• In conclusion, multiple interactions of key complement inhibitors FH, FHR-1 and FHL-1 with Stx2 corroborate our hypothesis of a direct role of complement in EHEC-associated HUS. (leibniz-hki.de)
  • These two latter pathogenic mechanisms are the target of novel strategies of anti-complement treatments, which can be split into terminal and proximal complement inhibitors. (frontiersin.org)
  • Many novel terminal complement inhibitors are now in clinical development: they all target C5 (as eculizumab), potentially paralleling the efficacy and safety profile of eculizumab. (frontiersin.org)
  • Indeed, proximal inhibitors are designed to interfere with early phases of complement activation, eventually preventing C3-mediated extravascular hemolysis in addition to intravascular hemolysis. (frontiersin.org)
  • Indeed, we envision a new scenario of therapeutic complement inhibition, where proximal inhibitors (either anti-C3, anti-FD or anti-FB) may prove effective for the treatment of PNH, either in monotherapy or in combination with anti-C5 agents, eventually leading to drastic improvement of hematological response. (frontiersin.org)
  • The active ingredient comprises plasma proteins such as albumin , immunoglobulins, other globulins, coagulation factors, complement proteins and protease inhibitors. (rxlist.com)
  • Advancements in the understanding of the etiopathogenesis of aHUS paved the way for the successful development of anticomplement therapies (complement C5 inhibitors), which have revolutionized the treatment of aHUS. (jrheum.org)
  • Relevant Protein Targets include Carbonic Anhydrase (CA) inhibitors - IOP reduction by inhibitors decreases the rate of aqueous humor (AH) production. (chemdiv.com)
  • thus, PIGA mutations lead to a deficiency of GPI-anchored proteins, such as complement decay-accelerating factor (also known as CD55) and CD59 glycoprotein (CD59), which are both complement inhibitors. (medscape.com)
  • We then determined the protein cargo in the EV-enriched secreted fractions of T. crassiceps and M. corti conditioned media by LC-MS/MS. Among the identified proteins, eukaryotic vesicle-enriched proteins were identified as expected, but also proteins used for cestode disease diagnosis, proteins related to neurotransmission, lipid binding proteins as well as host immunoglobulins and complement factors. (conicet.gov.ar)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Complement Factor H Related Protein 3 (CFHR3) in samples from serum, plasma or other biological fluids. (orbitalbiosciences.com)
  • Description: A competitive ELISA for quantitative measurement of Human Complement factor H related protein 3(CFHR3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (orbitalbiosciences.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Complement Factor H Related Protein 3 (CFHR3) in serum, plasma and other biological fluids. (orbitalbiosciences.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Complement Factor H Related Protein 3 (CFHR3) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. (orbitalbiosciences.com)
  • The principal site of glycation of human complement factor B". The Biochemical Journal. (wikipedia.org)
  • Molecular cloning and characterization of the gene coding for human complement protein factor B". Proceedings of the National Academy of Sciences of the United States of America. (wikipedia.org)
  • Purified human complement Factor B. Factor B is one of the proteins unique to the Alternative Complement Pathway. (quidel.com)
  • Quidel's purified human complement components are useful in a wide variety of immunochemical and research applications. (quidel.com)
  • The Borrelia hermsii factor H binding protein FhbA is not required for infectivity in mice or for resistance to human complement in vitro. (canlyme.com)
  • Another important mechanism by which bacteria resist human complement is the production of proteases that efficiently degrade complement components. (lu.se)
  • The dosage of Octaplas for replacement of multiple coagulation factors in patients with acquired deficiencies is 10 to 15 milliliters per kg. (rxlist.com)
  • Anti-complement Treatment for Paroxysmal Nocturnal Hemoglobinuria: Time for Proximal Complement Inhibition? (frontiersin.org)
