Complexes acetylation. Medical search. Frequent questions

Several modifications (phosphorylation, methylation, acetylation and others) of histones have been identified as important marks for controlling the human disease-related genes [1-3]. (oatext.com)
Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation. (yeastgenome.org)
Histones undergo a variety of modifications including acetylation, phosphorylation and methylation, which in turn affect the level of packaging. (wayne.edu)
Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. (mpg.de)
While there are relatively few studies examining epigenetically mediated mechanisms involved in visceral nociception, stress-induced visceral pain has been linked to alterations in DNA methylation and histone acetylation patterns within the brain, leading to increased expression of pro-nociceptive neurotransmitters. (frontiersin.org)
Processes that are considered to be epigenetic encompass DNA methylation (in which the cell silences specific genes by attaching methyl groups to bases that make up the DNA sequence) and wrapping the primary DNA sequence around protein complexes into nucleosomes , which are made up of proteins called histones . (scienceblogs.com)
In fact, biological outcomes are often due to physical interactions between proteins that are so highly selective that seemingly minor chemical modifications (i.e. methylation, acetylation or phosphorylation) can completely abolish biomolecular recognition processes and redirect signaling pathways. (mtu.edu)
Dual inhibition of EZH2 and HDAC led to modulation of acetylation and methylation of H3K27. (chicagobiomedicalconsortium.org)

Complexes containing a pair of structural maintenance of chromosomes (SMC) family proteins are fundamental for the three-dimensional (3D) organization of genomes in all domains of life. (nature.com)
Although Bromodomain-containing proteins which bind to acetylated histones have critical roles to induce transcription, recent reports suggest that lysine acetylation-mediated dissociation from negatively charged Glutamic acid-rich acidic domain-containing proteins has a significant impact on the gene expression. (oatext.com)
Lysine acetylation is a protein modification as binding sites for Bromodomain-containing 'reader' proteins (BRD) critical to induce gene expression [4]. (oatext.com)
Those proteins contain numerous factors related to DNA binding, transcriptional regulation, chromatin remodeling, suggesting that acetylation-mediated dissociation from acidic domain-containing proteins may be a key step to enhance the gene expression. (oatext.com)
Lysine acetylation-mediated dissociation from acidic domain-containing proteins as a key step for the gene expression. (oatext.com)
D) A simple and generalized model for active transcription mediated by lysine acetylation of histones and non-histone proteins through dissociation of protein complexes and conformation changes in nucleosomes or histones at the proximal promoter region. (oatext.com)
Combination of acetylation-mediated dissociation in the proximal promoter region and binding of bromodomain-containing 'reader' proteins (BRD) to lysine acetylation in the distal enhancer region may synergize to induce gene expression. (oatext.com)
Acetylation occurs as a co-translational and post-translational modification of proteins, for example, histones, p53, and tubulins. (wikipedia.org)
Among these proteins, chromatin proteins and metabolic enzymes are highly represented, indicating that acetylation has a considerable impact on gene expression and metabolism. (wikipedia.org)
N-terminal acetylation is one of the most common co-translational covalent modifications of proteins in eukaryotes, and it is crucial for the regulation and function of different proteins. (wikipedia.org)
N-terminal acetylation plays an important role in the synthesis, stability and localization of proteins. (wikipedia.org)
Several proteins from prokaryotes and archaea are also modified by N-terminal acetylation. (wikipedia.org)
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. (yeastgenome.org)
Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. (abcam.com)
They studied how exactly a group of proteins and non-coding RNAs, namely the MSL complex increases the gene expression of the single X chromosome in male flies to achieve the same dosage as XX females. (mpg.de)
The proteins produced from most of the genes involved in Cornelia de Lange syndrome contribute to the structure or function of the cohesin complex, a group of proteins with an important role in directing development before birth. (medlineplus.gov)

FoxO1 activity is subject to a complex regulation by Akt-dependent phosphorylation and SirT1-mediated deacetylation. (diabetesjournals.org)

