Complexes binds n ethylmaleimide sensitive proteins. Medical search. Frequent questions

A vesicle trafficking protein αSNAP regulates Paneth cell differentiation in vivo. (nih.gov)
According to this model, membrane proteins from the vesicle (v-SNAREs) and proteins from the target membrane (t-SNAREs) govern the specificity of vesicle targeting and docking through mutual recognition. (wikipedia.org)
To achieve this, the neuronal SNARE (i.e., soluble N -ethylmaleimide-sensitive factor attachment protein receptor) complex brings the vesicle and presynaptic membranes in close proximity, thereby, mediating the fusion of the two membranes resulting in exocytosis of neurotransmitters. (nature.com)
750 kDa), conserved macromolecular machines that are essential for soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-mediated membrane fusion in all eukaryotes.MTCs are thought to organizemembrane trafficking by mediating the initial long-range interaction between a vesicle and its target membrane and promoting the formation of membrane-bridging SNARE complexes. (princeton.edu)
This structure suggests how theDsl1 complex might tether a vesicle to its target membrane by binding at one end to the COPI coat and at the other to ER-associated SNAREs. (princeton.edu)
Key interacting proteins of the plasma membrane, the cytosol and the vesicle membrane which function in the membrane fusion pathway, have been identified in a variety of cell types and characterized at the molecular level [10-14] . (ommegaonline.org)
Munc18-1 also binds to synaptobrevin, forming a template to assemble the SNARE complex when Munc13-1 opens syntaxin-1 while bridging the vesicle and plasma membranes. (elsevierpure.com)
More than 90% of extracellular miRNAs are vesicle-free, but form a complex with proteins such as Agonaute2 (AGO2) ( 22 , 23 ). (frontiersin.org)
The controversy would be solved if binding to closed syntaxin1 were shown to be stimulatory for vesicle fusion and/or additional essential interactions were identified between Munc18-1 and the fusion machinery. (jneurosci.org)
A mutation that diminished Munc18 binding to syntaxin1 in vitro attenuated the vesicle-docking step but rescued vesicle priming in excess of docking. (jneurosci.org)
Conversely, expressing the Munc18-2 isoform, which also displays binding to closed syntaxin1, rescued vesicle docking identical with Munc18-1 but impaired more downstream vesicle priming steps. (jneurosci.org)
In conclusion, binding of Munc18-1 to closed syntaxin1 stimulates vesicle docking and a distinct interaction mode regulates the consecutive priming step. (jneurosci.org)
In a third model, Munc18-1 actively promotes SNARE complex formation and vesicle fusion. (jneurosci.org)
However, the use of mutant expression in the presence of endogenous protein left it unclear how the observed effects were related to the defect of vesicle docking in (M)unc18-1 knock-outs. (jneurosci.org)
The results show that vesicle docking correlates with the ability of Munc18-1 to bind to closed syntaxin1. (jneurosci.org)
Vesicle-associated membrane proteins 721 and 722 (VAMP721/722) are secretory vesicle-localized arginine-conserved soluble N -ethylmaleimide-sensitive factor attachment protein receptors (R-SNAREs) to drive exocytosis in plants. (molcells.org)
We have found that the calcium-activated protein for secretion (CAPS) protein is required for dense core vesicle docking but not synaptic vesicle docking. (rupress.org)
CAPS function in dense core vesicle docking parallels UNC-13 in synaptic vesicle docking, which suggests that these related proteins act similarly to promote docking of independent vesicle populations. (rupress.org)

