• First, it is binding importin alpha - another type of karyopherin that binds the cargo protein in the cytoplasm-before the cargo protein is imported into the nucleus through the nuclear pore using energy derived from the Ran gradient. (wikipedia.org)
  • mRNA is exported in the form of very large mRNP complexes, which begin to form during RNA processing when the transcription export (TREX) complex binds to the mRNA. (prospecbio.com)
  • HIV-1 IN also binds the karyopherin TNPO3, however the significance of this interaction during viral replication remains to be explored. (biomedcentral.com)
  • Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. (utsouthwestern.edu)
  • The transcriptional activator NF-Y is a heterotrimeric complex made up of NF-YA, NF-YB, and NF-YC, which specifically binds the CCAAT consensus within about 30% of eukaryotic promoters. (irjs.info)
  • The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. (utsouthwestern.edu)
  • Small RNAs are exported using Ran-GTP for directionality by karyopherin transport receptors, but mRNA is exported using a different mechanism that involves various quality controls. (prospecbio.com)
  • This process requires the involvement of nuclear transport receptors, collectively termed karyopherin-ß (Kap-ß) in yeast, and various regulatory factors. (sinica.edu.tw)
  • Many nuclear transport procedures are mediated by soluble transportation receptors that understand particular sequences or structural characteristics of their cargoes and facilitate the passage of receptor-cargo complexes through the NPC. (irjs.info)
  • The largest class of nuclear transport receptors is the superfamily of importin -like factors (also named karyopherins) that PCI-32765 distributor can be classified as importins (import karyopherin) and exportins (export karyopherin) depending on the direction in which they transport the cargo (reviewed PCI-32765 distributor in references 25, 32, 43, 72, and 80). (irjs.info)
  • Karyopherins can act as importins (i.e. helping proteins get into the nucleus) or exportins (i.e. helping proteins get out of the nucleus). (wikipedia.org)
  • It is found as a subunit of protein complexes that are in involved in the enzymatic modification of histones including the Mi2 and Sin3 histone deacetylase complexes and the polycomb repressive complex 2. (lookformedical.com)
  • Mammalian H3.1 and H3.2 are deposited by the heterotrimeric chromatin assembly complex 1 (CAF1), whereas H3.3 is deposited at transcriptionally active regions by the Histone Regulator A (HIRA) complex [ 15 , 16 ]. (biomedcentral.com)
  • Karyopherins are proteins involved in transporting molecules between the cytoplasm and the nucleus of a eukaryotic cell. (wikipedia.org)
  • Karyopherins are proteins that help eukaryotic cells transport molecules between their cytoplasm and nucleus. (prospecbio.com)
  • Structural inventory of cotranslational protein folding by the eukaryotic RAC complex, Structural inventory of cotranslational protein folding by the eukaryotic RAC complex, Nat. (db-engine.de)
  • Transformation of Chaetomium thermophilum and affinity-purification of native thermostable protein complexes. (db-engine.de)
  • The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4, is also a component of several other protein complexes involved in chromatin remodeling. (lookformedical.com)
  • here, we investigated the nucleo-cytoplasmic shuttling mechanism that transports xyr1 across the nuclear pore complex. (liverpool.ac.uk)
  • the velvet complex in the gray mold fungus botrytis cinerea: impact of bclae1 on differentiation, secondary metabolism, and virulence. (liverpool.ac.uk)
  • Signalling then converges to nuclear accumulation of transcriptionally active SMAD complexes and gives rise to a plethora of specific functional responses in both embryos and adult organisms. (nature.com)
  • Upon stress, several karyopherins stop shuttling between the nucleus and the cytoplasm and are sequestered in stress granules, cytoplasmic aggregates of ribonucleoprotein complexes. (wikipedia.org)
  • Several karyopherins are sequestered in stress granules, cytoplasmic aggregates of ribonucleoprotein complexes, as they avoid shuttling between the nucleus and the cytoplasm. (prospecbio.com)
  • Here we report a class of mRNA granules in human neuronal processes that are enriched in the nuclear cap-binding protein complex (CBC) and exon junction complex (EJC) core components, Y14 and eIF4AIII. (frontiersin.org)