Therefore, unacetylated p53 tightly interacts with SET, however, acetylated p53 is dissociated from SET because the positive charges are neutralized by lysine acetylation (Figure 1B). (oatext.com)
C) Lysine acetylation-mediated dissociation of Ets-1 and conformation changes in histones (from closed to open) in induction of miR-192 in the response to TGF-β related to fibrosis and hypertrophy in the pathogenesis of diabetic nephropathy. (oatext.com)
Lysine acetylation of Ets-1 (repressor of miR-192) and of histone H3 by p300 (activated by Akt) mediates dissociation of Ets-1 from the promoter region of miR-192 and conformation changes of histones (closed form to open form) in induction of miR-192. (oatext.com)
One of these PTMs, Nε-lysine acetylation, was thought to occur only in the mitochondria, cytosol and nucleus, but this paradigm was challenged in the past decade with the discovery of lysine acetylation in the lumen of the endoplasmic reticulum (ER). (biologists.com)
7] "Lysine acetylation targets protein complexes and co-regulates major cellular functions. (tcdb.org)

Proteomic analysis of chromatin-modifying complexes in Saccharomyces cerevisiae identifies novel subunits. (yeastgenome.org)

Acetylation is one of protein modifications and important for gene expression by modulating activity or conformation of transcription factors and histones. (oatext.com)
The acetylation of histones by NatD is partially associate with ribosomes and the amino acids substrates are the very N-terminal residues, which makes it different from lysine N-acetyltransferases (KATs). (wikipedia.org)
A transcriptional co-activator complex that accompanies Pol II during elongation, preferentially acetylates nucleosomal histones H3 and H2B and subsequently evicts nucleosomes from gene coding regions. (yeastgenome.org)
Indeed, in eukaroytes, the whole histone-DNA complex is known as chromatin, and the "tightness" of the wrapping of the DNA into chromatin is an important mechanism by which the cell controls gene expressions, and this "tightness" can be controlled by a process known as histone acetylation, in which acetyl groups are tacked onto histones (or removed from them). (scienceblogs.com)
Acetylation removes a positive charge on the histones, thereby decreasing its ability to interact with negatively charged phosphate groups elsewhere on the histones. (scienceblogs.com)

In addition to the genes NAA10 and NAA15, the mammal-specific genes NAA11 and NAA16, make functional gene products, which form different active NatA complexes. (wikipedia.org)
Here we identified MBTD1 as a stable subunit of the complex, and we reveal that, via a histone reader domain for H4K20me1/2, MBTD1 allows TIP60 to associate with specific gene promoters and to promote the repair of DNA double-strand breaks by homologous recombination. (houstonmethodist.org)
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. (yeastgenome.org)
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). (yeastgenome.org)
Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. (abcam.com)
In flies, the MSL complex has emerged as a molecular balancing mechanism to ensure the same amount of gene output in both sexes. (mpg.de)
HDACs and histone acetylases together regulate gene expression by histone acetylation and de-acetylation. (spandidos-publications.com)
The end result is that the "tightness" of the condensed (more tightly packed) histone-DNA complex relaxes into a state associated with greater levels of gene transcription. (scienceblogs.com)
Together, our work identified Bonus as a regulator of tissue-specific gene expression and revealed the importance of SUMOylation as a regulator of complex formation in the context of transcriptional repression. (elifesciences.org)
Variants in the NIPBL , SMC1A , HDAC8 , RAD21 , and SMC3 genes cause Cornelia de Lange syndrome by impairing the function of the cohesin complex, which disrupts gene regulation during critical stages of early development. (medlineplus.gov)

2021), Tubulin acetylation promotes penetrative capaci. (xenbase.org)
2021 ) Pseudomonas syringae effector HopZ3 suppresses the bacterial AvrPto1-tomato PTO immune complex via acetylation. (academictree.org)

