• Common inbred strains include BALB/c, C3H, C57BL/6 and DBA. (uwm.edu)
  • In particular, the topic of improving the low fertility rate of cryopreserved sperm in the C57BL/6 strain of mouse, the most common inbred strain used as a base for genetically engineered mice, has been garnering much attention. (go.jp)
  • This review focuses on recent work regarding various attractive technologies in the fields of sperm cryopreservation and efficient embryo production using cryopreserved C57BL/6 mouse sperm. (go.jp)
  • C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced. (mmpc.org)
  • C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. (mmpc.org)
  • Congenic BALB/c CL4 strain expressing C57Bl/6 Thy 1.1 allele. (ncard.org.au)
  • JAX stock No# 002216 or C57BL/6J isogenic Rag1 knock-out strain is also available as Stock No. 034159 . (ncard.org.au)
  • 150 one-cell embryos from the C57BL/6J strain background or an alternative background as the project necessitates. (fredhutch.org)
  • In this study we have increased the density of microsatellite markers 2- to 5-fold in each of several major RI sets that share C57BL/6 as a parental strain (AXB, BXA, BXD, BXH, and CXB). (nervenet.org)
  • CB6F1 hybrid mice, a cross between C57BL/6 and Balb/c mice, were tested for learning and memory using a radial water tread maze. (antpublisher.com)
  • We now report confirmation of this locus in congenic strains carrying the MOLF-derived susceptibility allele in the C57BL/6J-Ldlr Ϫ/Ϫ genetic background. (scite.ai)
  • We then generated conplastic strains on the C57BL/6J background for 12 mtDNA variants with one to three functional mtDNA mutations. (uni-luebeck.de)
  • For instance, C57BL/6J mice are resistant to hepatic, renal and cardiac fibrosis but susceptible to pulmonary and intestinal fibrosis. (biomedcentral.com)
  • In this study, the inbred mouse strains A/J and C57BL/6J were used to determine whether their specific strain differences correlate with differences in susceptibility to respiratory depression and constipation. (pacific.edu)
  • C57BL/6J mice showed a greater degree of change in several respiratory parameters, resulting in more pronounced respiratory depression. (pacific.edu)
  • This study demonstrates that the strain differences between A/J and C57BL/6J mice have a major effect on opioid-induced constipation and respiratory depression. (pacific.edu)
  • Note to the Reader Please cite this work as: Williams RW, Gu J, Qi S, Lu L (2001) The genetic structure of recombinant inbred mice: High-resolution consensus maps for complex trait analysis. (nervenet.org)
  • Common laboratory inbred mouse strains such as BALB/c and C57Bl6/J form the backbone of much of our pre-clinical work. (ncard.org.au)
  • BALB/cJ : a commonly used inbred mouse stain. (ncard.org.au)
  • BALB/c based mouse model in which the administration of diphtheria toxin (DT) leads to specific depletion of regulatory T cells (Treg) due to expression of DT receptor-enhanced GFP under the control of the Foxp3 promoter. (ncard.org.au)
  • BALB/c nude mice: A spontaneous mutation in Foxn1 nu induces abnormal hair growth (nude phenotype). (ncard.org.au)
  • 15-11C5 is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from Balb/c mice immunized with WAG/Rij spleen cells. (hycultbiotech.com)
  • However, BALB/c mice are resistant to pulmonary fibrosis but susceptible to hepatic fibrosis. (biomedcentral.com)
  • Because it is unethical to expose humans to induce DA, we postulated that the use of a genetically diverse mouse model, the Collaborative-Cross (CCRIL), compared to an inbred mouse, BALB/cJ, will demonstrate how each reacts to low, medium, and high levels of HDI-IC to aid in the understanding of the cause of and susceptibility to DA in humans. (cdc.gov)
  • The Collaborative Cross (CC) is a mouse reference population with high allelic diversity that is being constructed using a randomized breeding design that systematically outcrosses eight founder strains, followed by inbreeding to obtain new recombinant inbred strains. (ornl.gov)
  • In the review, Chesler and colleagues focus on two reference populations based on the same eight founder strains. (jax.org)
  • The other population, Diversity Outbred (DO), is bred to produce individual mice whose genetics derive equally from the eight founder strains but in a random configuration. (jax.org)
  • Between strains, the mouse shows great differences in susceptibility to noise as well as differences in prebycusis. (cdc.gov)