  • At the moment there are three strategies of proximal complement inhibition: anti-C3 agents, anti-factor D agents and anti-factor B agents. (frontiersin.org)
  • Preliminary data clearly demonstrate that proximal complement inhibition is pharmacologically feasible and apparently safe, and may drastically improve the hematological response to complement inhibition in PNH. (frontiersin.org)
  • In this review we discuss current evidence that complement activation contributes to progression of CKD, how complement could cause renal inflammation and whether complement inhibition would slow progression of renal disease. (wjgnet.com)
  • For the design of the screening library, we use emerging Targets: retinol-binding protein 4 (RBP4), factor D inhibition as alternative complement pathway, and VEGF pathway. (chemdiv.com)
  • Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition. (cdc.gov)
  • Shiga toxin 2 (Stx2) is believed to be a major virulence factor of enterohemorrhagic Escherichia coli (EHEC) contributing to hemolytic uremic syndrome (HUS). (leibniz-hki.de)
  • Complement factor I (FI) is a central inhibitor of the complement system, and impaired FI function increases complement activation, contributing to diseases such as age-related macular degeneration (AMD) and atypical hemolytic uremic syndrome (aHUS). (lu.se)
  • Congenital complement disorders may also increase the risk of hemolytic-uremic sydrome (HUS) following infection. (merckmanuals.com)
  • The role of complement dysregulation on vascular endothelial cells has been well established in atypical hemolytic uremic syndrome (aHUS), a thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and target organ injury. (jrheum.org)
  • 7 - 9 A TMA is called "primary" when a genetic or acquired defect in a complement protein is identified (as in atypical hemolytic uremic syndrome [aHUS]) or "secondary" when occurring in the context of another disease process or factor such as infection, autoimmune disease, malignancy, or drugs. (jrheum.org)
  • Factor I has a molecular weight of about 88 kDa, consists of two disulfide-linked polypeptide chains (50 kDa and 38 kDa, respectively), and is synthesized as a single-chain precursor in the liver [ 24 , 25 ]. (hindawi.com)
  • Proteins enriched in HDL from patients with ESRD (ESRD-HDL) included surfactant protein B (SP-B), apolipoprotein C-II, serum amyloid A (SAA), and α-1-microglobulin/bikunin precursor. (lww.com)
  • See the reference protein sequence for complement factor H precursor (NP_569093.2). (nih.gov)
  • Complement dysregulation is usually from a mutation in genes controlling complement proteins or factors but sometimes from acquired autoantibodies to certain complement factors. (merckmanuals.com)
  • Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. (wikipedia.org)
  • Abcam: antibodies, proteins, kits. (abcam.com)
  • Most patients develop antibodies against the hemidesmosomal protein BP180, also known as BPAG2 or collagen XVII. (medscape.com)
  • 5, 6] Historically known as herpes gestationis factor, these circulating antibodies belong to the complement-fixing immunoglobulin G1 subclass. (medscape.com)
  • BTA works by using antibodies to identify concentrations of complement factor H-related proteins in urine that were raised as a result of BC. (researchsquare.com)
  • The complement decay-accelerating factor CD55 exhibited the greatest reduction in cell surface levels during infection. (imperial.ac.uk)
  • The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. (nih.gov)
  • 18057) MazG nucleotide pyrophosphohydrolase CP001857 CDS Arcpr_0020 complement(18059. (go.jp)
  • This binding is dependent on the expression of proteins termed complement-regulator acquiring surface proteins (CRASPs). (ox.ac.uk)
  • Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease). (medlineplus.gov)
  • List of genes also include 53 hypothetical proteins. (cdc.gov)
  • The complement system comprises a group of proteins which, when activated, provide one of the first lines of defence by promoting lysis and the removal of invading microbes. (hindawi.com)
  • The complement system is a group of proteins that work together to destroy foreign invaders (such as bacteria and viruses), trigger inflammation, and remove debris from cells and tissues. (medlineplus.gov)
