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  • phagocytosis
  • It is produced by the liver and binds to phosphocholine on microbes assisting in complement binding to foreign and damaged cells and enhancing phagocytosis by macrophages expressing CRP receptors. (hindawi.com)
  • On the other hand, many highly dangerous particles, such as bacteria and yeast, are recognized with the aid of opsonins-proteins that bind specifically to the intruder as a signal for phagocytosis (Griffin, 1977). (springer.com)
  • fragment
  • Here we demonstrate that the extracellular fibrinogen-binding protein (Efb) from S. aureus acts as an allosteric inhibitor by inducing conformational changes in complement fragment C3b that propagate across several domains and influence functional regions far distant from the Efb binding site. (nih.gov)
  • Bind
  • Since C3b is free and abundant in the plasma, it can bind to either a host cell or a pathogen surface. (wikipedia.org)
  • C3b product is very reactive and can bind to invader's cell surface. (epomedicine.com)
  • If C3b cannot find the cell surface to bind within 60 microseconds - it is hydrolyzed. (epomedicine.com)
  • deposition
  • Additionally, the deposition of complement components C3, C6, and C5b-9 was enhanced on the surface of the CspA mutant compared to that of the wild-type strain. (asm.org)
  • The combined data lead us to conclude that the CspA-mediated binding of human FH confers serum resistance by directly inhibiting complement deposition on the surface of B. burgdorferi . (asm.org)
  • The inhibitory activity was investigated in the intestine of A. aegypti as well as in the saliva and intestine of other three triatomine species (T. brasiliensis, T. infestans and Rhodnius prolixus) using an immunological method able to determine the level of deposition of some complement factors (C1q, C3b, or C4b) on the surface of complement activator molecules linked to microplates. (nih.gov)
  • Molecular
  • CRP is a 224-residue protein with a monomer molecular mass of 25 kDa. (hindawi.com)
  • So far, it has been difficult to study the exact molecular arrangement of C5 convertases, because their non-catalytic subunits (C3b) are covalently linked to biological surfaces through a reactive thioester. (biomedcentral.com)
  • Combining our results with molecular modeling explains how high C3b densities may facilitate intermolecular interactions that only occur on target surfaces. (biomedcentral.com)
  • The developed model and molecular insights are essential to understand the molecular basis of deregulated complement activity in human disease and will facilitate future design of therapeutic interventions against these critical enzymes in inflammation. (biomedcentral.com)
  • With state-of-the art molecular biology and protein biochemistry labs, we work with our clients to rapidly evaluate in parallel to identify the optimal expression system for candidate proteins. (abgent.com)
  • Although many evasion proteins have been described, little is known about their molecular mechanisms of action. (nih.gov)
  • C ) Comparison of R G for the two predominant MES conformers of either C3b (black) or C3b/Efb-C (blue) as obtained by molecular dynamics conformational sampling with their maximal dimensions ( D max ). (nih.gov)
  • lectin
  • The lectin pathway consists of C2, C3, C4 and some calcium-dependent lectin family proteins which are homologous to C1 component. (epomedicine.com)
  • In the blood, MBL (Mannose Binding Lectin) binds to another protein called MASP (Mannan Associated Serine Protease). (epomedicine.com)
  • opsonize
  • Complement system is a group of more than 23 proteins that interacts with each other to opsonize the pathogen and induces a series of inflammatory responses that helps to generate immune response against that pathogen. (periobasics.com)
  • susceptibility
  • Esparza-Gordillo J (2005) Predisposition to atypical hemolytic uremic syndrome involves the concurrence of different susceptibility alleles in the regulators of complement activation gene cluster in 1q32. (springer.com)
  • Fremeaux-Bacchi V, Dragon-Durey MA, Blouin J et al (2004) Complement factor I: a susceptibility gene for atypical haemolytic uraemic syndrome. (springer.com)
  • system
  • The syndromes can be classified based on which component of the immune system is deficient: B cells, T cells, phagocytic cells or complement components. (pgpreparation.in)
  • Dysregulation of the complement system has been implicated in several diseases and pathologies. (wikipedia.org)
  • In renal transplant, the allograft is responsible for triggering many innate and adaptive immune mechanisms, either mediated by cells, such as macrophages and lymphocytes, or by soluble components, such as antibodies and the complement system, which can ultimately lead to graft rejection [ 1 ]. (hindawi.com)
  • The principal participants in this system are 11 proteins designated C1 through C9, B, and D . Term complement means to augment the effect of other complements of immune system. (periobasics.com)
  • Complement system can be activated by immune complexes and immunologic molecules like endotoxins. (periobasics.com)
  • The complement system is a major target of immune evasion by Staphylococcus aureus. (nih.gov)
  • The complement system is composed of about 20 different proteins released into the blood after production in the liver. (epomedicine.com)
  • To date, most, if not all, of the serum proteins that constitute the complement system have been identified and their activities characterized. (springer.com)
  • mammalian
  • Abgent has over fifteen years of experience producing recombinant proteins in E. coli and mammalian cells (CHO and HEK293, etc), and we have added a powerful yeast expression platform to our menu of services. (abgent.com)
  • components
  • Consistent with this notion, the terminal complement components (C5b, C6, C7, C8, and C9) are deposited more efficiently and abundantly on the surface of serum-sensitive strains of Borrelia spp. (asm.org)
  • Ionizing radiation perturbs hematopoiesis in bone marrow, which, in turn, depresses the innate immune responses against infectious agents, including production of immunoglobulins, and disturbs the inflammatory responses, including C-reactive protein (CRP), the components of complement, and the normal balance among the inflammatory and anti-inflammatory cytokines and chemokines. (hindawi.com)
  • Raised levels of complement components, are particularly C3 and C4, merely reflect an acute phase response. (tripod.com)
  • Determination of a normal range for the complement components is beset by several problems. (tripod.com)
  • Serum levels of complement components tend to increase during infections as part of an acute phase response. (tripod.com)
  • IgG1
  • We investigated a strategy to exploit binding of the complement inhibitor Factor H (FH) to NTHi as a functional target for an immunotherapeutic containing the NTHi binding domain of FH fused to the Fc domain of IgG1. (frontiersin.org)