  • Phenotypic analysis of the conplastic strains demonstrated that mtDNA variations affect susceptibility to experimental autoimmune encephalomyelitis and anxiety-related behavior, which confirms that mtDNA variations affect complex traits. (uni-luebeck.de)
  • To meet the existing concern of deepening hereditary susceptibility to disease and dissection of hereditary traits evaluation well-defined mouse hereditary guide populations (GRPs) have already been a powerful push. (healthdisparitiesks.org)
  • There is mounting evidence suggesting that inbred mouse strains with different genetic backgrounds demonstrate variable susceptibility to a fibrotic injury. (biomedcentral.com)
  • We performed a systematic review of the literature describing strain and organ specific response to injury in order to determine whether genetic susceptibility plays a role in fibrogenesis. (biomedcentral.com)
  • There is evidence that mouse strain differences influence susceptibility to fibrosis and this appears to be organ specific. (biomedcentral.com)
  • The majority of genomic studies used to identify susceptibility pathways involved in disease pathologies have been performed in the mouse. (biomedcentral.com)
  • Mice are also easy to breed with a short generation time and a short life span allowing direct study of disease development and can accurately eludicidate how genetic sequences may vary in different strains and result in susceptibility to fibrotic pathologies. (biomedcentral.com)
  • Mouse model demonstrates strain differences in susceptibility to opioi" by Andrew L. Young, Archana Viswanath et al. (pacific.edu)
  • Unfortunately, a multitude of genetic backgrounds and experimental setups, together with inter-individual variation, complicates cross-study comparisons and a global understanding of the mouse microbiota landscape. (nih.gov)
  • Here, we investigate the variability of the healthy mouse microbiota of five common lab mouse strains using 16S rDNA pyrosequencing. (nih.gov)
  • Genetic distance correlates positively to microbiota distance, so that genetically similar strains have more similar microbiota than genetically distant ones. (nih.gov)
  • The detection of enterotypes suggests a common ecological cause, possibly low-grade inflammation that might drive differences among gut microbiota composition in mammals. (nih.gov)
  • The adventitious pathogen status of a transgenic mouse line may impact breeding efficiency, health and life span and experimental variables such as immune response or microbiota. (fredhutch.org)
  • Abstract The study was aimed to assess impact of high fat diet (HFD) and synthetic human gut microbiota (GM) combined with HFD and chow diet (CD) in inducing type-2 diabetes (T2D) using mice model. (bvsalud.org)
  • Here, we have performed an analysis of associations between the gut microbiota and T1D genetic risk using the non-obese diabetic (NOD) mouse model of T1D and the TwinsUK cohort. (biomedcentral.com)
  • Increased T1D disease risk from IL-2 pathway loci in the TwinsUK cohort of human subjects resulted in some similar microbiota changes to those observed in the NOD mouse. (biomedcentral.com)
  • In the inbred non-obese diabetic (NOD) mouse model of T1D, susceptible NOD mice were shown to harbor a distinct gut microbiota to a variety of T1D-protected inbred strains [ 8 ]. (biomedcentral.com)
  • These studies indicate that in the steady state, NOD mice harbor a "diabetes-permissive" microbiota, and major perturbations in the microbiota can both reduce and accelerate disease. (biomedcentral.com)
  • The microbiota of obese mice differed from that of the lean mice, with a higher level of gut-derived bacteria such as E. coli . (the-scientist.com)
  • Initially, the founder strains, which include five common laboratory and three wild-derived strains, were selected to establish the Collaborative Cross (CC), a panel of high diversity recombinant inbred strains. (jax.org)
  • A mouse genetics approach can simplify the genetic analysis and provide tools for mechanistic studies. (scite.ai)
  • Key Words: atherosclerosis Ⅲ congenic strain Ⅲ genetics Ⅲ extracellular matrix Ⅲ mapping S usceptibility to atherosclerosis is influenced by both genetic and environmental factors, with approximately 40% to 60% of interindividual variation attributed to genetic factors. (scite.ai)
  • His Ph.D. training on Mouse Genetics was done at Institut Pasteur, Paris, France (with Dr. Jean-Louis Guénet as PhD mentor). (vallhebron.com)
  • He has published several books, chapters and reviews on Mouse Genetics and Genetic Quality Controls in mice and rats. (vallhebron.com)
