Crystallography, X-RayModels, MolecularProtein BindingBinding SitesMolecular Sequence DataProtein Structure, TertiaryProtein ConformationAmino Acid SequenceProtein Structure, QuaternaryMultiprotein ComplexesDimerizationProtein Structure, SecondaryHydrogen BondingCatalytic DomainProtein Interaction Domains and MotifsProtein MultimerizationSequence AlignmentCrystallographySequence Homology, Amino AcidLigandsSubstrate SpecificityMutationHelix-Turn-Helix MotifsNucleic Acid ConformationMolecular ConformationAmino Acid MotifsEscherichia coliProtein SubunitsBacterial ProteinsNuclear Magnetic Resonance, BiomolecularDNAMutagenesis, Site-DirectedSaccharomyces cerevisiae ProteinsStatic ElectricityCalorimetryStructure-Activity RelationshipCatalysisMacromolecular SubstancesCryoelectron MicroscopyCrystallizationSaccharomyces cerevisiaeMutant ProteinsBase SequenceMolecular StructureUbiquitin-Conjugating EnzymesRecombinant ProteinsElectronsStructural Homology, ProteinProtein FoldingProtein Interaction MappingKineticsMagnetic Resonance SpectroscopyEscherichia coli ProteinsModels, ChemicalCarrier ProteinsTranscription FactorsDNA-Binding ProteinsModels, BiologicalThermodynamicsHydrophobic and Hydrophilic InteractionsSignal TransductionUbiquitinAmino Acid SubstitutionPeptidesRepressor ProteinsConserved SequenceSolutionsMembrane ProteinsMutagenesisMass SpectrometryRNA-Binding ProteinsTranscription, GeneticMolecular Dynamics SimulationWaterMultienzyme ComplexesX-Ray DiffractionCell Cycle ProteinsGuanosine TriphosphateNuclear ProteinsChromatography, GelCell LineAdenosine TriphosphatasesMicroscopy, ElectronAdenosine TriphosphateEnzyme InhibitorsComputer SimulationPhosphorylationPhylogenyGene Expression ProfilingSequence Analysis, DNAEvolution, MolecularPhenotypeRNA, MessengerCloning, MolecularGene Expression RegulationGene Expression Regulation, DevelopmentalSpecies SpecificityOligonucleotide Array Sequence AnalysisMice, Inbred C57BLCells, Cultured