• T-prolymphocytic leukemia (T-PLL) is an aggressive mature T-cell neoplasm that responds poorly to conventional chemotherapy and has a dismal outcome. (haematologica.org)
  • However, in a recent COG report, the authors demonstrated that intensive multimodal therapies-including high-dose chemotherapy, radiation, and bone marrow transplantation-have enabled improved efficacy for curing patients with regional extraocular retinoblastoma (87% event-free survival [EFS] at 36 months) and metastatic retinoblastoma not involving the CNS (79% EFS at 36 months), while rates for patients with CNS disease continue to be dismal (8% EFS at 36 months). (aao.org)
  • Hodgkin Lymphoma treatment is multimodal and includes chemotherapy, radiotherapy and stem cell transplantation. (jcimcr.org)
  • Even patients who are not cured with initial therapy can often be salvaged with alternate chemotherapy combinations, the novel antibody-drug conjugate brentuximab, or high-dose autologous or allogeneic hematopoietic stem cell transplantation. (johnshopkins.edu)
  • The patient went on to have chemotherapy and autologous stem cell transplantation with a good outcome. (2011globalhealth.org)
  • Data about sociodemographic characteristics, the type of neoplasm and the chemotherapy scheme proposed were collected. (bvsalud.org)
  • Multiple chromosomal abnormalities and gene mutations previously reported in patients with myeloid and selected lymphoid neoplasms were identified in approximately 60% of patients with BPDCN. (elsevierpure.com)
  • Myeloproliferative neoplasms (MPNs) are a group of disorders characterized by a proliferation of normally developed (nondysplastic) multipotent hematopoietic stem cells from the myeloid cell line . (amboss.com)
  • Immunophenotypic and Molecular Features of Acute Myeloid Leukemia with Plasmacytoid Dendritic Cell Differentiation Are Distinct from Blastic Plasmacytoid Dendritic Cell Neoplasm. (atlasgeneticsoncology.org)
  • Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are myeloid neoplasms characterized by the presentation of overlapping features from both myelodysplastic syndromes and myeloproliferative neoplasms. (encyclopedia.pub)
  • Although the classification of MDS/MPN relies largely on clinical features and peripheral blood and bone marrow morphology, studies have demonstrated that a large proportion of patients (~90%) with this disease harbor somatic mutations in a group of genes that are common across myeloid neoplasms. (encyclopedia.pub)
  • Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) constitute a heterogeneous group of clonal myeloid malignancies with clinical, laboratory, morphologic and genetic features that overlap with myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN). (encyclopedia.pub)
  • Its occurrence is linked to leukemic diseases of the myeloid cell line, most commonly in acute myeloid leukemia (AML) and less commonly in chronic myeloid leukemia (CML), myelodysplastic syndrome (MDS) or other myeloproliferative disorders [ 4 ]. (biomedcentral.com)
  • Some case reports identified MYC or MLL gene amplification performing as dmin in myeloid neoplasms. (hindawi.com)
  • FLT3 ( FMS -related tyrosine kinase 3) acts as an oncogene in myeloid neoplasms which is associated with several signal transduction pathways. (hindawi.com)
  • Background: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with an aggressive clinical course. (elsevierpure.com)
  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive disease with historically poor outcomes. (medpagetoday.com)
  • For years the disease known as BPDCN had many different names, including natural killer cell leukemia/lymphoma, and only with the discovery that the disease is derived from plasmacytoid dendritic cells was the term established as blastic plasmacytoid dendritic cell neoplasm by the World Health Organization in 2008, and listed as its own entity in 2016. (medpagetoday.com)
  • The liver is the second most commonly transplanted major organ, after the kidney. (medscape.com)
  • [ 3 ] . An increasing number of orthotopic and living-donor liver transplantations are being performed to salvage patients with otherwise incurable end-stage liver disease (ESLD). (medscape.com)
  • [ 4 ] Doppler ultrasonography plays an important role in the postoperative management of liver transplantation. (medscape.com)
  • Spectral Doppler ultrasonographic waveform of the right hepatic artery in a 60-year-old man, 8 years after orthotopic liver transplantation. (medscape.com)