  • Mice provide a suitable model for the study of human genetics because more than 95% of the genome is identical. (biomedcentral.com)
  • Research with inbred mouse strains-that is, mice inbred for generations until their genetics are identical, or as nearly so as possible-has yielded countless biological discoveries and led to significant medical progress. (jax.org)
  • Our results demonstrate that statistical interactions between genetic variants and chromatin accessibility are common throughout the genome. (elifesciences.org)
  • Physical distance along a linear genome is a common metric for determining whether a putative regulatory element will affect a given gene's transcription. (elifesciences.org)
  • Our genetically engineered mouse model, or GEMM, team offers state-of-the-art services for the development and maintenance of transgenic mouse strains, including all modern genome editing tools and expertise in mouse transgenesis. (fredhutch.org)
  • We provide a four-phase CRISPR/Cas9 genome-editing service that allows researchers to acquire desired alleles (null, conditional, precisely mutated reporter or tagged alleles) in mice. (fredhutch.org)
  • To date, the Mouse Genome Database through The Jackson Laboratory, lists 24 QTL in mice associated with fibrosis of which all but 3 are phenotypes in the lung. (biomedcentral.com)
  • A strain is inbred when it has undergone at least 20 generations of brother x sister or offspring x parent mating, at which point at least 98.6% of the loci in an individual of the strain will be homozygous, and each individual can be treated effectively as clones. (wikipedia.org)
  • This causes the genes to become homozygous (same strain) at nearly all the loci on the chromosomes. (uwm.edu)
  • The final consensus maps are based on 1578 microsatellite loci and these maps have a cumulative length of approximately 1400 cM after adjustment for recombination frequencies of RI strains. (nervenet.org)
  • Recombinant inbred (RI) strains have been used to map a wide range of Mendelian loci and quantitative traits (Taylor, 1989). (nervenet.org)
  • The pre-publication data that we release is embargoed for publication except for analyses of single chromosomes in single strains or single gene loci across multiple strains. (mousegenomes.org)
  • Quantitative trait locus (QTL) analysis is a common genetic approach that has been used in the past two decades to identify loci involved in differences in fibrotic response between inbred strains of mice [ 9 ]. (biomedcentral.com)
  • Quantitative trait loci analysis can be time consuming and can only analyse two different mouse strains at a time. (biomedcentral.com)
  • Homozygous congenic mice exhibited up to 4.5-fold greater lesion area compared to noncongenic littermates (PϽ0.0001). (scite.ai)
  • Learn about breeding schemes that generate coisogenic, recombinant inbred, consomic and congenic mice. (jax.org)
  • Breeding of inbred strains is often towards specific phenotypes of interest such as behavioural traits like alcohol preference or physical traits like aging, or they can be selected for traits that make them easier to use in experiments like being easy to use in transgenic experiments. (wikipedia.org)
  • One of the key strengths of using inbred strains as a model is that strains are readily available for whatever study one is performing and that there are resources such as the Jackson Laboratory, and FlyBase, where one can look up strains with specific phenotypes or genotypes from among inbred lines, recombinant lines, and coisogenic strains. (wikipedia.org)
  • The strains are highly useful for trait correlation studies, as phenotypes from a CC panel can be compared across experiments and laboratories. (jax.org)
  • Five of the eight founders are common laboratory strains, and three are wild-derived. (ornl.gov)
  • Mouse GRPs can be found as inbred lab and wild-derived mouse strains recombinant inbred strains interspecific recombinant inbred strains chromosome substitution strains and consomic strains [13]. (healthdisparitiesks.org)
  • homozygous nude mice lack T cells and suffer from a lack of cell-mediated immunity. (ncard.org.au)
  • Mice homozygous for the Rag1 tm1Mom mutation produce no mature T cells or B cells. (ncard.org.au)
  • Mice homozygous for the severe combined immune deficiency spontaneous mutation Prkdcscid, commonly referred to as scid, are characterized by an absence of functional T cells and B cells, lymphopenia, hypogammaglobulinemia, and a normal hematopoietic microenvironmentsevere combined immune deficient phenotype on Non obese diabetic genetic background. (ncard.org.au)
