Compartments antigen presentation. Medical search. Frequent questions

Brodsky discovered that the pathway of MHC class II export meets the antigen import pathway in a specialized endocytic compartment where antigens can be processed into peptides and loaded onto the MHC class II molecule for presentation. (wikipedia.org)
The saga of MHC-bound peptides: a renaissance for antigen presentation? (jci.org)
peptides bound to HLA-DR17 from bronchoalveolar lavage cells of sarcoidosis patients were analyzed in order to identify target antigens of the autoimmune response (see the related article beginning on page 3576). (jci.org)
the modulation of epitope immunodominance and the processing and presentation of HIV peptides for MHC class I recognition were shown to be dependent on flanking residues that were N terminal to the natural epitopes (see the related article beginning on page 3563). (jci.org)
Antigen presentation refers to the display of short process peptides on so-called MHC, or major histocompatibility complex molecules. (hstalks.com)
2. The cell biology of MHC class II-restricted antigen processing and presentation: A generally accepted paradigm in fundamental immunology is that CD4+ T cells recognize peptides derived from exogenous (internalized) sources of antigen while CD8+ recognize peptides derived from endogenous sources of antigen (generally, proteins synthesized within the antigen-presenting cell). (upenn.edu)
I have had a longstanding interest in MHC class II-bound peptides derived from endogenous sources of antigen. (upenn.edu)
This unique pathway of receptor-mediated uptake proves to be necessary for presentation of antigenic peptides at low doses of ligand. (exbio.cz)
Their major function is to present antigen-processed peptides to the T-cytotoxic cells by the cytosolic pathway. (microbenotes.com)
The class II MHC genes encode glycoproteins expressed primarily on antigen-presenting cells (macrophages, dendritic cells, and B cells), where they present processed antigenic peptides to TH cells. (microbenotes.com)
MHC I presents peptides to cytotoxic T-lymphocytes, whereas MHC II displays peptides or larger antigen fragments to T-lymphocytes with helper or regulator function ( Jensen, 2007 ). (silverchair.com)
Peptides loaded on MHC I are mainly derived from endogenous antigens. (silverchair.com)

Autoantibodies can bind to basic structural molecules and interfere with the synthesis of structural elements and facilitate the uptake of antigen. (hindawi.com)
After processing, antigen is presented on MHC molecules. (hindawi.com)
Antigen-presenting cells survey their environment and present captured antigens bound to major histocompatibility complex (MHC) molecules. (edu.au)
Autophagy is a route that enables the presentation of cytosolic antigen by MHC class II molecules. (edu.au)
Some reports also implicate autophagy in the presentation of extracellular, endocytosed antigen by MHC class I molecules, a pathway termed "cross-presentation. (edu.au)
To counter this, cancer cells can be silicified ex vivo, creating surface masks that can be decorated with microbial-associated molecules that are readily recognized by antigen-presenting cells (APCs). (bvsalud.org)
The resulting personalized cancer vaccine, when returned to the patient, engages molecules on the surface of APC, activating signaling pathways that lead to immune cell activation, vaccine internalization, processing of tumor antigens, and major histocompatibility complex peptide presentation to T cells. (bvsalud.org)
Antigens are processed in the lysosome and presented on MHC class I molecules at the cell surface of antigen presenting cells (APCs). (technologynetworks.com)
Mitochondrial antigen-specific T lymphocytes are then activated through binding of T cell receptors to MHC class I molecules. (technologynetworks.com)
Further characterization of a fraction of SLE monocytes inducing allogeneic T cell proliferation revealed that upon contact with T cells, SLE monocytes secrete proinflammatory cytokines such as IL-1 and IL-6 and do upregulate expression of innate immunity receptors involved in DC differentiation and molecules responsible for antigen presentation. (tdl.org)
These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. (sysmex-flowcytometry.com)
In B-lymphocytes, endocytosis of MHC I and MHC II molecules is important for the cross-priming and presentation of labile antigens, respectively. (silverchair.com)
Furthermore, reduction of surface expression of co-stimulatory molecules and major histocompatibility complex molecules in GBC-PC correlated with a failure of antigen presentation to T cells and the acquisition of the ability to supress T cell responses. (oncotarget.com)

