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  • bone marrow
  • When a transferrin protein loaded with iron encounters a transferrin receptor on the surface of a cell , e.g., erythroid precursors in the bone marrow, it binds to it and is transported into the cell in a vesicle by receptor-mediated endocytosis . (wikipedia.org)
  • transferrin
  • Transferrin glycoproteins bind iron tightly, but reversibly. (wikipedia.org)
  • Although iron bound to transferrin is less than 0.1% (4 mg) of total body iron, it forms the most vital iron pool with the highest rate of turnover (25 mg/24 h). (wikipedia.org)
  • When not bound to iron, transferrin is known as "apotransferrin" (see also apoprotein ). (wikipedia.org)
  • to about 5.5, causing transferrin to release its iron ions. (wikipedia.org)
  • The receptor with its ligand bound transferrin is then transported through the endocytic cycle back to the cell surface, ready for another round of iron uptake. (wikipedia.org)
  • It enables ligand bonding to the transferrin, as each monomer can bind to one or two atoms of iron. (wikipedia.org)
  • hematite
  • A schematic shows the atomic arrangement of iron (blue) and oxygen (white) atoms in hematene, a two-dimensional material that was exfoliated from hematite for the first time by Rice University scientists and their international partners. (phys.org)
  • While native hematite is antiferromagnetic, tests showed that hematene is ferromagnetic, like a common magnet. (phys.org)
  • A transmission electron microscope image shows bi-layer and monolayer hematene, exfoliated from hematite, a common iron ore, by scientists at Rice University and their international partners. (phys.org)
  • Aravind Puthirath Balan et al, Exfoliation of a non-van der Waals material from iron ore hematite, Nature Nanotechnology (2018). (phys.org)
  • The most common ore is hematite, which is frequently seen as black sands along beaches and banks of streams. (lanl.gov)
  • causes
  • We are seeing a variety of additional causes of iron deficiency these days. (savannahnow.com)
  • However, the more common causes arise from disorders with the respiratory or cardiovascular systems. (healthhype.com)
  • There's also an inherited disease, hemochromatosis, which causes your body to accumulate excessive and dangerously damaging levels of iron. (mercola.com)
  • Iron causes all this harm by catalyzing a reaction within the inner mitochondrial membrane. (mercola.com)
  • intestine
  • As in your case, the use of aspirin, non-steroid anti-inflammatory drugs is the leading cause of iron deficiency due to the irritation of the stomach and small intestine that can occur with excessive use of these medications. (savannahnow.com)
  • Dietary iron in meat and greens requires acid to be converted to a form of iron that is absorbed by the intestine. (savannahnow.com)
  • Iron from food is absorbed into your bloodstream in your small intestine. (wordpress.com)
  • Hepcidin blocks the intestine from taking up iron. (nih.gov)
  • Hepcidin prevents iron from leaving cells where it is stored or from being absorbed in the duodenum, the first part of the small intestine just beyond the stomach. (nih.gov)
  • zinc
  • In addition, iron and zinc are major targets of crop biofortification to improve human nutrition. (frontiersin.org)
  • mechanisms
  • Iron is a powerfully reactive pro-oxidant, so much so that the body has several mechanisms in place to prevent free iron from being released. (metabolichealing.com)
  • Despite significant advances in the plant nutrition field, the mechanisms underlying the adaptation of common bean to low nutrient input remains largely unknown. (frontiersin.org)
  • Traits
  • Associations between Common Variants in Iron-Related Genes with Haematological Traits in Populations of African Ancestry. (lshtm.ac.uk)
  • nutrient
  • Developing common bean varieties able to thrive under nutrient limiting conditions will have a major impact on human nutrition, particularly in countries where dry beans are the main source of carbohydrates, protein and minerals. (frontiersin.org)
  • Additionally
  • Additionally, low thyroid activity can result in many abnormalities related to: lipid dysregulation, poor iron utilization, digestive inadequacies, blood sugar-handling issues, adrenal-related issues, fluid retention , and liver issues. (metabolichealing.com)
  • copper
  • The Richmond Mine of the Iron Mountain copper deposit contains some of the most acid mine waters ever reported. (pnas.org)
  • differences
  • These studies are important given interethnic differences in iron status and the disproportionate burden of iron deficiency among African ancestry populations. (lshtm.ac.uk)
  • In 2014, the genome of common bean became available, offering a unique opportunity to compare and understand, at the molecular level, the similarities and differences that make these species so unique and important for human nutrition around the globe. (frontiersin.org)
  • marker
  • Not only will the GGT test tell you if you have liver damage, it can also be used as a screening marker for excess free iron and is a great indicator of your sudden cardiac death risk. (mercola.com)
  • scientists
  • In the wake of its recent discovery of a flat form of gallium, an international team led by scientists from Rice University has created another two-dimensional material that the researchers said could be a game changer for solar fuel generation.Rice materials scientist Pulickel Ajayan and colleagues extracted 3-atom-thick hematene from common iron ore. (phys.org)
  • genetic
  • Large genome-wide association (GWA) studies of European ancestry individuals have identified multiple genetic variants influencing iron status. (lshtm.ac.uk)
  • While there is now evidence for the associations of a number of genetic variants with iron status in both European and African ancestry populations, the considerable lack of concordance highlights the importance of continued ancestry-specific studies to elucidate the genetic underpinnings of iron status in ethnically diverse populations. (lshtm.ac.uk)
  • magnetic
  • Our findings indicate that common in vitro cell endpoint assays do not give detailed and complete information on cellular state and it is essential to explore novel approaches and carry out more in-depth studies to elucidate cellular response mechanism to magnetic nanoparticles. (biomedcentral.com)
  • important
  • Common bean ( Phaseolus vulgaris ) and soybean ( Glycine max ) are two of the most important sources of protein for humans and livestock. (frontiersin.org)
  • For the basic soil analysis, free iron is the major analytical item because it is an important indicator for understanding the genesis of soil, soil classification, and soil distribution behavior [ 1 , 2 ]. (hindawi.com)
  • For example, the ratio of the amorphous iron and free iron is an important indicator to distinguish the weathering extent of soil horizon. (hindawi.com)
  • absence
  • Moreover, finding a common source does not a theory make in the absence of clear, falsifiable, dynamics. (tripod.com)
  • total
  • In this study, an alternative analytical method (chemisorption) based on thermodynamic knowledge was proposed for measurement of total free iron oxides in soils. (hindawi.com)
  • Several representative soil samples belonging to alfisols, ultisols, inceptisols, and entisols were collected from Taiwan and tested by the chemisorption, and the estimated total free iron oxides were compared with those measured from the traditional citrate bicarbonate dithionite (CBD) method. (hindawi.com)
  • The estimated total free iron oxides for soil samples determined from the chemisorption in the presence of CO were very close to those from the CBD technique. (hindawi.com)
  • In soil science, iron species can be generally classified into several groups, including organically bounding iron, amorphous iron, free iron, and total iron. (hindawi.com)
  • free iron
  • In fact, under periods of increased oxidative stress and free radical activity, the cells cleverly are programmed to rapidly degrade heme, presumably to prevent free iron from entering circulation. (metabolichealing.com)
  • Free iron is one of the major analytical items for soil basic properties. (hindawi.com)
  • Free iron is defined as the iron coated/adsorbed on the surface of soil but not counting in the lattice structure of the soil. (hindawi.com)
  • High
  • This solid shaft of wrought iron is about 7 1/4 m high by 40 cm in diameter. (lanl.gov)
  • If left untreated, high iron can contribute to cancer , heart disease , diabetes , neurodegenerative diseases and many other health problems, including gouty arthritis. (mercola.com)