The SNARE complex assembles from vesicular Synaptobrevin-2 as well as Syntaxin-1 and SNAP25 both anchored to the presynaptic membrane. (nature.com)
While the general sequence of SNARE complex formation is well-established, our knowledge on possible intermediates and stable off-pathway complexes is incomplete. (nature.com)
We, therefore, follow the stepwise assembly of the SNARE complex and target individual SNAREs, binary sub-complexes, the ternary SNARE complex as well as interactions with Complexin-1. (nature.com)
Importantly, we find that interactions with Complexin-1 reduce multimerisation of the ternary SNARE complex. (nature.com)
In summary, we unravel the stoichiometry of intermediates and off-pathway complexes and compile a road map of SNARE complex assembly including regulation by Complexin-1. (nature.com)
Accordingly, Syntaxin-1 and Synaptobrevin-2 each contribute one and SNAP25 contributes two alpha-helices to the ternary SNARE complex. (nature.com)
Based on the presence of glutamine or arginine residues in the zero layer, the SNAREs are classified as Qa- (Syntaxin-1), Qb- and Qc- (SNAP25) or R-SNAREs (Synaptobrevin-2) resulting in the formation of the ternary QabcR (3Q:1R) SNARE complex 8 . (nature.com)
Biphasic glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells involves soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptor (SNARE) proteinregulated exocytosis. (ttu.edu)
SNARE complex assembly further requires the regulatory proteinsMunc18c,Munc18-1 and Doc2b. (ttu.edu)
We found that distal regions of each leg bind N-terminal Habc domains of the ER SNAREs Sec20 (a Qb-SNARE) and Use1 (a Qc-SNARE). (princeton.edu)
The observed binding modes appear to anchor the Dsl1 complex to the ER target membrane while simultaneously ensuring that both SNAREs are in open conformations, with their SNARE motifs available for assembly. (princeton.edu)
The proximity of the two SNARE motifs, and therefore their ability to enter the same SNARE complex, will depend on the relative orientation of the two Dsl1 legs. (princeton.edu)
Syntaxins are membrane integrated Q-SNARE proteins known to participate in exocytosis. (ommegaonline.org)
Although the members of Q-SNARE proteins are characterized in somatic cells, it is not known whether related proteins function in the sperm acrosome reaction. (ommegaonline.org)
In this model, the soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor (SNARE) proteins syntaxin-1, SNAP-25, and synaptobrevin form tight complexes that bring the membranes together and are crucial for membrane fusion. (elsevierpure.com)
NSF and SNAPs disassemble SNARE complexes and ensure that fusion occurs through an exquisitely regulated pathway that starts with Munc18-1 bound to a closed conformation of syntaxin-1. (elsevierpure.com)
Synaptotagmin-1 and complexin bind to partially assembled SNARE complexes, likely stabilizing them and preventing fusion until Ca2+ binding to synaptotagmin-1 causes dissociation from the SNARE complex and induces interactions with phospholipids that help trigger release. (elsevierpure.com)
Membrane mix inside endomembrane technique comes after a detailed purchase associated with events: membrane tethering, mediated by Rabs and also tethers, assemblage regarding disolveable N-ethylmaleimide-sensitive factor (NSF) attachment health proteins receptor (SNARE) buildings, and also lipid bilayer combining. (notes.io)
Furthermore, many of us noticed which Vps16, Vps18, as well as the Sec1/Munc18 proteins Vps33, which part of the HOPS complex, hole towards the Q-SNARE complicated. (notes.io)
Exocytosis of secretory or synaptic vesicles is executed by a mechanism including the SNARE (soluble N -ethylmaleimide-sensitive factor attachment protein receptor) proteins. (jneurosci.org)
This inhibition reflects the binding of Munc18-1 to a closed conformation of the target-SNARE syntaxin1. (jneurosci.org)
Using this framework to analyze the SM (Sec1/Munc18)-SNARE ( N -ethylmaleimide-sensitive factor activating protein receptor) system in exocytic membrane fusion in yeast and neurons, we find that the SM-SNARE network motifs of yeast and neurons show distinct dynamical behaviors. (biomedcentral.com)
We identify the closed binding mode of neuronal SM (Munc18-1) and SNARE (syntaxin-1) as the key factor leading to mechanistic divergence of membrane fusion systems in yeast and neurons. (biomedcentral.com)
SNAREs (N-ethylmaleimide-sensitive factor adaptor protein receptors) are small polypeptides characterized by a particular domain, the SNARE motif, that can form a coiled-coil structure. (unisalento.it)
Via hetero-oligomeric interactions, these proteins form highly stable protein-protein interactions, the so called SNARE-complex, that allow membrane fusion. (unisalento.it)
SNAREs also interact with several proteins acting as regulators of SNARE-complex formation. (unisalento.it)
In fact, few SNARE proteins are known to interact with ion channels, notably mammalian Syntaxin 1A, which binds several different Ca2+ and K+ channels in nerves. (unisalento.it)
Here we show that AtSYP51 interacts directly with a non-SNARE protein, AtNLM1, probably regulating autophagocytosis processes. (unisalento.it)
2011) The Dsl1 Tethering Complex Actively Participates in Soluble NSF (N-Ethylmaleimide-sensitive Factor) Attachment Protein Receptor (SNARE) Complex Assembly at the Endoplasmic Reticulum in Saccharomyces cerevisiae. (columbiabiosciences.com)
To overcome energetically unfavorable lipid fusion, they form a SNARE complex in which four α-helices are bundled. (molcells.org)
The SYP121-SNAP33-VAMP721/722 ternary SNARE complex drives an immune exocytosis. (molcells.org)
strongly suggests that at least one regulatory protein should control the SNARE complex formation of VAMP721/722 with a specific Qa-SNARE in a particular biological process in plants. (molcells.org)
by binding to the N-terminus of respective Qa-SNARE. (molcells.org)
Both the CAPS and UNC-13 docking pathways converge on syntaxin, a component of the SNARE (soluble N -ethyl-maleimide-sensitive fusion protein attachment receptor) complex. (rupress.org)