  • Lee et al retrospectively enrolled 75 patients who had undergone liver transpalantation and found that although MDCT in the late period should be interpreted with caution in patients with suspected biliary complication, MDCT is a reliable diagnostic technique for the identification of early and late abdominal complications after liver transplantation. (medscape.com)
  • We present here a case of a 70-year-old woman with extensive eruptive syringomas that developed after deceased donor liver transplantation (DDLT). (medicaljournals.se)
  • The diagnostic difficulty of the present case owed to the fact that the patient was referred 11 years after liver transplantation and each lesion was larger than a typical syringoma. (medicaljournals.se)
  • To our knowledge, this is the first case of eruptive syringoma occurring after liver transplantation. (medicaljournals.se)
  • The prognostic value of ZIP4 in HCC after liver transplantation was evaluated. (ijbs.com)
  • Immunohistochemical analysis was used to evaluate ZIP4 expression in HCC tissues from 60 patients undergoing liver transplantation, 36 cirrhotic tissue samples, and 6 normal tissue samples. (ijbs.com)
  • Multivariate analysis revealed that ZIP4 was an independent predictor of overall survival ( P = 0.037) after liver transplantation. (ijbs.com)
  • ZIP4 could promote migration, invasiveness, and suppress apoptosis in hepatocellular carcinoma, and represent a novel predictor of poor prognosis and therapeutic target for patients with HCC who undergo liver transplantation. (ijbs.com)
  • Liver resection and liver transplantation (LT) remain the most effective treatments for HCC [ 2 ]. (ijbs.com)
  • We report a case of a rapidly growing, symptomatic giant hepatic hemangioma with diffuse hepatic hemangiomatosis in a 50-year-old female patient who was treated by living-donor liver transplantation. (e-cmh.org)
  • Although this case could not meet the criteria for transplantation according to the MELD (model for end-stage liver disease) score system, it should be considered as an exceptional indication for deceased-donor liver allocation. (e-cmh.org)
  • We experienced a case of living donor liver transplantation in a 50 year old female patient with hepatic hemangiomatosis and hepatic hemangioma with increased size and symptoms. (e-cmh.org)
  • Most cases of paraneoplastic AN involve an adenocarcinoma,[5] most commonly one arising in the gastrointestinal tract (stomach or liver[3] ) and less commonly in the lungs, ovaries, uterus, breasts, kidneys, prostate or bladder. (medscape.com)
  • Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors. (mycancergenome.org)
  • BACKGROUND: During recent years, the incidence of serious infections caused by opportunistic fungi has increased dramatically due to alterations of the immune status of patients with hematological diseases, malignant tumors, transplantations and so forth. (who.int)
  • Less common MPNs, which are not associated with the driver mutations, include chronic eosinophilic leukemia (CEL), chronic neutrophilic leukemia , and myeloproliferative neoplasm , unclassifiable. (amboss.com)
  • Myelofibrosis (MF) is a hematopoietic stem cell malignancy classified as a myeloproliferative neoplasm (MPN). (cancernetwork.com)
  • 3 Myelofibrosis (MF) refers to the Philadelphia chromosome ( BCR-ABL1 )-negative myeloproliferative neoplasm (MPN) originating at the level of the multipotent hematopoietic stem cell. (haematologica.org)
  • The first-ever online and open-access education e-course, brought to you by The EBMT Trainee Committee, designed to cover all aspects surrounding hematopoietic cell transplantation and cellular therapy with a focus on trainee-relevant knowledge and skills. (ebmt.org)
  • Most patients with BPDCN have skin lesions and simultaneous involvement of the peripheral blood, bone marrow, and lymph nodes.Methods: A search of PubMed and Medline was conducted for English-written articles relating to BPDCN, CD4+CD56+ hematodermic neoplasm, and blastic natural killer cell lymphoma. (elsevierpure.com)
  • While the skin is the most commonly involved site of the disease (usually presenting as dark and purplish skin lesions) it can progress with bone marrow involvement and a decrease in red blood cell, white blood cell, and platelet counts, as well as possible lymph node and spleen involvement, and the involvement of other extramedullary organs. (medpagetoday.com)
  • A number of studies indicate that bone marrow fibrosis is an adverse prognostic variable in myeloproliferative neoplasms. (haematologica.org)
