Common beta chain cytokine receptor common beta subunit. Medical search. Frequent questions

Brines has proposed that Belinostat Epo mediates its neuroprotective effects via a heterodimeric EpoR made up of one EpoR and one common beta chain which is similar to the signal-transducing subunit shared by granulocyte-macrophage colony stimulating factor interleukin- 3 and interleukin-5 receptors (28). (bibf1120.com)
The 3D7 antibody reacts with CD131, the 120 kD common β chain (βc) which is shared with the receptor complexes for human granulocyte-macrophage colony stimulating factor (GM-CSFR), interleukin-3 (IL-3R) and interleukin-5 (IL-5R). (bdbiosciences.com)
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. (cusabio.com)

The functions of APOE co-expressed genes were mainly enriched in adaptive immune response, protein-lipid complex subunit organization, actin cytoskeleton reorganization, cell chemotaxis, protein activation cascade and transcriptional misregulation in cancer. (jcancer.org)
Belinostat models of hypoxia-ischemia it decreases neuronal and oligodendrocyte death and promotes neurogenesis angiogenesis and oligodendrogenesis (16 17 21 EpoR has a 66kDa protein component that belongs to the single chain cytokine type I receptor superfamily and confers Epo binding property (22). (bibf1120.com)
A proportion of these will alter protein sequences, the most common of which is the non-synonymous single nucleotide polymorphism (nsSNP). (biomedcentral.com)
The most identifiable category of SNP is the small proportion (less than 1%) that change protein sequence, the most common of which is the non-synonymous SNP. (biomedcentral.com)
The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). (thermofisher.com)
The protein encoded by this gene represents the beta subunit and is a type I membrane protein. (cancer-genetics.org)
Recall that an adhesin is a protein or glycoprotein found on the surface of a pathogen that attaches to receptors on the host cell. (pressbooks.pub)
The subunit produced from OSMR can also pair with a different protein to form the OSM receptor type II. (medlineplus.gov)
OSM receptor type II interacts with a protein called oncostatin M (OSM). (medlineplus.gov)
Intersecting analysis, molecular docking, and pathway validation analysis showed that risperidone influences the adipocytokine signaling pathway by targeting MAPK14 (mitogen-activated protein kinase 14), MAPK8 (mitogen-activated protein kinase 8), and RXRA (retinoic acid receptor RXR-alpha), thereby inhibiting long-chain fatty acid β-oxidation by decreasing STAT3 (signal transducer and activator of transcription 3) expression and phosphorylation. (frontiersin.org)
The protein encoded by this gene is a member of the G-protein-coupled receptor family. (cancerindex.org)
This protein is a receptor for interleukin 8 (IL8). (cancerindex.org)
This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. (cancerindex.org)
events have receptors stimulated with students( GAGs), unregulated chains docking of a inactive actin, all of an been protein respiration cell a considerable subunits. (evakoch.com)
Nuclear Receptors the nuclear receptor family consists of two types of receptors that have similar protein structure. (spiritsong.org)
TRV130 is a potent, selective G protein biased ligand at the mu-opioid receptor. (paintherapeuticsummit.com)
IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. (medchemexpress.com)
IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 328 amino acids (M1-S328) with a fibronectin type-III domain (237-328 a.a). (medchemexpress.com)
IL-12 beta Protein, Human (I23-S328) is produced in HEK293 cells with tag free. (medchemexpress.com)
IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT [3] . (medchemexpress.com)
IL-12 beta Protein consists of 328 amino acids (M1-S328) with a fibronectin type-III domain (237-328 a.a). (medchemexpress.com)
IL-12 beta Protein, as known as IL12 p40 subunit or IL-12B, heterodimerizes with the IL-12 p35 subunit (IL-12A) to form IL-12 and with the IL23 p19 subunit to form IL-23, exerting different regulating functions [1] . (medchemexpress.com)

A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)
FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE. (thermofisher.com)
Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. (thermofisher.com)
[7] Each type I IFN ligand contains a "hotspot", or a sequence of conserved amino acids that are involved in binding to the receptor, specifically the high affinity receptor IFNAR2, which determines the affinity of each ligand for the receptor. (wikidoc.org)

or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)

The alpha subunit of the IL3 receptor binds IL 3 with low affinity. (reactome.org)
The 75 kDa IL-2 R beta, which is also a component of the IL-15 receptor, binds IL-2 with intermediate affinity. (rndsystems.com)
In chain DEFB1 is also induce N-terminal print but binds a blueprint of SNPs( Hollox et al. (erik-mill.de)
VLDL binds undergo defined by cell reaction microdomains and created in receptors been nationally. (erik-mill.de)
The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. (wikidoc.org)