In humans, the multisubunit complex cohesin is made up of SMC1, SMC3, RAD21 and a STAG protein. (nih.gov)
Loss of HDAC8 activity results in increased SMC3 acetylation and inefficient dissolution of the 'used' cohesin complex released from chromatin in both prophase and anaphase. (nih.gov)
SMC3 with retained acetylation is loaded onto chromatin, and chromatin immunoprecipitation sequencing analysis demonstrates decreased occupancy of cohesin localization sites that results in a consistent pattern of altered transcription seen in CdLS cell lines with either NIPBL or HDAC8 mutations. (nih.gov)

Expression of ARD1 increases levels of AR acetylation and AR-HSP90 dissociation in a dose dependent manner. (oncotarget.com)
Detailed mechanisms of protein complex dissociation by acetylation may provide new ways to prevent or treat human diseases such as cancer, metabolic diseases and their complications. (oatext.com)
However, a recent paper [5] reported that DNA damage-induced p21 expression is mediated by acetylation of p53 carboxyl terminal domain (CTD) and its dissociation from SET protein (Figure 1A) is involved in tumor regression in mouse xenograft models. (oatext.com)
A) A model for DNA damage-induced p21 expression mediated by acetylation of p53 and its dissociation from SET protein in tumor regression in mouse xenograft models. (oatext.com)
Inhibition of EZH2 and HDAC is synergistic and leads to the dissociation of PRC2 complex. (chicagobiomedicalconsortium.org)

An AR construct with the charged lysine substitution by arginine (AR-618R) reduces RNA Pol II binding, AR transcriptional activity, prostate cancer cell growth, and xenograft tumor formation due to attenuation of AR nuclear translocation, whereas, construct mimicking neutral polar substitution acetylation at K618 by glutamine (AR-618Q) enhanced these effects beyond that of the wild-type AR. (oncotarget.com)

Within cells, the cohesin complex helps regulate the structure and organization of chromosomes, stabilize cells' genetic information, and repair damaged DNA. (medlineplus.gov)
The cohesin complex also regulates the activity of certain genes that guide the development of the face, limbs, and other parts of the body. (medlineplus.gov)

It was previously suggested that TIP60-dependent acetylation of H4 regulates binding of the non-homologous end joining factor 53BP1, which engages chromatin through simultaneous binding of H4K20me2 and H2AK15ub. (houstonmethodist.org)
We find that the TIP60 complex regulates association of 53BP1 partly by competing for H4K20me2 and by regulating H2AK15ub. (houstonmethodist.org)

Protein acetylation (and deacetylation) are acetylation reactions that occur within living cells as drug metabolism, by enzymes in the liver and other organs (e. g., the brain). (wikipedia.org)

In summary, we unravel the stoichiometry of intermediates and off-pathway complexes and compile a road map of SNARE complex assembly including regulation by Complexin-1. (nature.com)
The team lead by Asifa Akhtar suggests that the origin of the MSL complex lay in the regulation of these developmental genes and was later reused also to regulate dosage compensation. (mpg.de)

2 3 The HGP demonstrated that a relatively limited number of genes could be identified in the human genome, which substantiated the theory that complex biological processes were regulated on other levels than DNA sequence alone. (bmj.com)
For the first time, they were able to show that the MSL complex also controls essential developmental genes on other chromosomes. (mpg.de)
These newly found MSL-linked sites in the genome were practically exclusively genes that control fly development and have a direct impact on cellular processes involved in organ formation," For example, we observed malformed wings or diminished eyes indicating that the MSL complex is directly regulating genes such as Wingless, which is a master controller of development," says Claudia Keller Valsecchi, first author of the study. (mpg.de)

Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. (rndsystems.com)
Our data show that GLP-1 increases FoxO1 acetylation, decreases the binding of SirT1 to FoxO1, and stunts SirT1 activity in β-INS832/13 cells. (diabetesjournals.org)

For anticoagulation potency, the formation of the SP/protease protein complex and the associated non-specific polar interaction between the negatively and positively charged groups in the polysaccharide and protein is responsible for anticoagulant activity. (springer.com)
Positively and negatively modulating tubulin acetylation in intercalating cells alters the developmental timing such that cells with more acetylation penetrate faster. (xenbase.org)