Left panel: antigen bound by antibody is taken up via FcR on APCs such as dendritic cells or macrophages. (hindawi.com)
B cells are highly efficient APCs in situations of low antigen concentrations. (hindawi.com)
Likewise, antigen/antibody complexes are bound by the FcR of APCs and processed in a unique fashion dependent on the epitope specificity of the bound antibody. (hindawi.com)
The T cell recognition of globular protein antigens requires the processing and presentation of the antigen by Ia-expressing APCs. (silverchair.com)
CD154) is a transmembrane protein expressed on the surface of activated T cells, particularly on CD4 T cells, which stimulates CD40-dependent activation of antigen-presenting cells (APCs), resulting in enhancement of T cell and antibody responses. (biospace.com)

Peptide presentation is critical for immune recognition of pathogen-infected cells by CD8+ T lymphocytes. (jci.org)
Although a limited number of immunodominant peptide epitopes are consistently observed in diseases such as HIV-1 infection, the relationship between immunodominance and antigen processing in humans is largely unknown. (jci.org)
It's the recognition of these peptide MHC complexes by the T cell antigen receptors that initiates most immune responses. (hstalks.com)
In addition, we have proposed a model in which the almost instantaneous processing of cytosolic antigens is not due to defectiveness on the part of the antigen but, rather, unchaperoned nascent peptide. (upenn.edu)
No amount of exogenous, inactivated virus, displaying abundant amounts of NA at the virion surface, could be converted to class II-bound peptide by antigen-presenting B cells. (upenn.edu)
A peptide binding protein having a role in antigen presentation is a member of the HSP70 heat shock family. (silverchair.com)
We previously described a peptide binding protein of 72/74 x 10(3) Mr (PBP72/74) that plays a role in antigen presentation as shown by the ability of an antiserum raised in rabbits to affinity-purified PBP72/74 to block presentation of cytochrome c to a cytochrome c-specific T cell hybrid. (silverchair.com)
Exogenous antigens can also serve as the peptide source in a process called cross-presentation. (silverchair.com)
Human CD4 + DQw6 + double transgenic mice are tolerant to DQw6 and the DQw6 molecule functions in antigen presentation, effectively generating a human MHC class II-restricted T cell response to streptococcal M6C2 peptide. (elsevierpure.com)

To activate antigen-specific CD4 T cells in vivo, the investigators utilized the nucleic acid vaccine platform, UNITE (UNiversal Intracellular Targeted Expression), which fuses a tumor-associated antigen with lysosomal-associated membrane protein 1 (LAMP1). (biospace.com)
Different from pre-cDCs, tDCs have less turnover, capture antigen, respond to stimuli and activate antigen-specific naive T cells, all characteristics of differentiated DCs. (stanford.edu)

Naive CD4 + T cells can develop into various helper T (Th) subsets with different cytokine profiles and play a discriminative role in translating antigen-specific immune responses into tissue functions or immunopathology. (atsjournals.org)

Processing is believed to involve the uptake of antigen into an acidic compartment where proteolysis occurs. (silverchair.com)

Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)
Mutant forms of CD1b lacking the endosomal targeting motif are expressed at high levels on the cell surface but are unable to efficiently present lipid antigens acquired either exogenously or from live intracellular organisms. (elsevierpure.com)
These results define the functional role of the CD1b targeting motif in a physiologic setting and demonstrate its importance in delivery of this antigen-presenting molecule to appropriate intracellular compartments. (elsevierpure.com)
These posters to be presented at the AACR Meeting focus on the investigational nucleic acid platform, UNITE™ (UNiversal Intracellular Targeted Expression) for two vaccines, ITI-3000 for Merkel cell carcinoma (targeting the large T antigen of the Merkel cell polyomavirus) and Her2/Neu-LAMP DNA vaccine, both of which fuse a tumor associated antigen with lysosomal associated membrane protein 1 (LAMP-1). (biospace.com)
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. (biomedcentral.com)

Mahnke K, Guo M, Lee S, Sepulveda H, Swain SL, Nussenzweig M, Steinman RM: The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments. (exbio.cz)
This process requires Snx9 and Rab9 for MVD formation and Rab7 for fusion with the endosomal/lysosomal compartments. (technologynetworks.com)
This proprietary lysosomal targeting technology results in enhanced antigen presentation and a balanced T cell response. (biospace.com)
This presentation reports results of preclinical mouse studies on a HER2/Neu-LAMP DNA vaccine that included a bicistronic DNA construct in which both the tumor antigen (HER2) fused with LAMP-1 (lysosomal- associated membrane protein 1) and sCD40L were expressed separately. (biospace.com)

The establishment of immune tolerance during Glioblastoma Multiforme (GBM) progression, is characterized by high levels expression of anti-inflammatory cytokines, which suppress the function of tumor assocciated myeloid cells, and the activation and expansion of tumor antigen specific T cells. (oncotarget.com)