and the cytosolic proteins N-ethylmalemide sensitive factor (NSF), a trimeric ATPase required for membrane fusion, and the α-β-Y-SNAPs (soluble NSF attachment proteins), which function in binding NSF to the membrane [10,14] . (ommegaonline.org)
By combining lipidomics and molecular dynamic simulations the authors show that oxidatively truncated (ox-tr) triacylglycerides accumulate in large lipid droplets of tumour-associated mouse DCs, and that these highly electrophilic species are predicted to preferentially occupy the droplet surface where they can directly access cytosolic proteins. (biomedcentral.com)

In the trans-Golgi network (TGN), phosphorylated lysosomal enzymes bind to M-6-P receptors, which direct the enzymes into clathrin-coated vesicles. (biomedcentral.com)
Transmitter receptors reveal segregation of the arcopallium/amygdala complex in pigeons (Columba livia). (uniklinik-duesseldorf.de)
G protein-coupled receptors (GPCRs) as well as heterotrimeric G proteins are also involved in regulating neurite outgrowth. (biomedcentral.com)
2009) Transforming Growth Factor beta can stimulate Smad1 phosphorylation independently of Bone Morphogenic Protein receptors. (columbiabiosciences.com)
Regulatory proteins that down-regulate phosphorylated G-protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors. (lookformedical.com)
A family of serine-threonine kinases that are specific for G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
The adrenergic beta-2 receptors are more sensitive to EPINEPHRINE than to NOREPINEPHRINE and have a high affinity for the agonist TERBUTALINE. (lookformedical.com)
A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS and a variety of other G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. (lookformedical.com)
The first layer of immunity, known as pathogen-associated molecular pattern- (PAMP-) triggered immunity (PTI), is activated following recognition of the fungal pattern molecule chitin, by four lysin motif- (LysM-) containing protein (LYP) receptors, i.e., chitin elicitor binding protein (CEBiP), chitin elicitor receptor kinase (CERK1), LYP4 and LYP6 (Shimizu et al. (biomedcentral.com)

Enables syntaxin binding activity. (nih.gov)
Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex. (nih.gov)
Platelets contain some of the same proteins, including NSF, p115/TAP, alpha-SNAP (this protein), gamma-SNAP, and the t-SNAREs syntaxin-2 and syntaxin-4, that are used in many vesicular transport processes in other cell types. (wikipedia.org)
These distinct Munc18-1 and Munc18c roles are related to their transient high-affinity binding with their cognate target (t-)SNAREs, Syntaxin 1A and Syntaxin 4 respectively. (ttu.edu)

Because Doc2b binds to Munc18-1 and Munc18c via its distinct C2A and C2B domains respectively, we hypothesized that Doc2b may provide a plasma membranelocalized scaffold/platform for transient docking of theseMunc18 isoforms during GSIS. (ttu.edu)
Towards this, macromolecular complexes composed of Munc18c, Doc2b and Munc18-1 were detected in β-cells. (ttu.edu)
Competitionbased GST-Doc2b interaction assays revealed that Doc2b could simultaneously bind both Munc18-1 and Munc18c. (ttu.edu)
This binding mode prompted the "negative regulator" hypothesis according to which Munc18-1 sequesters syntaxin1 and inhibits exocytosis. (jneurosci.org)
In plants, three groups of regulatory proteins such as Sec1/Munc18 (SM), small GTPase and synaptotagmin (SYT) have been studied for modulating the trafficking functionality of SNAREs. (molcells.org)