  • blood transfusion), spinal cord, lung cancer (oncology), respiratory cancer, radiology Background Multiple myeloma is a malignant proliferation of plasma cells mostly affecting the bone marrow and commonly presents with anaemia, hypercalcaemia, renal dysfunction, bone and skeletal involvement. (2011globalhealth.org)
  • Late effects following bone marrow transplantation are discussed in Bone Marrow Transplantation, Long-Term Effects . (medscape.com)
  • MS occurs in most cases meta-chronous to the hematological disease and most commonly affects the cutis. (biomedcentral.com)
  • The myeloproliferative neoplasms (MPNs) are a heterogeneous group of chronic hematological malignancies that are generally divided into the Philadelphia chromosome-positive (Ph-positive) MPNs, which refers to chronic myelogenous leukemia (CML) and the Philadelphia chromosome-negative (Ph-negative) MPNs. (cancernetwork.com)
  • Representative examples include epithelial neoplasms (e.g. lung carcinoma, prostate carcinoma, breast carcinoma, colon carcinoma), and neoplasms arising from the soft tissues and bones (e.g. leiomyosarcoma, liposarcoma, chondrosarcoma, osteosarcoma). (mycancergenome.org)
  • Keratoacanthomas may occur within Muir-Torre syndrome along with sebaceous neoplasms and adenomatous colon carcinoma or other low-grade internal malignancies. (logicalimages.com)
  • In addition toallograft rejection (a topic covered elsewhere in this series), a multitude of medical complications mark the post-transplantation course. (ersjournals.com)
  • By 6 months post-transplantation, the reconstituted mice had developed a clonal myeloproliferative/myelodysplastic disorder originating from the cells with aberrantly reduced Mybl2 expression. (elifesciences.org)
  • LAM represents a low-grade, destructive, metastasizing neoplasm, perhaps of uterine origin, that spreads through the lymphatic system. (msdmanuals.com)
  • Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
  • However, tissue oximetry sensors commonly used in clinical practice instead rely on measuring oxygen saturation ([Formula: see text]), largely due to the lack of reliable, affordable [Formula: see text] sensing solutions. (bvsalud.org)
  • There are 5 clinical trials for solid neoplasm, of which 1 is open and 4 are completed or closed. (mycancergenome.org)
  • BRAF is the most frequent gene inclusion criterion for solid neoplasm clinical trials [ 3 ]. (mycancergenome.org)
  • ABL1 is an inclusion eligibility criterion in 1 clinical trial for solid neoplasm, of which 0 are open and 1 is closed. (mycancergenome.org)
  • Diagnosing hematolymphoid neoplasm by evaluating fine-needle aspiration (FNA) cytology sample is controversial and requires experience and clinical skills. (cytojournal.com)
  • that are commonly encountered in the clinical setting. (who.int)
  • MF is a clonal bone narrow neoplasm which can emerge either as primary MF (PMF), polycythemia vera (PV) or essential thrombocythemia (ET). (antengene.com)
  • See the images below of transplantation complications. (medscape.com)
  • However, such treatment is commonly associated with a high rate of complications and treatment-related deaths. (antengene.com)
  • Identifying and understanding acute complications after allogeneic haematopoietic cell transplantation (alloHCT). (ebmt.org)
  • ABO incompatible living donor kidney transplantation after conditioning with rituximab, plasmapheresis/immunoadsorption and immunoglobulins is a valid option offering excellent outcomes.as survival and acute rejections without increasing infectious complications. (revistanefrologia.com)
  • 1 T-PLL cells commonly demonstrate rearrangements involving T-cell leukemia/lymphoma 1 (TCL1) family genes TCL1A, MTCP1 (mature T-cell proliferation), or TCL1B as molecular hallmarks. (haematologica.org)
  • Methods: A search of PubMed and Medline was conducted for English-written articles relating to BPDCN, CD4 + CD56 + hematodermic neoplasm, and blastic natural killer cell lymphoma. (elsevierpure.com)
  • Hodgkin lymphoma is a lymphoproliferative malignancy originating from B cells of the immune system and is most commonly seen in adolescents and young adults. (jcimcr.org)
  • Primary Mediastinal Large B-Cell Lymphoma (PMBL) is a rare neoplasm that arises in the mediastinum, and then forms a mass. (jcimcr.org)
  • Hodgkin lymphoma (HL) is a unique hematopoietic neoplasm characterized by cancerous Reed-Sternberg cells in an inflammatory background. (johnshopkins.edu)
  • Transplantation of patients with underlying cystic fibrosis (CF), whose native airways and sinuses are chronically infected with virulent bacterial pathogens, initially raised unique concerns about the potential excessive risk of postoperative infections. (ersjournals.com)
