Complex cellular. Medical search. Frequent questions

UPR is a cellular response to the accumulation of a large number of incorrectly folded proteins in the ER. (phys.org)
This method is used to identify which cellular proteins are bound by a drug. (phys.org)
Despite the broad toxic effects of TRIP, the team was able to identify 89 individual, dose-dependent, potential cellular target proteins in a line of ovarian cancer cells-this is called the target landscape for TRIP. (phys.org)
Similarly, primary cilia have been implicated in regulation of mTOR signaling, in which Tuberous Sclerosis Complex proteins 1 and 2 (TSC1/2) negatively regulate protein synthesis by inactivating the mTOR complex 1 (mTORC1) at energy limiting states. (springer.com)
They also hope to study whether Myo1c forms complexes with other proteins key for the maintenance of healthy renal function. (sciencedaily.com)
HSNO passes readily through cell membranes and can nitrosylate proteins, transferring its nitrosyl group (-N=O) to other residues, especially cysteine, which represents an important step in a number of cellular regulation mechanisms. (chemistryviews.org)
The biological system is complex with many regulatory features such as DNA, mRNA, proteins, metabolites, and epigenetic features such as DNA methylation and histone post-translational modifications (PTMs). (rsc.org)
It does not address the more fundamental question of whether the intensity of staining for the two proteins vary in synchrony, as would be predicted if they are components of the same complex. (jneurosci.org)
This protein is one part (subunit) of the ribonucleoprotein complex, which is composed of proteins and molecules of RNA, DNA's chemical cousin. (medlineplus.gov)
When a cell is perturbed, it responds by altering expressing levels of specific proteins and adjusting cellular functions in response to the new environmental stimuli. (cdc.gov)

We investigated the effect of mtDNA haplogroups on the assembly of oxidative phosphorylation (OXPHOS) complexes in transmitochondrial hybrids (cybrids) harboring the three common LHON mutations. (nih.gov)
Additionally, cellular stressors, including oxidative stress to cellular DNA and other key cell structures, challenge cellular heath. (home-essential-oils.com)

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doTERRA Alpha CRS+ Cellular Vitality Complex is a propriety formula combining natural botanical and nutrients involved in the production of energy within the body. (santenewcastle.com.au)
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SPECIAL ISSUE 19th International Workshop on Cellular Automata and Discrete Complex Systems (AUTOMAT. (researchgate.net)
A cellular automaton (pl. cellular automata, abbrev. (wikipedia.org)
Cellular automata have found application in various areas, including physics, theoretical biology and microstructure modeling. (wikipedia.org)
The primary classifications of cellular automata, as outlined by Wolfram, are numbered one to four. (wikipedia.org)
They are, in order, automata in which patterns generally stabilize into homogeneity, automata in which patterns evolve into mostly stable or oscillating structures, automata in which patterns evolve in a seemingly chaotic fashion, and automata in which patterns become extremely complex and may last for a long time, with stable local structures. (wikipedia.org)
Special types of cellular automata are reversible, where only a single configuration leads directly to a subsequent one, and totalistic, in which the future value of individual cells only depends on the total value of a group of neighboring cells. (wikipedia.org)
Cellular automata can simulate a variety of real-world systems, including biological and chemical ones. (wikipedia.org)
The latter assumption is common in one-dimensional cellular automata. (wikipedia.org)
Cellular automata are often simulated on a finite grid rather than an infinite one. (wikipedia.org)
Instead, he began pursuing investigations into cellular automata , [ citation needed ] mainly with computer simulations. (wikipedia.org)
He produced a series of papers systematically investigating the class of elementary cellular automata , conceiving the Wolfram code , a naming system for one-dimensional cellular automata, and a classification scheme for the complexity of their behaviour. (wikipedia.org)
[4] [27] Wolfram's cellular-automata work came to be cited in more than 10,000 papers. (wikipedia.org)
In the mid-1980s, Wolfram worked on simulations of physical processes (such as turbulent fluid flow ) with cellular automata on the Connection Machine alongside Richard Feynman [28] and helped initiate the field of complex systems . (wikipedia.org)
The model is shown to be able to exhibit a wide range of behaviours analogous to the types of behaviour seen in other more general cellular automata. (complex-systems.com)
This paper explores the potential of elementary cellular automata to model the dynamics of riot. (complex-systems.com)
S. Roy, S. Das and A. Mukherjee, "Elementary Cellular Automata along with Delay Sensitivity Can Model Communal Riot Dynamics," Complex Systems , 31 (3), 2022 pp. 341-361. (complex-systems.com)