  • The content and distribution of plasma proteins in Octaplas are comparable to reference ranges for healthy blood donors, except for Protein S and alpha2-antiplasmin. (rxlist.com)
  • Activation of the complement system in response to an infection or foreign antigen is achieved via three complement pathways, the classical pathway, which is activated by antigen-antibody complexes, the lectin pathway, which is activated by the interaction of microbial carbohydrates with mannose-binding proteins in the plasma and tissue fluids, and the alternative complement pathway, which is activated by C3b binding to microbial surfaces and to antibody molecules. (hindawi.com)
  • A further complicating factor is the cross-talk between complement, neutrophils, and coagulation pathways in the pathophysiology of TMA. (jrheum.org)
  • Activation of the complement system occurs through the classical (CP), lectin (LP), or alternative (AP) pathways. (jrheum.org)
  • Factor I cleaves C3b and C4b in a reaction, where fI is dependent on various cofactors, such as factor H, C4b-binding protein CR1 and membrane cofactor protein (MCP) [ 26 ]. (hindawi.com)
  • mouse homolog is a regulatory serine proteinase of the complement cascade that cleaves C3b and C4b and inactivates them [RGD, Feb 2006]. (genscript.com)
  • Autoantibodies to the hemidesmosomal protein BPAG2 deposit in the skin and cause C3 deposition along the dermal-epidermal junction. (medscape.com)
  • In this paper, we show that the mean level of factor I activity in the ASD group is significantly higher than in the control group of typically developed and healthy children, suggesting that high activity of complement factor I might have an impact on the development of ASD. (hindawi.com)
  • Recent research clearly indicates that the underlying causes of autism are neurobiological disorders and combinations of different factors, such as environmental and genetic factors, and abnormality in the communication between neurons, probably associated with an abnormal set of neuropeptides in the brain [ 3 - 9 ]. (hindawi.com)
  • It is unclear how variations in this gene affect the regulation of the complement system, and researchers are still working to determine how these genetic changes contribute to disease risk. (medlineplus.gov)
  • Genetic variation in complement factor I (CFI) has been identified in both AMD and aHUS, with more than half of these variants leading to reduced FI secretion levels. (lu.se)
  • 10 This distinction is not absolute because genetic defects in complement proteins have been identified in secondary TMA. (jrheum.org)
  • Immune system abnormalities may be caused partly by complement system factor I deficiency. (hindawi.com)
  • Factor I deficiency can be conferred by a C3 deficiency, since this also increases susceptibility to pyogenic infections by Neisseria meningitides, Haemophilus influenza, and Streptococcus pneumonia and increases the incidence of immune complex diseases due to impaired complement-mediated function [ 30 ]. (hindawi.com)
  • Complement factor H regulates a part of the body's immune response known as the complement system. (medlineplus.gov)
  • Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection. (nih.gov)
  • How the immune response can activate the cascade process is still unknown but it is proposed to act in synergy with additional exacerbating factors such as predisposing maternal and ambient factors [ 12 ]. (hindawi.com)
  • The complement system is an integral part of the innate immune system but also augments adaptive immune responses. (wjgnet.com)
  • The complement system involves a complex cascade of proteins that enhance the body's innate immune system", shares Majowicz. (selectscience.net)
  • The complement system is a tightly regulated, cascading protein network representing a key component linking the innate and humoral immune systems. (jrheum.org)
  • The complement system is a tightly regulated, cascading protein network that performs multiple roles in homeostasis and disease prevention and is a key component of both the innate and the humoral immune systems. (jrheum.org)
