Complement receptors igg. Medical search. Frequent questions

Neutrophils are professional phagocytes: they are ferocious eaters and rapidly engulf invaders coated with antibodies and complement, as well as damaged cells or cellular debris. (wikipedia.org)
Initially, all antibodies are of the first form, attached to the surface of a B cell - these are then referred to as B-cell receptors (BCR). (wikipedia.org)
Similar to monoclonal antibodies, sialic acid inhibited the increased C1q binding to galactosylated Fc fragments in human polyclonal IgG. (jci.org)
The induced IgG and IgM antibodies were able to stimulate various Fc-mediated effector mechanisms associated with protection against malaria, including phagocytosis, release of reactive oxygen species, production of IFN-γ as well as complement activation and fixation. (nature.com)
Complement activation predicts adverse pregnancy outcome in patients with systemic lupus erythematosus and/or anti-phospholipid antibodies. (hss.edu)
A number of important cells, including toll-like receptors, mast cells, anti-citrullinated protein antibodies, complement and interferon, all play their own role in this process. (the-rheumatologist.org)
Furthermore they established that anti-CD79a/b antibodies (intact, or mutants incompetent to bind IgG receptors and activate the complement cascade) block the development of disease and ameliorate ongoing target organ injury in MRL/LPR mouse model of Rheumatoid Arthritis, NOD mice for Type 1 Diabetes and EAE mouse model for MS. (nationaljewish.org)
For confirming the S protein-specificity of IgG4-expressing B lymphocyte clones, four mAbs (monoclonal antibodies) were cloned from the BCR (B cell receptor) sequences, and their RBD binding and S protein-binding were assessed. (news-medical.net)
This kit includes capture and detection antibodies and an IgG standard. (stemcell.com)
FcRn expressed in endosomal compartment of intestinal epithelium, vascular endothelium and macrophages regulates the serum IgG levels by binding to the pinocytosed antibodies and recirculating them to cell surface without intracellular degradation. (academie-medecine.fr)
Chromatin IgG, double-stranded DNA, Smith, and RNA antibodies were all negative by ELISA. (cdc.gov)
Neonatal Fc receptor inhibition helps to reduce immunoglobulin G (IgG) recycling and IgG antibodies by binding to and blocking the Fc receptor. (ajmc.com)
Secondary antibodies against chicken IgYs don't cross-react with mammalian IgGs. (linscottsdirectory.com)
However, despite the ability of KEL RBCs to induce anti-KEL antibodies in the absence of complement, removal of C3 or complement receptors 1 and 2 (CR1/2) rendered recipients completely reliant on CD4+ T cells for IgG anti-KEL antibody formation. (jci.org)
Rho (D) immune globulin is available as a sterile, lyophilized or liquid gamma globulin (IgG) fraction containing antibodies to the Rh0 (D) antigen (D antigen) under the name Rhophylac (IM/IV). (drugbank.com)
When testing for food sensitivities, the test uses immunoglobins antibodies found in the blood, IgG (1,2,3). (urmindmatters.com)
Antibodies, the complement system, and the cellular receptors regulating signaling, such as Fc receptors and integrins, are natural components to study. (lu.se)

The terms antibody and immunoglobulin are often used interchangeably, [1] though the term 'antibody' is sometimes reserved for the secreted, soluble form, i.e. excluding B-cell receptors. (wikipedia.org)
ACPA-positive RA patients have higher levels of immunoglobulin-G (IgG). (the-rheumatologist.org)
In a recent study published in Science Immunology , researchers evaluated immunoglobulin G (IgG) responses to coronavirus disease 2019 (COVID-19) messenger ribonucleic acid (mRNA) vaccinations. (news-medical.net)
After 5.0 months to 7.0 months of the second mRNA vaccination, anti-SARS-CoV-2 IgG responses primarily comprised the non-inflammatory immunoglobulin G4 subclass and were enhanced by the booster dose or breakthrough infection. (news-medical.net)
The Mouse Immunoglobulin G (IgG) ELISA Antibody Pair Kit is intended for those who want the flexibility of setting up their own ELISA assay. (stemcell.com)
IgG is the major immunoglobulin found in blood, lymph fluid, cerebrospinal fluid, and peritoneal fluid. (stemcell.com)
IgG is the most abundant immunoglobulin in serum, comprising approximately 80% of all serum immunoglobulins. (stemcell.com)
Different immunoglobulin G (IgG) subclasses produced by class-switched B cells help in opsonization and virus neutralization and hence, facilitate viral clearance from the host. (researchsquare.com)
We also have observed that Fcγ receptors (FcγR), proteins present on the surface of microglia that bind immunoglobulin G (IgG) and other ligands, are key modulators of α-SYN-induced neurodegeneration. (biomedcentral.com)
The most common example of this type of fusion protein combines the hinge and Fc regions of an immunoglobulin (Ig) with domains of a cell-surface receptor that recognizes a specific ligand (Box 1). (coek.info)
Complement gene variants determine the risk of immunoglobulin-associated MPGN and C3 glomerulopathy and predict long-term renal outcome. (cdc.gov)
Either the virus is complexed with antiviral IMMUNOGLOBULIN G and binds to Fc receptors, or virus is coated with antiviral IMMUNOGLOBULIN M and binds to complement receptors. (bvsalud.org)

