Complex integrin alphaxbeta2. Medical search. Frequent questions

The alphaM subunit of integrin Mac-1 contains several distinct regions in its extracellular segment. (embl.de)
Integrators of epidermal growth and differentiation: distinct functions for beta 1 and beta 4 integrins. (embl.de)
Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. (wikidoc.org)

Our data provide new insights into how different domains in the integrin alpha and beta subunits may interact. (embl.de)

The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods. (embl.de)
Integrin alpha (beta-propellor repeats). (embl.de)
Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. (embl.de)
The structure of the beta-propeller domain and C-terminal region of the integrin alphaM subunit. (embl.de)

Integrin alpha-2 or CD49b (cluster of differentiation 49b) is a protein which in humans is encoded by the CD49b gene . (wikidoc.org)
The CD49b protein is an integrin alpha subunit. (wikidoc.org)

Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. (embl.de)
Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. (wikidoc.org)

Integrin cytoplasmic domains are normally less than 50 amino acids in length, with the beta-subunit sequences exhibiting greater homology to each other than the alpha-subunit sequences. (embl-heidelberg.de)
Inside-out signaling takes place upon association of intracellular activators ( e.g. , talin, kindlins) with integrin cytoplasmic domains, leading to transition of integrin conformation to high affinity for binding ligands. (biomedcentral.com)
Upon ligand binding, integrins undergo clustering and transmit their outside-in signals to the cytoplasmic domains, leading to forming focal adhesions that connect to actin filaments for many cellular processes. (biomedcentral.com)

We are involved in several collaborative applications in various fields including immunological protein complexes, viral proteins, membrane receptor complexes, and eye lens crystallins. (nih.gov)
An integrin receptor is a heterodimer composed of alpha and beta subunits. (embl-heidelberg.de)
Integrins frequently intercommunicate, and binding at one integrin receptor activate or inhibit another. (embl-heidelberg.de)
An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans. (uchicago.edu)

Many integrins require activation on the cell surface before they can bind ligands. (embl-heidelberg.de)
The integrin activation by chemokine enables abrupt arrest of cells on endothelial integrin ligands. (biomedcentral.com)
Binding of chemokines to G protein-coupled receptors (GPCRs) triggers rapid arrest of rolling leukocytes in which leukocyte integrins ( e.g. , αLβ2 or α4β1) are activated to adhere to the ligands such as intercellular adhesion molecule 1 (ICAM1) or vascular cell-adhesion molecule 1 (VCAM1) on endothelial cells [ 65 ]. (biomedcentral.com)

Integrins mediate leukocyte accumulation to the sites of inflammation, thereby enhancing their potential as an important therapeutic target for inflammatory disorders. (biomedcentral.com)

Portion of beta integrins that lies N-terminal to their EGF-like repeats. (embl-heidelberg.de)
Some members of this family have EGF repeats at the C terminus and also have a vWA domain inserted within the integrin domain at the N terminus. (embl-heidelberg.de)
Integrin alpha (beta-propellor repeats). (embl.de)

They are heterodimeric complexes, each containing a unique alpha-subunit noncovalently associated with a common beta-subunit. (johnshopkins.edu)

A subset of four mAbs that reacted with the alphaM/beta2 complex but not with the unassociated alphaM subunit were mapped to one subregion, residues 718-759, and five other mAbs that recognized both the unassociated and the complexed alphaM subunit were localized to three other subregions, residues 599-679, 820-882, and 943-1047. (embl.de)

Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. (embl-heidelberg.de)

While integrins are expressed virtually in all cell types, a subset of integrins including αLβ2, αMβ2, α4β1, and α4β7 are predominantly expressed on leukocytes, thereby regulating immune cell trafficking to lymphoid tissues and sites of inflammation. (biomedcentral.com)

The alphaM subunit of integrin Mac-1 contains several distinct regions in its extracellular segment. (embl.de)

While typical integrin antagonists that block integrin activation target the initiation of leukocyte migration, a novel class of experimental compounds has been designed to block integrin deactivation, thereby perturbing the progression of cell migration. (biomedcentral.com)
Here we review the molecular mechanisms that regulate integrin activation and deactivation. (biomedcentral.com)

The structure of the beta-propeller domain and C-terminal region of the integrin alphaM subunit. (embl.de)

Integrins on resting cells are maintained in a default inactive state, in which the headpiece is folded back to the leg pieces [ 8 ], thereby exhibiting a bent conformation (Fig. 1a ). (biomedcentral.com)

Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed). (embl-heidelberg.de)