The E histolytica galactose/ N -acetyl-D-galactosamine (Gal/GalNAc) lectin is an adhesion protein complex that sustains tissue invasion. (medscape.com)
N-acetyl-D-galactosamine 6-phosphate is a galactosamine phosphate that involved in galactose metabolism and phosphotransferase system (PTS). (medchemexpress.com)
Necrosis5
Acute liver failure is a life-threatening clinical syndrome characterized by rapid development of hepatocellular necrosis leading to high mortality and resource costs. (springer.com)
Acute liver failure (ALF) is a life-threatening clinical syndrome characterized by rapid hepatocellular necrosis due to various acute injuries induced by hepatotoxic drugs, immune-mediated attack, or viral infections. (springer.com)
③ Examination of liver tissue sections from the mice showed that, under the protection of ganodermanontriol, liver cell necrosis was significantly less severe. (xianzhilou.com)
Inflammation and necrosis in liver tissue were observed with hematoxylin-eosin staining. (jcimjournal.com)
Hepatotoxicity is commonly associated with necrosis, an increase in oxidative stress markers such as Nitrates and Nitrites (NOx) assay, Malondialdehyde levels, reduced glutathione (GSH) levels depletion, and increased liver markers. (fortunepublish.com)
Oxidative stress3
There is also growing evidence that FFA-mediated oxidative stress contributes significantly to mitochondrial dysfunction in the liver. (spandidos-publications.com)
Fuzheng recipe exerts a good effect in attenuating hepatocyte apoptosis in vivo, which has synergistic effects with Huayu recipe in attenuating hepatocyte apoptosis, and the potential mechanism is partially due to their different effects in alleviating oxidative stress in liver and down-regulating the expression of TNFR1 protein. (jcimjournal.com)
Recent research suggests that ethanol-induced oxidative stress plays a key role in the development and progression of alcoholic liver disease [10-12]. (fortunepublish.com)
Acute liver f5
Numerous treatment strategies for acute liver failure simply prevent complications and decelerate disease progression. (springer.com)
In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment. (lookformedical.com)
Hepatic4
Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)
Although the mechanisms responsible for fatty liver are not fully elucidated, an increased delivery and transport of FFAs into the liver, and augmented hepatic fatty acid synthesis are likely to play a significant role in the pathogenesis of NAFLD. (spandidos-publications.com)
18) have reported the protective action of an adzuki extract against acetaminophen-induced hepatotoxicity via a hepatic γ-glutamylcysteinylglycine-mediated antioxidation/detoxification system in rat liver after four weeks of feeding. (healthjade.com)
In rats, liver toxicity was created by giving them a daily dose of ethanol, which caused hepatic derangement and an increase in various liver markers when compared to a control group. (fortunepublish.com)
Apoptosis3
Liver cell apoptosis is a prominent feature of NAFLD and correlates with disease severity ( 2 ). (spandidos-publications.com)
Hepatocyte apoptosis in mice was induced by intraperitoneal injection of lipopolysaccharide (10 μg/kg) and galactosamine (900 mg/kg). (jcimjournal.com)
Compared with the untreated group, Fuzheng Huayu recipe, Fuzheng recipe and Huayu recipe attenuated hepatocyte apoptosis, decreased the serum ALT and AST activities and MDA content, and improved the SOD activity in liver tissues. (jcimjournal.com)
Progression1
Insulin resistance occurs in almost all patients with non-alcoholic fatty liver disease (NAFLD), and mitochondrial dysfunction likely plays a pivotal role in the progression of fatty liver into non-alcoholic steatohepatitis (NASH). (spandidos-publications.com)
Mice4
After a 70% PH, mig-6 knockout mice display an increase in hepatocytes re-entering the cell cycle at early time points during liver regeneration, which correlated with enhanced EGFR signaling. (jnksignaling.com)
The increased expression of the EGFR ligand HB-EGF in mig-6 knockout mice appears to be a consequence of EGFR activation upon liver injury. (jnksignaling.com)
The mice in drug-treated groups were administered with Fuzheng Huayu recipe, Fuzheng recipe and Huayu recipe by garvage respectively 3 days before injection of lipopolysaccharide and galactosamine. (jcimjournal.com)
The mice were sacrificed 6 hours after the administration of lipopolysaccharide and galactosamine. (jcimjournal.com)
Spleen3
Candida is also deposited in lungs, liver, spleen and kidney 1 . (ijpsr.com)
3) Enlarged liver and spleen return to normal or shrink to varying degrees. (xianzhilou.com)
T he liver-protecting effect of Reishi is also related to the descriptions in ancient Chinese medical texts of Reishi's ability to supplement liver qi and boost spleen qi. (xianzhilou.com)
NAFLD3
Little Sotrastaurin in vivo is known about the effects of non-alcoholic fatty liver disease (NAFLD) on energy metabolism, although this disease is associated with metabolic syndrome. (jnksignaling.com)