In addition, secretions from the primary granules of neutrophils stimulate the phagocytosis of IgG antibody-coated bacteria. (wikipedia.org)
IgG plays a key role in the humoral immune response, plays a critical step in the opsonization process by interacting with the Fcγ receptor on macrophages, neutrophils, and natural killer cells, and is able to activate the complement system. (stemcell.com)
This agent inhibits chemotaxis of eosinophils and locomotion of neutrophils and impairs complement-dependent antigen-antibody reactions. (medscape.com)
2 The interaction of IVIG with a large number of components of the immune system including Fc receptors, complement molecules, cytokines, B and T lymphocytes, neutrophils and NK cells, may explain at least in part their anti-inflammatory effects. (academie-medecine.fr)
Receptors able to mediate phagocytosis are expressed almost exclusively in neutrophils, monocytes and macrophages, and receptor clustering is thought to occur upon particle binding which in turn generates a phagocytic signal, activating the phagocytic process [ 3345 ]. (nanomedicine.com)
The enhancement was both dose- and time-dependent, and highly selective for the eosinophil since there was no evidence that C3b receptors on neutrophils or monocytes were altered by these pharmacologic agents even when varying concentrations of C3 were added to the indicator red cells. (aai.org)
Fc gamma receptors (FcγR) are proteins expressed on the surface of microglia as well as other cell types, including natural killer cells, neutrophils, and mast cells. (biomedcentral.com)

Cluster of Differentiation 79 (CD79) is a transmembrane protein found exclusively in B cells that is the transducer component of B-cell receptor (BCR), generating a signal following recognition of antigen by the BCR. (nationaljewish.org)
Dr. Cambier and his laboratory discovered that in certain circumstances, subunits of the B cell antigen receptor (BCR) become dissociated rendering the receptor incompetent to transduce activating signals. (nationaljewish.org)
B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation. (nationaljewish.org)
Antigen-stimulated dissociation of BCR mIg from Ig-alpha/Ig-beta: implications for receptor desensitization. (nationaljewish.org)
Four hours after antigen challenge, immune complexes were localized at the ciliary body and iris of receptor-deficient mice. (elsevierpure.com)
CD32 enables interaction between Fc γ RII-expressing cells and opsonized antigen or IgG-containing immune complexes. (bioxcell.com)
This molecule constitutes the specific receptor for the antigen on the B lymphocyte (BCR). (allergy-link.com)
Rho-specific IgG may inhibit the late stages of B cell activation by being internalized with Rho antigen by B cells, which alters the antigen processing and presentation. (drugbank.com)
In response to the IgG-antigen complex formation, the immune globulin enhances the presentation of specific peptides and proliferation of epitope-specific T cells 4 . (drugbank.com)

IgG2a also engages in high affinity interactions with Fc receptors on immune cells which can result in antibody-dependent cell-mediated cytotoxicity (ADCC) as well as antibody-dependent cellular phagocytosis (ADCP) by phagocytosing cells like macrophages 3-8 . (researchsquare.com)
Does not bind to mammalian Fc receptors, avoiding non-specific binding to cells expressing such receptors (e.g., macrophages and dendritic cells). (linscottsdirectory.com)
IgG-opsonized RBCs may interact with activating IgG receptors (FcγRs) on effector cells and elicit phagocytosis via mononuclear phagocytic system, primarily by macrophages. (drugbank.com)

