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  • molecules
  • A structural model for this quaternary complex is presented in which the C-terminal sequence of p21 acts like double-sided tape and docks to both the PCNA and cyclin molecules. (rcsb.org)
  • peptide
  • X-ray studies with a 30-residue CDC6 peptide in complex with pCDK2/cyclin A showed binding of a dodecamer peptide at the recruitment site and a heptapeptide at the catalytic site, but no density for the linking 11 residues. (rcsb.org)
  • We present the x-ray crystal structure of PCNA complexed with a 16-mer peptide related to p21 that binds with a Kd of 100 nM. (rcsb.org)
  • cell
  • First, mice carrying a transgene programmed to express cyclin E at an elevated level and without cell cycle regulation in the mammary epithelium during pregnancy and lactation develop mammary adenocarcinomas ( Bortner and Rosenberg, 1997 ). (rupress.org)
  • In cervical carcinoma cell line C33A, which was previously shown to be sensitive to p107 but resistant to pRB growth suppression, only the cyclin binding domain is active as a growth suppressor. (uu.nl)
  • While SWI-SNF complexes are nonessential in yeast, a second related complex, RSC, is required for yeast cell growth ( 3 , 4 , 32 ). (asm.org)
  • By immunoprecipitation analysis of various cell lines using antibodies against cyclin E, we identified the presence of two components of the SWI-SNF apparatus, BAF155 and BRG1. (asm.org)
  • What do we use (complex) to regulate the cell cycle? (brainscape.com)
  • Components
  • Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. (reactome.org)
  • suggest
  • Altogether, our results suggest that Cyclin G, PRC1 and PR-DUB cooperate for developmental stability. (plos.org)