Taken together, these data point to the Fe-S cluster biogenesis factor NUBP2 as the probable starting point for the cellular processes triggered by TRIP. (phys.org)
This review presents a complex summary of GVHD pathogenesis with focus on references considering basic biological processes such as DNA damage response and cellular senescence. (hindawi.com)
This review summarizes the updated GVHD pathogenesis linking GVHD with biological processes such as DNA damage response (DDR) and cellular senescence (Figure 1 ). (hindawi.com)
Age-related and metabolic diseases such as type 2 diabetes (T2D) represent a source of cellular stress due to their disruptive effect on normal physiological processes and, therefore, can induce premature senescence ( 10 ). (frontiersin.org)
Genomics has led to valuable insights into the complex processes influencing health and disease. (cdc.gov)
Translating proteomics research findings is challenging in the face of complex and dynamic cellular-level processes. (cdc.gov)

Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)
Extracellular antigens (eg, from many bacteria) that are phagocytosed or endocytosed can be processed into peptides and complexed with surface class II MHC molecules on professional APCs, which specialize in presenting antigens to CD4 helper T (Th) cells. (msdmanuals.com)

Primary cilia are sensory organelles that coordinate multiple cellular signaling pathways, including Hedgehog (HH), Wingless/Int (WNT) and Transforming Growth Factor-β (TGF-β) signaling. (springer.com)
Timothy H. Warren, Georgetown University, Washington, D.C., USA, and colleagues have been able to stabilize, isolate, and characterize two of the species tied to these signaling pathways through binding to a zinc complex. (chemistryviews.org)
The AAA-ATPase (ATPases associated with diverse cellular activities) valosin-containing protein (VCP), is essential for many cellular pathways including but not limited to endoplasmic reticulum-associated degradation (ERAD), DNA damage responses, and cell cycle regulation. (portlandpress.com)
Due to its abundance and versatile function, VCP participates in many cellular pathways including ERAD, endolysosomal trafficking, selective autophagy, cell cycle regulation, and DNA damage signaling [ 1 ]. (portlandpress.com)

In summary, our results support distinct functions of Tsc1 and Tsc2 in cellular signaling as the two genes affect ciliary length control and HH signaling via different mechanisms. (springer.com)
In this review, we will discuss the mechanisms according to which T2D induces cellular senescence and the role of type 2 diabetes-induced cellular senescence in the pathogenesis and progression of colorectal cancer. (frontiersin.org)
Work across many laboratories is geared toward elucidating the genetics behind cancer, discovering cellular mechanisms that lead to cancer, and elucidating intracellular and intercellular interactions that allow this progression. (medscape.com)

These pro-ligands react with [AuCl(tht)] in the presence of base to form N-heterocyclic carbene (NHC) complexes, [AuCl(L)]. Two X-ray structures represent a pro-ligand and complex pairing: the latter reveals the two-coordinate linear geometry of the NHC-Au(I) species, as well as intermolecular interactions supported by both ligand π-π stacking and a weak aurophilic interaction of 3.3205(6) Å. (soton.ac.uk)
A major challenge of single-molecule localization microscopy is the long acquisition time, leading to low throughput, as well as to a poor temporal resolution that limits its use to visualize the dynamics of cellular structures in live cells. (bvsalud.org)

A cellular automaton consists of a regular grid of cells, each in one of a finite number of states, such as on and off (in contrast to a coupled map lattice). (wikipedia.org)
Typically, the rule for updating the state of cells is the same for each cell and does not change over time, and is applied to the whole grid simultaneously, though exceptions are known, such as the stochastic cellular automaton and asynchronous cellular automaton. (wikipedia.org)
While studied by some throughout the 1950s and 1960s, it was not until the 1970s and Conway's Game of Life, a two-dimensional cellular automaton, that interest in the subject expanded beyond academia. (wikipedia.org)
One way to simulate a two-dimensional cellular automaton is with an infinite sheet of graph paper along with a set of rules for the cells to follow. (wikipedia.org)
The former, named after the founding cellular automaton theorist, consists of the four orthogonally adjacent cells. (wikipedia.org)
[25] He conjectured that the Rule 110 cellular automaton might be Turing complete , which a research assistant to Wolfram, Matthew Cook , later proved correct. (wikipedia.org)
The basic model is a cellular automaton, where the cells represent small groups of neurons in the cortex. (complex-systems.com)

