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  • membrane protein
  • Outer-membrane protein P5 has been implicated in FH binding by NTHi, and FH6,7/Fc binding was greatly diminished in five of seven P5 deficient isogenic mutant strains tested, implicating an alternative FH binding protein in some strains. (frontiersin.org)
  • human
  • Chimeric proteins containing the regions that most FH-binding bacteria use to engage human FH, domains 6 and 7 (FH6,7/Fc) and/or 18 through 20 (FH18-20/Fc), were evaluated for binding to NTHi. (frontiersin.org)
  • functional
  • We investigated a strategy to exploit binding of the complement inhibitor Factor H (FH) to NTHi as a functional target for an immunotherapeutic containing the NTHi binding domain of FH fused to the Fc domain of IgG1. (frontiersin.org)
  • receptor
  • The C3b cleavage product iC3b binds to tumor cells and through the interaction with complement receptor 3 (CD11b/CD18) on mononuclear phagocytes and natural killer (NK) cells enhances antibody-dependent cellular cytotoxicity (ADCC). (nih.gov)
  • Membrane attack complex (MAC), properdin (P), factor H (fH) and Complement receptor type 1 (CR1) were quantified in urine samples from 71 patients with IgAN and 72 healthy controls. (biomedcentral.com)
  • lectin
  • TM is a complex membrane protein with a lectin-like domain from the amino terminus, six epidermal growth factor (EGF)-like repeats, a region with O-linked sugar addition sites that also contains the sites for the addition of chondroitin sulfates, a transmembrane domain, and a short cytoplasmic tail. (rupress.org)
  • gene
  • Esparza-Gordillo J (2005) Predisposition to atypical hemolytic uremic syndrome involves the concurrence of different susceptibility alleles in the regulators of complement activation gene cluster in 1q32. (springer.com)
  • Fremeaux-Bacchi V, Dragon-Durey MA, Blouin J et al (2004) Complement factor I: a susceptibility gene for atypical haemolytic uraemic syndrome. (springer.com)
  • This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. (nih.gov)
  • beta1H
  • This protein was identified as beta1H and found to have a serum concentration of 516 +/- 89 mug/ml (mean +/- 1 SD). (pnas.org)
  • interacts
  • It also interacts with anticoagulant protein S and with serum amyloid P component. (nih.gov)
  • Complement system is a group of more than 23 proteins that interacts with each other to opsonize the pathogen and induces a series of inflammatory responses that helps to generate immune response against that pathogen. (periobasics.com)
  • immune
  • Allosteric inhibition of complement function by a staphylococcal immune evasion protein. (nih.gov)
  • The complement system is a major target of immune evasion by Staphylococcus aureus. (nih.gov)
  • As this enzyme complex is critical for both activation and amplification of the complement response, its allosteric inhibition likely represents a fundamental contribution to the overall immune evasion strategy of S. aureus. (nih.gov)
  • Previous studies have suggested that complement proteins can contribute to the immune surveillance of malignant tumors. (nih.gov)
  • Complement is one of the most powerful innate immune defense mechanisms in vertebrate animals' blood. (frontiersin.org)
  • Borrelia burgdorferi has developed efficient mechanisms for evading the innate immune response during mammalian infection and has been shown to be resistant to the complement-mediated bactericidal activity of human serum. (asm.org)
  • The syndromes can be classified based on which component of the immune system is deficient: B cells, T cells, phagocytic cells or complement components. (pgpreparation.in)
  • The principal participants in this system are 11 proteins designated C1 through C9, B, and D . Term complement means to augment the effect of other complements of immune system. (periobasics.com)
  • Complement system can be activated by immune complexes and immunologic molecules like endotoxins. (periobasics.com)
  • Ionizing radiation perturbs hematopoiesis in bone marrow, which, in turn, depresses the innate immune responses against infectious agents, including production of immunoglobulins, and disturbs the inflammatory responses, including C-reactive protein (CRP), the components of complement, and the normal balance among the inflammatory and anti-inflammatory cytokines and chemokines. (hindawi.com)
  • inhibitory activity
  • The inhibitory activity was investigated in the intestine of A. aegypti as well as in the saliva and intestine of other three triatomine species (T. brasiliensis, T. infestans and Rhodnius prolixus) using an immunological method able to determine the level of deposition of some complement factors (C1q, C3b, or C4b) on the surface of complement activator molecules linked to microplates. (nih.gov)
  • The inhibitory activity was found to reside in a protein that was purified to homogeneity and elicited a monospecific antibody in a rabbit. (pnas.org)
  • Regulation of complement activation by C-reactive protein: targeting of the inhibitory activity of C4b-binding protein. (semanticscholar.org)
  • IgG1
  • We investigated a strategy to exploit binding of the complement inhibitor Factor H (FH) to NTHi as a functional target for an immunotherapeutic containing the NTHi binding domain of FH fused to the Fc domain of IgG1. (frontiersin.org)
  • amplification
  • Amplification of C3 cleavage by C3bBb may well determine whether initial complement activation by the classical or alternative activating sequence is beneficial or detrimental to the host. (pnas.org)
  • Antibodies
  • The terminal complement complex (TCC) is thought to contribute to complement-dependent cytotoxicity (CDC), which is one of the mechanisms for eliminating tumor cells by therapeutic antibodies. (nih.gov)
  • Regulation
  • In the following sections we will try to understand the functioning of complement system, its regulation and disorders related to its function and regulation. (periobasics.com)
  • deposition
  • Additionally, the deposition of complement components C3, C6, and C5b-9 was enhanced on the surface of the CspA mutant compared to that of the wild-type strain. (asm.org)
  • Ultimately, it is thought that the inactivation of C3b to iC3b inhibits the deposition of terminal complement components, which then prevents the formation of the bactericidal membrane attack complex. (asm.org)
  • distinct
  • Five distinct proteins with allergenic activity have been isolated from short ragweed pollen. (naver.com)
  • These findings indicate a strong restriction of distinct borrelial proteins toward binding of polymorphic FH of various vertebrate hosts. (frontiersin.org)
  • properdin
  • The stabilization of C3bBb by activated properdin minimizes intrinsic decay and protects C3b in the bimolecular complex from C3b inactivator. (pnas.org)
  • fragment
  • Here we demonstrate that the extracellular fibrinogen-binding protein (Efb) from S. aureus acts as an allosteric inhibitor by inducing conformational changes in complement fragment C3b that propagate across several domains and influence functional regions far distant from the Efb binding site. (nih.gov)
  • components
  • SUBJECTS AND METHODS: Plasma concentrations and functional activity of complement components were measured by conventional techniques. (biomedsearch.com)
  • Consistent with this notion, the terminal complement components (C5b, C6, C7, C8, and C9) are deposited more efficiently and abundantly on the surface of serum-sensitive strains of Borrelia spp. (asm.org)
  • terminal
  • The terminal complement complex (TCC) can be incorporated into cell membranes at sublytic doses and activate target cells. (nih.gov)