Les IgIV intéragissent avec de nombreux composants du système immunitaire comme les récepteurs Fc, le complément, les cytokines, les lymphocytes T et B, les cellules dendritiques, les granulocytes et les cellules NK, ce qui explique en partie leurs effets anti-inflammatoires. (academie-medecine.fr)
In previous studies, we have used a mouse model in which α-SYN is overexpressed using an adeno-associated viral vector (AAV) to reproduce many of these features, including IgG deposition, classical microglial activation with increased production of pro-inflammatory cytokines, and B- and T-lymphocyte infiltration in the SN [ 11 ]. (biomedcentral.com)
When receptors for these cytokines were deleted, the severity of immune complex-induced uveitis was profoundly reduced. (elsevierpure.com)
For immunomodulation - not fully understood, though believed to have multiple effects on T cells, B cells, cytokines, complement and Fc-receptors. (medschool.co)

We know that uncontrolled activation of the complement pathway is responsible for many devastating diseases, and through the development of the first two complement inhibitors - SOLIRIS and ULTOMIRIS - we have shown the transformative impact of C5 inhibition on several of these diseases," said John Orloff, M.D., Executive Vice President and Head of Research & Development at Alexion. (businesswire.com)
Over the next couple of decades, there was work looking at the role of complement inhibition in experimental models. (medscape.com)
Administration of QIV with the two adjuvants, individually or combined, resulted in enhanced HA-specific serum ELISA IgG titers, serum hemagglutination inhibition (HAI) titers and splenic T cell responses as examined by IFN-γ and IL-4 enzyme-linked immunosorbent spot (ELISPOT) assays, 4-weeks post-prime and post-boost vaccination in BALB/c mice. (researchsquare.com)
In the case of receptor-mediated phagocytic binding, dansylcadaverine, amantadine, and rimantadine induce inhibition of endocytosis of complement-coated zymosan particles by human peripheral PMN leukocytes. (nanomedicine.com)
Complement inhibition blocks cleavage of C5 into C5a and b, thereby preventing a membrane attack complex. (ajmc.com)

It is designed for the quantitative detection and measurement of total mouse IgG in biological fluids such as serum, plasma, and cell culture supernatants. (stemcell.com)
Our findings suggest that susceptibility to recurrent lymphocytic meningitis might be caused by low serum IgG subclass 2 immunodeficiency. (cdc.gov)
Previous research has reported an association of low serum IgG subclass 1 (IgG1) and IgG subclass 3 (IgG3) levels with increased frequency of RBLM ( 2 ). (cdc.gov)
We report an unusual case of serum IgG subclass 2 immunodeficiency in a patient with 8 lifetime episodes of RBLM. (cdc.gov)
The Synthesis Rate Igg Csf reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (genscanner.com)
Human serum albumin (HSA) antiserum was injected into the vitreous of 'knockout' or 'double knockout' mice genetically deficient in IL-1 receptor type I (IL-1RI(-/-)), TNF receptors p55 and p75 (TNFR p55(-/-)/p75(-/-)), IL-1RI and TNFR p55 (IL-1RI(-/-)/TNFR p55(-/-)), and controls. (elsevierpure.com)
The vaccine was safe and well tolerated, induced potent serum IgG & IgA responses waning post last vaccination, and low and intermittent mucosal IgG, but did not induce neutralizing activity neither in serum nor vaginal samples. (europa.eu)

IgG Fc is a homodimer that is composed of the constant region of the two heavy chains that form the IgG molecule. (biolegend.com)
IgG functions - functional sites on the IgG molecule (complement and Fc receptor). (lu.se)
Immunoadhesin structure The majority of immunoadhesins combine the hinge and Fc regions of an IgGl heavy chain with the extracellular domain (ECU) of a type I transmembrane protein, usually a receptor or an adhesion molecule (Fig. 1). (coek.info)

