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  • Innate
  • During this journey, from circulating cells to endothelial cells, C. pneumoniae encounters the innate immune system, in which the complement system may play a fundamental role in controlling Chlamydia infection. (pubmedcentralcanada.ca)
  • Links between the complement system, an arm of innate immunity, and age-related macular degeneration (AMD) have been provided by analyses of the composition of the extracellular deposits that form subretinally as drusen 1 2 3 4 and by molecular genetic studies. (arvojournals.org)
  • The complement system constitutes a critical component of the innate immune response. (bl.uk)
  • Soluble factors from the innate immune system such as complement or pentraxins can opsonize apoptotic cells, thereby promoting their removal by phagocytes ( 6 , 7 , 8 ). (jimmunol.org)
  • initiate
  • Ando B, Wiedmer T, Hamilton KK, Sims PJ (1988) Complement proteins C5b-9 initiate secretion of platelet storage granules without increased binding of fibrinogen or von Willebrand factor to newly expressed cell surface GPIIb-llla. (springer.com)
  • regulation
  • These data indicated that OB induction is in part complement dependent due to IL-17 mediated down regulation of CRPs on airway epithelium. (iupui.edu)
  • C3a and IL-17 are part of a feed forward loop that may enhance CRP down regulation, suggesting that complement blockade could be a therapeutic strategy for OB. (iupui.edu)
  • Furthermore, inadequate regulation of fluid-phase alternative pathway activation is a primary cause of dense deposit disease (DDD) ( 11 , 12 ). (jimmunol.org)
  • occlusion
  • Mechanism of complement activation after coronary artery occlusion: evidence that myocardial ischemia in dogs causes release of constituents of myocardial subcellular origin that complex with human C1q in vivo. (ahajournals.org)
  • To evaluate whether ischemic myocardium releases molecules that react with the first component of complement, we studied cardiac lymph from eight dogs before and at intervals after coronary artery occlusion and reperfusion. (ahajournals.org)
  • allograft
  • However, the specific role of complement activation in lung allograft pathology, IL-17 production, and OB are unknown. (iupui.edu)
  • Uncontrolled complement activation causes renal injury in a number of diseases, including immune-complex glomerulonephritis ( 1 - 3 ), ischemic acute kidney injury ( 4 , 5 ), and acute renal allograft rejection ( 6 ). (jimmunol.org)
  • molecules
  • The possible role of the curvature of the nanoparticles for the orientation of adsorbed IgG molecules, and how this can affect the subsequent activation of the IC, are discussed. (dovepress.com)
  • evaluate
  • Nonparametric analyses were used to evaluate differences between groups and to evaluate correlations between complement staining, numbers of melanized neurons, and the duration of PD. (biomedcentral.com)