• 5-ARIs are sometimes used as antiandrogens in feminizing hormone therapy for transgender women to help reduce body hair growth and scalp hair loss. (wikipedia.org)
  • In a clinical trial, daily doses of 5 mg (10 times the therapeutic dose) were administered to 60 subjects for 6 months with no additional adverse effects to those seen at therapeutic doses.5. (edkless.com)
  • If the steroid 5α-reductase is overexpressed it causes overproduction of DHT that can lead to androgenic disorders in humans. (wikipedia.org)
  • N. Serizawa and T. Matsuoka, "A two component-type cytochrome P-450 monooxygenase system in a prokaaryote that catalyzes hydroxylation of ML-236B to pravastatin, a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl coenyme A reductase",Biochimica et Biophysica Acta 1084:35-40 (1991). (patentgenius.com)
  • The mechanism of lack of hypocholesterolemic effects of pravastatijn sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in rats", Biochimica et Biophysica Acta 1254:7-12 (1995). (patentgenius.com)
  • T and 5α-DHT play an important role in regulating physiology of the muscle, adipose tissue, liver, bone, and central nervous system, as well as reproductive and sexual functions. (springer.com)
  • The Type II 5a-reductase isozyme is primarily found in prostate, seminal vesicles, epididymides, and hair follicles as well as liver, and is responsible for two-thirds of circulating DHT. (drugbank.ca)