• 44 proteins were commonly identified in two different strains, isolated from distinct hosts, then composing a core C. pseudotuberculosis exoproteome. (biomedcentral.com)
  • Here we compared the amino-acid sequences of putative HmuY homologues deposited in databases. (erksignal.com)
  • This bacterium is grown at 37 °C under aerobic or anaerobic conditions, thus C. pseudotuberculosis is a facultative anaerobe. (wikipedia.org)
  • Corynebacterium pseudotuberculosis is a facultative intracellular pathogen that belongs to the so-called CMN ( Corynebacterium-Mycobacterium-Nocardia ) group, a distinct subgroup of the Actinobacteria that also includes other highly important bacterial pathogens, such as Corynebacterium diphtheriae and Mycobacterium tuberculosis . (biomedcentral.com)
  • Corynebacterium diphtheriae is responsible for both endemic and epidemic diphtheria. (who.int)
  • Corynebacterium diphtheriae est responsable à la fois de la diphtérie endémique et épidémique. (who.int)
  • Subespecies identification by hsp65 and rpoB genes sequencing and erm(41) and rrl genes for mutation detection and primer design were performed. (bvsalud.org)
  • to identify the genetic basis of toxin production and other potential virulence factors in this strain, a whole genome sequencing approach was applied to the isolate. (cdc.gov)
  • However, strain RAH1 also possessed the venom serine protease gene ( vsp2 ), which, in C. ulcerans strain 809, has been implicated in the increased virulence in humans. (cdc.gov)
  • Comparative analyses of the exoproteomes of two C. pseudotuberculosis strains, in addition to comparison with other experimentally determined corynebacterial exoproteomes, were helpful to gain novel insights into the contribution of the exported proteins in the virulence of this bacterium. (biomedcentral.com)
  • In fact, one might expect that the majority of the virulence determinants of C. pseudotuberculosis would be present in the exoproteome, i.e . the entire set of bacterial proteins found in the extracellular milieu [ 7 ]. (biomedcentral.com)
  • Two isolates (1.0â %) were discordant by mqPCR compared to rrl gene sequencing. (bvsalud.org)
  • Corynebacterium pseudotuberculosis is a Gram-positive bacterium known globally to infect ruminants, horses, and rarely people. (wikipedia.org)
  • shows high identity to proteins identified in several P. gingivalis strains [17, 19]. (erksignal.com)
  • citation needed] Shortly after, it was sampled from abscesses in a sheep by Hugo von Preisz [hu], and the bacterium was named the "Preisz-Nocard" bacillus until further work by German microbiologists in the mid-1900s, when it was recategorized into the Corynebacterium genus. (wikipedia.org)
  • C. pseudotuberculosis is a Gram-positive bacterium that can be either coccoid or filamentous rods, which can be organized into palisades. (wikipedia.org)
  • and were mapped onto the published genome sequences of a Shiga-like toxin-producing clinical isolate 809, asymptomatic canine strain BR-AD22 ( 3 ), and diphtheria-like toxin-producing strain 0102 ( 4 ). (cdc.gov)
  • citation needed] Development of a vaccine was completed in 1983, and it was added to the recommended clostridial vaccines for sheep. (wikipedia.org)
  • citation needed] Although few recent studies have been conducted into its prevalence, data from slaughterhouses in Australia in the late 1980s suggested that C. pseudotuberculosis was affecting 50-60% of sheep. (wikipedia.org)
  • A disease known as ulcerative lymphagenitis can also result from infection with C. pseudotuberculosis in the distal limbs of horses. (wikipedia.org)
  • Further efforts to identify the strain by using VITEK MS and VITEK2 ANC card systems (bioMérieux, Marcy l'Etoile, France) to evaluate the swab samples suggested that the infection was caused by either C. ulcerans or C. pseudotuberculosis (50% CI). (cdc.gov)
  • Genome-based phylogenetic analysis of the RAH1 strain (ClonalFrame analysis [ 5 ]) and strains 809, BR-AD22, and 0102 indicates a much wider phylogenetic diversity of C. ulcerans strains than previously appreciated (data not shown). (cdc.gov)