  • Over the years, while permanent inbreeding effectively eliminates a proportion of new mutant alleles, another undetected fraction may become progressively fixed in the homozygous state, replacing the original allele, a process known as genetic drift. (vallhebron.com)
  • Although this strain is refractory to many tumors, it is a permissive background for maximal expression of most mutations. (mmpc.org)
  • Cryopreservation success depends on the strain, transgenic mutations, age, breeding history and health of the donor male. (fredhutch.org)
  • Previous reports have demonstrated that the mtDNA of mouse common inbred strains (CIS) originated from a single female ancestor and that mtDNA mutations occurred during CIS establishment. (uni-luebeck.de)
  • Phylogenetic analysis demonstrated that 50 of the 52 CIS descended from a single female Mus musculus domesticus mouse, and mtDNA mutations have accumulated in 26 of the CIS. (uni-luebeck.de)
  • The starting animal line can be from an inbred strain or outbred stock, a commercially-available GEM strain, or a novel GEM designed to mimic relevant human mutations. (cnybac.com)
  • Dr. Benavides has a strong background in positional cloning of spontaneous mutations and has described several new mouse models. (vallhebron.com)
  • [4] Familiar albino animals include in-bred strains of laboratory animals (rats, mice and rabbits), but populations of naturally occurring albino animals exist in the wild, e.g. (wikipedia.org)
  • There are many preclinical models of NASH, using both rats and mice, and novel models continue to be developed. (cnybac.com)
  • Most mouse users are not fully aware that inbred strains of mice (same for rats) are actually distributed in "families" of related substrains that stem from a common ancestral strain and that these present several genetic differences. (vallhebron.com)
  • Genomes of individuals strains typically incorporate 45-55 recombinations between parental chromosomes. (nervenet.org)
  • The technology of sperm cryopreservation is widely used for storage of genetically engineered mice produced by global large-scale knockout mice or mouse mutagenesis projects in mouse banks. (go.jp)
  • Genotypes of more than 100 RI strains were extensively error checked and regenotyped. (nervenet.org)
  • A third advantage of RI strains is that genotypes generated by different groups using a variety of methods can be pooled to generate high-density linkage maps. (nervenet.org)
  • Plastic restraint devices can be used to hold mice and other rodents for longer periods of time. (uwm.edu)
  • Diet conditioning is a common approach to generate NASH rodents. (cnybac.com)
  • Furthermore, the observed environmental and genetic effects have important consequences for experimental design in mouse microbiome research. (nih.gov)
  • The seven isolates were subsequently used as synthetic gut microbiome (GM) for their role in inducing T2D in mice. (bvsalud.org)
  • Through the analysis of five separate colonies of T1D susceptible NOD mice, we identified similarities in NOD microbiome that were independent of animal facility. (biomedcentral.com)
  • The microbiome may lack statistical power to detect common, tumour site concordances can also play a critical part in host an increase in tumour incidence at among the species studied. (who.int)
  • Immunodeficient mice serve as critical hosts for transplantation of xenogeneic cells for in vivo analysis of various biological processes. (nih.gov)
  • Because investigators typically select one or two immunodeficient mouse strains as recipients, no comprehensive study has been published documenting differences in human tumor engraftment. (nih.gov)
  • Taking advantage of the increased metastatic potential of RhoC-expressing human (A375) melanoma cells, we evaluate four immunodeficient mouse strains: severe combined immunodeficiency (scid), nonobese diabetic (NOD)-scid, NOD-scid beta2m(null), and NOD-scid IL2Rgamma(null) as xenograft tumor recipients. (nih.gov)
  • Murine NKG2D recognition of MICA/B is an important receptor-ligand interaction used by NK cells in immunodeficient strains to limit engraftment of human tumors. (nih.gov)
  • NCARD uses a variety of immunodeficient mice, which are mostly sourced from commercial vendors. (ncard.org.au)
  • Immunodeficient mouse strains are invaluable when assessing the role of immune cell subsets in anti‑tumour immunity. (ncard.org.au)