Because age-related cellular senescence and type 2 diabetes (T2D) have been recognised as risk factors for CRC development, the recent finding that type 2 diabetic patients present an elevated circulating volume of senescent cells raises the question whether type 2 diabetes facilitates the process of CRC tumorigenesis by inducing premature cell senescence. (frontiersin.org)
More recently, cellular senescence has been considered as an additional cause of age-related tumorigenesis. (frontiersin.org)
Senescence is a stress-response cellular state characterised by proliferative arrest but active metabolism ( 7 ). (frontiersin.org)
However, cellular senescence is not exclusive to ageing. (frontiersin.org)

Analytical solutions for the model point out the cellular- and kinetic aspects of inhibition. (plos.org)
von Kleist M, Metzner P, Marquet R, Schütte C (2012) HIV-1 Polymerase Inhibition by Nucleoside Analogs: Cellular- and Kinetic Parameters of Efficacy, Susceptibility and Resistance Selection. (plos.org)
The activity of complexes II (succinate:ubiquinone oxidoreductase) and III (ubiquinol:cytochrome c oxidoreductase) of mitochondrial ETC from liver, brain, and heart showed greater inhibition by Cd than the other complexes. (cdc.gov)
The primary mechanism of injury is cellular hypoxia from Complex IV (CIV) inhibition. (lu.se)

The heterodimeric TSC complex negatively regulates mTORC1 activity via the GTPase activity of TSC2, towards the small G-protein RHEB (Ras homologue enriched in brain) [ 5 ]. (springer.com)
HER2 belongs to the ErbB sub-family of receptor tyrosine kinases and regulates cellular proliferation and growth. (bvsalud.org)

This induces humoral and cellular immune responses against the encoded antigens. (bvsalud.org)

I've just been introduced to the Eilenberg-Steenrod axioms, and as an example, we are constructing cellular homology. (stackexchange.com)
Chain complexes crucially come with their chain homology groups . (ncatlab.org)

These syntaxin 1 protein complexes may play distinct roles in presynaptic biology. (jneurosci.org)

The main objective of the joint SERPICO Project-Team ( INRIA Rennes - Bretagne Atlantique - UMR 144 CNRS Institut Curie ("Subcellular Structure and Cellular Dynamics" Unit ) is to decipher the dynamic coordination and organization of molecular complexes at the single cell level. (inria.fr)

In the journal Angewandte Chemie , a research team has now described how a very low dose of a rhenium metal complex interferes with cellular metabolism to such an extent that it kills ovarian cancer cells. (phys.org)

When regarding chain maps between them that induce isomorphisms on these groups ( quasi-isomorphisms ) as weak equivalences , chain complexes form a useful presentation for aspects of stable homotopy theory . (ncatlab.org)
Conventional coimmunoprecipitation (coIP) and pull-down assays were used to test for stable protein complexes. (jneurosci.org)

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies ( Molecular Function , Biological Process , and Cellular Component ), a reference, and an evidence code. (yeastgenome.org)
Thus, syntaxin 1 appears to be a component of two separate complexes at the presynaptic terminal, a minor one at the transmitter release site with Ca V 2.2 and Gα O , as well as in large clusters remote from the release site with MUNC18-1. (jneurosci.org)

This age-related inflammation, also referred to as inflammaging, increases the risk for tissue damage and genetic aberrations that cause cellular transformation and cancer development ( 8 , 9 ). (frontiersin.org)
This is the multihit theory of tumorigenesis, in which a series of multiple triggering events in the genetic and cellular makeup of a cell ultimately cause cancer. (medscape.com)

However, an accumulation of low molecular weight subcomplexes suggested a complex I assembly/stability defect, which was further demonstrated by reversibly inhibiting mitochondrial protein translation with doxycycline. (nih.gov)
The results of kinetic studies and electron turnover experiments suggest that Cd may bind between semiubiquinone and cytochrome b566 of the Q0 site of cytochrome b of complex III, resulting in accumulation of semiubiquinones at the Q0 site. (cdc.gov)