A proinflammatory cytokine produced primarily by T-LYMPHOCYTES or their precursors. (edu.au)
We investigated whether expression of non-selective cation channels of the transient receptor potential canonical (TRPC) channel family are associated with proinflammatory cytokines in monocytes. (shengsci.com)
In various proinflammatory cytokine-stimulated cells, ligand-receptor interactions initially activate TAK1. (xiahepublishing.com)

Members of the common beta-chain family signal through heterodimeric receptor complexes that contain the common beta-chain subunit, while members of the common gamma-chain family signal through heterodimeric or heterotrimeric receptor complexes that contain the common gamma-chain subunit. (rndsystems.com)
Members of the IL-10 family cytokines have structural similarities and signal through heterodimeric receptor complexes with common subunits. (rndsystems.com)
Besides IL-2, the gamma chain has been shown to be a component of the functional receptor complexes for IL-4, IL-7, IL-9 and IL-15. (novusbio.com)
The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes (5-7). (rndsystems.com)

The receptor, found on pluripotent progenitor cells, induces tyrosine phosphorylation within the cell and promotes proliferation and differentiation within the hematopoietic cell lines. (wikipedia.org)
The four short-chain helix bundle cytokines that signal through class III receptor tyrosine kinases include M-CSF, SCF, Flt-3 Ligand, and IL-34, and are shown in columns four and five of the poster. (rndsystems.com)
The receptors for these cytokines contain extracellular Ig-like domains, similar to the IL-1 R family, but they have cytoplasmic domains with tyrosine kinase activity. (rndsystems.com)
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. (joplink.net)
Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. (joplink.net)
For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. (joplink.net)
This leads to homodimerization and activation of receptor associated tyrosine kinase (Janus Kinase 2). (bibf1120.com)
The beta and gamma subunits possess immunoreceptor tyrosine-based activation motifs (ITAM). (thermofisher.com)
Anterograde IFT remains records from the normal amino along the water to the clear subunits in a polymerase that depends the adhesion was kinesin KIF3 palmitoylation tyrosine and the IFT-B degree branching, while major endoderm frequently to the first shape is on the ability flipped translation residue and the IFT-A site. (evakoch.com)
What are physical characteristics found in all tyrosine kinase receptors? (flashcardmachine.com)
How is the insulin tyrosine kinase receptor unusual? (flashcardmachine.com)
How is a tyrosine kinase receptor activated? (flashcardmachine.com)

The short-chain helical cytokine family includes members of the common gamma-chain and common beta-chain families of cytokines. (rndsystems.com)
Detects human Common gamma Chain/IL‑2 R gamma in direct ELISAs and Western blots. (novusbio.com)
In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse IL-2 R gamma is observed, less than 10% cross-reactivity with recombinant human (rh) IL-2 R beta is observed, and less than 2% cross-reactivity with rhIL-2 R alpha is observed. (novusbio.com)
The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. (novusbio.com)
Although IL-2 R gamma by itself does not bind IL-2 with any appreciable affinity, it is required for IL-2 receptor signaling. (novusbio.com)
It has been proposed that IL-2 R gamma be designated the common gamma chain ( gamma c ). (novusbio.com)
In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. (joplink.net)
The 64 kDa common gamma chain gamma c/IL-2 R gamma, which is shared with the receptors for IL-4, -7, -9, -15, and -21, does not independently interact with IL-2. (rndsystems.com)
Upon ligand binding, signal transduction is performed by both IL-2 R beta and gamma c. (rndsystems.com)
Fc epsilon RI alpha forms a tetrameric complex with one beta and two gamma subunits. (thermofisher.com)
In mammals, enolase molecules are dimers composed of three distinct subunits ,alpha, beta and gamma). (healthcarecoremeasures.com)
The gamma subunit is expressed primarily in neurons, in normal and in neoplastic neuroendocrine cells. (healthcarecoremeasures.com)
However, CD25 associates with CD122 (IL-2 receptor beta chain) and CD132 (common gamma chain) to form the high affinity IL-2 receptor. (thermofisher.com)
IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. (thermofisher.com)
The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. (cancer-genetics.org)

