as an induced proximity model. (wikipedia.org)
Fundamental studies of photoelectrochemical processes in complex materials, including photophysics and photochemistry of light-harvesting and light-emitting molecules, as well as energy and electron transfer processes in supramolecular systems and molecular-semiconductor hybrid nanomaterials. (lu.se)

The Streptococcus bovis/Streptococcus equinus complex (SBSEC) contains known IE-pathogens, but there is limited research on the different subspecies ability to interact with platelets and what signaling pathways are involved. (lu.se)
This study reports that 22 of 26 tested isolates of different subspecies within SBSEC can induce aggregation, and that aggregation is host dependent. (lu.se)
This shortcoming is partly because of the inability of currently available laboratory and in silico tools to accurately identify all subspecies of the Mycobacterium tuberculosis complex (MTBC). (cdc.gov)

The reactivity of these complexes as a function of Group 8 metal and solvent system is nicely predicted using the charge transfer theories of Marcus and Hush, with the source of the differential reactivity being the shift in the relative activation barriers for the conversion of a one-electron [Fe III , Pt III , Fe II ] intermediate to the observed two-electron products or to the starting material. (princeton.edu)

This work demonstrates that complex I loss exposes fermentation as a therapeutic target in HTC and has implications for other tumors bearing mutations that irreversibly damage mitochondrial respiration. (figshare.com)
HTC is enriched in somatic mtDNA mutations predicted to affect complex I of the electron transport chain (ETC). We demonstrate that these mutations impair respiration and induce a therapeutically tractable reliance on aerobic fermentation for cell survival. (figshare.com)

photoisomerization of azobenzene units induced morphological changes that lead to reversible, macroscopic gel-to-sol transition phenomena. (elsevierpure.com)

Tetradentate pyridinophane ligands have been shown to stabilize uncommon high-valent palladium and nickel organometallic complexes. (illinois.edu)

Potentiation of noise-induced hearing loss by low concentrations of hydrogen cyanide in rats. (cdc.gov)
1989. Hexachlorobenzene-induced hyperthyroidism and osteosclerosis in rats. (cdc.gov)

The bis-imidazophenanthroline copper(ii) complexes, viz. (edu.in)
The copper(ii)-based d-d band was observed near 600 nm in DMF-Tris-HCl buffer (1:1 v/v). The ferrocenyl complexes showed low dark toxicity, but remarkably high photocytotoxicity in human cervical HeLa and human breast adenocarcinoma MCF-7 cancer cells giving an excellent photo-dynamic effect while their phenyl analogues were inactive. (edu.in)
Scholars@Duke publication: Light uncages a copper complex to induce nonapoptotic cell death. (duke.edu)

Inflammation-induced reprogramming of the mitochondrial cytochrome c oxidase complex: mechanisms and consequences. (ox.ac.uk)

Overall, these results suggest that the ( R N4)Ni II Me 2 complexes with more weakly donating axial ligands are more reactive toward ethane formation, likely due to destabilization of the corresponding high-valent Ni intermediates and formation of 5- and 4-coordinate conformations for these Ni species. (illinois.edu)

This study demonstrates that light induced 3D printing and microwave-induced chemistry can be used together effectively, and used to produce functional devices. (polito.it)

This association leads to the formation of the DISC, thereby inducing apoptosis. (wikipedia.org)
Increased cytoplasmic β-catenin levels and the associated nuclear β-catenin/T-cell factor (Tcf)-lymphoid enhancer factor (LEF)complex formation have been frequently found in colon cancer. (aacrjournals.org)
Addition of PCer (2.5-10 nmol) to the POPC:PSM (80:20 by nmol) bilayersattenuated StnII-induced pore formation, again in a concentration-dependent fashion. (abo.fi)
Après des études de médecine à l'Université de Genève et une formation clinique en pathologie, médecine interne et maladies infectieuses à Genève et au Massachusetts General Hospital de Boston, Didier Trono s'engage dans une carrière scientifique au Whitehead Institute du MIT. (epfl.ch)

