• In 1962, Italian geneticist Ferruccio Ritossa reported that heat and the metabolic uncoupler 2,4-dinitrophenol induced a characteristic pattern of "puffing" in the chromosomes of Drosophila. (wikipedia.org)
  • The peak values of delta psi and ROS generation are under succinate oxidation and delta psi is modified using either an uncoupler or complex II inhibitor, so, as so often, we are a long way from physiology here but the general principle that ROS generation rises rapidly above a threshold delta psi appears to hold good today. (blogspot.com)
  • Summary so far: The very high membrane voltages needed to inhibit respiration at complex IV will cause excess ROS generation. (blogspot.com)
  • So we can limit respiration by inhibiting complex IV using this system at a membrane potential below 140mV with limited ROS generation or we can inhibit it at above 140mV accepting ROS generation using the Mitchell concept. (blogspot.com)
  • Next we can think about the control of ATP synthesis by complex IV, synonymous with cytochrome c oxidase. (blogspot.com)
  • MATERIALS AND METHODS: The inhibitory effect of SD decoction and POG on type I allergy and its possible mechanism were evaluated by using RBL-2H3 cells model in vitro and the passive cutaneous anaphylaxis (PCA) mouse model in vivo. (bvsalud.org)
  • The invention also provides cells producing the antibodies, and methods of making and using the same. (justia.com)
  • METHODS: We constructed a mouse model of OVA-induced asthma. (bvsalud.org)
  • There is a second system to control respiration through complex IV. (blogspot.com)
  • In addition, the lung function was detected by mouse lung function apparatus. (bvsalud.org)
  • Corilagin also suppressed airway resistance and lung function in mice. (bvsalud.org)
  • The red line is the rate of respiration through complex IV as a function of the delta psi generated. (blogspot.com)
  • These effects translated to rodents, where UA improved exercise capacity in two different mouse models of age-related decline of muscle function, as well as in young rats. (lsd1receptor.com)
  • A single intrapharyngeal instillation of SWCNTs induced activation of heme oxygenase-1 (HO-1), a marker of oxidative insults, in lung, aorta, and heart tissue in HO-1 reporter transgenic mice. (nih.gov)
  • Because these modifications have been related to cardiovascular diseases, we evaluated whether repeated exposure to SWCNTs (20 μg/mouse once every other week for 8 weeks) stimulates the progression of atherosclerosis in ApoE −/− transgenic mice. (nih.gov)
  • Development of a monoclonal antibody immunoassay for the detection of gasoline and diesel fuel in the environment. (cdc.gov)
  • It is perhaps best known for its influence on the formation, growth, survival, and development of neurons and for its role in mediating the beneficial cognitive effects associated with exercise . (foundmyfitness.com)
  • In vitro culture and light microscopic observation were employed to study its developmental process from spore germination to the formation of young gametophyte, as well as effects of light and temperature on its spore germination and protonemal development. (scielo.br)
  • PMID- 5097518 TI - Effects of -amanitin on mouse and rat liver cell nuclei. (nih.gov)