  • In contrast, AP-Variant 1 does not infect the white-footed mouse, DBA/2, and severely immunocompromised (SCID) mice ( 8 ). (cdc.gov)
  • Melanoma metastases growth is delayed and variable in scid and NOD-scid mice. (nih.gov)
  • In contrast, NOD-scid beta2m(null) and NOD-scid IL2Rgamma(null) mice show rapid tumor engraftment, although tumor growth is variable in NOD-scid beta2m(null) mice. (nih.gov)
  • NK cells were detected in all strains except NOD-scid IL2Rgamma(null), and in vitro activated scid, NOD-scid, and NOD-scid beta2m(null) NK cells kill human melanoma lines and primary melanoma cells. (nih.gov)
  • The absolute NK deficiency in NOD-scid IL2Rgamma(null) animals makes this strain an excellent recipient of melanoma and potentially other human malignancies. (nih.gov)
  • severe combined immune deficiency (scid) and a complete null allele of the IL2 receptor common gamma chain (IL2rgnull). (ncard.org.au)
  • Recent studies that compared the prevalence of AP-ha to AP-Variant 1 in tick populations showed the variant to be the predominant strain at 2 of 3 sites and suggest that AP-Variant 1 is common in nature ( 4 , 5 ). (cdc.gov)
  • All such populations may be subject to consequences of inbreeding depression. (ornl.gov)
  • Phenotypic variation in the CC breeding population exceeds that of existing mouse genetic reference populations due to both high founder genetic diversity and novel epistatic combinations. (ornl.gov)
  • Cell populations derived from these transgenic mice can be distinguished from syngeneic host and other mice with the alternate allele via flow cytometry. (ncard.org.au)
  • New genetically diverse mouse populations mirror human genetic variation, providing a powerful new experimental platform to complement human data insights, particularly for complex trait and complex disease research. (jax.org)
  • For this reason, researchers are increasingly focusing on mouse populations with high genetic diversity. (jax.org)
  • The JAX Genetic Diversity Initiative is a strategic effort to increase the awareness and availability of diversity mouse populations and associated tools across the research community. (jax.org)
  • When investigated within diverse mouse populations, traits show a range similar to those observed in human populations, and they can be genetically mapped with high precision. (jax.org)
  • Although progress with research methods has only recently made work with DO mouse populations readily feasible, DO studies have already successfully mapped complex traits related to cardiovascular function, addiction, metabolic syndrome, cancer, behavior and more. (jax.org)
  • [3] It is a common misconception that all albino animals have characteristic pink or red eyes (resulting from the lack of pigment in the iris allowing the blood vessels of the retina to be visible), however this is not the case for some forms of albinism. (wikipedia.org)
  • Inbred strains of albino mice were divided into four groups and were fed with CD, HFD, GM+HFD and GM+CD. (bvsalud.org)
  • Jessica Steinbach '17 and partner Elizabeth Garza '17 are spending their summer researching the effects of Oxytocin on maternal behavior in inbred autistic mice. (redlands.edu)
  • The first paper will examine correlates among attending, impulsive behavior, and short-term remembering in a mouse model of Alzheimer's disease. (abainternational.org)
  • Handbook of mouse auditory research: from behavior to molecular biology. (cdc.gov)
  • Interestingly, comparative mapping revealed that the Athsq1 congenic interval contains the mouse region homologous to a widely-replicated CHD locus on human chromosome 9p21. (scite.ai)
  • Nowadays, due to standardized ways of maintaining animal colonies and the availability of mouse strains with known genetic backgrounds and approaches to reduce the variability of tumor size between animals, transplantable mouse tumor models can be widely used in translational cancer research. (bvsalud.org)
  • AGGREGATION"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "In mice, amyloidogenic type C apolipoprotein A-II (apoA-II) forms amyloid fibrils in age-associated amyloidosis. (nii.ac.jp)
  • Strains on common inbred backgrounds are most successful. (fredhutch.org)
  • Inbred strains of animals are frequently used in laboratories for experiments where for the reproducibility of conclusions all the test animals should be as similar as possible. (wikipedia.org)
  • This investigation was aimed at dissecting the mechanisms of C. pneumoniae pathogenesis by multivariate analysis of challenge experiments in a mouse model of C. pneumoniae lung infection. (auburn.edu)