Pre-incubation of MEC with Pam2CSK4 enhanced baseline and induced expression of bactericidal (beta-defensin;SLPI) and membrane protecting factors (SAA3, TGM3), while reducing the expression of cytokine-and chemokine-encoding genes (TNF, IL1 beta) after a subsequent pathogen challenge, the latter, however, not as efficiently as after LPS priming. (uni-muenchen.de)

These findings demonstrate that CCN1 induces cholangiocyte proliferation and ductular reaction and identify CCN1/α v β 5 /NF-κB/JAG1 as a critical axis for biliary injury repair. (jci.org)

Fundamental aspects of chemical reactions and complex molecular processes in extreme environments relevant is presented in a popular science presentation entitled "The molecular evolution of the universe" loosely based on the book chapter "Molecular awakenings" ("Molekylära uppvaknanden" in Swedish) in P. Persson, in Liv - Utomjordiskt, Syntetiskt, Artificiellt , J. Abbott and E. Persson (Eds. (lu.se)

Vaccine-induced anti-RH5 serum antibodies exhibited cross-strain functional growth inhibition activity (GIA) in vitro, targeted linear and conformational epitopes within RH5, and inhibited key interactions within the RH5 invasion complex. (jci.org)
Didier Trono s'est beaucoup intéressé aux interactions entre les virus et leurs hôtes, ce qui l'a conduit à étudier la biologie de pathogènes comme le VIH et le virus de l''hépatite B, et à créer des outils de transfert génétique dérivés du VIH aujourd'hui utilisés avec succès en thérapie génique. (epfl.ch)

We report upon a 46-year-old woman, who developed immune complex disease after treatment with clonidine for one year. (medicaljournals.se)
Hence, triggering immune functions via the TLR axis, but not through those histone modifiers, induced the beneficial phenomenon of ET in MEC. (uni-muenchen.de)

The inflammasome complex subsequently activates Casp-1, which in turn initiates downstream responses, including the maturation and release of interleukin-1β (IL-1β) and IL-18 ( 4 , 5 , 10 , 11 ). (frontiersin.org)

Noise-induced hearing loss is the most prevalent occupational injury in the United States despite the adoption of clear permissible exposure limits and protocols for hearing conservation. (cdc.gov)
This study identifies low-level chemical asphyxiant exposure as a risk factor capable of potentiating noise-induced hearing loss. (cdc.gov)
The lower bound to the HCN dose that produced a 1 SD elevation in noise-induced hearing loss was 16 ppm. (cdc.gov)
Estimation of occupational noise -induced hearing loss using kurtosis-adjusted noise exposure levels. (cdc.gov)
Design: In this study, the combined effects of energy and kurtosis on noise -induced hearing loss (NIHL) were investigated using data collected from 2601 Chinese workers exposed to various industrial noises. (cdc.gov)
Noise -induced permanent threshold shift at test frequencies 3, 4, and 6 kHz (NIPTS346) was used as the indicator of NIHL. (cdc.gov)
When LAeq,8h is below 70 dBA, neither continuous noise nor complex noise produced significant NIPTS346. (cdc.gov)
Conclusions: Because non-Gaussian complex noise is ubiquitous in many industries, the temporal characteristics of noise (i.e., kurtosis) must be taken into account in evaluating occupational NIHL. (cdc.gov)

Il participe aujourd'hui activement à la coordination des efforts de la Suisse en vue de l'intégration des nouvelles technologies dans le domaine de la médecine de précision et de la santé personnalisée. (epfl.ch)

These investigations uncover a mechanism whereby a HFD-induced adipocyte/ART dialog involving MHCII instigates adipose inflammation and, together with ATM MHCII, escalates its progression. (nih.gov)

Light- induced polymeric 3D printing is becoming a well-established fabrication method, showing manifold advantages such as control of the local chemistry of the manufactured devices. (polito.it)
A research project to develop and characterize "Photofunctional Iron Complexes" involving the Theoretical Chemistry Division at Lund University has been awarded 35,000,000 SEK in funding from the Knut and Alice Wallenberg Foundation for the five-year period 2020 - 2024. (lu.se)