  • and other extracellular proteins. (embl-heidelberg.de)
  • Although the majority of VWA-containing proteins are extracellular, the most ancient ones present in all eukaryotes are all intracellular proteins involved in functions such as transcription, DNA repair, ribosomal and membrane transport and the proteasome. (embl-heidelberg.de)
  • VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). (embl.de)
  • To display all proteins with a VWC domain in a specific node, click on it. (embl-heidelberg.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing VWA domain in the selected taxonomic class. (embl.de)
  • Yet, a great deal of complexity exists around the role of complement in TMA associated with other diseases. (jrheum.org)
  • Defining the role of complement in TMA in these conditions will help to guide timely diagnosis and management. (jrheum.org)
  • The complement system has recently been found to be involved in the pathogenesis of EHEC-associated HUS. (leibniz-hki.de)
  • Complement factor I is a serine protease present in human plasma that is involved in the degradation of complement protein C3b, which is a major opsonin of the complement system. (hindawi.com)
  • It has been shown by comparison with healthy control children that several differentially expressed proteins are related to the complement system in children with ASD [ 22 ]. (hindawi.com)
  • Complement C3b is the major opsonin of the complement system which facilitates the phagocytosis process by coating antigens (each of the phagocytes expresses a complement receptor such as CR1, CR3, or CR4 that binds C3b, C4b, or C3bi) [ 28 , 29 ]. (hindawi.com)
  • GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. (genscript.com)
  • Complement factor H helps to protect healthy cells by preventing the complement system from being turned on (activated) when it is not needed. (medlineplus.gov)
  • Studies suggest that complement factor H-related 5 also plays a role in controlling the complement system. (medlineplus.gov)
  • The duplication alters the structure and function of complement factor H-related 5, preventing it from regulating the complement system effectively. (medlineplus.gov)
  • As a result, the complement system becomes overactive, which damages structures called glomeruli in the kidneys. (medlineplus.gov)
  • Vn is known to inhibit the terminal complement complex, C5b-9, of the complement system, by forming SC5b-9. (lu.se)
  • It can mediate adhesion to the shunt surface and it can also block the inhibitory effect of Vn on the complement system. (lu.se)
  • Heat inactivation of FBS blocks the complement system. (sigmaaldrich.com)
  • Additionally, in some gene therapy trials in which high doses of AAV vectors were administered systemically, toxicities related to the activation of the complement system have been reported. (selectscience.net)
  • Therefore, a clearer understanding of the role of the complement system in TMA associated with other conditions will help to identify patients who would benefit from these therapies. (jrheum.org)
  • 8 , 11 - 14 Numerous stimuli can drive the activation of the complement system, including apoptotic debris, pathogens, and antibody-antigen complexes, in addition to ischemia-reperfusion injuries associated with organ transplantation. (jrheum.org)
  • The plasma glycoprotein factor I (C3b/C4b inactivator) is a serine protease that acts as a regulator of the complement C3 cascade. (hindawi.com)
  • This work demonstrates that pathogens interact with complement regulators in ways that are distinct from the mechanisms used by the host and are thus obvious targets for drug design. (ox.ac.uk)
  • 4 , 13 Complement plays a crucial role in host defense against foreign bodies by promoting phagocyte-mediated clearance of cell debris through activation of an inflammatory response, opsonization of pathogens, and lysis of susceptible bacteria and cells. (jrheum.org)
  • As a first line of defense against pathogens and a mediator between innate and adaptive immunity, complement is a particular focus of evasion strategies developed by pathogens. (lu.se)
  • The molecular genetics and polymorphism of C2 and factor B". British Medical Bulletin. (wikipedia.org)
