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  • pathways
  • You need to have more background on the various complement factors, their function, the 3 different pathways of activation etc) NCIPH is a liver disorder of vascular origin defined by a portal venous pressure exceeding 5mm Hg between portal vein and inferior vena cava (sanyal 2008), characterized by occlusion of the 3rd /4th order branches of the hepatic portal vein ( madhu 2008). (ukessays.com)
  • Complement Factor I (CFI) is a serum protease capable of inhibiting all complement pathways. (arvojournals.org)
  • innate
  • The complement system is a fundamental element of the innate immune system as well as the adaptive immune responses. (ukessays.com)
  • Whereas much attention has been focused on the properties and activities of the TLRs in this process ( 13 ), many other innate immune molecules expressed by glia and neurons have been described (e.g., complement, lectins, scavenger receptors) ( 14 ). (jimmunol.org)
  • Despite its important role in innate immunity, very little is known about complement production, regulation, and function in the CNS of healthy or diseased individuals. (uiowa.edu)
  • The complement system, an important component of innate immunity, is the most widely accepted pathogenic pathway of the immune system implicated in AMD. (molvis.org)
  • Mutations
  • Mutations in the complement factor H gene (CFH) region associate with renal-limited mesangial proliferative forms of glomerulonephritis including IgA nephropathy (IgAN), dense deposit disease (DDD) and C3 glomerulonephritis (C3GN). (nih.gov)
  • role
  • The regulatory role of Factor H is essential because C3bBb is not only a C5 convertase but a C3 convertaseand so has a positive feedback effect, potentially consuming the entire C3 pool if unregulated. (acris-antibodies.com)
  • liver
  • Factor H is mainly synthesised in the liver but also in macrophages and endothelium. (acris-antibodies.com)
  • Second-generation antisense oligonucleotides (ASOs) targeting mouse and monkey factor B mRNA were administered by subcutaneous injection to healthy mice or monkeys, and the level of factor B mRNA was assessed in the liver and the eye. (molvis.org)
  • acute
  • Immunostaining for membrane attack complex of complement is related to cell necrosis in fulminant and acute hepatitis," Gastroenterology , vol. 108, no. 2, pp. 495-504, 1995. (hindawi.com)