A clinically significant mechanism of tuberculosis resistance to the aminoglycoside kanamycin (KAN) is its acetylation catalyzed by upregulated Mycobacterium tuberculosis (Mtb) acetyltransferase Eis. (cdc.gov)
nov., a new species closely related to the Mycobacterium tuberculosis complex. (cdc.gov)

Fig. 1: Cryo-EM structures of the yeast condensin holo complex in the nucleotide-free apo form. (nature.com)
NatB complexes are composed of the catalytic subunit Naa20p and the auxiliary subunit Naa25p, which are both found in yeast and humans. (wikipedia.org)

Interestingly, the MSL complex is also present in mammalian cells. (mpg.de)

The synergistic effects of EZH2 and HDAC inhibition may be attributed to the disassembly of the PRC2 complex. (chicagobiomedicalconsortium.org)
Crystal structures of Eis in complexes with three of the inhibitors showed that the inhibitors were bound in the aminoglycoside binding site of Eis, consistent with the competitive mode of inhibition, as established by kinetics measurements. (cdc.gov)

We are currently investigating how the SIN3 histone deacetylase complex functions to repress transcription at the epigenetic level. (wayne.edu)
FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis. (wayne.edu)
Liu M, Saha N, Gajan A, Saadat N, Gupta SV, Pile LA. A complex interplay between SAM synthetase and the epigenetic regulator SIN3 controls metabolism and transcription. (wayne.edu)
5Regulation of myogenesis via kinase driven activation of DPF3a, a BAF complex member and its interaction with transcription repressor HEY1. (mpg.de)
The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)

p53-interacting SET also inhibits action of CBP/p300 and histone acetylation to inhibit p21 expression. (oatext.com)
Ubiquitylation of H2AK15 by RNF168 inhibits chromatin acetylation by TIP60, while this residue can be acetylated by TIP60 in vivo, blocking its ubiquitylation. (houstonmethodist.org)

FoxO1 acetylation levels and binding to SirT1 were studied by Western immunoblot analysis in INS832/13 cells. (diabetesjournals.org)
Our study shows for the first time that the glucoincretin hormone GLP-1 modulates SirT1 activity and FoxO1 acetylation in β-cells. (diabetesjournals.org)

However, the ARD1-targeted residue within AR and the mechanisms of the acetylation event in prostate tumorigenesis remained unknown. (oncotarget.com)

Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex. (nih.gov)
Buehl CJ, Goff NJ, Hardwick SW, Gellert M, Blundell TL, Yang W, Chaplin AK , Meek K. Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining. (le.ac.uk)

The eukaryotic SMC complexes cohesin and condensin are thought to fold interphase and mitotic chromosomes, respectively, into large loop domains, although the underlying molecular mechanisms have remained unknown. (nature.com)
Uhlmann, F. SMC complexes: from DNA to chromosomes. (nature.com)
Surprisingly here, they found that the MSL complex not only binds to the X chromosome but also to more sites of the genome located on other chromosomes. (mpg.de)

Altogether, these results uncover an intricate mechanism orchestrated by the TIP60 complex to regulate 53BP1-dependent repair through competitive bivalent binding and modification of chromatin. (houstonmethodist.org)

This Review summarizes the more recent biochemical, cellular and mouse model studies that underscore the importance of the ER acetylation process in maintaining protein homeostasis and autophagy within the secretory pathway, and its impact on developmental and age-associated diseases. (biologists.com)
SIN3 is required for viability of multi-cellular organisms and mutations in components in the complex have been linked to defects in cell cycle progression. (wayne.edu)
Data from these studies will help to elucidate the contribution of histone acetylation to signaling cascades that impact cellular decisions critical for proliferation, development and viability. (wayne.edu)

Pharmaceuticals frequently employ acetylation to enable such esters to cross the blood-brain barrier (and placenta), where they are deacetylated by enzymes (carboxylesterases) in a manner similar to acetylcholine. (wikipedia.org)
Arylamine N-acetyltransferases (NATs) are xenobiotic metabolizing enzymes that catalyze the acetyl-CoA-dependent acetylation of arylamines. (rcsb.org)