  • With this presentation, I want to create awareness on the existence of a variety of substrains of mice that, if ignored, could potentially affect the results and/or repeatability of some experiments. (vallhebron.com)
  • More often than not, when I ask investigators, postdocs or students what particular substrain of a common inbred stain are they using, I get that "what are you talking about? (vallhebron.com)
  • Our team transfers two-cell-stage embryos to pseudo-pregnant recipient mice the following day (~25 embryos per recipient). (fredhutch.org)
  • These mice have deficiencies in their immune systems and thereby prove valuable in the study of immune diseases and cancer. (uwm.edu)
  • Disease-protected strains exhibited a restoration of immune regulatory pathways within the gut which could also be reestablished using IL-2 therapy. (biomedcentral.com)
  • In a study published November 8 in Cell Reports , researchers found that thanks to differences in their vaginal microbiomes compared with lean mice, obese mice fed a high-fat diet had stronger immune responses against HSV-2, which causes genital herpes in humans. (the-scientist.com)
  • In comparing the immune response of lean and obese female mice, the study authors write in the study that they hoped to find out how obesity affects the immune response of the genital mucosa. (the-scientist.com)
  • They then intravaginally infected all of the mice with HSV-2 virus and observed their immune response over the course of three weeks. (the-scientist.com)
  • In their review " Natural and Adaptive Immunity to Cancer ", Vesely and colleagues draw from recent mouse models of cancer and human clinical data to describe how cells, effector molecules, and pathways of the immune system act to suppress and control tumor cells. (massgenomics.org)
  • Strains of laboratory mice that are inbred for higher metabolic rates show stronger immune responses to immune challenge with stronger antigen-specific IgM production than strains bred for lower metabolic rates. (cdc.gov)
  • The breeding history of these inbred panels may influence detectable allelic and phenotypic diversity. (ornl.gov)
  • The construction of this population provided a unique opportunity to observe phenotypic variation as new allelic combinations arose through intercrossing and inbreeding to create new stable genetic combinations. (ornl.gov)
  • Processes including inbreeding depression and its impact on allelic and phenotypic diversity were assessed. (ornl.gov)
  • This mouse population segregates millions of variants from eight inbred founders, enabling precision genetic mapping with extensive genotypic and phenotypic diversity. (elifesciences.org)
  • Inbred strains have been extensively used in research. (wikipedia.org)
  • We establish the extent and structure of genotype-by-epigenotype interaction using embryonic stem cells derived from Diversity Outbred mice. (elifesciences.org)
  • High quality reference genomes and annotation are available for seventeen inbred mouse strains. (mousegenomes.org)
  • In 2018, we produced the first draft reference genomes for sixteen inbred strains (described in this paper ). (mousegenomes.org)
  • Whilst these genomes were informative for establishing the extent of non-reference haplotype variation and have very good representation for protein coding genes, we do not recommend using them for NGS analysis due to the lack of representation for common repeat sequences. (mousegenomes.org)
  • Thus outbred strains of most laboratory animals are also available, where an outbred strain is a strain of an organism that is effectively wildtype in nature, where there is as little inbreeding as possible. (wikipedia.org)
  • Certain plants including the genetic model organism Arabidopsis thaliana naturally self-pollinate, which makes it quite easy to create inbred strains in the laboratory (other plants, including important genetic models such as maize require transfer of pollen from one flower to another). (wikipedia.org)
  • lab: PSU-m lab description: Hardison - Penn State University datatype: ChipSeq datatype description: Chromatin IP Sequencing cell: MEL cell organism: mouse cell description: Leukemia (K562 analog) cell sex: U antibody: Pol2-4H8 antibody antibodydescription: Mouse monoclonal to RNA polymerase II CTD repeat YSPTSPS antibody (4H8) - ChIP Grade. (nih.gov)