  • swab samples from the exudative membrane and throat produced small, black colonies indicative of Corynebacterium spp. (cdc.gov)
  • The declining costs of next-generation sequencing and availability of easy-to-handle bioinformatics tools emphasize the suitability of deep-sequencing technology for rapid diagnostics and for the development of high-resolution genotyping. (cdc.gov)
  • We performed whole genome sequencing of 40 C. tuberculostearicum isolates cultured from the skin of five healthy individuals across seven skin sites. (nih.gov)
  • to identify the genetic basis of toxin production and other potential virulence factors in this strain, a whole genome sequencing approach was applied to the isolate. (cdc.gov)
  • Toxigenic Corynebacterium ulcerans is an increasingly reported cause of diphtheria in the United Kingdom and is often associated with a zoonotic origin ( 1 , 2 ). (cdc.gov)
  • Further efforts to identify the strain by using VITEK MS and VITEK2 ANC card systems (bioMérieux, Marcy l'Etoile, France) to evaluate the swab samples suggested that the infection was caused by either C. ulcerans or C. pseudotuberculosis (50% CI). (cdc.gov)
  • The isolate detected from this process was sent to the Streptococcus and Diphtheria Reference Unit, Public Health England, Colindale, UK, and was confirmed to be a toxigenic C. ulcerans strain that we designated RAH1. (cdc.gov)
  • However, strain RAH1 also possessed the venom serine protease gene ( vsp2 ), which, in C. ulcerans strain 809, has been implicated in the increased virulence in humans. (cdc.gov)
  • Genome-based phylogenetic analysis of the RAH1 strain (ClonalFrame analysis [ 5 ]) and strains 809, BR-AD22, and 0102 indicates a much wider phylogenetic diversity of C. ulcerans strains than previously appreciated (data not shown). (cdc.gov)
  • Surface and Extracellular Proteome of the Emerging Pathogen Corynebacterium ulcerans. (uni-bielefeld.de)
  • Corynebacterium is a predominant genus in the skin microbiome, yet its genetic diversity on skin is incompletely characterized and lacks a comprehensive set of reference genomes. (nih.gov)
  • citation needed] Shortly after, it was sampled from abscesses in a sheep by Hugo von Preisz [hu], and the bacterium was named the "Preisz-Nocard" bacillus until further work by German microbiologists in the mid-1900s, when it was recategorized into the Corynebacterium genus. (wikipedia.org)
  • and were mapped onto the published genome sequences of a Shiga-like toxin-producing clinical isolate 809, asymptomatic canine strain BR-AD22 ( 3 ), and diphtheria-like toxin-producing strain 0102 ( 4 ). (cdc.gov)
  • The declining costs of next-generation sequencing and availability of easy-to-handle bioinformatics tools emphasize the suitability of deep-sequencing technology for rapid diagnostics and for the development of high-resolution genotyping. (cdc.gov)
  • We used V1-V3 16S rRNA gene sequencing data from 14 body sites of 23 healthy volunteers to characterize Corynebacterium diversity and distribution across healthy human skin. (nih.gov)
  • citation needed] Although few recent studies have been conducted into its prevalence, data from slaughterhouses in Australia in the late 1980s suggested that C. pseudotuberculosis was affecting 50-60% of sheep. (wikipedia.org)
  • citation needed] Distribution of C. pseudotuberculosis is mostly traced by examining prevalence of caseous lymphadenitis, the bacterium's main pathological disease. (wikipedia.org)
  • A comprehensive proteome map of the lipid-requiring nosocomial pathogen Corynebacterium jeikeium K411", PROTEOMICS , vol. 7, 2007, pp. 1076-1096. (uni-bielefeld.de)
  • Corynebacterium jeikeium is a lipid-requiring pathogen that is considered as part of the normal microflora of the human skin and associated with severe nosocomial infections. (uni-bielefeld.de)
  • Molecular basis of human body odour formation: insights deduced from corynebacterial genome sequences. (uni-bielefeld.de)
  • citation needed] Development of a vaccine was completed in 1983, and it was added to the recommended clostridial vaccines for sheep. (wikipedia.org)