Shortly post-double COVID-19 vaccinations, the IgG antibody responses primarily comprise IgG1 and IgG3, which are predominantly inflammatory-type subclasses, whereas IgG2 and IgG4 responses are rarely observed. (news-medical.net)
Further, flow cytometry analysis was performed to characterize anti-S memory B lymphocytes by IgG subclasses among PBMC (peripheral blood mononuclear cells) samples, obtained from 11 individuals post-second dose and third dose administration. (news-medical.net)
IgG subclasses showed decreased IgG2 at 130.3 mg/dL (reference range 242-700 mg/dL) and normal (reference) levels of IgG1, IgG3, and IgG4. (cdc.gov)
She includes four subclasses: IgG1, IgG2, IgG3 and IgG4 and which represent 66%, 23%, 7% and 4% of IgG respectively. (allergy-link.com)

Several pathways of phagocytic signal transduction have been identified [ 3345 ], including the activation of tyrosine kinases or serine/threonine kinase C, leading to phosphorylation of the receptors and other proteins which are recruited at the sites of phagocytosis. (nanomedicine.com)
The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. (mybiosource.com)
Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. (embl.de)
Attack by phagocytic cells can be facilitated when antigens are coated with antibody (Ab), which is produced as part of acquired immunity, or when complement proteins opsonize antigens. (msdmanuals.com)

More than a decade ago myasthenic symptoms were observed in rabbits immunized with acetylcholine receptor (AChR) [119] and AChR deficiency was found at the neuromuscular junction in human myasthenia gravis (MG) [36]. (nih.gov)

Complement inhibitors are relatively new, though we've known about complement at the neuromuscular junction since the 1950s, when Arthur Strauss was measuring complement levels in myasthenic patients and noted some changes. (medscape.com)
But it was the seminal work of Andrew Engel and his team at the Mayo Clinic in the mid-1970s that demonstrated complement at the neuromuscular junction in a debris field of a postjunctional image that had been relatively destroyed. (medscape.com)
Approximately 85% of MG cases spring from autoantibodies that target acetylcholine receptors (AChRs) on the postsynaptic membrane of the neuromuscular junction, and 10% from autoantibodies that target muscle specific tyrosine kinase (MuSK) and low density lipoprotein receptor-related protein 4. (ajmc.com)

Human peripheral blood lymphocytes were stained with CD19 FITC and anti-human IgG Fc (clone M1310G05) APC/Cyanine7 (left) or rat IgG2a, κ APC/Cyanine7 isotype control (right). (biolegend.com)
Some models of human IgG1 - illustrating differences in human IgG isotype and allotype. (lu.se)

Clone M1310G05 recognizes IgG in the membrane of memory B cells, has a stronger affinity for IgG1 and IgG3 than for IgG2 and IgG4, and does not cross react with IgD, IgE, or IgM. (biolegend.com)

Here, we report that IgG Fc sialylation of human monoclonal IgG1 molecules impairs their efficacy to induce complement-mediated cytotoxicity (CDC). (jci.org)

Complement Component 3a Receptor 1 (C3AR1) IgG antibody, Polyclonal. (creative-biolabs.com)
The distribution of immune complexes in eyes was observed by immunohistochemical staining for IgG and complement component C3. (elsevierpure.com)
Unexpectedly, our findings demonstrated that KEL RBCs actually possess the ability to induce antibody formation independent of CD4+ T cells or complement component 3 (C3), two common regulators of antibody formation. (jci.org)

Igg Antibody Laboratories manufactures the synthesis rate igg csf reagents distributed by Genprice. (genscanner.com)
Igg Elisa Laboratories manufactures the getting an igg elisa test reagents distributed by Genprice. (genscanner.com)

Innate immunity includes barriers such as the epithelium, mucus, pH, complement system, and cells of the immune system. (hindawi.com)

Once physical contact with a phagocyte has occurred, particle binding to specific cell surface receptors is the first step in the phagocytosis of a medical nanorobot. (nanomedicine.com)
Phagocytosis is a term coined from the Greek to describe the receptor-mediated engulfment and degradation of dead cells and microbes. (frontiersin.org)
IgG may also stimulate complement activation on the RBC surface, followed by RBC lysis or complement receptor-mediated phagocytosis but to smaller extent 4 . (drugbank.com)
In vitro studies of cytokine expression in human monocytes and granulocytes exposed to anti-D coated red blood cells have demonstrated enhanced secretion of interleukin 1 receptor antagonist resulting in down-regulation of FcγR mediated phagocytosis. (drugbank.com)

receptors that bind to IgG and IgA are used to help with this task. (wikipedia.org)
The N-terminal type A repeats in LDL receptor bind the lipoproteins. (embl.de)