Further, expression of PSMA in a karyotypically stable cell line induces aneuploidy. (nih.gov)
The induced mRNAs include both novel and previously described genes, with diverse time courses of expression. (jneurosci.org)
miR-147b specifically decreases expression of NDUFA 4, a component of the mitochondrial cytochrome c oxidase (CcO) complex. (ox.ac.uk)
CCN1 also induced Jag1 expression in hepatic stellate cells, whereupon they interacted with hepatic progenitor cells to promote their differentiation into cholangiocytes. (jci.org)

In this work 3D printing is combined with another green technology, microwave-assisted reaction, to fabricate objects of complex geometry with controllable surface properties, exploiting the presence of remaining functional groups on the surface of 3D printed specimens. (polito.it)

Environmentally Induced Population Movements: Their Complex Sources and Consequences. (researcher.life)
K Skivington and evaluating complex interventions have consequences for health. (cancercentrum.se)

The kurtosis-adjusted LAeq,8h better estimated hearing loss caused by various complex noises. (cdc.gov)

A very similar set of genes is induced in unlesioned animals by administration of the psychostimulant cocaine or the antipsychotic eticlopride, although in distinct striatal cell populations. (jneurosci.org)

The physiology of hemostasis is remarkably complex and reflects a fine balance between an uninterrupted flow of blood (ie, fluid) and a rapid, localized response to vascular injury (ie, clotting). (medscape.com)

The capacity for bacteria-induced platelet aggregation was also shown to be transferable between donors through serum. (lu.se)
NLR family pyrin domain-containing 1 (NLRP1), encoded by NLRP1 , was the first NLR to be shown to form an inflammasome complex ( 3 , 4 ). (frontiersin.org)

We currently focus on ultrafast light-induced processes in earth-abundant photocatalytic systems in collaboration with colleagues at the Chemical Physics Division at Lund University. (lu.se)

MW-functionalized filter-type structures have been tested against Staphylococcus aureus bacteria, showing high bactericidal activity on the surface along all areas of the complex-shaped structure. (polito.it)
The complexes are characterized by IR, UV-Vis spectroscopy and cyclic voltammetric studies and the structures are conclusively established by single crystal X-ray diffraction study. (uea.ac.uk)

UK Medical Research Council (MRC) published a takes account of recent developments framework for researchers and research funders on developing and evaluating complex interventions in in theory and methods and the need to 2000 and revised guidance in 2006.1-3 Although these maximise the efficiency, use, and documents continue to be widely used and are now impact of research. (cancercentrum.se)

The properties of good transparency, fluorescence and near-infrared light induced shape-recovery were also achieved. (edu.au)
This work provides an approach to prepare novel SMPCs with different properties including high strength, fluorescence, and light-induced shape-recovery. (edu.au)

Hence, the complex interplay between Yurt, aPKC, Pak1 and PP2A contributes to the functional plasticity of Crumbs. (elifesciences.org)

Here, we describe class II major histocompatibility complex (MHCII) as an important component of high-fat-diet (HFD)-induced obesity. (nih.gov)

Phosphorescent materials are mostly based on metal complexes. (rsc.org)

Anatomy20

Organisms10

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes62

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Health Care1

Epithelial cells2

Inflammasome complexes3

Ligand6

Receptors3

Inhibitors3

Irradiation2

Protein2

Metabolism1

Inflammasomes1

Proteins2

Selectively1

Kinase1

Immunization2

Gene4

Organic2

Exhibit4

Anaphase-promoti2

Molecules2

Subspecies3

Solvent1

Mutations2

Reversible1

Tetradentate1

Rats2

Copper3

Mechanisms1

Ligands1

Demonstrates1

Formation4

Membrane1

Findings1

Molecular1

Interactions2

Immune2

Downstream1

Noise8

Coordination1

Inflammation1

Chemistry2

Expression4

Presence1

Consequences2

Hearing1

Cell1

Remarkably1

Shown2

Processes1

Structures2

Framework1

Light2

Contributes1

Describe1

Metal1