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  • Heterologous
  • While ~40% of the variation in hybridization ratio can be accounted for by variation in sequence identity of the heterologous sample relative to D. melanogaster, other individual characteristics of the DNA sequences, such as GC content, also contribute to variation in hybridization ratio, as does technical variation. (utexas.edu)
  • species
  • These results support the hypothesis that by gain and loss of functions, Shigella species became successful human pathogens through convergent evolution from diverse genomic backgrounds. (biomedcentral.com)
  • Results: We found a consistent and linear relationship between hybridization ratio and sequence divergence of the sample to the platform species. (utexas.edu)
  • differences
  • The aim of this technique is to quickly and efficiently compare two genomic DNA samples arising from two sources, which are most often closely related, because it is suspected that they contain differences in terms of either gains or losses of either whole chromosomes or subchromosomal regions (a portion of a whole chromosome). (wikipedia.org)
  • Data
  • We also explain how to construct the problem in a more appropriate, hypothesis testing framework, and provide comparative analyses of data from patients with lung cancer to illustrate the concepts. (aacrjournals.org)
  • patients
  • The authors painted a series of individual human chromosomes from a DNA library with two different fluorophores in different proportions to test the technique, and also applied CGH to genomic DNA from patients affected with either Downs syndrome or T-cell prolymphocytic leukemia as well as cells of a renal papillary carcinoma cell line. (wikipedia.org)
  • study
  • This study aimed to identify genomic regions of EHEC O157:H7 that contribute to colonization and multiplication at this site. (frontiersin.org)
  • results
  • A major drawback of genomic profiling for embryo quality is that the results generally rely on the assessment of a single cell, PGP has inherent limitations as the tested cell may not be representative of the embryo because of mosaicism. (wikipedia.org)
  • diagnosis
  • Although fluorescence in situ hybridization (FISH) remains the gold standard for clinical diagnosis of MYCN status in neuroblastoma, its limitations warrant the identification of rapid, reliable, less technically challenging, and inexpensive alternate approaches. (biomedcentral.com)