Does not activate mammalian complement systems, allowing the use of chicken IgYs in in vivo applications. (linscottsdirectory.com)
IgG is an antibody that can activate the pro-inflammatory complement system (complement cascade) associated with chronic inflammatory conditions. (urmindmatters.com)

In order to be internalized, the receptor-ligand complex must first cluster into clathrin-coated pits. (embl.de)

Serological IgG responses to TT (tetanus toxoid) were evaluated among 23 TT recipients (median of 6.0 TT doses) using enzyme-linked immunosorbent assays (ELISA). (news-medical.net)

Mast cells respond to toll-like receptor ligands with the production of IL-8, he noted. (the-rheumatologist.org)
Mast cells respond to ACPA, and endogenous toll-like receptor ligands enhance mast cell activation by ACPA. (the-rheumatologist.org)
Moreover, these receptors are functional, as treatment of FRT tissue cells with ligands for TLR and NOD induces production of proinflammatory CXCL8 [ 13 ], and those receptors actively participate in immune response to pathogens, as Neisseria gonorrhea and HIV-1 [ 14 ]. (hindawi.com)

The LDL receptor binds LDL and transports it into cells by acidic endocytosis. (embl.de)

Thus, impairment of CDC represents an FcγR-independent mechanism by which Fc-sialylated glycovariants might limit proinflammatory IgG effector functions. (jci.org)

This includes work on Fc-receptors, complement and glycosylation of IgG where he studies its significance in human immune responses. (peace-conference.org)
The Fc regions of IgGs bear a highly conserved N-glycosylation site. (mybiosource.com)
Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. (mybiosource.com)

IgG molecules exert both pro- and antiinflammatory effector functions based on the composition of the fragment crystallizable (Fc) domain glycan. (jci.org)

Human Siglec-E-IgG Fc fusion protein. (biolegend.com)
A phase 2 trial was designed that gave a signal, and then the landmark REGAIN trial was our first complement inhibitor targeting the fifth protein of the complement cascade. (medscape.com)
Cell-bound or soluble protein A produced by Staphylococcus aureus [ 1728 ] attaches to the Fc region of IgG and blocks the cytophilic (cell-binding) domain of the antibody. (nanomedicine.com)

It's an analog of eculizumab - the original complement inhibitor. (medscape.com)
Ravulizumab is a complement inhibitor, but it's engineered so that the dosing interval is every 8 weeks rather than every 2 weeks for patient convenience. (medscape.com)

Fc sialylation of a CD20-targeting antibody had no impact on antibody-dependent cellular cytotoxicity and did not change the affinity of the antibody for activating Fcγ receptors. (jci.org)
In sera derived from patients with chronic inflammatory demyelinating polyneuropathy, an autoimmune disease of the peripheral nervous system in which humoral immune responses mediate tissue damage, induction of IgG Fc sialylation was associated with clinical disease remission. (jci.org)

Mast cells express many pattern recognition receptors," said Dr. Toes. (the-rheumatologist.org)
Are human mast cells activated through toll-like receptors? (the-rheumatologist.org)
Both cultured and synovial mast cells express the receptor FCγRIIA. (the-rheumatologist.org)
Most IgE are found to be fixed on basophils and mast cells by receptors specific to the constant part (RFCεI). (allergy-link.com)

In mammals, there are five classes of immunoglobulins (IgG, IgM, IgA, IgE and IgD) which differ in their Phi, the half-life, the number of constant domains and the role of the constant parts. (allergy-link.com)

Sialylated IgG Fc domains have antiinflammatory properties that are attributed to their ability to increase the activation threshold of innate effector cells to immune complexes by stimulating the upregulation of the inhibitory Fcγ receptor IIB (FcγRIIB). (jci.org)
Responds to T cell replacement factor by increasing the number of IgG secreting cells. (hsanmartino.it)
The low-density lipoprotein receptor (LDLR) is the major cholesterol-carrying lipoprotein of plasma, acting to regulate cholesterol homeostasis in mammalian cells. (embl.de)

Polymorphism of the FcgammaRIIalpha IgG receptor in patients with lupus nephritis and glomerulopathy. (cdc.gov)

Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. (embl.de)

We've demonstrated that by targeting a membrane attack complex, or the terminal complement complex, we've been able to improve patients' well-being. (medscape.com)