Gurer C, Strowig T, Brilot F, Pack M, Trumpfheller C, Arrey F, Park CG, Steinman RM, Münz C: Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses. (exbio.cz)
The presence or absence of EBV viral capsid antigen (VCA) IgG, VCA IgM and EBV nuclear antigen (EBNA) IgG antibodies was recorded. (who.int)

Figure depicting antigen presentation by the dendritic cell, with the lymphocyte and cytokine response leading to airway inflammation and asthma symptoms. (medscape.com)

CHC22 clathrin mediates traffic from early secretory compartments for human GLUT4 pathway biogenesis. (academictree.org)
Subsequently, my laboratory demonstrated that this NA epitope and another residing within the hemagglutinin molecule are produced by a processing pathway that is much more class I-like in character, involving delivery of antigen to the cytosol, and being dependent upon activity of both the proteasome and TAP (transporter associated with antigen processing). (upenn.edu)
These findings highlight the differential use of autophagy and its machinery by primary cells equipped with specific immune function, and prompt careful reassessment of the participation of this endocytic pathway in antigen cross-presentation. (edu.au)
Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification. (sysmex-flowcytometry.com)

They have a restricted tissue distribution and they are chiefly found on macrophages, dendritic cells, B-cells, and other antigen-presenting cells. (microbenotes.com)

MHC-I and MHC-II proteins are key components of the antigen presentation machinery responsible for neoantigen presentation to CD8 + and CD4 + T lymphocytes, respectively. (portlandpress.com)
1. The cell biology of MHC class I-restricted antigen processing and presentation: My laboratory continues to explore the forces that drive the extremely rapid MHC class I-restricted presentation of both cytosolic and endoplasmic reticulum-targeted proteins, and how differential processing could impact both the induction and effector phases of CD8+ T cell responses. (upenn.edu)
Thus, it appears that characteristics of the heat shock proteins are shared by a protein playing a role in antigen presentation, suggesting some commonality in function. (silverchair.com)

c) Effect of antibodies and antigen-specific B cells on antigen uptake. (hindawi.com)
The adaptive immune system, discovered by Paul Ehrlich, involves the production of circulating antibodies that can provide long lasting, systemic immunity that is specific to antigens expressed by a given pathogen. (aacrjournals.org)

CD1b is an antigen-presenting molecule that mediates recognition of bacterial lipid and glycolipid antigens by specific T cells. (elsevierpure.com)
We report that expression of human CD4 molecule in mCD4/8 -/− mice rescues thymocyte development and completely restores the T cell compartment in peripheral lymphoid organs. (elsevierpure.com)

Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
A key mechanism of immune evasion deployed by tumour cells is to reduce neoantigen presentation through down-regulation of the antigen presentation machinery. (portlandpress.com)
This association afforded us a unique opportunity to identify a sarcoidosis-specific antigen recognized by AV2S3+ T cells. (jci.org)
To identify candidates for the postulated sarcoidosis-specific antigen, lung cells from 16 HLA-DRB1*0301pos patients were obtained by bronchoalveolar lavage. (jci.org)
The role of B cells in autoimmune diseases involves different cellular functions, including the well-established secretion of autoantibodies, autoantigen presentation and ensuing reciprocal interactions with T cells, secretion of inflammatory cytokines, and the generation of ectopic germinal centers. (hindawi.com)
Likewise B cells function as crucial antigen presenting cells in autoimmune diseases that are traditionally viewed as T cell mediated. (hindawi.com)
Independent of antibody secretion B cells secrete proinflammatory cytokines, support the formation of ectopic GCs, and serve as antigen presenting cells. (hindawi.com)
Both secreted autoantibodies and BCR on B cells can modulate the processing and presentation of antigen and thereby affect the nature of presented T-cell determinants. (hindawi.com)
Right panel: antigen binds to the BCR of antigen-specific B cells and is internalized. (hindawi.com)
But these T cells must have already been activated by a different type of antigen presenting cell. (hstalks.com)
Studies to antigen uptake, processing and presentation to T cells, the biology of dendritic cells and the regulation of immunity are aimed to raise our understanding of the immune reactions to tumor cells and improve immunotherapy of cancer. (universiteitleiden.nl)
CD205 is responsible for uptake and processing of captured antigens for dendritic cells. (exbio.cz)
Here we demonstrate that dendritic cells (DCs) of the lamina propria can sample and process both circulatory and luminal antigens. (listlabs.com)
Surprisingly, antigen cross-presentation by resident CX3CR1(+) DCs induced differentiation of precursor cells into CD8(+) T cells that expressed interleukin-10 (IL-10), IL-13, and IL-9 and could migrate into adjacent compartments. (listlabs.com)
We conclude that lamina propria CX3CR1(+) DCs facilitate the surveillance of circulatory antigens and act as a conduit for the processing of self- and intestinally absorbed antigens, leading to the induction of CD8(+) T cells, that partake in the control of T cell activation during mucosal immune responses. (listlabs.com)
This may be due to studies using different types of antigen presenting cells for which the use of autophagy is not well defined. (edu.au)
Dendritic cells (DC) are responsible for initiating all antigen-specific immune responses. (aacrjournals.org)
They are exceptionally efficient at antigen presentation and also adept at generating just the right type of T cells in response to a given pathogen. (aacrjournals.org)
Upon completion of this activity, the participant should understand the critical roles of dendritic cells in guiding host immune responses, and the details of how they mature, process, and present antigens. (aacrjournals.org)
Coculture of isolated/generated DCs with CD4+ T cells obtained from PBMCs of allergic subjects allows the study of antigen-specific T cell immune responses against food allergens. (bvsalud.org)
The transformation process renders the tumor cells nonviable and preserves the integrity of the cell and associated tumor antigens. (bvsalud.org)
In cells that lack functional PINK1 or Parkin, inflammation induces the formation of mitochondria-derived vesicles (MDVs) containing mitochondrial antigens. (technologynetworks.com)
These cells can then recognize mitochondrial antigens on DA neurons, trigger cytotoxic responses and cell death. (technologynetworks.com)
Dendritic cells (DCs) comprise heterogeneous subsets of professional antigen-presenting cells, linking innate and adaptive immunity. (biomedcentral.com)
The impacts of proinflammatory cytokines and antigen presentation by pleural mesothelial cells (PMCs) on Th22-cell differentiation were explored. (atsjournals.org)
In particular, PMCs were able to function as antigen-presenting cells to stimulate CD4 + T-cell proliferation and Th22-cell differentiation. (atsjournals.org)
Pleural mesothelial cells stimulate CD4 + T-cell proliferation and Th22 cell differentiation in response to tuberculosis antigen. (atsjournals.org)
There, contact with T cells would lead to the acquisition of antigen presenting function and skewing from tolerogenic to immunogenic responses. (tdl.org)
T cells are collected from healthy donors (allogeneic therapy) or patient's own blood (autologous therapy), genetically modified, and then administered to the patient to target a tumor surface antigen. (appliedcells.com)
γδ T-cells have been shown to constitute promising effector cell compartments for cancer immunotherapy, because of their ability to recognize and kill transformed cell without dependending on HLA-antigen presentation. (appliedcells.com)
MCPyV integrates into the host genome, resulting in expression of a truncated form of the viral large T antigen (LT) in infected cells, and makes LT an attractive target for therapeutic cancer vaccines. (biospace.com)
Vaccination with LTS220A-UNITE (ITI-3000) induced antigen-specific CD4 Th1 cells that was associated with delayed tumor growth and enhanced survival in treated mice in both the prophylactic and therapeutic settings. (biospace.com)
The consequences of possible interactions between cancer cells and the perivascular compartment might affect the tumor growth. (oncotarget.com)
or (f) living vectored cells expressing specific heterologous antigens. (who.int)

Under cellular stress conditions such as inflammation, PINK1 and Parkin repress mitochondrial antigen presentation (MitAP) by mediating the proteasomal degradation of Sorting nexin 9 (Snx9). (technologynetworks.com)

Formation of MHC-antigen complexes occurs in specialized compartments where multiple protein trafficking routes, still incompletely understood, converge. (edu.au)

Here, we have demonstrated that endogenous processing and presentation of a human immunodominant HIV-1 epitope is more efficient than that of a subdominant epitope. (jci.org)
Recently, we have assessed the prevalence of this alternative, endogenous MHC class II-restricted antigen processing. (upenn.edu)

Comparison of data obtained in meningeal and white matter infiltrates revealed higher expression of genes related to interferonγ production, B cell differentiation, cell proliferation, lipid antigen presentation, and T cell and myeloid cell recruitment, as well as more widespread EBV infection in the meningeal samples. (biomedcentral.com)