  • Twenty bacteria (T2D1-T2D20) from stool samples of confirmed T2D subjects were found to be morphologically different and subjected to purification on different media both aerobically and anerobically, which revealed seven bacteria more common among 20 isolates on the basis of biochemical characterization. (bvsalud.org)
  • One type of inbred strain that either has been altered, or naturally mutated so that it is different at a single locus. (wikipedia.org)
  • We provide two-locus correlograms that can be used to detect and correct for non-syntenic association and to reduce error rates in QTL mapping studies that exploit RI strains. (nervenet.org)
  • Human alcoholism studies of genes identified through mouse quantitative trait locus analysis. (colorado.edu)
  • Here, we describe the induction of different subcutaneous tumor models in mice, in particular xenograft and syngeneic that can be used as experimental tumor models. (bvsalud.org)
  • To our knowledge, this is the first study using selected human GM transplantation via culture based method coupled dietary modulation in mice for in vivo establishment of inflammation leading to T2D and gut dysbiosis. (bvsalud.org)
  • Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)
  • Since its inception, the partially inbred CC has been characterized for physiological, morphological, and behavioral traits. (ornl.gov)
  • Recombinant inbred (RI) strains of mice are an important resource used to map and analyze complex traits. (nervenet.org)
  • We used upstream stimulatory factor 1 (USF1) knock-out mice as a genetic model of constitutively activated BAT and positive cardiometabolic traits, and we found a reduction of depression-like and anxiety-like behaviours associated with USF1 deficiency. (researchsquare.com)
  • DO mice have profound trait differences between individual mice, providing a powerful genetic mapping platform to identify associations between the traits and specific genomic regions. (jax.org)
  • The CC, DO and founder mice as well as associated analysis tools will greatly improve mouse-based research into complex traits and disease and complement human genetic analyses. (jax.org)
  • As the authors conclude, "These diversity mice can be used to dissect complex traits at multiple levels by establishing heritability, identifying coregulation with other traits, finding interesting model strains, and making mechanistic genetic insights. (jax.org)
  • The aim of this study was to evaluate cognitive impairment in a mouse model of AD-associated amyloidosis. (abainternational.org)
  • Potential factors contributing to lack of impairment in DMTP/3CSRT performance in the APPswe/PS1dE9 double mouse model of AD-associated amyloidosis will be discussed. (abainternational.org)
  • Asbestos induced mesothelioma mouse model in which expression of the Simian Virus 40 large T antigen (SV40 TAg) is controlled by mesothelin tissue‑specific promoter. (ncard.org.au)
  • The aging CB6F1 mouse would be a potential model to study the relationship between changes in brain morphometry and cognitive impairment and the identification of possible therapeutic targets. (antpublisher.com)
  • Variance in germ-line response to radiation among individuals has been widely recognized, but it is difficult to address due to the use of inbred strains and the limited number of offspring that can be produced by a pair of mice, the common model used to study genetic effects of radiation. (uky.edu)
  • Herein is the first study to examine individual family responses to ionizing radiation using a parent-pedigree approach in an outbred strain of a vertebrate model, the Japanese medaka fish. (uky.edu)
  • In conclusion, this study provides critical insight into how genetically different mice react to different levels of HDI-IC exposure and further shows that the use of the genetically diverse mouse model is required to investigate the mechanism and risk of skin sensitization and development of DA due to diisocyanate exposure. (cdc.gov)
  • Notes: Frequencies are based on 392 mice from 21 inbred strains on 15 tests (Table 1). (jax.org)
  • Bacterial strains including Bacteroides gallinarum (MT152630), Ruminococcus bromii (MT152631), Lactobacillus acidophilus (MT152632), Parabacteroides gordonii (MT152633), Prevotella copri (MT152634) and Lactobacillus gasseri (MT152635) were isolated from mice treated with GM+modified diet (HFD/CD) compared to strains Akkermansia muciniphila (MT152625), Bacteriodes sp. (bvsalud.org)
  • Susceptible A/J mice showed significantly higher bacterial burden higher cytokines and chemokines levels but lower leukocyte recruitment particularly neutrophils when compared to C3H/HeOuJ resistant mice. (healthdisparitiesks.org)