Today, we'll take a closer look at recently approved and emerging drug therapies, such as complement inhibitors , FcRn inhibitors , and other novel therapeutics. (medscape.com)

CITE (cellular indexing of transcriptomes and epitopes)-sequencing was performed for labeling anti-S and anti-S RBD (receptor-binding domain)-binding B lymphocytes. (news-medical.net)

In our previous studies in vivo , we have found that the Fc receptors appear to have a key role in α-SYN-induced inflammation: deficiency of FcγRs blocks α-SYN-induced NF-κB-driven pro-inflammatory signaling, and attenuates microglial activation and DA neurodegeneration [ 15 ]. (biomedcentral.com)

For instance, IgG2a engages with complement system components through their Fc region 2 . (researchsquare.com)
Mouse IgG2a - a structure of a complete mouse IgG antibody. (lu.se)

In the present study, researchers reported assessed IgG titers induced by mRNA vaccinations in the long term. (news-medical.net)
Flow cytometry analysis was performed to measure the serological anti-SARS-CoV-2 spike (S) IgG titers after 10.0 days of each vaccine dose, 210.0 days post-second dose and 180.0 days post-booster dose vaccinations. (news-medical.net)
Among all anti-S IgG titers, IgG4 titers elevated from a mere 0.04 percent shortly post-second dose to 19 percent late post-third dose. (news-medical.net)

The Fc fragment mediates opsonization, antibody dependent cellular cytotoxicity (ADCC), and complement activation through binding to Fc receptors such as CD16, CD32, CD64, and the complement factor C1. (biolegend.com)

IVIG contains at least 96 % IgG with traces of IgA and IgM. (academie-medecine.fr)
The size of the plasma pool ensures the vast diversity of IgG repertoire in IVIG that interacts with a large number of self-antigens, in addition to pathogens and external antigens [2]. (academie-medecine.fr)

Why don't we start with complement inhibitors? (medscape.com)

These results suggest that pharmacologic mediators of hypersensitivity may regulate certain eosinophil-dependent biologic reactions and that there may be a direct relationship between the cell surface "recognition unit" for eosinophil locomotion and some of the membrane receptors that promote the adhesion of eosinophils to opsonized particles. (aai.org)

With the rosette technique, the ECF-A tetrapeptides (Val-Gly-Ser-Glu and Ala-Gly-Ser-Glu) and histamine, agents previously shown to be preferentially chemotactic for the eosinophil, markedly enhanced the expression of human eosinophil receptors for C3b. (aai.org)
A human lung anaphylactic diffusate also enhanced eosinophil C3b receptors. (aai.org)
123I and 131I are used medically and all four are sufficiently long-lived to be transported to human receptors after their release into the environment. (cdc.gov)

This study details the benefit of adjuvants that target multiple innate immune receptors to shape the host vaccine response. (researchsquare.com)

We believe that peptide-based therapies hold great promise in inhibiting complement activation. (businesswire.com)
We sought to explore the role of platelet-derived SDF-1alpha and its receptors, CXCR4 and CXCR7 in facilitating platelet activation and determine the mechanism facilitating SDF-1alpha-mediated regulation of platelet function. (bioxcell.com)

Mutations in the LDL receptor gene cause familial hypercholesterolemia. (embl.de)

Anatomy26

Organisms15

Diseases9

Chemicals and Drugs104

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes35

Information Science3

Antibodies17

Immunoglobulin12

Neutrophils7

Antigen9

Macrophages3

Cytokines4

Inhibition5

Serum7

Molecule3

Subclasses4

Proteins4

AchR1

Neuromuscular junction3

Isotype2

IgG1 and IgG31

Monoclonal1

Component3

Reagents distributed2

Immune system1

Phagocytosis4

Bind2

Activate2

Ligand1

ELISA1

Ligands3

Binds1

Proinflammatory1

Glycosylation3

Effector functions1

Protein3

Inhibitor2

Sialylation2

Mast Cells4

Immunoglobulins1

Cells3

Lupus1

Lipoprotein1

Membrane attack1

FcRn1

Lymphocytes1

Deficiency1

IgG2a2

Titers3

Cytotoxicity1

IVIg2

Inhibitors1

Eosinophils1

Human3

Innate1

Activation2

Gene1