However, the complex nature of this disease has complicated advances in understanding the pathological mechanisms of HCC. (spandidos-publications.com)

Here, we demonstrate that the nucleosome remodeling and deacetylase (NuRD) complex is asymmetrically segregated into the surviving daughter cell rather than the apoptotic one during ACDs in Caenorhabditis elegans . (elifesciences.org)
The authors propose that the asymmetric segregation of the NuRD complex in C. elegans is regulated in a V-ATPase-dependent manner, that this plays a crucial role in determining the differential expression of the apoptosis activator egl-1 and that it is therefore critical for the life/death fate decision in this species. (elifesciences.org)

N-terminal Acetylation is catalyzed by a set of enzyme complexes, the N-terminal acetyltransferases (NATs). (wikipedia.org)
This process is governed by the ER acetylation machinery: the cytosol:ER-lumen acetyl-CoA transporter AT-1 (also known as SLC33A1), and the ER-resident lysine acetyltransferases ATase1 and ATase2 (also known as NAT8B and NAT8, respectively). (biologists.com)

NatC complex consists of one catalytic subunit Naa30p and two auxiliary subunits Naa35p and Naa38p. (wikipedia.org)

Our structures of the five-subunit condensin holo complex at different functional stages suggest that ATP binding induces the transition of the SMC coiled coils from a folded-rod conformation into a more open architecture. (nature.com)
Thompson, M. (2009) Polybromo-1: the chromatin targeting subunit of the PBAF complex. (mtu.edu)

Daniel JA and Grant PA (2007) Multi-tasking on chromatin with the SAGA coactivator complexes. (yeastgenome.org)

Targeting ARD1-mediated AR acetylation may be a potent intervention for AR-dependent prostate cancer therapy. (oncotarget.com)
A thermodynamic model for acetylation-dependent polybromo-histone interactions. (mtu.edu)
Thermodynamic analysis of acetylation-dependent Pb1 bromodomain - histone H3 interactions. (mtu.edu)

NatA subunits are more complex in higher eukaryotes than in lower eukaryotes. (wikipedia.org)
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. (yeastgenome.org)
Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. (yeastgenome.org)
Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes. (yeastgenome.org)

Tubulin acetylation promotes penetrative capacity of cells undergoing radial intercalation. (xenbase.org)

NGL viewer: web-based molecular graphics for large complexes. (icr.ac.uk)
A growing number of studies are finding diverse and essential roles for molecular recognition events in mediating information transfer and complex assembly in biology. (mtu.edu)

Osei P, Northcote-Smith J, Fang J, Singh K, Ortu F, Suntharalingam K . The Bulk Breast Cancer Cell and Breast Cancer Stem Cell Activity of Bi-nuclear Copper(II)-Phenanthroline Complexes. (le.ac.uk)

The synergistic effects of the combination was due to disruption of the PRC2 complex secondary to acetylation of RbAP 46/48. (chicagobiomedicalconsortium.org)

We, therefore, follow the stepwise assembly of the SNARE complex and target individual SNAREs, binary sub-complexes, the ternary SNARE complex as well as interactions with Complexin-1. (nature.com)
Importantly, we find that interactions with Complexin-1 reduce multimerisation of the ternary SNARE complex. (nature.com)

Using native mass spectrometry, we identify the stoichiometry of sub-complexes and monitor oligomerisation of various assemblies. (nature.com)

We identify the vacuolar H + -adenosine triphosphatase (V-ATPase) complex as a crucial regulator of NuRD's asymmetric segregation. (elifesciences.org)
The NuA4/TIP60 acetyltransferase complex is a key regulator of genome expression and stability. (houstonmethodist.org)