This Notice of Funding Opportunity (NOFO) encourages research on the biology of high-confidence risk factors associated with complex brain disorders, with a focus on the intracellular, transcellular, and circuit substrates of neural function. (nih.gov)

The cellular longevity polyphenol blend found in Alpha CRS+ includes herbal extracts of scutellaria root containing baicalin, Fullopia juponica- resveratrol, pomegranate - ellagic acid, grape seeds- proanthocyanidins, milk thistle- silymarin and curcumin derived from turmeric root. (santenewcastle.com.au)

The resulting complexes may contribute to the initiation of neurodegenerative diseases, cancer, and bacterial and viral diseases, or act as therapeutics. (mdpi.com)

We investigated the effects of Cd on the individual complexes of the electron transfer chain (ETC) and on the stimulation of reactive oxygen species (ROS) production in mitochondria. (cdc.gov)

Interaction of the retinol/cellular retinol-binding protein complex with isolated nuclei and nuclear components. (rupress.org)
We have previously reported that purified cellular retinol-binding (CRBP) will mediate specific binding of retinol to nuclei isolated from rat liver. (rupress.org)

The current understanding of aGVHD pathogenesis can be summarized as (1) initial tissue damage induced by the conditioning regimen followed by the denudation of auto- and alloantigens accompanied by massive inflammatory cytokine secretion ("cytokine storm") activating APCs, (2) auto- and alloantigen presentation mediated by APCs together with the costimulatory signaling prime donor's cytotoxic T lymphocytes and their proliferation, and (3) the migration of activated cellular effectors toward GVHD target tissues. (hindawi.com)

Studies should not attempt to model disorders but instead should aim to elucidate the neurobiological impact of individual or combined risk factor(s), such as the affected molecular and cellular components and their relationships within defined biological process(es). (nih.gov)

Snake venoms are complex mixtures of protein and peptide toxins, varying from one species to another, and even within species. (who.int)

Leber's hereditary optic neuropathy (LHON), the most frequent mitochondrial disorder, is mostly due to three mitochondrial DNA (mtDNA) mutations in respiratory chain complex I subunit genes: 3460/ND1, 11778/ND4 and 14484/ND6. (nih.gov)
Mutations in the tumor suppressor genes encoding TSC1 (Hamartin) and TSC2 (Tuberin) cause a multisystemic tumor syndrome termed tuberous sclerosis complex (TSC). (springer.com)
Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)

Metal-containing complexes have taken up center stage in the search for new cancer drugs that are as free of side effects as possible. (phys.org)

Understanding how the brain transforms sensory input into complex behavior is a fundamental question in systems neuroscience. (harvard.edu)

Pom Cellular Beauty Complex combines clinically studied extracts and a powerful blend of CPTG ® essential oils to provide powerful antioxidant support for healthy, luminous skin with an irresistible glow from the inside out. (doterra.com)
Proteomics provides valuable information on cellular activities, which is integral for identifying and monitoring clinically relevant biomarkers, advancing our understanding of health and medicine. (cdc.gov)

The motor protein Myo1c binds to Neph1, a protein crucial for ensuring effective filtration by the kidney, and serves as one mode of its cellular transport, according to findings by investigators at the Medical University of South Carolina (MUSC) and their collaborators reported in the May 16, 2016 issue of Molecular and Cellular Biology . (sciencedaily.com)
The team stabilized the SNO − and SSNO − anions through binding to a special zinc complex inspired by a common environment for zinc in biology. (chemistryviews.org)

This vegan-friendly complex promotes cellular function and rejuvenation. (doterra.com)
Healthy tissues, organs, and, ultimately, healthy organisms depend on cellular reproduction and specialized function, energy production, and timely cell death when cells are not functioning at optimal levels. (home-essential-oils.com)
As we age, cellular function can deteriorate and we gradually begin to experience decreased energy and performance. (home-essential-oils.com)
Providing cells with essential nutrients and metabolic factors of cellular energy and protecting our cells from toxic stressors supports healthy cell function, vitality, and wellness. (home-essential-oils.com)
Protein also plays an important role in cellular function and enzyme action while also supporting hair, skin, and nails. (standardprocess.com)
While the cardiac effects of cyanide are well known, the cerebral effects on cellular function are less well described. (lu.se)

