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  • desArg
  • It was concluded that C5a and C5a desarg may play a role in lung injury by interactions with AM, inducing the secretion of acid hydrolases and proteolytic enzymes that can cause tissue damage, and by regulating the influx of other inflammatory cells into the interstitium and air spaces. (jimmunol.org)
  • inflammation
  • In an era that nurtures the integrated study of biological systems as the prevalent concept in contemporary scientific thinking, complement research is being revisited and our current knowledge of this innate immune system is enriched by findings that point to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or inflammation. (upenn.edu)
  • Complement C5a-Induced Changes in Neutrophil Morphology During Inflammation. (upenn.edu)
  • higher susceptibility
  • Studies have shown that high C5a levels may lead to higher susceptibility for septic shock, as well as various systemic and renal diseases. (scistart.co)
  • further we showed that mice genetically deficient of complement component C5 revealed a higher susceptibility to KA neurodegeneration [ 11 , 12 ] suggesting that in addition to their pro-inflammatory mechanisms, specific complement components may also mediate neuroprotection. (biomedcentral.com)
  • Inhibitors
  • Inhibitors of the complement system have long been of interest as potential drugs for the treatment of diseases such as sepsis, rheumatoid arthritis, Crohn's disease and ischaemia-reperfusion injuries1. (ovid.com)
  • antagonist
  • Structure-activity relationships for 60 cyclic analogs were evaluated by competitive radioligand binding with C5a (affinity) and myeloperoxidase release (antagonist potency) from human PMNLs, with 20 compounds having high antagonist potencies (IC 50 , 20 nM-1 μM). (aspetjournals.org)
  • pathway
  • The ability for doctors to predict C5a levels and therefore tailor their treatment would allow for personalized medicine that would take into account not only patient susceptibility to infection, but also tolerance to drugs targeting this pathway. (scistart.co)
  • innate
  • The complement system has been long appreciated as a major effector arm of the innate immune response. (upenn.edu)
  • Complement, a phylogenetically conserved arm of innate immunity, functions together with the adaptive immune response by serving as an important inflammatory mediator of antigen-antibody interactions. (upenn.edu)
  • clinically
  • No clinically available tests for risk stratification of complications due to high C5a complement levels are currently available. (scistart.co)
  • These attributes are complemented by sophisticated, clinically relevant in vitro and in vivo models of the trauma impact and resulting complications to gain deep insights into the mechanistic complexity and regeneration potential post trauma as well as to evaluate innovative cell- and molecular based therapies. (uni-ulm.de)
  • Alzheimer's
  • More recently, a role of C5a in neurodegenerative conditions such as Alzheimer's disease has been identified3. (ovid.com)
  • system
  • The complement system plays a crucial role in the progression of age-related macular degeneration (AMD). (arvojournals.org)
  • Problem or Unmet Need: The complement system is an important part of the immune system and is responsible for the clearance of infectious agents, such as bacteria or fungi. (scistart.co)
  • The complement system is an essential effector of the humoral and cellular immunity involved in cytolysis and immune inflammatory responses. (biomedcentral.com)
  • Using complement as a model system we apply ideas and methods embodied in engineering, computer science, physics, chemistry, and other fields to address today's challenges in biomedical research. (upenn.edu)
  • vivo
  • In the long-term perspective, a valid functional immune monitoring of the individual danger response on the background of various co-morbidities and adapted immune- and cell-based therapies, for example by complement intervention and large-scale GMPgrade cellular ex vivo expansion, are anticipated. (uni-ulm.de)
  • mediator
  • TABLE 1 Regulation of macrophage-derived mediators by C5a C5a promotes release of G-CSF via Akt and MEK1/2 The current studies were focused on G-CSF, which was the mediator most potently enhanced by C5a in PEMs(Table 1). (bio-zentrum.com)
  • species
  • C5a is a potent chemotaxin for inflammatory cells and causes smooth muscle spasmogenesis as well as release of lysozomal enzymes, reactive oxygen species, and inflammatory cytokines (e.g. (aspetjournals.org)
  • Human
  • In this study, the authors sought to evaluate the pathophysiologic roles of complement components C3a and C5a in the human choroid in AMD. (arvojournals.org)
  • Organ cultures of human choroid were incubated in C5a or bovine serum albumin (BSA) followed by quantitative immunohistochemistry and quantitative PCR for ICAM-1. (arvojournals.org)