  • Two recent series from North American centres with extensive experience in transplantation of CF patients have documented 1-yr survival rates of 50% versus 83% and 67% versus 96% among CF patients with and without B. cepacia , respectively 7 , 8 . (ersjournals.com)
  • Patients are commonly diagnosed with HL in their 20s and 30s, and they present with supradiaphragmatic lymphadenopathy, often with systemic B symptoms. (johnshopkins.edu)
  • ABL1 is altered in 1.76% of solid neoplasm patients [ 2 ]. (mycancergenome.org)
  • BCR is altered in 1.37% of solid neoplasm patients [ 2 ]. (mycancergenome.org)
  • BRAF is altered in 6.45% of solid neoplasm patients [ 2 ]. (mycancergenome.org)
  • NF1 is altered in 7.01% of solid neoplasm patients [ 2 ]. (mycancergenome.org)
  • Patients on immunosuppressants (eg, immunosuppression after solid organ transplantation) have increased numbers of more persistent and more chronic keratoacanthomas. (logicalimages.com)
  • Patients with deep mycoses may present with a primary infection of the oral mucosa, but, more commonly, they present with an extension of an established paranasal infection. (medscape.com)
  • although whole-body fluorine-18 fluorodeoxyglucose ((18)f-fdg) positron emission tomography (pet)/computed tomography (ct) ((18)f-fdg pet/ct) is commonly used for m staging of newly diagnosed nasopharyngeal carcinoma (npc), some patients may not benefit from this procedure. (liverpool.ac.uk)
  • Combination therapies involving melphalan, a small-molecule DNA alkylating agent, are commonly prescribed to patients with relapsed or refractory MM, necessitating the stratification of responding patients to minimize toxicities and improve quality of life. (snmjournals.org)
  • Patients usually report few systemic symptoms but are commonly troubled by persistent pain and drainage through sinus tracts. (forexmangates.com)
  • Genetic Aspects of Myelodysplastic/Myeloproliferative Neoplasms" Encyclopedia , https://encyclopedia.pub/entry/10288 (accessed December 10, 2023). (encyclopedia.pub)
  • A common deleted region (CDR) in both myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) affects the long arm of chromosome 20 and has been predicted to harbor a tumor suppressor gene. (elifesciences.org)
  • When the number of plasma cells in the peripheral blood exceeds 2 x 10 9 L the neoplasm is referred to as plasma cell leukaemia. (microscopic-haematology.com)
  • The eruptive variant of syringoma, which is observed less commonly than other subtypes, is 1-5 mm in size and is predominantly distributed over the anterior trunk, neck, abdomen and axillae (2, 3). (medicaljournals.se)
  • Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. (lookformedical.com)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • Transplantation of an individual's own tissue from one site to another site. (lookformedical.com)
  • The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. (lookformedical.com)
  • [ 3 ] A biopsy should be performed for any lesion suspected of being a cutaneous neoplasm. (medscape.com)
  • A biopsy should be performed for any lesion suspected of being a cutaneous neoplasm to rule out basal cell carcinoma and other dermal lesions. (medscape.com)
  • Dendritic cells (DC) for cancer immunotherapy protocols are generated most commonly by in vitro differentiation of monocytes with exogenous cytokines (Mo-DC). (nih.gov)
  • Cholangiocarcinoma is a rare malignant neoplasm and accounts for only 3% of gastrointestinal tumours. (unizg.hr)
  • TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in solid neoplasm [ 2 ]. (mycancergenome.org)
  • Here we report that multiple independent somatic hematopoietic clones arise early in life, most commonly harboring heterozygous mutations in EIF6 or TP53 . (nature.com)
  • HCC is commonly lethal because of its aggressive metastasis and most cases are diagnosed at an already advanced stage. (ijbs.com)
  • Biliary tree cholangiocarcinoma and pancreatic ductal carcinoma are highly aggressive cancers - both which are commonly diagnosed via endoscopic bile duct brushings. (swimacrossamerica.org)
  • Prof. Depei Wu, Director of Hematology Department at the First Affiliated Hospital Soochow University, and the principal investigator of the study, noted: "MF is a relatively rare form of proliferative neoplasm in the bone narrow that has long lacked effective treatment options before the emergence of targeted therapies. (antengene.com)
  • The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause. (lookformedical.com)
  • The most commonly affected nonhematopoietic organ is the skin. (elsevierpure.com)