  • In addition to the cis -elements in its 3′UTR and trans -acting factor Staufen, posterior localization of oskar mRNA requires deposition of exon junction complex (EJC) in its first exon through splicing ( Hachet and Ephrussi, 2004 ). (frontiersin.org)
  • Following the entry of the HIV-1 viral core into the cytoplasm of a target cell, reverse transcription of the retroviral RNA into a linear double strand cDNA copy takes place within the reverse transcription complex (RTC) [ 1 , 2 ]. (biomedcentral.com)
  • This complex is transported to the nucleus where the viral cDNA integrates into a host cell chromosome, a key step that is under the control of the retroviral enzyme IN [ 7 - 9 ]. (biomedcentral.com)
  • The team led by Dr. Kuo-Chiang Hsia (Institute of Molecular Biology, Academia Sinica) and Dr. Wei-Yi Chen (Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University) presents a cryo-EM structure of Kap114p, one of the Kap-βs, in complex with TATA box binding protein and reveals a non-canonical function beyond nuclear transport that modulates TBP-dependent transcription. (sinica.edu.tw)
  • Component of TRiC, a molecular chaperone complex that regulates telomere maintenance. (plurisomes.com)
  • Cac2, a putative subunit of H3.1 deposition complex CAF1, is not required for growth, whereas the expression of the putative ortholog of the H3.3-specific chaperone Hir1 is essential in Tetrahymena . (biomedcentral.com)
  • RD and RI H3s are deposited onto chromatin by distinct chaperone complexes. (biomedcentral.com)
  • Importin beta is a variety of karyopherin that facilitates the transport of cargo proteins into the nucleus. (wikipedia.org)
  • Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. (utsouthwestern.edu)
  • Generally, karyopherin-mediated transport occurs through nuclear pores which act as a gateway into and out of the nucleus. (wikipedia.org)
  • In most cases, karyopherin-mediated transport occurs through nuclear pores, which serve as a portal into and out of the nucleus. (prospecbio.com)
  • Karyopherins may act as imports (helping proteins enter the nucleus) or exports (helping proteins leave the nucleus) (i.e., helping proteins get out of the nucleus). (prospecbio.com)
  • The canonical TGFβ signalling pathway involves ligand-dependent assembly of a heteromeric receptor complex, receptor-kinase activation and subsequent phosphorylation and activation of SMAD proteins, which are transcriptional regulators that consequently accumulate in the nucleus. (nature.com)
  • As a long-term goal, we like to pursue the structural and biochemical studies of HCs and address questions of: What are structural features of those HCs as it is and as a complex with its substrates, histones? (umich.edu)
  • Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)
  • The mechanistic target of rapamycin complex 1 (mTORC1) plays a central role in this regulation and therefore has long been considered as an attractive target for type II diabetes. (umich.edu)
  • Our work on the large-scale annotation of enzyme function is helping to define the metabolic repertoire that exists in Nature and is providing new insights into the contributions of the gut microbiome to human health, the realization of new chemical processes for industry, and expanding our understanding of critical environmental issues, including global nutrient cycles and the evolution of complex microbial communities. (einsteinmed.edu)
  • 2016) "Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3. (einsteinmed.edu)
  • NGL viewer: web-based molecular graphics for large complexes. (icr.ac.uk)
  • Pharmacological disruption of the Notch transcription factor complex. (harvard.edu)
  • The Seelig group is interested in understanding how biological organisms process information using complex biochemical networks and how such networks can be engineered to program cellular behavior. (unibas.ch)
  • Crystal structures of Rea1-MIDAS bound to its ribosome assembly factor ligands resembling integrin-ligand-type complexes. (db-engine.de)
  • Proteína homeótica y factor de transcripción que se localiza en el núcleo celular donde activa la expresión de genes tiroideos específicos como el de la TIROGLOBULINA y el RECEPTOR DE TIROTROPINA. (bvsalud.org)
  • natural variation in bcvel1 encoding the ortholog of aspergillus nidulans vea, a member of the velvet complex, was previously shown to affect light-dependent differentiation, the formation of oxalic acid (oa), and virulence. (liverpool.ac.uk)
  • In addition, nuclear accumulation of active nuclear SMAD complexes is dynamically maintained in strict accordance with the degree of receptor activation at any time of signalling. (nature.com)