Compartment SyndromesArthroplasty, Replacement, HipHormone Replacement TherapyArthroplasty, Replacement, KneeEstrogen Replacement TherapyCell CompartmentationRenal Replacement TherapyArthroplasty, ReplacementHeart Valve Prosthesis ImplantationHeart Valve ProsthesisMolecular Sequence DataEndosomesAortic ValveAmino Acid SequenceEnzyme Replacement TherapyGolgi ApparatusEndocytosisTime FactorsProtein TransportLysosomesModels, BiologicalReoperationMutationProsthesis FailureBiological TransportTreatment OutcomeProsthesis DesignCell MembraneBody Fluid CompartmentsCell LineHip ProsthesisAortic Valve StenosisKnee ProsthesisKineticsTotal Disc ReplacementBase SequenceEndoplasmic ReticulumJoint ProsthesisVacuolesMembrane ProteinsSubcellular FractionsPostoperative ComplicationsCells, CulturedFasciaAortic Valve InsufficiencyOsteoarthritis, KneeMutagenesis, Site-DirectedMicroscopy, FluorescenceKnee JointRecombinant Fusion ProteinsMitral ValveOrganellesHeart Valve DiseasesOsteoarthritis, HipFollow-Up StudiesBrefeldin ACytoplasmrab GTP-Binding ProteinsProtein Structure, TertiaryProtein BindingIntracellular MembranesRecombinant ProteinsMicroscopy, ConfocalMice, Inbred C57BLMicroscopy, ImmunoelectronMicroscopy, ElectronGreen Fluorescent ProteinsCell NucleusAmino Acid SubstitutionModels, MolecularHydrogen-Ion ConcentrationSignal TransductionVesicular Transport ProteinsBinding SitesSequence Homology, Amino AcidImmunohistochemistryCell DifferentiationRetrospective StudiesHip JointTransfectionProspective StudiesCricetinaetrans-Golgi NetworkCarrier ProteinsHeLa CellsTransport VesiclesFluorescent Antibody TechniqueArthroplasty, Replacement, AnkleEscherichia coliCloning, MolecularStructure-Activity RelationshipProtein ConformationHypopituitarismEstrogensCytosolOvariectomyCell FractionationMice, TransgenicPhenotypeTibia