Once the 2 classes of SNAREs bind to each other, they form a complex that recruits the general elements of the fusion apparatus, namely NSF (N-ethylmaleimide-sensitive factor) and SNAPs (soluble NSF-attachment proteins), to the site of membrane fusion, thereby forming the 20S fusion complex. (wikipedia.org)

It was shown (1) that they may assemble to form non-fusogenic complexes acting as interfering-SNAREs or iSNARE (2) as in the case of AtSYP51 and SYP52. (unisalento.it)

N-ethylmaleimide-sensitive factor Attachment Protein Alpha, also known as SNAP-α, is a SNAP protein that is involved in the intra-cellular trafficking and fusing of vesicles to target membranes in cells. (wikipedia.org)
Fusion of synaptic vesicles with the presynaptic membrane occurs in the presence of the NSF (N-ethylmaleimide-sensitive-factor) / α-SNAP (α-soluble NSF attachment protein) disassembly machinery. (nature.com)
NGF is a neurotrophic factor critical for the survival and maintenance of sympathetic and sensory neurons, and it binds to the high-affinity tyrosine kinase receptor, TrkA, leading to its phosphorylation and the subsequent activation of PI3K/Akt/GSK3β pathways. (biomedcentral.com)
The M-type phospholipase A2 receptor (PLA2R), thrombospondin type 1 domain-containing 7A (TSHD7A), and neural epidermal growth factor-like 1 protein (NELL-1) are major autoantigens against podocyte antigens in idiopathic membranous nephropathy (IMN) [ 1 ]. (biomedcentral.com)

Altogether, our results demonstrate that βγ subunit of heterotrimeric G proteins play a critical role in neurite outgrowth and differentiation by interacting with MTs and modulating MT rearrangement. (biomedcentral.com)
They share a common structure and signal through HETEROTRIMERIC G-PROTEINS. (lookformedical.com)

It is a substrate recognition domain which binds polypeptides, prevents protein aggregation, and catalyses refolding of permissive substrates. (embl-heidelberg.de)

By capturing the evolutionary dynamics of target biological systems, the comparative modeling framework is empowered to (i) identify the functional roles of poorly characterized proteins and interactions and (ii) further decipher the underlying regulatory mechanisms of complicated cellular processes. (biomedcentral.com)
They are regulatory proteins that play a role in G-protein-coupled receptor densensitization. (lookformedical.com)

This process, termed cross-presentation, involves loading tumour-derived peptides onto major histocompatibility complex I (MHC-I) molecules. (biomedcentral.com)

The N-terminal domain of VCP acts as a binding site for a group of adaptor proteins through their Arg/Lys-rich peptide motifs. (eu.org)
Adaptor Proteins, Vesicular Transport" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found. (jefferson.edu)
This graph shows the total number of publications written about "Adaptor Proteins, Vesicular Transport" by people in this website by year, and whether "Adaptor Proteins, Vesicular Transport" was a major or minor topic of these publications. (jefferson.edu)
Below are the most recent publications written about "Adaptor Proteins, Vesicular Transport" by people in Profiles. (jefferson.edu)

ATPase N-ethylmaleimide-sensitive Fusion Protein: A Novel Key Player for Causing Spontaneous Network Excitation in Human Temporal Lobe Epilepsy. (uniklinik-duesseldorf.de)
This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. (embl-heidelberg.de)
The CDC48 N-terminal domain is a protein domain found in AAA ATPases including cell division protein 48 (CDC48), VCP-like ATPase (VAT) and N-ethylmaleimide sensitive fusion protein. (embl-heidelberg.de)
BACKGROUND: The VAT protein of the archaebacterium Thermoplasmaacidophilum, like all other members of the Cdc48/p97 family of AAAATPases, has two ATPase domains and a 185-residue amino-terminalsubstrate-recognition domain, VAT-N. VAT shows activity in protein foldingand unfolding and thus shares the common function of these ATPases indisassembly and/or degradation of protein complexes. (embl-heidelberg.de)
Riemer A, Dobrynin G, Dressler A, Bremer S, Soni A, Iliakis G, Meyer H. The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation. (jefferson.edu)
An AAA ATPase that binds and severs MICROTUBULES. (bvsalud.org)