  • Factor I-mediated cleavage of the α chain of C3b liberates 3 fragments with molecular weights of 68 kDa, 43 kDa, and 2 kDa. (hindawi.com)
  • Of these four proteins, from 16, 21, 38 and 52 kDa molecular weights, the 52 kDa protein had the highest affinity for Vn. (lu.se)
  • Similarly, sEng is a truncated form of receptor for two subtypes of transforming growth factor beta (TGF β ) specifically, TGF β 1 and TGF β 2 which are highly expressed by vascular endothelial cells and syncytiotrophoblasts. (hindawi.com)
  • and 3) task performance in aged rats only (soluble fibroblast growth factor receptor IIIb, osteoregulin, and osteocalcin). (cdc.gov)
  • We now show that complement factor H-related protein 1 (FHR-1) and factor H-like protein 1 (FHL-1), proteins of the FH protein family that show amino acid sequence and regulatory function similarities with FH, also bind to Stx2. (leibniz-hki.de)
  • Phyletic distributions of eukaryotic signalling domains were studied using recently developed sensitive methods for protein sequence analysis, with an emphasis on the detection and accurate enumeration of homologues in bacteria and archaea. (embl.de)
  • Here we employed 'plasma membrane profiling', a quantitative cell-surface proteomics technique, to identify host proteins whose cell-surface levels are altered during infection. (imperial.ac.uk)
  • 22 host proteins were significantly reduced on the surface of infected epithelial cells. (imperial.ac.uk)
  • Immediately after insertion host proteins are adsorbed to the surface of the implant. (lu.se)
  • Vn and terminal complement complex were shown to be present in CSF and on removed CSF shunts. (lu.se)
  • Deficiency in factor I activity is associated with an increased incidence of infections in humans. (hindawi.com)
  • The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. (wikipedia.org)
  • Production and interferon-gamma-mediated regulation of complement component C2 and factors B and D by the astroglioma cell line U105-MG". The Biochemical Journal. (wikipedia.org)
  • Serum protein electrophoresis (SPEP) is used to quantify the serum monoclonal component or M-protein, for diagnosis and monitoring of monoclonal gammopathies. (degruyter.com)
  • ACIP also recommends routine vaccination for persons at increased risk for meningococcal disease (i.e., persons who have persistent complement component deficiencies, persons who have anatomic or functional asplenia, microbiologists who routinely are exposed to isolates of N. meningitidis, military recruits, and persons who travel to or reside in areas in which meningococcal disease is hyperendemic or epidemic). (cdc.gov)
  • The domain is named after the von Willebrand factor (VWF) type C repeat which is found in multidomain protein/multifunctional proteins involved in maintaining homeostasis. (embl-heidelberg.de)
  • For the von Willebrand factor the duplicated VWFC domain is thought to participate in oligomerization, but not in the initial dimerization step. (embl-heidelberg.de)
  • The von Willebrand factor is a large multimeric glycoprotein found in blood plasma. (embl.de)
  • In von Willebrand factor, the type A domain (vWF) is the prototype for a protein superfamily. (embl.de)
  • Previously undetected bacterial homologues were identified for# plant pathogenesis-related proteins, Pad1, von Willebrand factor type A, src homology 3 and YWTD repeat-containing domains. (embl.de)
  • Multiple organs develop bland platelet- von Willebrand factor (VWF) thrombi localized primarily to arteriocapillary junctions, described as thrombotic microangiopathy. (merckmanuals.com)
  • Complement factor B is a protein that in humans is encoded by the CFB gene. (wikipedia.org)
  • Different factors contribute to residual anemia during eculizumab treatment: underlying bone marrow dysfunction, residual intravascular hemolysis and the emergence of C3-mediated extravascular hemolysis. (frontiersin.org)
  • Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder characterized by complement-mediated intravascular hemolysis, bone marrow failure, and severe thrombophilia ( 1 ). (frontiersin.org)
  • Interaction of Shiga toxin 2 with complement regulators of the factor H protein family. (leibniz-hki.de)