The Periodic Table of Cytokine and Chemokine Families poster includes members of the tumor necrosis factor (TNF) superfamily, and cytokines belonging to the different families of interleukins, interferons, and chemokines. (rndsystems.com)
The final family of interleukins shown in the poster is the IL-17 family cytokines listed in column 10. (rndsystems.com)
Furthermore, IL-21 promotes differential expression of many cytokines including interleukins and chemokines. (intechopen.com)
While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. (lookformedical.com)

Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. (joplink.net)
Mice holding both rearranged receptor genes had been produced by crosses between one targeted mice, and so are known as 17/9 mice. (healthcarecoremeasures.com)
These genes are regulated by a transcriptional factor known as peptide chain release factor 1 (PrfA). (pressbooks.pub)
The OSMR and IL31RA genes provide instructions for making parts (subunits) of the interleukin-31 (IL-31) receptor. (medlineplus.gov)
It is also related to increased adiponectin (APN) expression associated with adipocyte differentiation, as well as the expression of adipogenic genes such as peroxisome proliferator-activated receptor ( PPAR) ( 22 , 23 ). (frontiersin.org)
2 , 3 These NF-κB subunits form various homodimers or heterodimers that bind to κB enhancers of target genes and regulate their transcription. (xiahepublishing.com)

The receptor belongs to the type I cytokine receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CD131) subunit. (wikipedia.org)
Additionally, it is shown whether each cytokine belongs to the beta-trefoil, four helix bundle, or cysteine-knot superfamily and their subfamily designation. (rndsystems.com)
IL-21R is a type-1 cytokine receptor and belongs to the IL-2R and IL-15R family. (intechopen.com)

Disturbances in mitochondrial dynamics may influence many cellular and molecular pathways, as calcium-dependent immune activation, transcription factors phosphorylation, cytokine secretion, organelle transference and even cell death. (frontiersin.org)

Herein, we demonstrate that agonistic ligation of these receptor subunits rapidly induces proteasomal degradation of the betac, but not the Ralpha, cytoplasmic domain, resulting in termination of signal transduction and yielding a truncated betac isoform ligated to the Ralpha subunit. (tamu.edu)
Proteasomal degradation of the betac cytoplasmic domain was also a prerequisite for endocytosis and lysosomal degradation of the ligated receptor subunits. (tamu.edu)
These data provide the first evidence for ligand-dependent proteasomal degradation of the betac cytoplasmic domain, and they establish a novel mechanism for heterotypic desensitization of shared cytokine receptor signaling. (tamu.edu)
Each subunit of IFNAR contains an N-terminal ligand binding domain (with two or four fibronectin type II-like subdomains, for IFNAR2 and IFNAR1, respectively), a transmembrane (TM) domain, and a cytoplasmic domain. (wikidoc.org)

Receptor density is regulated by endocytosis of the cell surface receptor followed by lysosomal degradation (27). (bibf1120.com)

Each domain consists of two antiparallel beta sheets and is folded topologically identically to single fibronectin type III domains from the extracellular matrix proteins tenascin and fibronectin. (embl.de)
All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α receptor ( IFNAR ) that consists of IFNAR1 and IFNAR2 chains. (wikidoc.org)

Recent models of receptor activation suggest a sequential activation that is initiated by the low-affinity interaction of ligand with the alpha chain to form a binary complex. (reactome.org)
The activation of T cells is typically accompanied by inhibitory mechanisms within which the programmed cell death (PD1) receptor stands out. (bvsalud.org)
The dsRNA acts like a trigger for the production of interferon (via Toll Like Receptor 3 ( TLR 3 ) a pattern recognition receptor of the innate immune system which leads to activation of the transcription factor IRF3 and late phase NF kappa Beta). (wikidoc.org)
A common feature of neurodegenerative and neuroinflammatory diseases is the activation of CNS resident cells ( 2 - 4 ). (frontiersin.org)
Activation of Kupffer cells and neutrophils leads to release of inflammatory cytokines and free radicals, which further aggravate liver injury [ 4 , 5 ]. (ijbs.com)
Subjects dosed with TRV130, experienced a dose dependent increase in pupil constriction, a classical effect of mu opioid receptor activation. (paintherapeuticsummit.com)
Ligand binding to either subunit is required for and precedes dimerization and activation of the receptor. (wikidoc.org)

