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  • proteins
  • In analogy to the newly described neuroimmune regulatory proteins also known as "don't eat me" signals (CD200, CD47, CD22, fractalkine, semaphorins), we herein identify the key role of complement regulator factor H (fH) in controlling neuroinflammation initiated in an acute mouse model of Ab-dependent experimental autoimmune encephalomyelitis. (jimmunol.org)
  • leukocyte
  • We found that the accumulation of human fH in the brain parenchyma protected neurons from complement opsonization, axonal injury, and leukocyte infiltration. (jimmunol.org)
  • The interaction of Factor H with leukocyte L-selectin was shown to induce the secretion of tumour necrosis factor-α (TNF-α). (biochemj.org)
  • nephropathy
  • Regulating complement in the kidney: insights from CFHR5 nephropathy. (nih.gov)
  • Mutations in the complement factor H gene (CFH) region associate with renal-limited mesangial proliferative forms of glomerulonephritis including IgA nephropathy (IgAN), dense deposit disease (DDD) and C3 glomerulonephritis (C3GN). (nih.gov)
  • role
  • The regulatory role of Factor H is essential because C3bBb is not only a C5 convertase but a C3 convertaseand so has a positive feedback effect, potentially consuming the entire C3 pool if unregulated. (acris-antibodies.com)