  • Poolpol K, Orth-Höller D, Speth C, Zipfel PF, Skerka C, de Córdoba SR, Brockmeyer J, Bielaszewska M, Würzner R (2014) Interaction of Shiga toxin 2 with complement regulators of the factor H protein family. (leibniz-hki.de)
  • Angiogenic factors and their receptors are important regulators of placental vascular development [ 13 ]. (hindawi.com)
  • Vascular adhesion protein-1 (VAP-1) is a homodimeric sialylated glycoprotein. (chemdiv.com)
  • The purpose of this study was to systematically review the effects of bladder tumor antigen (BTA) stat and nuclear matrix protein (NMP) 22 as a screening method in an asymptomatic population. (researchsquare.com)
  • It also analyzes the strengths and weaknesses of screening methods and associated results using two non-invasive screening methods for bladder cancer-bladder tumor antigen (BTA) stat and nuclear matrix protein 22 (NMP 22)-in an asymptomatic population and in patients with suspicion of or a history of BC. (researchsquare.com)
  • Killing of Streptococuss pneumoniae by capsular polysaccharide-specific polymeric IgA complement and phagocytes, J. Clin Invest 104:1139-1147, 1999. (quidel.com)
  • 9766 conserved hypothetical protein CP001857 CDS Arcpr_0009 complement(9767. (go.jp)
  • 10378) hypothetical protein CP001857 CDS Arcpr_0010 complement(10422. (go.jp)
  • 13428) hypothetical protein CP001857 CDS Arcpr_0013 complement(13425. (go.jp)
  • 13751) hypothetical protein CP001857 CDS Arcpr_0014 complement(13789. (go.jp)
  • 19702 hypothetical protein CP001857 CDS Arcpr_0022 complement(19723. (go.jp)
  • 21298 hypothetical protein CP001857 CDS Arcpr_0025 complement(21287. (go.jp)
  • 23242 hypothetical protein CP001857 CDS Arcpr_0028 23232. (go.jp)
  • 29158) hypothetical protein CP001857 CDS Arcpr_0035 complement(29143. (go.jp)
  • 29526) hypothetical protein CP001857 CDS Arcpr_0036 29596. (go.jp)
  • 36678) hypothetical protein CP001857 CDS Arcpr_0042 complement(36769. (go.jp)
  • 42520) hypothetical protein CP001857 tRNA Arcpr_R0002 complement(42639. (go.jp)
  • 43572) hypothetical protein CP001857 CDS Arcpr_0052 43655. (go.jp)
  • 47353) hypothetical protein CP001857 CDS Arcpr_0058 complement(47350. (go.jp)
  • 52977 conserved hypothetical protein CP001857 CDS Arcpr_0062 complement(52960. (go.jp)
  • 53727) hypothetical protein CP001857 CDS Arcpr_0063 complement(53793. (go.jp)
  • We showed that one common strategy is to bind complement inhibitor C4BP, which leads to decreased opsonisation of bacteria with C3b impairing phagocytosis and allowing bacterial survival. (lu.se)
  • Stx2 was shown to activate complement via the alternative pathway, to bind factor H (FH) at short consensus repeats (SCRs) 6-8 and 18-20 and to delay and reduce FH cofactor activity on the cell surface. (leibniz-hki.de)
  • Serum-resistant B. burgdorferi strains bind complement factor H (FH) and FH-like protein 1 (FHL-1) on the spirochaete surface. (ox.ac.uk)
  • When the alternative pathway is activated either directly or by the classical pathway via the amplification loop, C3b can bind whole Factor B. Factor D can then cleave Factor B in a single site to yield Ba and Bb. (quidel.com)
  • and 3) task performance in aged rats only (corticotropin releasing hormone, interleukin 4, interferon regulatory factor 1, inhibin alpha, and interleukin 6). (cdc.gov)
  • 42329 iron %28metal%29 dependent repressor%2C DtxR family CP001857 CDS Arcpr_0049 complement(42326. (go.jp)
  • The strain, which adhesion was dependent on Vn was shown to express four binding proteins in its cell wall. (lu.se)
  • RTX's mechanism of action includes complement‑dependent cytotoxicity (CDC) and antibody‑dependent cellular cytotoxicity (ADCC). (spandidos-publications.com)
  • The mechanisms of action by which RTX kills FL cells include complement-dependent cytotoxicity (CDC) ( 3 ), antibody-dependent cellular cytotoxicity (ADCC) ( 4 , 5 )-herein referred to as 'effector function' mechanisms-as well as CD20 signaling effects ( 6 ). (spandidos-publications.com)
  • According Light et al's criteria for pleural fluid, an exudate is considered if one of the following parameters are met: the total protein fluid-to-serum ratio is higher than 0.5, the LDH fluid-to-serum ratio is more than 0.6, or the LDH fluid level exceeds two thirds of upper limit of normal serum level. (medscape.com)