Despite the high prevalence of NAFLD and its potential to cause serious liver injury, the current therapies for NAFLD are limited. (spandidos-publications.com)
Injury2
The research results show that Ganoderma lucidum can provide significant protection against liver injury caused by excessive inflammation. (xianzhilou.com)
Because of their antioxidant capacity and low side effects, medicinal plants and their active phytochemicals have piqued researchers' interest as potential medicines against alcoholic liver injury. (fortunepublish.com)
Occurs2
Liver involvement occurs following invasion by E histolytica into mesenteric venules. (medscape.com)
Peak incidence of amebic liver abscess occurs in people in their third, fourth, and fifth decades of life, although it can occur in any age group. (medscape.com)
Clinical1
Professor Lin Zhibin has pointed out in his speeches that Reishi has a good liver-protecting effect in clinical practice. (xianzhilou.com)
Metabolism3
The bioavailability of valsartan is 23% indicating extensive first pass metabolism in liver. (iajpr.com)
2,6-Dihydroxybenzoic acid is a secondary metabolite of salicylic acid which has been hydrolyzed by liver enzymes during phase I metabolism. (medchemexpress.com)
The liver is an important organ that is involved in metabolism, storage, secretion, and detoxification. (fortunepublish.com)
Greatly reduced1
It finds that both treatment Dawa-Ul-Kurkum and its extract were helpful in preventing ethanol induced liver damage in rats, as they greatly reduced hepatotoxic damage markers. (fortunepublish.com)
Mechanisms1
Previous studies have proven that rodent and human MSCs can differentiate into HLCs in vitro and in vivo , which is one of the mechanisms of MSCs in the treatment of liver failure. (springer.com)
Dietary2
It's also commonly taken in dietary supplements . (webmd.com)
Curcumin has recently received attention as a promising dietary supplement for liver protection ( 5 ). (spandidos-publications.com)
Acid2
One of the pentacyclic triterpenes is 2α,3β,19α-trihydroxyurs-2-en-28-oic acid known as tormentic acid (TA). (encyclopedia.pub)
GroEL was also found to be a contributor to the FimA-independent INAC by live A. oris cells stimulated with non-ionized acid. (biomedcentral.com)
Activities1
NBL in C. depressa is also linked to hepatoprotective activities in liver-injuries induced by acetaminophen. (wikipedia.org)
Compound1
The mystery carbohydrate compound in the living body will be uncovered. (chemicalbook.com)
Treatment3
Prompt recognition and appropriate treatment of amebic liver abscess lead to improved morbidity and mortality. (medscape.com)
Galactosylated lipid substances allowed liver specific uptake of AZT at enhanced parenchymal: non-parenchymal selectivity ratios and at the same time could deliver MCZ for treatment of fungal infections. (ijpsr.com)
The only curative treatment for ALF is liver transplantation, but there are many restrictions on the application of liver transplantation because of financial considerations, a shortage of donor livers, and immunosuppression-related complications [ 3 ]. (springer.com)
Important1
Amebic liver abscess is an important cause of space-occupying lesions of the liver, mainly in developing countries. (medscape.com)
Extract1
17) have shown recently that a water-soluble extract of the adzuki beans could inhibit acetaminophen-induced liver damage. (healthjade.com)
Regulation2
Though commonly used as a fruit juice and considered an aid in metabolic health, C. depressa can potentially also aid in fat regulation. (wikipedia.org)
been implicated in the negative regulation of EGFR signaling23 and such proteins eventually account for EGFR regulation at later time points during liver regeneration. (jnksignaling.com)
Cell2
Furthermore, we were able to show that negative regulators of the cell cycle like retinoblastoma are inactivated in regenerating mig-6 knockout livers. (jnksignaling.com)
Along these lines, it has been shown that overexpression of mig-6 in Rat2 fibroblasts leads to activation of retinoblastoma resulting in a cell cycle arrest.24 Notably, we found elevated levels of the activator protein-1 transcription factor c-Jun in mig-6 knockout livers after PH. (jnksignaling.com)
People1
People commonly use L. acidophilus for diarrhea from antibiotics, as well as irritable bowel syndrome (IBS), overgrowth of bacteria in the vagina, and an infection caused by the bacteria Helicobacter pylori (H. pylori). (medlineplus.gov)
Found1
Specific strains of L. paracasei are commonly added to fermented foods like yogurt and are also found in probiotic supplements . (webmd.com)
Levels1
When compared to controls, ethanol induced liver damage was associated with higher levels of Malondialdehyde levels and Nitrates and Nitrites (NOx) assay, but lower levels of reduced glutathione (GSH) levels. (fortunepublish.com)
Higher1
Amebic liver abscess is marked by a 7-12-fold higher incidence in males than in females despite an equal sex distribution of noninvasive colonic amebic disease among adults. (medscape.com)
Abnormal morphological changes in liver mitochondria have been observed in patients and animal models with non-alcoholic steatohepatitis (NASH) ( 4 ). (spandidos-publications.com)