  • In this study, we compiled the complete mtDNA sequences of 52 mouse CIS. (uni-luebeck.de)
  • Learn the basic naming conventions you need to communicate clearly and accurately about inbred and hybrid mice. (jax.org)
  • However, we were able to detect low levels of sensitization using biomarkers of allergy and asthma in lung fluid and plasma of the exposed CCRILs and inbred mice and to demonstrate inter-strain differences after exposure to HDI-IC. (cdc.gov)
  • We confirmed this finding with CTCF ChIP-seq that revealed strain-specific binding in the inbred founder mice. (elifesciences.org)
  • While infertility and other issues led to a high rate of attrition, approximately 50 CC strains are available today that capture a cross-section of founder contributions. (jax.org)
  • Inbred strains (also called inbred lines, or rarely for animals linear animals) are individuals of a particular species which are nearly identical to each other in genotype due to long inbreeding. (wikipedia.org)
  • Research using inbred (genetically nearly identical) mice has provided countless biological insights and has been vital for medical progress, but translation to clinical application has been difficult and inconsistent. (jax.org)
  • Mouse tumor models are essential in cancer research, especially in elucidating malignancy, developing prevention, diagnosis, and new therapeutic approaches. (bvsalud.org)
  • A lot more than 200 commercially obtainable phylogenetically varied inbred mouse strains which contain plenty of genetic diversity to recognize main variations in response to a particular infection are. (healthdisparitiesks.org)
  • Three international breeding sites began the work to produce hundreds of strains that maximized genetic diversity across strain panels. (jax.org)
  • Low virulence coupled with high diversity has led to the suggestion that bats have evolved mechanisms to control viral replication more effectively than have most mammals and that some attribute common to all bats might also explain the apparent low virulence of viral infections in these animals. (cdc.gov)
  • This sequence, referred to as the A. phagocytophilum human anaplasmosis (AP-ha) signature sequence, differs by 2 bp from the sequence of the 16S rRNA gene of a variant strain, AP-Variant 1. (cdc.gov)
  • Data were collected from studies that were deemed eligible for analysis based on set inclusion criteria, and findings were assessed in relation to strain of mouse, type of injury and organ of investigation. (biomedcentral.com)
  • Nonetheless, inbred mouse strains have limitations, and findings in them often don't translate well to humans or for clinical applications. (jax.org)
  • The existing panel of common inbred strains reflects historical selection biases, and existing recombinant inbred panels have low allelic diversity. (ornl.gov)
  • In this approach, two inbred strains that differ in fibrotic response are crossed and the F1 offspring are either mated together (intercross) or to one of the parental strains (backcross). (biomedcentral.com)
  • CD8 TCR transgenic mouse whose CD8 T cells predominantly recognise the MHC class I (H-2K d ) restricted CL4 epitope of PR8 influenza HA protein. (ncard.org.au)
  • CD4 TCR transgenic mouse whose CD4 T cells predominantly recognise the MHC class II (I‑A d )‑restricted TCR specific for the PR8 influenza HA peptide 126-138 (HNTngvtaacshe) ( PMID: 7889402 ). (ncard.org.au)
  • Old CB6F1 male mice (30 months of age) had severe cognitive impairment, while it was virtually absent in young (6 months old) male mice. (antpublisher.com)
  • Some inbred strains have been bred for over 150 generations, leaving individuals in the population to be isogenic in nature. (wikipedia.org)
  • Inbred strains are the result of at least 20 generations of brother-sister mating. (uwm.edu)
  • A hybrid between two inbred strains can be used to cancel out deleterious recessive genes resulting in an increase in the mentioned areas. (wikipedia.org)
  • Two strains may be bred together to produce a mixture of the genes of each strain. (uwm.edu)
  • Xlr genes are the mouse orthologues of the human FAM9 gene family and are implicated in the regulation of dendritic branching, dendritic spine number and morphology. (researchsquare.com)
  • Recently, RI strains have also been used to map QTLs that that are responsible for biometric variation in the architecture of the mouse CNS (Belknap et al. (nervenet.org)