Proteins in this family form homotrimers or in some cases, heterotrimers, and share a common extracellular domain known as the TNF homology domain (THD). (rndsystems.com)
Cytokines in the TNF superfamily bind to oligomeric, type I or type II transmembrane proteins that have multiple extracellular cysteine-rich domains. (rndsystems.com)
Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. (joplink.net)
It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. (lookformedical.com)
In nodular amyloidosis, the amyloids are composed of abnormal versions of proteins called immunoglobulin light chains released from certain blood cells called plasma cells. (medlineplus.gov)
proteins are 6 caused download rarefied receptors that in starts 1, 4A and 103( factor) have carefully cross-presented to obtain certain 1-5, 2-4, 3-6. (erik-mill.de)
The dysplasia receptor connect formed left into 12 processes, 1-12 with orange proteins from each ssDNA. (erik-mill.de)
Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. (medchemexpress.com)

It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action. (lookformedical.com)

When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine, which are responsible for allergy symptoms, are released. (thermofisher.com)
The reason is because many immune-related receptors and molecules are extensively produced by these cells, not only during disease but also during physiological processes ( 3 , 9 ). (frontiersin.org)
receptors of Kv 1-4 dysplasia both residues and stones, not, molecules of Kv 5-12 3-kinase morphological effects. (erik-mill.de)
Risperidone-induced weight gain is associated with a number of factors, including gene polymorphisms ( 12 - 14 ), exercise ( 15 - 17 ), peripheral molecules ( 18 ), and hyperphagia caused by regulating the expression of melanocortin-4 receptor (MC4R), neuropeptide Y (NPY), and agouti-related peptide (AgRP) ( 19 - 21 ). (frontiersin.org)

The gene that codes for this cytokine is switched on in an infected cell, and the interferon synthesized and secreted to surrounding cells. (wikidoc.org)
Furthermore, interferon leads to upregulation of MHC I and therefore to increased presentation of viral peptides to cytotoxic CD8 T cells, as well as to a change in the proteasome (exchange of some beta subunits by b1i, b2i, b5i - then known as the immunoproteasome) which leads to increased production of MHC I compatible peptides. (wikidoc.org)
NMR structure of the interferon-binding ectodomain of the human interferon receptor. (wikidoc.org)

The canonical pathway is activated by signals from various immune-related receptors. (xiahepublishing.com)

Ligands for the class I cytokine receptor family include short-chain and long-chain helical cytokines. (rndsystems.com)
Ligands for the class II cytokine receptor family includes the IL-10 family cytokines, along with the type I, type II, and type III interferons, which are shown in columns three, four, and nine of the poster. (rndsystems.com)
In activating cells, NF-κB signaling is activated through a series of signaling cascades, following the ligation of various cell surface receptors with paired ligands. (xiahepublishing.com)

Within each square, the full name of the cytokine is listed, along with its alternate names, a symbol to signify its structure, and the receptors that it utilizes to activate downstream signaling. (rndsystems.com)
Proteasomal regulation of betac signaling reveals a novel mechanism for cytokine receptor heterotypic desensitization. (tamu.edu)
Moreover, proteasome-dependent termination of signaling induced by one betac-engaging cytokine resulted in cellular desensitization to signal transduction by subsequent stimulation with another betac-engaging cytokine. (tamu.edu)
chain that inhibits cytokine signaling and exacerbates inflammation. (harvard.edu)
Conformational changes in the GM-CSF receptor suggest a molecular mechanism for affinity conversion and receptor signaling. (cusabio.com)
The IL-31 receptor interacts with IL-31, triggering signaling that promotes inflammation and itch (pruritus). (medlineplus.gov)
Fig. 1 Canonical and noncanonical NF-κB signaling pathways in resting vs. receptor-stimulated cells. (xiahepublishing.com)
Furthermore, while differential effects manifest after several days of chronic stimulation, changes to receptor structure, orientation, or stoichiometry have not elucidated the cause for differential signaling via different type I IFN subtypes. (wikidoc.org)

IFNAR is a heteromeric cell surface receptor composed of two subunits, referred to as the low affinity subunit, IFNAR1 , and the high affinity subunit, IFNAR2 . (wikidoc.org)
Type I IFN receptor forms a ternary complex, composed of its two subunits IFNAR1 and IFNAR2, and a type I IFN ligand. (wikidoc.org)
IFNAR1 is the low affinity subunit, originally cloned in 1990, and is composed of four fibronectin type II-like (FNII-like) subdomains, termed SD1-4. (wikidoc.org)

Binding of this dimer to the common beta subunit (Bc) confers high affinity binding. (reactome.org)

Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. (cancer-genetics.org)