Platelet exocytosis uses a molecular mechanism similar to that used by other secretory cells, such as neurons, although the proteins used by the platelet and their modes of regulation may be quite different. (wikipedia.org)

The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport. (lookformedical.com)

We propose that the binding site of the protein is similar tothat of aspartic proteinases, in that it lies between the psi-loops of theamino-terminal beta-barrel and that it coincides with a crescent-shapedband of positive charge extending across the upper face of the molecule. (embl-heidelberg.de)
Because we have shown earlier that prenylation and subsequent methylation/demethylation of γ subunits are required for the Gβγ-MTs interaction in vitro , small-molecule inhibitors (L-28 and L-23) targeting prenylated methylated protein methyl esterase (PMPMEase) were tested in the current study. (biomedcentral.com)
It is a complex consisting of a molecule of ROD OPSIN and a molecule of 11-cis retinal (RETINALDEHYDE). (lookformedical.com)
Here, we show that cyclin E/Cdk2 phosphorylates and stabilizes the pro-survival Bcl-2 family protein Mcl-1, a key cell death resistance determinant to the small molecule Bcl-2 family inhibitors ABT-199 and ABT-737, mimetics of the Bcl-2 homology domain 3 (BH3). (oncotarget.com)

VCP complexes are involved in many cellular processes, particularly in the endoplasmic reticulum (ER)‐associated degradation (ERAD) process for protein quality control, membrane trafficking, and DNA damage response. (eu.org)
The ERAD (ER-Associated Degradation) mechanism acts as a protein quality control and removes these misfolded proteins. (eu.org)
Nearly all ERAD substrates are ubiquitinated prior to their degradation and these ubiquitin chains provide a binding site for VCP (Valosin-Containing Protein). (eu.org)
And, a large number of protein biosynthesis, degradation and assembly-related were up-regulated by JA to promote tuber protein biosynthesis and maintain strict protein quality control during tuber development. (biomedcentral.com)

C-terminal PTS1 [(SAC)-(KRH)-(LM)] and N-terminal PTS2 [(RK)-(LIV)-X 5 -(HQ)-(LA)] targeting sequences are recognized by Pex5p and Pex7p, respectively, which may shuttle with the substrate protein to the peroxisomal lumen. (tcdb.org)
The structures of the substrate binding sites were also conserved, except for the region called S2-extensive, which is exploited by specific human DPP4 inhibitors currently used as antidiabetic drugs. (inra.fr)

As for many essential biological processes, intracellular membrane fusion is mediated by interactions among a series of evolutionarily conserved proteins. (biomedcentral.com)
The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)
Although 271 genes linked to hereditary retinal diseases have already been identified, these genes encode diverse functions, including phototransduction, retinol metabolism, and intracellular protein transport. (oist.jp)

Using native mass spectrometry, we identify the stoichiometry of sub-complexes and monitor oligomerisation of various assemblies. (nature.com)
Stoichiometry of these proteins reveals that they are more abundant than required for membrane traffic. (unisalento.it)
p47 binding to VCPapo/ATP can be either bipartite (UBX+SHPC) or tripartite (UBX+SHPC+SHPN), while binding to VCPADP is bipartite showing the stoichiometry of 3:6 for tripartite and 6:6 for bipartite ( Conicella,2020 ). (eu.org)

Structural studies of Derlin1-VCP ( 5GLF ) and UFD1-VCP ( 5C1B ) complexes show that the motif is bound to three highly conserved binding pockets in VCPNc. (eu.org)
The function of the SEDL protein is not known although it is speculated that it may participate in the ER-to-Golgi transport as part of a novel highly conserved multiprotein TRAPP complex. (nature.com)

Take a look at Ibrutinib chemical structure existing evidence how the vacuolar Jumps tethering complicated handles mix by means of particular interactions with the vacuolar Pitfall complex (made up of Vam3, Vam7, Vti1, and also Nyv1) as well as the N-terminal domains of Vam7 and Vam3. (notes.io)
Cellular processes are governed by complex molecular interaction networks where the molecular components and the interactions between them are represented by nodes and edges, respectively. (biomedcentral.com)
Though the VCP and their binding partners are conserved in eukaryotes, the sequences that mediate their interactions are significantly different across organisms showing that evolution has established more than one way for these proteins to interact. (eu.org)
The N-terminal loop region of the SHP motif interacts with the first pocket, while the central β strand of the motif makes key interactions with the second binding pocket. (eu.org)
In the UFD1-VCP complex ( 5C1B ), the SHP box hydrophobic interactions are mediated by four residues of the Ufd1 SHP box (Phe225, Phe228, Asn233 and Leu235), whose side chains are positioned toward the VCP Nc subdomain. (eu.org)