Researchers used small-angle X-ray scattering to determine the full structure of the motor protein Myo1c and its complex with Neph1, a protein crucial for kidney filtration. (sciencedaily.com)
The researchers revealed that zinc complexes containing the SNO − and SSNO − anions could be isolated and characterized. (chemistryviews.org)
Researchers have mapped the complex epigenetic and transcriptomic landscape of cancer, revealing key regulatory elements across 11 tumor types that could unlock new insights into cancer progression and metastasis. (news-medical.net)

The toxins in snake venoms are evolutionarily adapted to interact with a large variety of cellular targets in the organisms exposed to them. (who.int)

We demonstrate the library's potential diagnostic abilities on miRNA and mRNA combinations in cell lysate and its ability to operate in a cellular environment by using beacon-like c-jun mimicking substrate in living mammalian cells. (nature.com)

Widespread pathologic damage may occur via indirect cellular responses with the secretion of chemokines, proinflammatory cytokines, nitrous oxide, and other neurotoxic factors. (medscape.com)

Autophagy is an evolutionarily conserved catabolic process in eukaryotes, which involves the formation of double-membrane vesicles that enclose cellular components and fuse with lysosomes. (harvard.edu)

Fulvic minerals are one of nature's most effective and electron rich antioxidants, easily digested and absorbed into cells and shown to promote cellular health, regeneration and detoxification. (lolaglow.com)
Cytotoxic T lymphocytes were determined as the cellular effectors of GVHD, and the key role of antigen-presenting cells (APCs) in T-lymphocyte activation was established during the following years [ 11 , 12 ]. (hindawi.com)
they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)

Activation follows a spring-loaded mechanism not requiring further translation of other cellular factors in oocytes and is associated with unfolding of the inhibitory structure that blocks the tetramerization interface. (elifesciences.org)

The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. (nih.gov)

A basic example is the singular chain complex of a topological space , or the de Rham complex of a smooth manifold . (ncatlab.org)

For the purposes of this NOFO , the term complex can refer to a multifactorial contribution to risk (e.g., polygenic and/or environmental) and/or highly distributed functional features of the brain disorder. (nih.gov)

Molecular Components of the Immune System The immune system consists of cellular components and molecular components that work together to destroy antigens (Ags). (msdmanuals.com)

In particular this reasoning shows that connective chain complexes of abelian groups are a model for abelian ∞-groups (aka Kan complexes with abelian group structure). (ncatlab.org)

[29] In 1986, he founded the Center for Complex Systems Research (CCSR) at the University of Illinois at Urbana-Champaign . (wikipedia.org)
The term AIDS dementia complex was introduced by Navia and colleagues in 1986. (medscape.com)
[ 5 ] In 1986, the term AIDS dementia complex (ADC) was introduced to describe a unique constellation of neurobehavioral findings. (medscape.com)

These findings suggest that Myo1c uses the actin cytoskeleton as a "track" for cellular transport of its Neph1 cargo (bound to its C tail). (sciencedaily.com)

In addition, we also found decreased expression of Complex III and IV protein expression in brain tissue from the cyanide group. (lu.se)

The above findings could be explained if syntaxin 1 was a key element of a protein complex at the transmitter release site that included N-type Ca channels and Gα O . The primary motivation for this study was to test this hypothesis. (jneurosci.org)

The movement of Neph1 through cellular space is known to be linked to the injury/recovery response. (sciencedaily.com)

[30] In 1987, he founded the journal Complex Systems . (wikipedia.org)

Proteins10

Oxidative2

Vitality Complex3

Automata16

Processes6

Peptides2

Pathways4

Mechanisms3

Structures2

Automaton7

Senescence4

Inhibition4

Regulates2

Induces1

Homology2

Roles1

Dynamics1

Metabolism1

Stable2

Component2

Genetic2

Accumulation2

Intracellular1

Longevity1

Initiation1

Mitochondria1

Retinol2

Proliferation1

Biological process1

Mixtures1

Genes3

Search1

Sensory1

Clinically2

Biology2

Function6

Researchers3

Organisms1

MRNA1

Responses1

Autophagy1

Cells3

Mechanism1

Genome1

Singular1

Multifactorial1

Consists1

Model1

19863

Cytoskeleton1

Expression1

Primary1

Response1

Journal1