BCR-mediated antigen uptake can influence antigen processing and the nature of MHC-displayed T-cell determinants. (hindawi.com)
Therefore, receptor expression levels, speed of internalization, and/or the amount of Ag delivered can be excluded as major determinants that dictate Ag presentation efficiency in setting of Ab-targeted vaccination. (edu.au)

VirchowCRobin areas (VRS) are perivascular compartments encircling small vessels inside the CNS which donate to the BBB and BSB integrity and consist of PACAP and VIP receptors. (euromed2016.com)

Importantly, DCs also help guide the immune system to respond to foreign antigens while avoiding the generation of autoimmune responses to self. (aacrjournals.org)

This presentation reports results of pre-clinical mouse studies of a cancer vaccine that promotes potent, antigen-specific CD4 T cell responses to MCPγV-LT. The majority of Merkel cell carcinomas (MCC), a rare and highly aggressive type of neuroendocrine skin cancer, are associated with Merkel cell polyomavirus (MCPyV) infection. (biospace.com)

Currently, there is little consensus as to which criteria determine receptor selection to ensure superior Ag presentation and immunity. (edu.au)

A substance or combination of substances used in conjunction with a vaccine antigen to enhance (for example, increase, accelerate, prolong and/or possibly target) or modulate a specific immune response to the vaccine antigen in order to enhance the clinical effectiveness of the vaccine. (who.int)

Clathrin-mediated endocytosis is involved in the uptake of antigens from outside the cell that are eventually presented on the surface of the cell by the major histocompatibility complex class II (MHC class II). (wikipedia.org)
However, the contribution of autophagy to cross-presentation varied depending on the form of antigen: it was negligible in the case of cell-associated antigen or antigen delivered via receptor-mediated endocytosis, but more prominent when the antigen was a soluble protein. (edu.au)

This class retains control of immune responsiveness and the different allelic forms of these genes confer differences in the ability to mount an immune response against a given antigen. (microbenotes.com)

3. "Cryptic" MHC Class I-Restricted Epitopes: In MHC class I antigen processing and presentation, my laboratory has also explored the generation and significance of "cryptic" epitopes that are produced by errors during translation. (upenn.edu)
Exploiting these parameters in MHC class I (MHC I) and MHC class II (MHC II) Ag presentation assays, we showed that receptor expression level, proportion of surface turnover, or speed of receptor internalization did not impact MHC I or MHC II Ag presentation efficiency. (edu.au)
There are no known differences in the structure of the human MHC Class I antigen a chains encoded by the HLA-A locus compared to those encoded by the HLA-B or the HLA-C loci, or in the structure of the murine MHC Class I antigen a chains encoded by the H-2K locus compared to those encoded by the H-2D or H-2L loci. (microbenotes.com)

In this study, we investigated parameters of DC receptor internalization and determined how they impact Ag presentation outcomes. (edu.au)

However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)

Gene expression profiling to understand the alterations in the monocyte compartment of pediatric systemic lupus erythematosus. (tdl.org)

We have demonstrated that processing of antigen targeted to the endoplasmic reticulum is both qualitatively and kinetically distinct from antigen targeted to the cytosol. (upenn.edu)

This is a talk on antigen processing and presentation, and in particular how it's regulated by innate immune signals. (hstalks.com)

The role of autophagy in cross-presentation is controversial. (edu.au)
Here we report that active use of autophagy is evident only in DC subtypes specialized in cross-presentation. (edu.au)

Moreover, PMCs were able to stimulate CD4 + T-cell proliferation and Th22-cell differentiation by presenting tuberculosis-specific antigen. (atsjournals.org)
Airway hyperresponsiveness, an exaggerated bronchospastic response to nonspecific agents such as methacholine and histamine or specific antigens, is the physiologic cornerstone of this disorder. (jci.org)

Anatomy40

Organisms14

Diseases5

Chemicals and Drugs124

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes47

Disciplines and Occupations1

Information Science3

Health Care2

Peptides12

Molecules13

APCs5

Peptide9

Activate antigen-specific2

Translating antigen-specific1

Uptake of antigen1

Intracellular5

Lysosomal4

Tumor antigen1

Nuclear antigen2

Dendritic cell1

Pathway4

Macrophages1

Proteins3

Antibodies2

Molecule2

Cells34

Degradation1

Complexes1

Endogenous2

Lipid1

Determinants2

Perivascular1

Autoimmune1

Cancer vaccine1

Immunity1

Vaccine1

Endocytosis2

Immune response1

Class3

Internalization1

Facilitate1

Systemic1

Distinct1

Processing1

Cross-presentation2

Specific2