Major recent advances and previous data have led to a plausible model of how key proteins mediate neurotransmitter release. (elsevierpure.com)

Secondly, they find that HSP70 in turn regulates the trafficking of peptide-loaded major histocompatibility complex class I (pMHC-I) molecules, a complex that triggers the proliferation of cancer-killing T cells. (biomedcentral.com)

Orthologous to human NAPA (NSF attachment protein alpha). (nih.gov)

The sequence of the predicted 295-amino acid human protein encoded by NAPA shares 37%, 60%, and 67% identity with the sequences of yeast, Drosophila, and squid alpha-SNAP, respectively. (wikipedia.org)
Previously, we reported the structure of the yeast Dsl1 complex, the simplest known MTC, which is essential for coat protein I (COPI) mediated transport fromthe Golgi to the endoplasmic reticulum(ER). (princeton.edu)
In the budding yeast Saccharomyces cerevisiae , the minimal transport machinery includes the membrane proteins Pex13 and Pex14 and the cargo-protein-binding transport receptor, Pex5. (tcdb.org)
Ter94 in fly, CDC48 in yeast) is a hexameric multidomain protein belonging to the functionally highly diverse AAA+ (ATPases Associated with diverse cellular Activities) superfamily of proteins. (eu.org)

Neuronal outgrowth is a complex process in which two distinct domains emerge from the cell body: a long, thin axon that transmits signals, and multiple shorter dendrites, which are specialized primarily for receiving signals. (biomedcentral.com)

The Endoplasmic Reticulum (ER) is an important eukaryotic cell organelle that has various functions, including the synthesis of proteins for export and quality control of nascent proteins. (eu.org)

Integrating the dynamics across species is particularly important in modeling cellular processes through protein interaction networks. (biomedcentral.com)
Many of the biological processes mediated by protein interaction networks are highly evolutionarily conserved or related across species. (biomedcentral.com)
Mutations of a gene sequence can modify the interfaces or domains of its protein product and lead to the emergence of new or loss of existing protein interaction patterns [ 11 ]. (biomedcentral.com)
4) provided direct evidence that SYP121 is part of a scaffold of proteins associated, by direct interaction with channel KAT1, with the membrane transport of K+. (unisalento.it)
The cytoHubba plug-in were used to identify hub genes from the protein-protein interaction network. (biomedcentral.com)
The C-terminal region of the motif is stabilized by a loop-loop interaction at the third binding pocket. (eu.org)

Eye proteins are the biological molecules that make up the various structures of the eye and are essential for its proper function. (lookformedical.com)
These peptide-MHC-I complexes (pMHC-I) then traffic to the cell surface, where together with co-stimulatory molecules they trigger the proliferation and differentiation CD8 + T cells into cancer-specific cytotoxic T cells. (biomedcentral.com)
A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. (jefferson.edu)
They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. (jefferson.edu)

His-Ubiquitin recombinant protein probed with Mouse anti Histidine Tag ( MCA1396 ). (bio-rad-antibodies.com)

These diverse functions performed by the acrosomal segment during fertilization reveal the importance of identifying the specific signaling events and protein constituents which initiate and regulate the membrane fusion process of the acrosome reaction and prepare spermatozoa to fuse with the egg. (ommegaonline.org)
We show homotypic fusion and necessary protein sorting (HOPS) binds Vam7 by means of it's subunits Vps16 as well as Vps18. (notes.io)

60% of human protein-coding genes, mostly by binding to the 3′- untranslated region (3′UTR) of the target mRNAs ( 5 ) and, therefore, miRNAs affect gene expression networks of a variety of biological processes including development, apoptosis, proliferation, and metabolism ( 1 , 2 ). (frontiersin.org)
Over two dozen proteins involved in protein import and membrane insertion, peroxins, encoded by PEX genes, have been characterized. (tcdb.org)

Studies with Mcl-1 phosphorylation mutants show that cyclin E/Cdk2-dependent phosphorylation of Mcl-1 residues on its PEST domain resulted in increased Mcl-1 stability (Thr92, and Thr163) and Bim binding (Ser64). (oncotarget.com)