  • Within a mean total protein content of 57 mg/mL, albumin comprises ~50% and immunoglobulin classes G, A, and M comprise ~12%, ~3%, and ~1%, respectively. (rxlist.com)
  • Based on immunological and mass spectrometric analysis, SALSA was estimated to constitute up to 4-10% of the total protein amount in meconium, making it one of the most abundant proteins. (researchgate.net)
  • Provided with total protein (reverse biuret, Siemens), laboratories blindly analyzed samples according to their SPEP and immunofixation (IFE) or immunosubtraction (ISUB) standard operating procedures. (degruyter.com)
  • 55699) Ribosomal protein L15e CP001857 CDS Arcpr_0066 complement(55738. (go.jp)
  • 4. Investigate the utility of some biomarkers (e.g. complement reactive proteins, pro- calcitonin) and inflammatory cells in detecting neonatal sepsis. (who.int)
  • Complement activation occurs in progressive chronic kidney disease and may contribute to the chronic inflammation that is characteristically found in the kidney. (wjgnet.com)
  • Founded on the secretion of a monoclonal immunoglobulin (M-protein), plasma cell proliferative disorders are classified as monoclonal gammopathies and include multiple myeloma (MM), Waldenström's macroglobulinemia (WM), amyloidosis (AL), light chain deposition disease (LCDD), POEMS syndrome, and premalignant diseases such as monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). (degruyter.com)
  • Due to the wide range of disease presentations, identification of the M-protein by serum protein electrophoresis (SPEP) may be the first clue to the diagnosis of a monoclonal gammopathy followed by subsequent isotyping via immunofixation (IFE) or immunosubtraction (ISUB). (degruyter.com)
  • The term "nocturnal" refers to the belief that hemolysis is triggered by acidosis during sleep and activates complement to hemolyze an unprotected and abnormal RBC membrane. (medscape.com)
  • MCP, membrane cofactor protein. (bmj.com)
  • Transcriptome characterization by RNA-Seq reveals the involvement of the complement components in noise-traumatized rat cochleae. (genscript.com)
  • This review aims to provide an assessment of the nature and extent of complement involvement in TMA associated with autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, and scleroderma renal crisis. (jrheum.org)
  • 10 This review aims to provide an assessment of the nature and extent of complement involvement in the underlying pathophysiology of TMA associated with autoimmune diseases that will help to stratify patients for targeted therapy. (jrheum.org)
  • Is lung involvement a favorable prognostic factor for pancreatic ductal adenocarcinoma with synchronous liver metastases? (lu.se)
  • Maternal dietary factors have been suggested as possible contributing influences for congenital anomalies (CAs). (bvsalud.org)
  • Marks, R., Hindmarsh, E. Complement activation occurs on subendothelial extracelluslar matrix in vitro and is initiated by retraction or removal of overlying endothelial cells, J Immunol 160:6128-6136, 1998. (quidel.com)
  • Like sFlt1, soluble endoglin (sEng) is an antiangiogenic factor capable of inhibiting capillary tube formation in vitro [ 17 ]. (hindawi.com)
  • 14733) putative transcriptional regulator%2C AsnC family CP001857 CDS Arcpr_0015 complement(14711. (go.jp)
  • Using this method, we quantified more than 1100 proteins, 280 of which showed altered cell-surface levels after exposure to EHEC. (imperial.ac.uk)
  • Therefore, this study aims to assess the causative bacterial species, their antimicrobial susceptibility pattern and possible associated risk factors of neonatal sepsis. (who.int)
  • The most widely studied serum markers for PE, to date, are vascular endothelial growth factor (VEGF) and placental growth factor (PlGF). (hindawi.com)
  • Using therapeutic monoclonal antibody-spiked sera and a pooled beta-migrating M-protein, we aimed to assess SPEP limitations and variability across 16 laboratories in three continents. (degruyter.com)
  • In monoclonal gammopathies, M-proteins are visualized as a restricted area of migration in the electrophoretic pattern which can be gated and quantified [ 4 ]. (degruyter.com)