Moving to the right, the next eight families shown in the poster belong to the four-helix bundle cytokine superfamily. (rndsystems.com)
This superfamily is further subdivided into the class I and class II cytokine receptor families. (rndsystems.com)
These cytokines belong to the cysteine-knot superfamily and bind to members of the IL-17 receptor family. (rndsystems.com)

The gene for the alpha subunit is 40 kilobases long and has 12 exons. (wikipedia.org)
The receptors for these three cytokines consist of a cytokine-specific alpha (Ralpha) chain and a shared common beta (betac) chain. (tamu.edu)
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). (edu.au)
Interleukin-5 Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Several isoforms of the interleukin-5 receptor alpha subunit exist due to multiple ALTERNATIVE SPLICING. (harvard.edu)
This graph shows the total number of publications written about "Interleukin-5 Receptor alpha Subunit" by people in Harvard Catalyst Profiles by year, and whether "Interleukin-5 Receptor alpha Subunit" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Interleukin-5 Receptor alpha Subunit" by people in Profiles. (harvard.edu)
Description: The MAR-1 monoclonal antibody reacts with the Fc epsilon Receptor I alpha subunit, an IgE-binding subunit lacking signal-transducing ability. (thermofisher.com)
Fc epsilonR1 alpha is a tetrameric complex consisting of one alpha, one ß and two additional subunits. (thermofisher.com)
The alpha subunit is expressed in most tissues and the beta subunit only in muscle. (healthcarecoremeasures.com)
Description: The BC96 monoclonal antibody reacts with human CD25, the 55 kDa interleukin-2 receptor alpha chain (IL-2Ralpha). (thermofisher.com)
CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. (thermofisher.com)
Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. (thermofisher.com)
The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. (cancer-genetics.org)
subsequent specific chain bicarbonate( PPAR-alpha) regulates the odorant one-particle of spontaneous molecular enzyme in the transfer. (evakoch.com)

Are receptors always on the plasma membrane? (flashcardmachine.com)

The long-chain helical cytokine family includes the IL-6 family cytokines, G-CSF, erythropoietin, thrombopoietin, growth hormone, prolactin, and leptin, which are shown in columns five through eight of the poster. (rndsystems.com)

The interleukin-3 receptor (CD123) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system. (wikipedia.org)
The common growth SLC35C1 takes the damaged signal FUCT1. (evakoch.com)
What are the six general types of signal transducer receptors? (flashcardmachine.com)

This receptor mediates neutrophil migration to sites of inflammation. (cancerindex.org)

The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes. (wikipedia.org)
This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. (cancerindex.org)

Polypeptide chains, consisting of 211 to 217 amino acid residues and having a molecular weight of approximately 22 kDa. (lookformedical.com)

Two Ig light chains and two Ig heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) make one immunoglobulin molecule. (lookformedical.com)

Interferons belong to the large class of glycoproteins known as cytokines . (wikidoc.org)

These cytokines primarily have anti-viral, anti-proliferative, and immunoregulatory effects. (rndsystems.com)
Multiple sclerosis is a common, chronic demyelinating neurological disease primarily affecting young adults, with a prevalence of ~0.1% in the Caucasian population (Miller and Leary, 2007). (medscape.com)

Fibronectin type-III (FN3) repeats are both the largest and the most common of the fibronectin subdomains. (embl.de)
Structural analysis of type I IFN receptor with different type I IFN ligand subtypes revealed a similar binding site for the different agonists. (wikidoc.org)
[8] The evolutionary conservation of type I IFN subtypes binding the same IFNAR receptor at the same site with differing affinities suggests that type I IFNs are nonredundant and potentially regulate different cellular responses. (wikidoc.org)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)

IL-5, IL-3, and GM-CSF are hematopoietic cytokines that are key mediators of the allergic inflammatory response. (tamu.edu)

Organisms1

Diseases2

Chemicals and Drugs16

Information Science1

Granulocyte-macrop3

Protein22

Affinity receptor4

Antigen1

Binds5

Proinflammatory3

Complexes4

Tyrosine12

Gamma15

Interleukins4

Genes6

Belongs3

Phosphorylation1

Cytoplasmic domain4

Lysosomal degradation1

Consists2

Activation7

Proteins8

Monocytes1

Molecules4

Interferon3

Pathway1

Ligands3

Signaling8

IFNAR13

Confers1

Endocytosis1

Superfamily3

Alpha15

Plasma membrane1

Erythropoietin1

Signal3

Inflammation1

Gene2

Residues1

IMMUNOGLOBULIN HEAVY1

Glycoproteins1

Primarily2

Type4

Mediators1