Some cell wall polysaccharide synthesis and cytoskeleton formation-related proteins were up-regulated by JA to promote tuber cell expansion. (biomedcentral.com)
We focus on zebrafish mutants, in which photoreceptor degeneration is caused by defects in protein synthesis in ER, protein transport from ER to the apical photoreceptive membrane region, and phototransduction. (oist.jp)

Gabrilovich's team begins to answer this with an astonishing observation that either inhibiting or depleting HSP70 leads to a re-routing of pMHC-I complexes, which rather than reaching the plasma membrane, are sent to lysosomes instead. (biomedcentral.com)

The mature miRNAs are loaded onto ARGONAUTE (AGO) proteins, forming a miRNA-induced gene silencing complex (miRISC). (biomedcentral.com)
Then, the miRISC binds to target sites with sequences complementary to the miRNAs, leading to either cleavage or translational inhibition of the target mRNAs, or methylation of the target sequences, resulting in post-transcriptional and transcriptional gene silencing, respectively. (biomedcentral.com)

2011) addresses two of these aspects, the translocation of soluble proteins into the peroxisomal matrix and the biogenesis of the peroxisomal membrane. (tcdb.org)

Clathrin also interacts with cytoskeletal proteins. (lookformedical.com)

Sequence and structure analyses showed thatVAT-Nn is related to numerous proteins including prokaryotic transcriptionfactors, metabolic enzymes, the protease cofactors UFD1 and PrlF, andaspartic proteinases. (embl-heidelberg.de)

capping actin protein of muscle. (gsea-msigdb.org)

The results revealed that the levels of a number of proteins involved in various cellular processes were regulated by JA during tuber development. (biomedcentral.com)

pumilio RNA binding family memb. (gsea-msigdb.org)

Pex4p is a membrane protein that may facilitate cycling of Pex5p back to the cytosol. (tcdb.org)
small integral membrane protein. (gsea-msigdb.org)

ERAD enables ER processing to distinguish the properly and improperly folded proteins in the ER lumen and then extracts them through membrane channels (dislocation or retrotranslocation) in an energy-dependent manner for delivery to cytosolic proteasomes. (eu.org)

There are 6871 CDC48_N domains in 6866 proteins in SMART's nrdb database. (embl-heidelberg.de)
Taxonomic distribution of proteins containing CDC48_N domain. (embl-heidelberg.de)
The complete taxonomic breakdown of all proteins with CDC48_N domain is also avaliable . (embl-heidelberg.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing CDC48_N domain in the selected taxonomic class. (embl-heidelberg.de)

We present a comparative network motif experimental approach, which helps to explain complex biological phenomena and increases the understanding of biological functions at the molecular level by exploring evolutionary design principles of network motifs. (biomedcentral.com)
Three motifs known to bind to the N-terminal domain of VCP are the SHP box, VIM (VCP-Interacting Motif), and VBM (VCP-Binding Motif) and they help direct VCP into different cellular pathways. (eu.org)
The helical VIM and VBM motifs bind to the same groove but through different key residues. (eu.org)

Thus ERAD is essential for ER homeostasis and correct functioning by degrading misfolded proteins ( Hwang,2018 ). (eu.org)

Pex5p, the PTS1 receptor, is known to bind to the integral Pex13p and/or Pex17p and the peripheral Pex14p. (tcdb.org)

Vesicle18

SNARE34

Cytosolic proteins2

Receptors10

Syntaxin4

Munc185

Soluble NSF-attachment proteins1

SNAREs1

Factor4

Heterotrimeric G protei2

Polypeptides1

Regulatory2

Peptides1

Adaptor proteins5

ATPase6

Exocytosis1

Vesicular transport1

Molecule4

Degradation4

Substrate2

Intracellular3

Stoichiometry3

Highly conserved2

Interactions5

Mediate1

Regulates1

Attachment protein alpha1

Yeast4

Neuronal1

Endoplasmic Reticulum1

Interaction6

Molecules4

Recombinant protein1

Fusion2

Genes2

Phosphorylation1

Synthesis2

Hsp701

Gene2

Translocation1

Clathrin1

Cofactors1

Actin1

Cellular processes1

Family1

Membrane protein2

Lumen1

CDC484

Motifs3

20181

Known to bind1