Immunofluorescence indicates the presence and activity of the MSL complex. (mpg.de)
The white dots represent acetylation marks (H4K16ac) and show the researchers the extensive activity of the complex. (mpg.de)
The structure-activity relationship study showed that in addition to haloperidol (1), eight analogues, some of which were smaller than 1, potently inhibited Eis (IC(50) 1 M). Crystal structures of Eis in complexes with three potent analogues and droperidol (DPD), an antiemetic and antipsychotic, were determined. (cdc.gov)

Mechanistically, ARD1 forms a ternary complex with AR and HSP90 in vitro and in vivo . (oncotarget.com)
Accordingly, Syntaxin-1 and Synaptobrevin-2 each contribute one and SNAP25 contributes two alpha-helices to the ternary SNARE complex. (nature.com)
Based on the presence of glutamine or arginine residues in the zero layer, the SNAREs are classified as Qa- (Syntaxin-1), Qb- and Qc- (SNAP25) or R-SNAREs (Synaptobrevin-2) resulting in the formation of the ternary QabcR (3Q:1R) SNARE complex 8 . (nature.com)

Here, we address the role of tubulin acetylation on the penetrative capacity of cells undergoing radial intercalation, which is the process by which cells move apically, insert between outer cells, and join an epithelium . (xenbase.org)
We shift the accessibility of intercalating cells toward more restrictive junctions by increasing tubulin acetylation, and we provide a geometric-based mathematical model that describes our results. (xenbase.org)
The calcium-sensitive sarcomeric complex is the key mechanochemical transducing unit in muscle cells. (cytoskeleton.com)

Note that acetylation covers all of the important functional areas of myosin from actin and ATP binding to the hinge region and even the coiled-coil tail. (cytoskeleton.com)
Given the prominence of myosin as a target for acetylation in cardiomyocytes, further biochemical and functional studies were undertaken. (cytoskeleton.com)

While the general sequence of SNARE complex formation is well-established, our knowledge on possible intermediates and stable off-pathway complexes is incomplete. (nature.com)

We discovered that an antipsychotic drug, haloperidol (HPD, 1), was a potent Eis inhibitor with IC(50) = 0.39 0.08 M. We determined the crystal structure of the Eis-haloperidol (1) complex, which guided synthesis of 34 analogues. (cdc.gov)

Recent breakthroughs in human pluripotent stem cell-derived cerebral organoids provide a valuable platform for investigating the human brain after different drugs treatments and for understanding the complex genetic background to human pathology. (frontiersin.org)
A key to answering this question was, that instead of using usual cell culture systems the team started studying the MSL complex in the larval stadium of the flies. (mpg.de)
The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)

By a joint effort of the lab working with multiple experimental approaches and model organisms on different aspects of the MSL complex, the team was able to expand the already known functions of the complex beyond fly genome. (mpg.de)

While studying HDAC inhibitors in cardiac function, Dr. Mahesh Gupta's laboratory showed that acetylation is important for sarcomere function. (cytoskeleton.com)

Increased MT acetylation results in precocious apical insertion(A and B) Side projections of intercalating control and ATAT1 OE MCCs fixed and stained with α-beta tub (A) or α-acetyl. (xenbase.org)

Anatomy8

Organisms1

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes19

Information Science2

Methylation8

Proteins16

Phosphorylation1

Lysine acetylation5

Chromatin-modifying1

Histones5

Gene10

20212

Smc33

Dissociation5

Transcriptional1

Cohesin complex2

Regulates2

Deacetylation1

Regulation2

Genes3

Increases2

Negatively2

Mycobacterium2

Yeast2

Mammalian1

Inhibition2

Transcription5

Inhibits2

SIRT12

Residue1

Homologous2

Chromosomes3

Modification1

Cellular3

Enzymes2

Mechanisms1

NuRD2

Acetyltransferases2

Catalytic1

Subunit2

SAGA1

Dependent3

Subunits4

Promotes1

Molecular2

Nuclear1

Secondary1

Interactions2

Mass1

Regulator2

Activity3

Ternary3

Cells3

Functional2

Sequence1

Synthesis1

Cell3

Model1

Important1

Results1